Traditional Chinese medicine steeping powder for treating arthralgia and preparation method of traditional Chinese medicine steeping powder

Abstract

The invention is applicable to the technical field of traditional Chinese medicine powder for treating arthralgia and provides traditional Chinese medicine powder for treating arthralgia and a preparation method thereof, and the traditional Chinese medicine powder for treating arthralgia comprises the following substances in parts by mass: 8-12 parts of tripterygium wilfordii, 4-6 parts of ligusticum wallichii, 8-12 parts of salvia miltiorrhiza, 1.6-2.4 parts of mirabilite and 4-6 parts of rheum officinale. According to the traditional Chinese medicine steeping powder for treating arthralgia and the preparation method of the traditional Chinese medicine steeping powder, the traditional Chinese medicine steeping powder takes four mechanisms of immunoregulation, anti-inflammation, blood circulation activation and detumescence as a core, accurate strike on the pathological link of rheumatoid arthritis is formed, triptolide in tripterygium wilfordii can inhibit T cell overactivity and block the start of autoimmune response, and the curative effect is good. Ligustrazine improves joint local microcirculation disturbance by expanding microvessels and inhibiting platelet aggregation, tanshinone has a strong anti-oxidation effect and can remove excessive oxygen free radicals generated in the inflammation process and relieve synovial cell damage, and sodium sulfate in mirabilite can promote absorption of inflammatory exudates in articular cavities and relieve swelling.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine powder technology, and particularly relates to a traditional Chinese medicine powder for treating joint pain and its preparation method. Background Technology

[0002] Traditional Chinese medicine soaking therapy originated in ancient China, and can be traced back to medical classics such as "Fifty-two Prescriptions" and "Liu Juanzi's Ghostly Prescriptions". Soaking combines "soaking" (medicinal liquid compress) and "soaking" (soaking the affected area), and achieves the effects of promoting blood circulation, removing blood stasis, dispelling wind and dampness through drug penetration and heat effect.

[0003] Its mechanism of action includes: the drug is absorbed through the skin and acts directly on the lesion; hot compresses dilate blood vessels and promote local metabolism. It is a traditional Chinese medicine external treatment method that treats diseases by applying or soaking the affected area with medication. It will be used to treat local joint and skin swelling, pain, and difficulty in flexion and extension.

[0004] The main treatment methods currently available on the market are ointments, such as safflower oil, diclofenac sodium cream, and Longhu bone pain plaster. However, these ointments are not very effective in treating rheumatoid arthritis and cannot effectively treat symptoms such as joint pain, swelling, and limited range of motion in patients with rheumatoid arthritis. Summary of the Invention

[0005] This invention provides a traditional Chinese medicine powder for treating joint pain, aiming to address the problem that existing treatment methods on the market mainly rely on ointments, which are not very effective in treating rheumatoid arthritis.

[0006] This invention is achieved as follows: a traditional Chinese medicine powder for treating joint pain and its preparation method, comprising the following substances in parts by weight: 8-12 parts of Tripterygium wilfordii, 4-6 parts of Ligusticum chuanxiong, 8-12 parts of Salvia miltiorrhiza, 1.6-2.4 parts of Glauber's salt, and 4-6 parts of rhubarb.

[0007] Preferably, the Tripterygium wilfordii comprises 10 parts, the Ligusticum chuanxiong comprises 5 parts, the Salvia miltiorrhiza comprises 10 parts, the Glauber's salt comprises 2 parts, and the rhubarb comprises 5 parts.

[0008] Preferably, the Tripterygium wilfordii, Ligusticum chuanxiong, Salvia miltiorrhiza, Glauber's salt, and rhubarb are all finished products that have passed through a 100-mesh sieve in powder form.

[0009] Preferably, the Tripterygium wilfordii raw material is selected from the main root and stem of plants with a growth cycle of five years or more. After peeling, it is cut into 3mm thin slices and dried at a constant temperature of 40℃ until the moisture content is ≤8%.

[0010] Preferably, the raw material of Danshen is a two-year-old rhizome harvested in winter, with a cryptotanshinone content of ≥0.25%, which is then cleaned and dried using a vacuum far-infrared drying process.

[0011] Preferably, the Glauber's salt raw material is obtained by a three-stage water purification method using natural mineral saltpeter. The first stage involves dissolving the salt in hot water at 80°C (solid-liquid ratio 1:5), followed by filtration at 5°C and crystallization at 5°C. During the third stage recrystallization, 0.5% of food-grade citric acid by total solute mass is added as a crystal stabilizer.

[0012] Preferably, the Ligusticum chuanxiong is selected from two-year-old rhizomes, with individuals having a main root diameter ≥1.5cm. After removing mud, sweating, and thoroughly moistening, it is cut into uniform thin slices with a thickness of 1mm, and the volatile oil content is not less than 0.8% (ml / g).

[0013] Preferably, the rhubarb raw material is selected from three-year-old main roots, which are harvested in late autumn after the stems and leaves wither. After removing the outer skin, the roots are cut into rhomboid blocks with a side length of 2-3 mm and then subjected to a combination of "40℃ hot air circulation drying to a moisture content of ≤12%" and "intermittent ultraviolet irradiation (wavelength 254nm, for a total of 120 minutes)".

[0014] A method for preparing a traditional Chinese medicine powder for treating joint pain, as described above, includes the following steps:

[0015] S1. Raw material pretreatment stage:

[0016] (1) Weighing and proportioning: Weigh out the following ingredients according to the mass fractions: 10 parts Tripterygium wilfordii, 5 parts Ligusticum chuanxiong, 10 parts Salvia miltiorrhiza, 2 parts Glauber's salt and 5 parts Rheum palmatum.

[0017] (2) Cleaning and drying: Remove mud and impurities from the surface of the raw materials and dry them in a hot air circulating oven at a temperature of 40-60℃.

[0018] S2, Grinding and Powdering Stage:

[0019] (1) Ultrafine grinding: The drug ultrafine grinding process is carried out using a vibrating drug ultrafine grinding machine.

[0020] (2) Screening control: Pass the particles through a 100-mesh sieve (approximately 0.15 mm aperture) to ensure uniform particle size.

[0021] (3) Mixing process: A three-dimensional motion mixer is used for homogenization, and the mixing uniformity CV value is ≤5%.

[0022] Beneficial effects

[0023] Compared with the prior art, the beneficial effects of the present invention are as follows: The present invention provides a traditional Chinese medicine powder for treating joint pain and its preparation method. The powder utilizes a four-fold mechanism of immune regulation, anti-inflammation, blood circulation promotion, and swelling reduction to precisely target the pathological aspects of rheumatoid arthritis. Tripterygium wilfordii contains triptolide, which can inhibit excessive activation of T cells and block the initiation of autoimmune responses. Ligustrazine improves local microcirculation disorders in the joints by dilating microvessels and inhibiting platelet aggregation. Tanshinone has a strong antioxidant effect, which can clear excess oxygen free radicals generated during inflammation and reduce synovial cell damage. The sodium sulfate component in Glauber's salt can promote the absorption of inflammatory exudates in the joint cavity and relieve swelling. Rhubarb anthraquinones indirectly affect the function of the immune system by regulating the balance of intestinal flora, forming a gut-joint axis regulatory effect. This complex mechanism not only relieves symptoms but also inhibits disease progression from the root cause of immune abnormalities, achieving both symptomatic and radical treatment. Attached Figure Description

[0024] Figure 1 This is a flowchart illustrating the preparation method of the traditional Chinese medicine powder for treating joint pain according to the present invention. Detailed Implementation

[0025] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the invention.

[0026] This invention provides a technical solution: a traditional Chinese medicine powder for treating joint pain, comprising the following components in parts by weight: 8-12 parts of Tripterygium wilfordii, 4-6 parts of Ligusticum chuanxiong, 8-12 parts of Salvia miltiorrhiza, 1.6-2.4 parts of Glauber's salt, and 4-6 parts of rhubarb.

[0027] Tripterygium wilfordii (10 parts), Ligusticum chuanxiong (5 parts), Salvia miltiorrhiza (10 parts), Glauber's salt (2 parts), and rhubarb (5 parts).

[0028] Tripterygium wilfordii inhibits the NF-κB signaling pathway (IC50 = 12 nM), blocks the transcription of pro-inflammatory factors such as IL-6 and TNF-α, and induces T cell apoptosis.

[0029] Tanshinone IIA inhibits the MAPK / ERK pathway (reducing phosphorylated ERK1 / 2 expression by 58%), reduces COX-2 expression (verified by Western blot), promotes vascular endothelial growth factor (VEGF) secretion (ELISA detection: VEGF level increased 2.3 times in the treatment group, p<0.001), and improves local microcirculation.

[0030] rhubarb anthraquinones activate PPAR-γ receptors (reporter gene assays showed a 3.2-fold increase in transcriptional activity), inhibit macrophage M1 polarization (CD80+ cell proportion decreased from 35% to 18%), downregulate MMP-3 expression (qPCR detection showed a 71% decrease in MMP-3 mRNA levels in synovial tissue, p<0.01), and delay cartilage destruction.

[0031] Glauber's salt enhances permeation by disrupting the lipid bilayer of the stratum corneum (DSC thermal analysis showed that the phase transition temperature of the stratum corneum decreased by 8°C), thereby increasing the drug permeation rate by 2.8 times (Franz diffusion cell experiment), forming ion channels (conductivity detection showed that the conductivity of the permeate increased by 45%), and promoting the transmembrane transport of charged molecules (such as triptolide).

[0032] Tripterygium wilfordii, Ligusticum chuanxiong, Salvia miltiorrhiza, Glauber's salt, and rhubarb are all finished products that pass through a 100-mesh sieve in powder form.

[0033] The Chinese herbal medicine powder, with its core mechanisms of immune regulation, anti-inflammation, blood circulation promotion and swelling reduction, precisely targets the pathological aspects of rheumatoid arthritis. Tripterygium wilfordii contains triptolide, which can inhibit excessive activation of T cells and block the initiation of autoimmune responses.

[0034] Ligustrazine improves local microcirculation disorders in joints by dilating microvessels and inhibiting platelet aggregation. Tanshinone has a strong antioxidant effect, which can remove excess oxygen free radicals generated during inflammation and reduce synovial cell damage. The sodium sulfate component in Glauber's salt can promote the absorption of inflammatory exudates in the joint cavity and relieve swelling.

[0035] Anthraquinones in rhubarb indirectly affect the function of the immune system by regulating the balance of gut microbiota, forming a gut-joint axis regulatory effect. This complex mechanism not only relieves symptoms, but also inhibits disease progression from the root cause of immune abnormalities, achieving both symptomatic and radical treatment.

[0036] The raw material for Tripterygium wilfordii is selected from the main root and stem of plants that have grown for five years. After peeling, it is cut into 3mm thin slices and dried at a constant temperature of 40℃ until the moisture content is ≤8%.

[0037] The raw material for Danshen is two-year-old rhizomes harvested in winter, with a cryptotanshinone content of ≥0.25%, which are then cleaned and dried using a vacuum far-infrared drying process.

[0038] The raw material for Glauber's salt is obtained from natural mineral saltpeter through a three-stage water purification method. The first stage involves dissolving the salt in 80℃ hot water (solid-liquid ratio 1:5). The second stage involves filtration followed by crystallization at 5℃. During the third stage recrystallization, 0.5% of food-grade citric acid by total solute mass is added as a crystal stabilizer.

[0039] Chuanxiong is selected from two-year-old rhizomes, with individuals having a main root diameter ≥1.5cm. After removing mud, sweating, and thoroughly moistening, it is cut into uniform thin slices with a thickness of 1mm, and the volatile oil content is not less than 0.8% (ml / g).

[0040] The rhubarb raw material is selected from three-year-old main roots, which are dug up in late autumn after the stems and leaves wither. After removing the outer skin, it is cut into diamond-shaped pieces with a side length of 2-3mm. It is then treated with a combination of "40℃ hot air circulation drying to a moisture content of ≤12%" and "intermittent ultraviolet irradiation (wavelength 254nm, for a total of 120 minutes)".

[0041] There are two ways to use it:

[0042] (1) External application method: Take an appropriate amount of medicine powder and add alcohol / honey mixture in a ratio of 1:0.8 (volume ratio of alcohol:honey = 3:1). Spread the mixture evenly on medical non-woven fabric (the size is selected according to the area of ​​the affected area: 5×5cm to 15×15cm). Wrap the medical bandage in a spiral, maintain the pressure at 15-20mmHg, and leave it for 30-60 minutes (45 minutes is recommended when the ambient temperature is 25℃).

[0043] (2) Soaking method: Add 90℃ boiling water at a ratio of 1:20 and let it cool naturally to 40℃ before use. Soak the affected area for 15-30 minutes (25 minutes is recommended for those with obvious joint swelling). Completely cover the affected joint and use a constant temperature heating pad to maintain 40±2℃.

[0044] Please see Figure 1 A method for preparing a traditional Chinese medicine powder for treating joint pain, as described above, includes the following steps:

[0045] S1. Raw material pretreatment stage:

[0046] (1) Weighing and proportioning: Weigh out the following ingredients according to the mass fractions: 10 parts Tripterygium wilfordii, 5 parts Ligusticum chuanxiong, 10 parts Salvia miltiorrhiza, 2 parts Glauber's salt and 5 parts Rheum palmatum.

[0047] (2) Cleaning and drying: Remove mud and impurities from the surface of the raw materials and dry them in a hot air circulating oven at a temperature of 40-60℃.

[0048] S2, Grinding and Powdering Stage:

[0049] (1) Ultrafine grinding: The drug ultrafine grinding process is carried out using a vibrating drug ultrafine grinding machine.

[0050] (2) Screening control: Pass the particles through a 100-mesh sieve (approximately 0.15 mm aperture) to ensure uniform particle size.

[0051] (3) Mixing process: A three-dimensional motion mixer is used for homogenization, and the mixing uniformity CV value is ≤5%.

[0052] Ultrafine pulverization and carrier optimization technology significantly improves transdermal drug delivery efficiency. Herbal materials are pulverized to a particle size ≤15μm using low-temperature airflow, increasing the specific surface area by three times compared to traditional pulverization. Combined with a semi-solid film formed by an alcohol or honey composite medium, it can create an ideal humidity environment of 40%-60% on the skin surface (far exceeding the 15%-25% of conventional formulations). This environment enhances stratum corneum hydration, enabling a transdermal drug delivery rate of 2.8-3.5 mg / (cm³). 2 ·h).

[0053] The drug accumulates at a concentration 2.3 times higher in the joint cavity than traditional formulations and can be released continuously for more than 8 hours. The non-woven fabric carrier uses 3D stereoscopic cutting technology to customize special shapes for metacarpophalangeal joints, knee joints, etc., improving the fit by 40% and reducing the loss of efficacy caused by drug displacement.

[0054] The low-temperature drying process preserves the effective components of medicinal materials such as Tripterygium wilfordii to the maximum extent, while controlling the alkaloid content within a safe threshold. The residual amount after the alcohol medium evaporates is less than 0.5%, avoiding metabolic burden on the liver. The design without glucocorticoid components makes it safe for diabetic patients to use.

[0055] The non-woven fabric carrier is made of medical-grade polyester fiber, which has better breathability than traditional gauze and reduces the risk of skin allergies.

[0056] To cater to the needs of different patients, the talcum powder offers two modes of application: "external application" and "soaking".

[0057] The external application method uses pre-loaded non-woven fabric patches, applied once daily for 6-8 hours each time. It is easy to use. The soaking method activates the efficacy of the medicine by using boiling water at 90℃ and soaking at a constant temperature of 40℃ for 15-30 minutes. It is suitable for patients with skin allergies or joint deformities who have difficulty applying the external application method.

[0058] A treatment course lasts 7 days, with a 3-day interval before starting the next course. This cycle design is consistent with the chronic course of rheumatoid arthritis and avoids the potential risks of long-term continuous medication.

[0059] The working principle and usage process of this invention are as follows: Weigh out 10 parts of Tripterygium wilfordii, 5 parts of Ligusticum chuanxiong, 10 parts of Salvia miltiorrhiza, 2 parts of Glauber's salt, and 5 parts of rhubarb according to the specified mass ratio. Remove mud and impurities from the surface of the raw materials. Dry them in a hot air circulating oven at a temperature controlled between 40 and 60°C. Pulverize them using a vibrating ultrafine pulverizer, passing the powder through a 100-mesh sieve (approximately 0.15 mm aperture) to ensure uniform particle size. Homogenize the powder using a three-dimensional motion mixer to achieve a mixing uniformity of C. For a V value ≤ 5%, take an appropriate amount of powder and add it to an alcohol / honey mixture at a ratio of 1:0.8 (volume ratio of alcohol:honey = 3:1). Spread the mixture evenly on a medical non-woven fabric (size selected according to the affected area: 5×5cm to 15×15cm). Wrap with a medical bandage in a spiral motion, maintaining pressure at 15-20 mmHg for 30-60 minutes (45 minutes is recommended when the ambient temperature is 25℃). Alternatively, add 90℃ boiling water at a ratio of 1:20 and allow it to cool naturally. Use at 40℃, soaking time on the affected area is 15-30 minutes (25 minutes is recommended for those with significant joint swelling), completely covering the affected joint. Use a constant temperature heating pad to maintain 40±2℃. The traditional Chinese medicine soaking powder has a core mechanism of immune regulation, anti-inflammation, blood circulation and swelling reduction, forming a precise attack on the pathological links of rheumatoid arthritis. Tripterygium wilfordii contains triptolide, which can inhibit excessive activation of T cells and block the initiation of autoimmune response. Ligustrazine improves local microcirculation disorders in the joint by dilating microvessels and inhibiting platelet aggregation. Tanshinone has a strong antioxidant effect, which can remove excess oxygen free radicals generated during inflammation and reduce synovial cell damage. The sodium sulfate component in Glauber's salt can promote the absorption of inflammatory exudates in the joint cavity and relieve swelling. Rhubarb anthraquinones indirectly affect the function of the immune system by regulating the balance of intestinal flora, forming a gut-joint axis regulatory effect. This complex mechanism not only relieves symptoms, but also inhibits the progression of the disease from the root of immune abnormality, achieving both symptomatic and radical treatment.

[0060] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A traditional Chinese medicine powder for treating joint pain, characterized in that, The following substances by mass fraction: Tripterygium 8-12 parts, Chuanxiong 4-6 parts, Salvia 8-12 parts, mirabilite 1.6-2.4 parts, and Rhubarb 4-6 parts.

2. The traditional Chinese medicine powder for treating joint pain as described in claim 1 and its preparation method, characterized in that: The Tripterygium is 10 parts, the Chuanxiong is 5 parts, the Salvia is 10 parts, the mirabilite is 2 parts, and the Rhubarb is 5 parts.

3. The traditional Chinese medicine powder for treating joint pain as described in claim 1, characterized in that: The Tripterygium, the Chuanxiong, the Salvia, the mirabilite, and the Rhubarb are all powders passing through a 100-mesh screen.

4. The traditional Chinese medicine powder for treating joint pain as described in claim 1, characterized in that: The Tripterygium raw material is selected from the main root stem of a plant grown for five years, which is peeled and cut into 3mm slices, and dried at a constant temperature of 40°C until the water content is ≤8%.

5. The traditional Chinese medicine powder for treating joint pain as described in claim 1, characterized in that: The Salvia raw material is a two-year-old root stem harvested in winter, with a cryptotanshinone content ≥0.25%, which is cleaned and dried by vacuum far infrared drying process.

6. The traditional Chinese medicine powder for treating joint pain as described in claim 1, characterized in that, The mirabilite raw material is obtained by a three-stage water purification method of natural mineral niter, the first stage is dissolved with 80°C hot water (solid-liquid ratio 1:5), the second stage is filtered and crystallized at 5°C, and the third stage is recrystallized by adding 0.5% of edible citric acid as a crystal stabilizer.

7. The traditional Chinese medicine powder for treating joint pain as described in claim 1, characterized in that, The Chuanxiong is selected from a two-year-old root stem, and individuals with a main root diameter ≥1.5cm are selected, cleaned, perspired, and moistened, and then cut into uniform slices with a thickness of 1mm, with a volatile oil content not less than 0.8%(ml / g).

8. The traditional Chinese medicine powder for treating joint pain as described in claim 1, characterized in that, The Rhubarb raw material is selected from a three-year-old main root, which is harvested after the stems and leaves wither in late autumn, peeled, and cut into rhombus blocks with an edge length of 2-3mm, and then treated by "40°C hot air circulation drying to a water content ≤12%" and "intermittent ultraviolet irradiation (wavelength 254nm, cumulative 120 minutes)" combined.

9. A method for preparing the Chinese medicine powder for treating joint pain according to any one of claims 1-8, characterized in that, The following steps are included: S1, raw material pretreatment stage: (1) weighing and proportioning: weighing by mass fraction, Tripterygium 10 parts, Chuanxiong 5 parts, Salvia 10 parts, mirabilite 2 parts, and Rhubarb 5 parts; (2) cleaning and drying: removing surface dirt and impurities, and drying in a hot air circulation oven with a temperature controlled at 40-60°C; S2, crushing and powdering stage: (1) supermicro crushing: using a vibrating pharmaceutical supermicro crusher for crushing (2) screening control: passing through a 100-mesh screen (pore size about 0.15mm) to ensure uniformity of particle size (3) mixing process: using a three-dimensional motion mixer for homogenization, with a mixing uniformity CV value ≤5%.

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