Three-yang antipyretic prescription and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine, in particular to a three-yang antipyretic prescription and a preparation method thereof.The three-yang antipyretic prescription is prepared from, by weight, gypsum, ephedra, notopterygium roots, semen armeniacae amarae, liquorice, radix bupleuri, scutellaria baicalensis, ginger processed pinellia, cassia twigs, radix paeoniae alba, the root of kudzu vine, smoked plums, blackberry lily, cicada slough and semen cuscutae. The invention aims to treat complex three-yang combined disease hyperpyrexia through a multi-target and multi-layer synergistic effect. Gypsum is used as a monarch drug, ephedra, notopterygium root, radix bupleuri and scutellaria baicalensis are used as ministerial drugs, semen armeniacae amarae, ginger processed pinellia, blackberry lily, cicada slough and kudzu vine root are used as adjuvant drugs, cassia twig, white peony root, semen cuscutae, dark plum and liquorice are used as conductant drugs, and the traditional Chinese medicine composition focuses on Qi heat of Yangming, and aims at the condition that interior heat is heavier, purgation and tonification are combined, and the body resistance is strengthened to eliminate pathogenic factors. The semen cuscutae is creatively added to warm and nourish the liver and the kidney, and the fructus mume is used for astringing phase-fire, so that lower-jiao essence and qi are fixed and protected while sweating and clearing heat, and the deep idea of'interior qi filling 'is embodied.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine, in particular to a three yang fever-reducing prescription and a preparation method thereof. BACKGROUND

[0002] Exogenous high fever belongs to the category of "exogenous febrile disease" in traditional Chinese medicine, and the main symptoms are fever, sore throat, cough, headache, body pain, and thirst, which are commonly seen in acute respiratory infections such as influenza. Modern Chinese medicine emphasizes syndrome differentiation and treatment and six-meridian differentiation and treatment, and has accumulated rich experience in treating exogenous fever in children and adults. At the same time, public health popularization also points out that high fever needs to be treated in time, and if necessary, it should be treated under the guidance of professionals and combined with traditional Chinese medicine external treatment methods to improve the stability and safety of fever reduction. The classical prescription path is to take the cold relieving, resolving Shaoyang, and clearing Yangming as the framework, and the common ideas include Xiaochaihu Decoction (resolving Shaoyang), Baihu Decoction (clearing Yangming), and Gegen Decoction (relieving the muscle and penetrating the surface), and the combined prescription is used in clinical practice to take into account "relieving the exterior and clearing the interior, reducing fever and preventing transmission and change". However, clinical high fever is often accompanied by complex symptoms such as sore throat, cough, thirst, and fatigue, and single target drugs are difficult to improve the overall discomfort simultaneously. At the same time, some cases have repeated fever and abnormal inflammation indicators, indicating the need for more comprehensive intervention of "treating the exterior and the interior, clearing heat and detoxifying, promoting the lung and relieving the throat, and protecting the body fluid and tonifying the body". SUMMARY

[0003] In order to overcome the shortcomings and deficiencies in the prior art, the purpose of the present application is to provide a three yang fever-reducing prescription for treating complex three yang combined high fever and a preparation method thereof.

[0004] The purpose of the present application is achieved by the following technical solutions: A three yang fever-reducing prescription, comprising the following raw materials by weight: Gypsum fibrosum 50-100 parts, Ephedra 5-15 parts, Notopterygium 10-30 parts, Bitter apricot kernel 5-15 parts, Licorice 20-40 parts, Bupleurum 50-70 parts, Scutellaria 10-20 parts, Pinellia 20-40 parts, Cinnamon twig 20-40 parts, White peony root 20-40 parts, Radix Puerariae 50-70 parts, Fructus Mume 10-30 parts, Belamcanda 20-40 parts, Cnidium 10-30 parts, Semen Nelumbinis 10-30 parts.

[0005] The mechanism of action of each raw material of the three yang fever-reducing prescription of the present application is as follows: 1. Gypsum fibrosum: sweet and pungent, extremely cold. It belongs to the lung and stomach meridians. It has the effects of clearing heat and purging fire, and relieving thirst. Gypsum fibrosum is a mineral medicinal material, and its main component is calcium sulfate, which has the effects of clearing heat and anti-inflammatory, and can inhibit the body temperature center during high fever, and has the effect of rapid fever reduction.

[0006] 2. Ephedra: Pungent and slightly bitter in taste, warm in nature. It enters the lung and bladder meridians. It has the effects of inducing sweating and dispelling cold, clearing the lungs and relieving asthma, and promoting diuresis and reducing edema. The main active components of ephedra are alkaloids, flavonoids, and volatile oils, which have pharmacological effects such as antitussive, antiasthmatic, diaphoretic, diuretic, analgesic, anti-allergic, anti-inflammatory, antiviral and antitumor, antioxidant, anticoagulant, immunosuppressive, central nervous system stimulant, antibacterial, antimicrobial, hypoglycemic, and promoting fat synthesis in adipocytes.

[0007] 3. Notopterygium root: Pungent and bitter in taste, warm in nature. It enters the bladder and kidney meridians. It has the effects of relieving exterior syndromes, dispelling cold, eliminating wind and dampness, and relieving pain. Notopterygium root mainly contains volatile oils, coumarins, alkaloids, sugars and glycosides, organic acids and organic acid esters, polyene, amino acids, etc., and has various pharmacological effects such as anti-inflammatory, antipyretic, analgesic, antithrombotic, antibacterial, antiviral, antiarrhythmic, antioxidant, and anti-cancer cell proliferation effects.

[0008] 4. Bitter Almonds: Bitter in taste, slightly warm in nature, and slightly toxic. They enter the lung and large intestine meridians. They have the effects of lowering qi, relieving cough and asthma, and moistening the intestines to promote bowel movements. The main active ingredient in bitter almonds is amygdalin, which has antitussive, antiasthmatic, anti-inflammatory, analgesic, antitumor, anti-fibrotic, immune-regulating, lipid-lowering, and anti-atherosclerotic effects.

[0009] 5. Licorice: Sweet in taste and neutral in nature. It enters the heart, lung, spleen, and stomach meridians. It has the effects of tonifying the spleen and replenishing qi, clearing heat and detoxifying, resolving phlegm and relieving cough, relieving spasms and pain, and harmonizing other medicines. The chemical components of licorice include triterpenoids, flavonoids, coumarins, amino acids, alkaloids, etc., and have a variety of pharmacological effects such as anti-oxidation, anti-inflammation, immunomodulation, anti-ulcer, antiviral, antidepressant, analgesic, hepatoprotective, and anti-atherosclerotic effects.

[0010] 6. Bupleurum: It has a pungent and bitter taste, and is slightly cold in nature. It enters the liver, gallbladder, and lung meridians. It has the effects of dispersing and reducing fever, soothing the liver and relieving depression, and raising yang qi. The main chemical components of Bupleurum include saikosaponins, volatile oils, flavonoids, and polysaccharides, etc., and mainly have anti-inflammatory, antipyretic, immunomodulatory, antibacterial, and antiviral pharmacological effects.

[0011] 7. Scutellaria baicalensis: Bitter in taste and cold in nature. It enters the lung, gallbladder, spleen, large intestine, and small intestine meridians. It has the effects of clearing heat and drying dampness, purging fire and detoxifying, stopping bleeding, and calming the fetus. The main compounds contained in Scutellaria baicalensis include flavonoids, volatile oils, organic acids, and others, which have various pharmacological effects such as antibacterial, antiviral, anti-inflammatory, antioxidant, antitumor, liver protection, immune regulation, and neuroprotection.

[0012] 8. Ginger-processed Pinellia: pungent in flavor and warm in nature. It enters the spleen, stomach, and lung meridians. It has the effects of warming the middle jiao (spleen and stomach), resolving phlegm, and relieving nausea and vomiting. The main components of ginger-processed Pinellia include alkaloids, organic acids, Pinellia polysaccharides, sterols, etc., and it has pharmacological effects such as relieving nausea, cough, and asthma, expectorant, anti-inflammatory, anti-epileptic, and anti-tumor properties.

[0013] 9. Ramulus cinnamomi: bitter, sweet, warm. Heart, lung, bladder meridian. Has the effect of sweat, muscle, warm, help Yang, gas, gas, the role of Pingchong. Ramulus cinnamomi mainly contains phenylpropanoid compounds, also have organic acids, glycosides, tannins, steroids, coumarins and other ingredients, has a wide range of pharmacological effects of regulating body temperature, analgesic, antibacterial, anti-inflammatory, anti-allergic, anti-viral, promote vasodilation, diuretic, sedative, anti-anxiety, anti-tumor, hypotensive.

[0014] 10. Radix paeoniae alba: bitter, sour, slightly cold. Liver, spleen meridian. Has the effect of blood, regulating menstruation, Yin, stop sweating, liver pain, liver Yang. Radix paeoniae alba main effective components of total glucosides, including paeoniflorin, lactone glycosides, hydroxy paeoniflorin, paeoniflorin and paeonol monomer composition, has analgesic, immune regulation, blood lipid regulation, liver function protection and other pharmacological effects.

[0015] 11. Radix puerariae: sweet, bitter, cool. Spleen, stomach, lung meridian. Has the effect of muscle fever, heat, thirst, rash, Yang, diarrhea, meridian, pain, alcohol toxicity. Pueraria main components include flavonoids, triterpenoids, coumarins, saponins and other components, has anti-inflammatory, anti-infection, hypotensive, hypoglycemic, hypolipidemic, improve reproductive function and other pharmacological effects.

[0016] 12. Fructus mume: sour, astringent, flat. Liver, spleen, lung, large intestine meridian. Has the effect of lung, astringent, heat, anemia. Fructus mume main chemical components include organic acids, flavonoids, sterols and other components, has antibacterial, antioxidant, anti-tumor, regulation of intestinal flora and other pharmacological effects.

[0017] 13. Belamcanda chinensis: bitter, cold. Lung meridian. Has the effect of heat, detoxification, phlegm, throat. Belamcanda chinensis contains the main components of iris glycosides and iris flavonoids, can inhibit inflammatory cells and various viruses, play an anti-inflammatory analgesic effect, in addition, Belamcanda chinensis also has cough, asthma, antipyretic, antispasmodic, antioxidant and other pharmacological effects.

[0018] 14. Cicada slough: sweet, cold. Lung, liver meridian. Has the effect of wind, heat, throat, rash, vision, anemia, spasm. Cicada slough chemical components mainly chitin, protein, amino acids, trace elements, has anti-inflammatory, cough, phlegm, asthma, sedation, analgesic, anticonvulsant, anticoagulant and other pharmacological effects.

[0019] 15. Semen cuscutae: bitter, sweet, flat. Liver, kidney, spleen meridian. Has the effect of liver and kidney, solid, urine, anemia, vision, diarrhea. Semen cuscutae chemical components mainly flavonoids, polysaccharides, alkaloids, volatile oils and other components, has immune regulation, improve myocardial ischemia, anti-aging, liver, vision, kidney, astringent and other pharmacological effects.

[0020] Based on the circulation of one body qi, six qi is the manifestation of one qi, the prescription treats the fever of three yang diseases, wind and cold attack, orifice closed, sun not open, from the label to the lung heat, evil qi into the earth, cold and heat knot and change into poison, fill the yangming qi and blood; Among them, the ma xing shi gan decoction opens and closes the heat and relieves the asthma, solves the orifice, lung heat and lung qi stagnation; Gypsum fibrosum is the monarch drug, clearing heat and purging fire, relieving thirst; Ephedra, recorded in Shennong's Herbal Classic, is used for treating wind injury, cold headache, warm evil, and cough and reverse gas, Ben Cao Chong Yuan said that it is "through the whole body of the hair", Professor Lv Ying pointed out in his book "Treatise on Cold One Yuan" that the most fundamental effect of ephedra is to open the orifice; Small bupleurum decoction turns the lesser yang, clears the evil heat, and opens the lesser yang; Pueraria root promotes the yangming earth qi and combines with the sun meridian; Qianghuo assists ephedra to open the orifice and penetrate evil, without too much suspicion; Cassia twig, red peony root and licorice root regulate the yin and yang of the nutrient and defensive systems, and six combinations; Cicada slough, belamcanda chinensis and fishy grass detoxify and disperse, resolve phlegm and soothe the throat; Semen cuscutae warms and nourishes liver and kidney essence, and is not greasy, warm and dry, supports the right and helps to resist evil. Plum astringes the relative fire and opens the lesser yang. The whole prescription is used together, fills the qi, clears the yangming evil toxin, turns the lesser yang, opens the sun orifice, resolves the exterior and clears the interior, supports the right and removes evil, and layers of penetration.

[0021] The present application aims to treat complex three yang combined disease high fever through multi-target and multi-level synergistic effect. Gypsum fibrosum is the monarch drug, ephedra, qianghuo, bupleurum, and radix scutellariae are the ministerial drugs, bitter apricot kernel, pinellia, belamcanda chinensis, cicada slough, pueraria root are the auxiliary drugs, cassia twig, white peony root, semen cuscutae, plum, and licorice are the ministerial drugs, and the emphasis is on clearing the yangming qi and blood, attacking and tonifying, supporting the right and removing evil. Semen cuscutae and plum are added innovatively to warm and nourish liver and kidney, and astringe the relative fire, which embodies the deep thought of "filling the qi" while sweating and clearing heat.

[0022] Fishy grass: pungent, slightly cold. Belongs to lung meridian. It has the effects of clearing heat and resolving toxicity, resolving abscess and pus, and diuresis and relieving stranguria. The main active ingredients are volatile oils, flavonoids, alkaloids, etc., and it has the pharmacological effects of antibacterial, antiviral and enhancing immunity. The three yang fever-reducing prescription of the present application can add 20-40 parts of fishy grass for patients with obvious phlegm heat.

[0023] The three yang fever-reducing prescription of the present application comprises the following raw materials in parts by weight: Gypsum fibrosum 50-70 parts, ephedra 5-15 parts, qianghuo 10-30 parts, bitter apricot kernel 5-15 parts, licorice 20-40 parts, bupleurum 50-70 parts, radix scutellariae 10-20 parts, pinellia 20-40 parts, cassia twig 20-40 parts, white peony root 20-40 parts, pueraria root 50-70 parts, plum 10-30 parts, belamcanda chinensis 20-40 parts, cicada slough 10-30 parts, semen cuscutae 10-30 parts, fishy grass 20-40 parts. Reducing the amount of gypsum fibrosum can avoid excessive cold and cold injury to the stomach.

[0024] For obvious sore throat belongs to upper yangming gas heat, for the patients with this symptom, the present application can further add Coptis, specifically, the three yang fever-reducing formula includes the following weight parts of raw materials: gypsum 50-70 parts, Ephedra 5-15 parts, Notopterygium 10-30 parts, bitter almond 5-15 parts, licorice 20-40 parts, Bupleurum 50-70 parts, Huangqi 10-20 parts, Jiangbanxia 20-40 parts, Cassia twig 20-40 parts, white peony root 20-40 parts, Gegen 50-70 parts, Fructus Mume 10-30 parts, Shegan 20-40 parts, Cynanchi 10-30 parts, Gossypium 10-30 parts, fishy grass 20-40 parts, Coptis 20-40 parts.

[0025] The three yang fever-reducing formula of the present application can further add 10-30 parts of Coptis to increase the potential of reducing deficiency heat, activating blood and dredging collaterals, prevent heat evil from moving blood and consuming blood, which is particularly crucial for patients with high fever, severe or blood heat tendency.

[0026] The three yang fever-reducing formula of the present application can further add 20-30 parts of Rehmannia to enhance the effect of nourishing yin, generating fluid, supporting healthy and eliminating evil, which is particularly suitable for heat disease with yin damage, red tongue, thirst, constipation with fluid damage.

[0027] The three yang fever-reducing formula of the present application can further add 5-15 parts of Schizonepeta and 5-15 parts of Ledebouriella to significantly enhance the surface resolving power, and Schizonepeta and Ledebouriella can help Ephedra and Notopterygium to open skin pores (tiaoli) and disperse wind-cold evil, so as to find an outlet for heat and toxin in the body. The three yang fever-reducing formula of the present application can further add 10-20 parts of Anemarrhena, which has "obvious and lasting antipyretic effect". The combination of the two can make the fever-reducing effect strong and lasting, effectively control high fever, and prevent evil from deepening or heat rebound.

[0028] The three yang fever-reducing formula is a tablet, a decoction, a capsule, a granule, a powder, a pill or an oral agent.

[0029] The three yang fever-reducing formula is a decoction, and the preparation method is as follows: the raw materials are weighed according to the weight parts, 5-10 times the weight of water of the total weight of the raw materials is weighed, gypsum is added to the water and decocted for 20-40 min, and then the remaining raw materials are added and decocted for more than 1 hour to obtain the decoction of the three yang fever-reducing formula.

[0030] The present application has the beneficial effect that: the present application aims to treat complex three yang combined disease high fever through multi-target, multi-level synergistic effect. The gypsum is used as the monarch drug, the Ephedra, Notopterygium, Bupleurum, Scutellaria as the ministerial drug, the bitter apricot kernel, Jiang Rhizoma Pinelliae, Belamcanda, Periostracum Cicadae, Pueraria as the auxiliary drug, and the Cinnamomum, Paeonia, Cuscuta, Prunus mume, Licorice as the servant drug, focusing on the heat of the large clear yangming, aiming at the case of more heat in the interior, and attacking and tonifying, supporting the healthy qi and eliminating the pathogenic factors. The Cuscuta is innovatively added to warm the liver and kidney, and the Prunus mume is added to converge the relative fire, which protects the lower jiao essence while sweating and clearing heat, and embodies the deep thought of "filling the interior with qi". DETAILED DESCRIPTION

[0031] In order to facilitate the understanding of those skilled in the art, the present application will be further described below in conjunction with examples, and the content mentioned in the embodiments is not a limitation on the present application.

[0032] Example 1 The preparation method of the present embodiment is as follows: each raw material is weighed according to the following grams: gypsum 90g, Ephedra 10g, Notopterygium 20g, bitter apricot kernel 10g, licorice 30g, Bupleurum 60g, Scutellaria 20g, Jiang Rhizoma Pinelliae 30g, Cinnamomum 30g, Paeonia 30g, Pueraria 60g, Prunus mume 20g, Belamcanda 30g, Houttuynia cordata 30g, Periostracum Cicadae 20g, Cuscuta 20g; 10 times the weight of water of the total weight of the raw materials is weighed, the gypsum is added to the water and decocted for 30min, and then the remaining raw materials are added for decoction for 2 hours, to obtain the decoction of the three yang fever-reducing prescription.

[0033] Example 2 The preparation method of the present embodiment is as follows: each raw material is weighed according to the following grams: gypsum 50g, Ephedra 5g, Notopterygium 10g, bitter apricot kernel 5g, licorice 20g, Bupleurum 50g, Scutellaria 10g, Jiang Rhizoma Pinelliae 20g, Cinnamomum 20g, Paeonia 20g, Pueraria 50g, Prunus mume 10g, Belamcanda 20g, Periostracum Cicadae 10g, Cuscuta 10g; 5 times the weight of water of the total weight of the raw materials is weighed, the gypsum is added to the water and decocted for 20min, and then the remaining raw materials are added for decoction for 1 hour, to obtain the decoction of the three yang fever-reducing prescription.

[0034] Example 3 The preparation method of the present embodiment is as follows: each raw material is weighed according to the following grams: gypsum 100g, Ephedra 15g, Notopterygium 30g, bitter apricot kernel 15g, licorice 40g, Bupleurum 70g, Scutellaria 20g, Jiang Rhizoma Pinelliae 40g, Cinnamomum 40g, Paeonia 40g, Pueraria 70g, Prunus mume 30g, Belamcanda 40g, Periostracum Cicadae 30g, Cuscuta 30g; 10 times the weight of water of the total weight of the raw materials is weighed, the gypsum is added to the water and decocted for 40min, and then the remaining raw materials are added for decoction for 2 hours, to obtain the decoction of the three yang fever-reducing prescription.

[0035] Example 4 The preparation method of this embodiment is as follows: each raw material is weighed according to the following weight parts: gypsum 80g, Ephedra 10g, Notopterygium 20g, bitter almond 10g, licorice 30g, Bupleurum 60g, Scutellaria 20g, Jiang Tianxia 30g, Cinnamomum 30g, White Peony Root 30g, Radix Puerariae 60g, Fructus Mume 20g, Belamcanda 30g, Houttuynia 30g, Periostracum Cicadae 20g, Semen Trichosanthis 20g, Peony Root 10g, Radix Isatidis 20g; 10 times the weight of water of the total weight of the raw materials is weighed, the gypsum is added to the water and decocted for 30 minutes, then the remaining raw materials are added and decocted for 1 hour, to obtain the decoction of the San Yang fever-reducing prescription.

[0036] Example 5 The preparation method of this embodiment is as follows: each raw material is weighed according to the following weight parts: gypsum 80g, Ephedra 10g, Notopterygium 20g, bitter almond 10g, licorice 30g, Bupleurum 60g, Scutellaria 20g, Jiang Tianxia 30g, Cinnamomum 30g, White Peony Root 30g, Radix Puerariae 60g, Fructus Mume 20g, Belamcanda 30g, Houttuynia 30g, Periostracum Cicadae 20g, Semen Trichosanthis 20g, Peony Root 30g, Radix Isatidis 40g; 10 times the weight of water of the total weight of the raw materials is weighed, the gypsum is added to the water and decocted for 30 minutes, then the remaining raw materials are added and decocted for 1 hour, to obtain the decoction of the San Yang fever-reducing prescription.

[0037] Example 6 The preparation method of this embodiment is as follows: each raw material is weighed according to the following weight parts: gypsum 80g, Ephedra 10g, Notopterygium 20g, bitter almond 10g, licorice 30g, Bupleurum 60g, Scutellaria 20g, Jiang Tianxia 30g, Cinnamomum 30g, White Peony Root 30g, Radix Puerariae 60g, Fructus Mume 20g, Belamcanda 30g, Houttuynia 30g, Periostracum Cicadae 20g, Semen Trichosanthis 20g, Peony Root 10g, Radix Isatidis 20g; 10 times the weight of water of the total weight of the raw materials is weighed, the gypsum is added to the water and decocted for 30 minutes, then the remaining raw materials are added and decocted for 1 hour, to obtain the decoction of the San Yang fever-reducing prescription.

[0038] Example 7 The preparation method of this embodiment is as follows: each raw material is weighed according to the following weight parts: gypsum 80g, Ephedra 10g, Notopterygium 20g, bitter almond 10g, licorice 30g, Bupleurum 60g, Scutellaria 20g, Jiang Tianxia 30g, Cinnamomum 30g, White Peony Root 30g, Radix Puerariae 60g, Fructus Mume 20g, Belamcanda 30g, Houttuynia 30g, Periostracum Cicadae 20g, Semen Trichosanthis 20g, Peony Root 10g, Radix Isatidis 20g; 10 times the weight of water of the total weight of the raw materials is weighed, the gypsum is added to the water and decocted for 30 minutes, then the remaining raw materials are added and decocted for 1 hour, to obtain the decoction of the San Yang fever-reducing prescription.

[0039] Biological experiment 1. Modeling A number of healthy SD rats were taken, and the rectal temperature was measured at a fixed time for 3 days before the experiment to take the average value; individuals with abnormal basal body temperature were excluded. 60 SD rats with normal body temperature were selected, 10 rats in each group, divided into 6 groups, namely the blank group, the model group, the control group, the low-dose experimental group, the medium-dose experimental group and the high-dose experimental group. Except for the blank group, the rest of the groups were established to establish a fever model: 20 μg / kg of LPS was injected intraperitoneally into the mice. One hour later, the rats in the three Yang antipyretic decoction of Example 1 were given gavage, the low-dose experimental group was 10 μl / g, the medium-dose experimental group was 20 μl / g, and the high-dose experimental group was 30 μl / g; the control group was given 1.5 mg / 20 g of acetaminophen; the model group was given 20 μl / g of normal saline. The body temperature was measured every 0.5 h, and the maximum body temperature rise height △T (the difference between the body temperature during fever and the basal body temperature) was recorded for 10 h.

[0040] 2. Results

[0041] Note: compared with the blank group, *P<0.05.

[0042] From the above results, it can be seen that except for the blank group, the body temperature of the rest of the groups increased significantly after intraperitoneal injection of LPS 20 μg / kg, and reached a peak at about 5.0-5.5 h, with a maximum temperature rise of about 0.91-1.21 ℃; thereafter, it slowly fell and was still higher than the baseline at 10 h. The blank group had small fluctuations in body temperature (about 0.06-0.15 ℃), which was consistent with the typical biphasic curve characteristics of acute endotoxin fever. The three Yang antipyretic decoction of the application can resolve exterior and antipyretic, eliminate dampness and detoxify, rapidly reduce body temperature, and compared with acetaminophen (ibuprofen), the high-dose group shows faster fever efficiency.

[0043] II. Clinical Experiment During December 2022, a total of 9 patients with fever were treated, and after taking the three Yang antipyretic decoction of the application, the condition was greatly improved.

[0044] Case 1 Hu, male, 21 years old (born on November 29, 2001), on December 29, 2022, with upper respiratory tract infection, fever, headache, dry cough and sore throat symptoms, the patient took one dose of the three Yang antipyretic decoction a day, divided into 4 times, the patient took it for 2 days, and on December 31, the patient's fever subsided, the headache was relieved, the sore throat was improved, and there was still dry cough.

[0045] Case 2 Luo Moumou, male, 15 years old (born on October 8, 2007), on December 26, 2022, suffered from upper respiratory tract infection with fever, headache, and general malaise. The patient took San Yang Fever Reducing Decoction one dose a day, taken in 4 times. After 3 days of taking the medicine, the patient's fever subsided on December 29, and the headache and general malaise were relieved.

[0046] Case 3 Zhangmou, female, 35 years old (born on June 2, 1987), on December 27, 2022, suffered from upper respiratory tract infection with fever, headache, sore throat, general malaise, and nasal congestion. She took ibuprofen several times but the symptoms did not improve. The patient took San Yang Fever Reducing Decoction one dose a day, taken in 4 times. After 3 days of taking the medicine, the patient's fever subsided on December 30, and the headache, sore throat, and general malaise were relieved.

[0047] Case 4 Husome, female, 38 years old (born on April 9, 1984), on December 24, 2022, suffered from upper respiratory tract infection with fever, chills, sore throat, and muscle soreness. The patient took San Yang Fever Reducing Decoction one dose a day, taken in 4 times. After 4 days of taking the medicine, the patient's fever subsided on December 29, and the sore throat and muscle soreness were relieved.

[0048] Case 5 Yanmou, female, 12 years old (born on January 10, 2010), on December 30, 2022, suffered from upper respiratory tract infection with fever and general malaise. The patient took San Yang Fever Reducing Decoction one dose a day, taken in 4 times. After 1 day of taking the medicine, the patient's fever subsided on December 31, and the general malaise disappeared.

[0049] Case 6 Luo Moumou, female, 35 years old (born on July 19, 1987), on December 28, 2022, suffered from upper respiratory tract infection with fever and sore throat. The patient took San Yang Fever Reducing Decoction one dose a day, taken in 4 times. After 2 days of taking the medicine, the patient's fever subsided on December 30, and the sore throat disappeared.

[0050] Case 7 Lusome, male, 43 years old (born on September 8, 1979), on December 26, 2022, suffered from upper respiratory tract infection with fever and sore throat. The patient took San Yang Fever Reducing Decoction one dose a day, taken in 4 times. After 5 days of taking the medicine, the patient's fever subsided on December 31, and the sore throat disappeared.

[0051] Case 8 Zhang, male, 38 years old (born in 1987 June 29), 2022 December 26, with upper respiratory tract infection, fever, chills symptoms. The patient takes three Yang fever-reducing recipe a day a dose, 4 times a day, the patient takes 2 days later, December 28, the patient's fever subsided.

[0052] Case 9 Yang, female, 34 years old (born in 1988 November 10), 2022 December 24, with upper respiratory tract infection, fever, obvious sore throat, cough and other discomfort. The patient takes three Yang fever-reducing recipe a day a dose, 4 times a day, the patient takes 3 days later, December 27, the patient's fever subsided, the sore throat eased significantly, still have cough symptoms.

[0053] The above examples are the preferred implementation of the present application, in addition to this, the present application can be implemented in other ways, without departing from the concept of the present application, any obvious replacement is within the scope of protection of the present application.

Claims

1. A formula for reducing fever in patients with three types of yang syndrome, characterized in that: The ingredients include the following parts by weight: Gypsum 50-100 parts, Ephedra 5-15 parts, Notopterygium root 10-30 parts, Bitter almond 5-15 parts, Licorice root 20-40 parts, Bupleurum root 50-70 parts, Scutellaria root 10-20 parts, Pinellia tuber 20-40 parts, Cinnamon twig 20-40 parts, White peony root 20-40 parts, Kudzu root 50-70 parts, Mume fruit 10-30 parts, Belamcanda rhizome 20-40 parts, Cicada slough 10-30 parts, Cuscuta seed 10-30 parts.

2. The antipyretic formula for three types of fever according to claim 1, characterized in that: It also includes 20-40 portions of houttuynia cordata.

3. The antipyretic formula for three types of fever according to claim 2, characterized in that: The ingredients include the following parts by weight: Gypsum 50-70 parts, Ephedra 5-15 parts, Notopterygium root 10-30 parts, Bitter almond 5-15 parts, Licorice root 20-40 parts, Bupleurum root 50-70 parts, Scutellaria root 10-20 parts, Pinellia tuber 20-40 parts, Cinnamon twig 20-40 parts, White peony root 20-40 parts, Kudzu root 50-70 parts, Mume fruit 10-30 parts, Belamcanda rhizome 20-40 parts, Cicada slough 10-30 parts, Cuscuta seed 10-30 parts, Houttuynia cordata 20-40 parts.

4. The antipyretic formula for three types of fever according to claim 2, characterized in that: It also includes 20-40 portions of Isatis root.

5. The antipyretic formula for three types of fever according to claim 2, characterized in that: It also includes 10-30 parts of peony bark.

6. The antipyretic formula for three types of fever according to claim 2, characterized in that: It also includes 20-30 parts of raw Rehmannia root.

7. The antipyretic formula for three types of fever according to claim 2, characterized in that: It also includes 5-15 parts of catnip and 5-15 parts of saposhnikovia.

8. The antipyretic formula for three types of fever according to claim 3, characterized in that: It also includes 10-20 parts of Anemarrhena asphodeloides.

9. A formula for reducing fever in patients with three yang syndromes according to any one of claims 1-8, characterized in that: The Sanyang Antipyretic Formula is available in tablet, decoction, capsule, granule, powder, pill, or oral form.

10. A method for preparing a Sanyang antipyretic formula according to any one of claims 8, characterized in that: The Sanyang Antipyretic Formula is a decoction, and its preparation method is as follows: Weigh each ingredient according to the weight proportions, weigh 5-10 times the weight of water as the total weight of the ingredients, add gypsum to the water and decoct for 20-40 minutes, then add the remaining ingredients and decoct for more than 1 hour to obtain the Sanyang Antipyretic Formula decoction.

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