Process for efficiently producing gallic acid under catalysis of alkali metal salt

By using an alkali metal salt catalytic process, copper hydroxide is used to catalyze the reaction of DHS fermentation broth under alkaline conditions through heating and stirring. This solves the problem of incomplete conversion of DHS to gallic acid, achieving efficient and low-cost gallic acid production suitable for industrial-scale production.

CN120864973APending Publication Date: 2025-10-31SHANGHAI ARTIFIENZYME BIOTECH CO LTD +2
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Patent Information

Application Number
CN202510959329.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-07-11
Publication Date
2025-10-31

AI Technical Summary

Technical Problem

Existing technologies have incomplete conversion rates from 3-dehydroshikimic acid (DHS) to gallic acid, resulting in problems such as byproduct generation, enzyme activity being affected by environmental conditions, high costs, significant environmental impact, difficulties in large-scale production, and low product purity.

Method used

An alkali metal salt catalytic process was adopted, using copper hydroxide to catalyze the DHS fermentation broth. The reaction was carried out under alkaline conditions with heating and stirring, and the pH value was controlled to directly convert DHS into gallic acid in one step. The purity of the supernatant was ensured by large-capacity refrigerated centrifugation and ultrafiltration membrane treatment.

Benefits of technology

It achieves 100% conversion of DHS to gallic acid with a yield of over 90%, and shortens the catalytic time to within 2 hours, meeting the needs of industrial production and reducing costs and environmental impact.

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Abstract

The invention discloses a process for efficiently producing gallic acid under catalysis of alkali metal salt, which comprises the following specific steps: S1, microorganisms produce DHS (docosahexaenoic acid) by using carbon and nitrogen sources such as glucose and peptone through fermentation, and DHS fermentation liquor is filtered or centrifuged to obtain supernate; s2, adding a copper hydroxide solid into the DHS fermentation supernatant, and stirring for dissolving; s3, adjusting the pH value of the DHS fermentation supernatant with a sodium hydroxide solution; s4, under the heating condition, stirring reaction is conducted, and the pH value is controlled in the process. According to the method, DHS is rapidly and thoroughly converted into gallic acid under the alkaline condition by means of catalysis of copper hydroxide, the conversion rate can reach 100%, the catalysis time can be shortened to be within 2 hours, the yield reaches 90% or above, and the production purpose of efficient catalysis is achieved. Therefore, the process for directly converting DHS into gallic acid in one step has the advantages of high yield, low cost, short time consumption and the like, and can meet the requirements of industrial production.
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