Preparation method of chloro-oxytetracycline additive for feed

Abstract

The invention belongs to a feed additive, and particularly relates to a preparation method of a chloro-oxytetracycline additive for feed, which comprises the following steps: step 1, spore preparation: inoculating preserved strains to a slant culture medium, culturing spores under proper temperature and humidity conditions, adding a proper amount of nutrient substances, and culturing the spores under proper temperature and humidity conditions; the method has the beneficial effects that oxytetracycline is released and impurities are removed through acidification and wall breaking of oxalic acid, the ammonia water promotes crystallization by adjusting the pH value, and the production efficiency and the product quality of oxytetracycline can be remarkably improved through combined use of the oxalic acid and the ammonia water; in addition, wastewater generated by using oxalic acid and ammonia water can be treated through a reasonable wastewater treatment process and recycling measures, so that the influence on the environment can be reduced; when the prepared oxytetracycline is used for producing chloro-oxytetracycline, the method has the advantages of raw material cost control, production process optimization, technical innovation and application, environmental protection, sustainability, market competitive advantage and the like.