Space omics bar code marking system based on fine tuning platform and application thereof

By using a spatial omics barcode labeling system based on a fine-tuning platform, the problems of high resolution and multi-omics compatibility were solved, enabling the capture of omics information at the single-cell level and in large-area tissue samples, and supporting compatible labeling of transcriptome and epigenome.

CN120924384APending Publication Date: 2025-11-11GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH CHINESE ACADEMY OF SCIENCES +1
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Patent Information

Application Number
CN202511095561.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-08-06
Publication Date
2025-11-11

AI Technical Summary

Technical Problem

Existing space omics technologies suffer from a conflict between high resolution and multi-omics compatibility. The limitations of microfluidic structures prevent resolutions from reaching below 10 μm, and their tissue generalization is low, making it difficult to achieve multi-omics compatible space omics labeling.

Method used

A spatial omics barcode labeling system based on a fine-tuning platform is adopted. Through the design of the fine-tuning platform and baffle, DNA barcodes are directly delivered to the surface of tissue slides, realizing fine movement of tissue slides and multi-omics compatibility. Gradual labeling is performed by the relative movement of the platform and the baffle, avoiding the limitations of microchannels.

Benefits of technology

It achieves omics information capture at single-cell level resolution and for large-area tissue samples, while supporting transcriptomics and epigenomic compatibility, thus improving spatial resolution and multi-omics compatibility.

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Abstract

The invention relates to a space omics bar code marking system based on a fine tuning platform and application thereof, and belongs to the technical field of space omics. According to the novel space omics bar code marking system designed by the invention, based on the design of the fine adjustment platform and the baffle plate, the tissue slice can move in a micrometer scale relative to the baffle plate and is marked round by round, the system does not depend on a space microarray or a micro-channel, and a DNA bar code carrying a space information sequence can be directly delivered to the surface of the tissue slice. The single cell level resolution can be achieved, bar code connection and omics information capture can be conducted on tissue samples with large areas, and meanwhile compatibility of transcriptomics and epigenomics can be achieved.
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