Antibacterial bone cement, bone cement set and preparation method of bone cement set

By introducing copper oxide/barium sulfate antibacterial contrast agent into PMMA bone cement, the problems of excessively high elastic modulus and insufficient antibacterial properties of bone cement were solved, achieving the effects of reducing secondary damage and improving antibacterial properties.

CN121371269APending Publication Date: 2026-01-23SHANDONG WEIGAO ORTHOPEDIC DEVICE COMPANY
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Patent Information

Application Number
CN202410976947.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-07-22
Publication Date
2026-01-23

AI Technical Summary

Technical Problem

Existing PMMA bone cement has problems such as secondary damage caused by excessively high elastic modulus, lack of antibacterial properties, and uneven mixing of antibacterial agents in the bone cement.

Method used

Copper oxide was used as an antibacterial contrast agent, which was combined with barium sulfate to prepare an antibacterial contrast agent with controllable particle size through an emulsion-chemical homogeneous precipitation method. This reduced the elastic modulus of bone cement, and a sealing protection device was used to ensure uniform mixing.

Benefits of technology

It reduces the elastic modulus of bone cement, preventing secondary damage, while improving antibacterial properties, reducing the risk of infection, and ensuring uniform mixing and biocompatibility.

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Abstract

The invention belongs to the field of biomedical materials, and relates to antibacterial bone cement, the bone cement comprises a powder and a liquid, the powder comprises polyacrylate and an antibacterial developer, and the liquid comprises N, N-dimethyl-p-toluidine, hydroquinone and methyl methacrylate; the antibacterial developing agent is a barium sulfate / copper oxide compound, the invention further provides a preparation method of the antibacterial developing agent in the antibacterial bone cement, an antibacterial bone cement set and a preparation method of the antibacterial bone cement set, the bone cement is endowed with certain antibacterial property by changing the composition of the developing agent, the elasticity modulus of the bone cement is reduced, and the bone cement set is prepared. And secondary injury caused by too high modulus of the bone cement is prevented.
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