Gel filler capable of promoting regeneration of collagen as well as preparation method and application of gel filler
By mixing polycaprolactone microspheres, cross-linked sodium hyaluronate and polynucleotides in a specific proportion, the gel filler formed solves the problems of uneven collagen regeneration and inflammatory response in the existing technology, achieves uniform regeneration and continuous filling effect of collagen, makes facial expressions natural, and avoids the window period.
Patent Information
- Application Number
- CN202510708779.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-05-29
- Publication Date
- 2025-09-26
- Estimated Expiration
- 2045-05-29
AI Technical Summary
Existing polycaprolactone fillers are prone to cause inflammatory reactions after subcutaneous injection, and collagen regeneration is uneven, leading to problems such as facial stiffness, keloids and wrinkles. There is also a window period between the immediate filling effect and the production of new collagen.
By mixing polycaprolactone microspheres, cross-linked sodium hyaluronate, polynucleotides and water-soluble amino acids in a specific proportion, a uniform gel filler is formed. The three-dimensional scaffold structure of the polynucleotides and the supporting effect of the cross-linked sodium hyaluronate are utilized to promote collagen regeneration and regulate the ratio of type I and type III collagen.
It achieves uniformity and continuity of collagen regeneration, reduces inflammatory response, makes facial expressions natural, avoids the window period, provides immediate and continuous filling effects, and reduces the number of injections.