Ten-peptide with antioxidant activity
By synthesizing and detecting a decapeptide with the amino acid sequence APKTLPWGPK, the problem of antioxidants in the prevention and treatment of oxidative stress diseases in the existing technology has been solved, achieving a highly efficient antioxidant effect and applying it to the development of antioxidants.
Patent Information
- Application Number
- CN202511202706.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-08-22
- Publication Date
- 2025-12-19
AI Technical Summary
In the current technology, the development of antioxidants has not effectively solved the prevention and treatment of oxidative stress-related diseases, especially the prevention and treatment of chronic diseases such as Alzheimer's disease, hypertension and Parkinson's syndrome caused by the imbalance between ROS production and clearance.
A decapeptide with the amino acid sequence APKTLPWGPK was developed. It was synthesized using a peptide synthesizer and analyzed by HPLC and mass spectrometry to ensure purity and molecular weight. Its antioxidant activity was determined using ABTS free radical scavenging ability, with an IC50 value of 11.06 μg/mL, indicating that it has high antioxidant performance.
This decapeptide can effectively scavenge excess reactive oxygen species, reduce oxidative stress damage, and has significant antioxidant activity, making it suitable for the prevention and treatment of oxidative stress-related diseases.