Application of agents related to expression of glutaminase 1

By detecting and regulating the expression of glutaminase 1, the diagnostic and treatment challenges of intervertebral disc degeneration have been solved, enabling early diagnosis and effective treatment of intervertebral disc degeneration and delaying the degenerative changes of the intervertebral disc.

CN121385300APending Publication Date: 2026-01-23THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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Patent Information

Application Number
CN202511033658.7
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-07-25
Publication Date
2026-01-23

AI Technical Summary

Technical Problem

Existing technologies are insufficient to fundamentally repair intervertebral disc degeneration, and there is a lack of in-depth research on the role of amino acid metabolism in intervertebral disc degeneration, especially the role of glutaminase 1 expression detection and regulation in intervertebral disc degeneration has not been fully utilized.

Method used

Reagents for detecting the expression level of glutaminase 1 are provided for the preparation of diagnostic products for intervertebral disc degeneration. Reagents that overexpress glutaminase 1 can regulate iron ion homeostasis, antagonize ferroptosis and senescence of nucleus pulposus cells, and thus delay the degenerative changes of intervertebral discs.

Benefits of technology

By detecting the expression level of glutaminase 1 and reagents that overexpress glutaminase 1, early diagnosis and effective treatment of intervertebral disc degeneration were achieved, thus delaying the degenerative changes of the intervertebral disc.

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Abstract

The invention belongs to the technical field of biological medicine, particularly relates to application of a reagent related to expression of glutaminase 1, and provides application of a reagent for detecting the expression quantity of GLS1 in preparation of a diagnostic product for intervertebral disc degeneration due to the fact that the expression level of GLS1 protein is found to be remarkably reduced in degenerated nucleus pulposus tissue. According to the present invention, the GLS1 regulates and controls the iron ion homeostasis by promoting the expression of cysteine desulfatase so as to antagonize ferroptosis and senescence of nucleus pulposus cells and further delay the degenerative change of the intervertebral disc, such that the GLS1 is adopted as the treatment target, and the GLS1 is overexpressed by using the overexpression reagent provided by the invention so as to achieve the intervertebral disc degeneration regulation and control effect of the GLS1; therefore, the invention provides application of a reagent for overexpressing GLS1 in preparation of a product for treating intervertebral disc degeneration.
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