Mouse model for advanced high metastatic renal clear cell carcinoma, mouse model for radical operation of renal clear cell carcinoma and construction method of mouse model
By implanting Renca cells into a mouse model and performing subcapsular suturing and radical surgery, a model of advanced, highly metastatic, and post-radical renal clear cell carcinoma was constructed. This solves the problem of the lack of corresponding models in existing technologies, provides an effective drug screening platform, and improves the feasibility of treatment.
Patent Information
- Application Number
- CN202410615410.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-05-17
- Publication Date
- 2025-11-18
AI Technical Summary
The lack of successful animal models of metastasis and mouse models of radical renal cell carcinoma surgery in the current technology makes the treatment of advanced and metastatic renal cell carcinoma difficult, especially the urgent need for treatment of highly metastatic advanced renal cell carcinoma.
Renca cells were implanted under the renal capsule of mice, the wound was sutured and the mice were fed. Tumor cell colonization was detected by in vivo imaging to construct a mouse model of advanced highly metastatic clear cell renal carcinoma. Radical nephrectomy was then performed to construct a mouse model of radical renal carcinoma.
The study successfully simulated the development stages of advanced highly metastatic clear cell renal cell carcinoma and the metastatic stage after radical resection, providing an effective model for screening therapeutic drugs and improving the success rate and safety assessment of drug screening.