Application of total glucosides of paeony in treatment of psoriasis by combining with judiciespecially and calcipotriol
By combining total glucosides of paeony, secukinol, and calcipotriol, the problem of insufficient efficacy of single-target therapy for psoriasis was solved. This approach achieved multi-target synergistic inhibition of the psoriatic inflammatory factor network, improving skin lesion symptoms and reducing disease severity.
CN121287902APending Publication Date: 2026-01-09ZHOUSHAN HOSPITAL
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Patent Information
- Application Number
- CN202511513017.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-10-22
- Publication Date
- 2026-01-09
AI Technical Summary
Technical Problem
Existing single-target therapies for psoriasis have limitations in efficacy and are difficult to fully inhibit complex cytokine networks.
Method used
The combined use of total glucosides of paeony, secukinol, and calcipotriol can inhibit the key inflammatory factor network in psoriasis through multi-target synergistic effects, thereby improving skin lesion symptoms.
Benefits of technology
It significantly reduces disease activity index scores, alleviates the severity of skin lesions, and synergistically inhibits the expression and release of key pro-inflammatory cytokines through multiple targets, thereby controlling the inflammatory response.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention discloses an application of total glucosides of paeony in treatment of psoriasis in combination with Jikukiespecially and calcipotriol, and relates to the technical field of medical treatment, a psoriasis-like mouse model induced by imiquimod is established, and the synergistic treatment effect of a triple therapy of total glucosides of paeony, Jikukiespecially and calcipotriol is verified; the application comprises the step of jointly applying the three medicines according to a specific dosage. The triple therapy can improve erythema, scale and infiltration symptoms of psoriasis-like skin lesion, effectively reduce the area and severity index score of psoriasis, and inhibit the protein and mRNA expression level of key proinflammatory cytokines in skin lesion tissues; compared with a single drug or a combination of two drugs, the triple therapy provided by the invention shows a better treatment effect, and a new and effective drug combination scheme is provided for clinical treatment of psoriasis.
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