Process for the preparation of diglyceride oils with improved high thrombotic efficacy by enzymatic hydrolysis and products and uses thereof

By employing a two-stage enzymatic hydrolysis and molecular distillation process, combined with the use and combination of specific enzymes, a highly effective diglyceride oil for improving high blood thrombosis was prepared. This solved the problems of low purity and yield of diglyceride oil in existing technologies, achieving significant thrombolytic effects and increased blood flow velocity.

CN120966924BActive Publication Date: 2026-05-01INNER MONGOLIA MENGQI PHARM CO LTD +1
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Patent Information

Application Number
CN202511512684.8
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-10-22
Publication Date
2026-05-01
Estimated Expiration
2045-10-22

AI Technical Summary

Technical Problem

Existing enzymatic methods for preparing diglyceride oil have low purity and yield, and have failed to effectively improve thrombotic efficacy. The synergistic effect of enzyme type and ratio on thrombolysis has not been fully utilized.

Method used

By employing two enzymatic hydrolysis and two molecular distillation processes, using a complex lipase and a glycerol lipase with specific components, and controlling the types and ratios of enzymes, combined with a gradient temperature molecular distillation process, low erucic acid rapeseed diester oil and corn diester oil are prepared. These are then mixed with Acer truncatum seed oil and peanut oil to form a diglyceride oil with the effect of improving high blood clots.

Benefits of technology

It significantly improved the yield and activity of diglyceride oil, enhanced the thrombolytic opening rate and blood flow velocity in arteries/veins, and had a significant ameliorative effect on hyperthrombosis.

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Abstract

The application provides a method for preparing diglyceride oil with improved high thrombus efficacy by enzymolysis, and products and applications thereof, and relates to the technical field of enzymatic processing. Low rapeseed diester oil and corn diester oil in the diglyceride oil are obtained by twice enzymolysis and twice molecular distillation, and the enzymes used in the twice enzymolysis include lipase and partial glyceride lipase; the lipase is a composite lipase of three enzymes, and the mass ratio of the composite lipase to the partial glyceride lipase is 1:2-4.5; the low rapeseed diester oil, the corn diester oil, the maple seed oil and the peanut oil are mixed to obtain the diglyceride oil. The preparation method improves the yield and activity of the diglyceride oil; and the obtained diglyceride oil has the effect of significantly improving blood flow speed and has good improvement effect on high thrombus.
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