Composition for treating chronic kidney disease as well as preparation method and application thereof

By improving the preparation methods of traditional Chinese medicine, including pulverizing leeches and silkworm pupae, ethanol extraction, microbial fermentation, and β-cyclodextrin encapsulation, the problems of stability and loss of effective ingredients in Shenshui Pill were solved, achieving higher therapeutic effects and stability.

CN120837554AActive Publication Date: 2025-10-28XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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Patent Information

Application Number
CN202511369439.6
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-09-24
Publication Date
2025-10-28
Estimated Expiration
2045-09-24

AI Technical Summary

Technical Problem

Existing methods of preparing traditional Chinese medicine result in poor stability of Shenshui Pills, especially due to their high hygroscopicity, which leads to the loss of effective drug components and limited therapeutic effects.

Method used

Leeches and silkworms were pulverized, concentrated, and precipitated. Then, ethanol extraction of rhubarb and astragalus was performed. Bacillus subtilis and Aspergillus oryzae were added for fermentation. Finally, β-cyclodextrin was added for inclusion complexation to improve the dissolution and stability of the active ingredients.

Benefits of technology

It significantly improved the stability of the composition and the dissolution of the active ingredient, enhanced the efficacy of treating chronic kidney disease, and improved patient compliance.

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Abstract

The invention provides a composition for treating chronic kidney diseases and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine compositions. In the preparation process, firstly, leech and stiff silkworm are crushed, so that effective components can be better dissolved out; secondly, the traditional Chinese medicine powder is fermented by adopting mixed strains, so that effective components are better separated out, the medicine effect is improved, and the treatment effect on patients is remarkably improved; beta-cyclodextrin is added in the preparation process of the composition, and the effective components of the medicine can be clathrated by adding the beta-cyclodextrin, so that the stability of the medicine is improved, the taste is covered, and the compliance of a patient is improved.
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