Tulobuterol transdermal patch and method for preparing the same

By optimizing the composition and preparation process of tuloterol transdermal patches, the problems of uneven drug crystallization and insufficient adhesion were solved, achieving consistent transdermal effects and product stability, while reducing production costs.

CN121370846BActive Publication Date: 2026-05-01ZHEJIANG HAIGETANG PHARM CO LTD
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Patent Information

Application Number
CN202511978608.6
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-12-25
Publication Date
2026-05-01
Estimated Expiration
2045-12-25

AI Technical Summary

Technical Problem

Existing tuloterol transdermal patches suffer from problems such as uneven drug crystallization, insufficient adhesion, and unstable processes during preparation, which affect efficacy and safety.

Method used

The preparation process is optimized by using pressure-sensitive adhesives, penetration enhancers, tackifiers and stabilizers with specific compositions. This includes selecting acrylic copolymers without functional groups as pressure-sensitive adhesives, using propylene glycol and ethyl oleate as penetration enhancers, adding polyisobutylene as a tackifier, selecting dibutylhydroxytoluene as a stabilizer, and using a bottom plate heating and drying method.

Benefits of technology

This approach achieves consistent transdermal efficacy and improved adhesion of tuloterrol transdermal patches, reduces drug loss, enhances product stability and quality, and lowers production costs.

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Abstract

The present application relates to the technical field of pharmaceutical preparation, and discloses a tulobuterol transdermal patch and a preparation method thereof.The tulobuterol transdermal patch comprises a backing layer, a paste layer and an anti-sticking layer, the paste layer comprises tulobuterol, pressure-sensitive adhesive and a penetration enhancer, the pressure-sensitive adhesive is a copolymer of 2-ethylhexyl acrylate, butyl acrylate, tertiary octyl acrylamide and methyl methacrylate, and the penetration enhancer contains propylene glycol and ethyl oleate.The present application adopts a new pressure-sensitive adhesive matrix, solves the problem that tulobuterol is easy to crystallize out in the patch, and enhances the transdermal effect of tulobuterol by using a penetration enhancer.The present application also discloses a preparation method of the tulobuterol transdermal patch, and the preparation process is improved, so that the loss of tulobuterol in the preparation process is reduced, the quality of the medicine is improved, and the cost is reduced.
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