Full-protection polypeptide and preparation method thereof

Stable bicyclic peptide compounds were prepared by using peptide cyclization and side chain binding technology, which solved the problem of easy degradation of GHK peptides under physiological conditions, achieved longer-lasting antioxidant and anti-inflammatory effects, and enhanced the expression of type I collagen.

CN121293280APending Publication Date: 2026-01-09HANGZHOU PEPTIDE BIOCHEM +1
0 Cites 0 Cited by

Patent Information

Application Number
CN202511502597.4
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-06-12
Publication Date
2026-01-09

AI Technical Summary

Technical Problem

GHK peptides have a short half-life under physiological conditions and are easily degraded, which affects their sustained function. Furthermore, existing technologies cannot provide peptide compounds with good stability and significant antioxidant and anti-inflammatory effects.

Method used

Using peptide cyclization and side-chain binding technology, a fully protected peptide resin is prepared through solid-phase synthesis. Monocyclic and dicyclic cyclization is then performed to form stable bicyclic peptide compounds, enhancing chemical stability and resistance to enzymatic degradation.

Benefits of technology

It improved the chemical stability and resistance to enzymatic degradation of peptide compounds, prolonged their effective concentration in vivo, enhanced their antioxidant and anti-inflammatory effects, and increased the expression of type I collagen.

✦ Generated by Eureka AI based on patent content.
Patent Text Reader

Abstract

The invention discloses a fully-protected polypeptide and a preparation method thereof, belongs to the technical field of polypeptide compound synthesis, and particularly relates to fully-protected peptide resin prepared through solid-phase synthesis. Carrying out cutting and unitary cyclization on the full-protection peptide resin to obtain unitary cyclic peptide; carrying out binary cyclization treatment on the unitary cyclic peptide to obtain a bicyclic peptide compound Cyclo (His-Cys-Lys-Gly-His-Cys-Lys-Gly-, and bridging a disulfide bond with Cysamp; the binary cyclization comprises cyclization under the action of iodo methanol and ascorbic acid; or the binary cyclization is cyclized in DMSO (Dimethylsulfoxide). The anti-aging and anti-oxidation bicyclic peptide compound prepared by the preparation method disclosed by the invention has the following beneficial effects of low toxicity, good stability, capability of improving I-type collagen expression, good anti-oxidation effect and good anti-inflammatory effect.
Need to check novelty before this filing date? Find Prior Art