Biomarker and target spot for prediction, diagnosis and / or prognosis evaluation of breast cancer and application of biomarker and target spot

By using hsa_circ_0051908 as a breast cancer biomarker, combined with specific detection and inhibition technologies, the accuracy and invasiveness issues of existing breast cancer detection methods have been resolved, enabling early, highly sensitive diagnosis and effective prognostic assessment, and significantly inhibiting breast cancer cell proliferation and migration.

CN121380338APending Publication Date: 2026-01-23THE FIRST PEOPLES HOSPITAL OF FOSHAN
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Patent Information

Application Number
CN202511474163.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-10-15
Publication Date
2026-01-23

AI Technical Summary

Technical Problem

Existing breast cancer detection methods suffer from low accuracy, complex operation, high invasiveness, and low patient acceptance. Furthermore, they lack highly sensitive and specific biomarkers, making it difficult to achieve early diagnosis and effective prognostic assessment.

Method used

Using hsa_circ_0051908 as a biomarker for breast cancer, we designed specific primers and kits, combined with RT-PCR, real-time quantitative PCR, in situ hybridization and high-throughput sequencing platforms, to detect its expression level. We also developed reagents to interfere with or inhibit the expression of hsa_circ_0051908, so as to achieve the prediction, diagnosis and prognostic assessment of breast cancer.

Benefits of technology

It achieves early detection of breast cancer with high sensitivity and specificity, provides a new diagnostic method, significantly inhibits the proliferation and migration of breast cancer cells, and provides a new direction for early clinical diagnosis and long-term prognostic assessment.

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Abstract

The invention belongs to the technical field of biological medicine, and particularly relates to a biomarker and a target spot for prediction, diagnosis and / or prognosis evaluation of breast cancer and application of the biomarker and the target spot. The hsacirc0051908 provided by the invention has expression difference in serum of healthy people and breast cancer patients, and can be used as a breast cancer prediction, diagnosis and / or prognosis biomarker or target; by detecting the expression level of the hsacirc0051908, early detection can be effectively carried out on breast cancer patients, and the kit has the advantages of high sensitivity, strong specificity and the like; according to the present invention, the Hsacirc0051908 gene, the reagent for interfering the expression of the Hsacirc0051908 or the hsacirc0051908 inhibitor are used for preparing the product for inhibiting the breast cancer proliferation or migration, such that the significant inhibition effect on the proliferation and migration ability of the breast cancer MDA-MB-231 cell is provided so as to provide the new direction for the early clinical diagnosis and the long-term prognosis evaluation of the breast cancer.
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