A composition for effectively removing dental plaque and a method for preparing the same

Abstract

The application discloses a composition capable of effectively removing dental plaque and a preparation method thereof, and particularly belongs to the technical field of oral care. The composition comprises core active ingredients and auxiliary materials, the core active ingredients comprise alpha-glucanase, glucose oxidase, magnolia officinalis extract, cherry blossom extract and calendula extract, and the auxiliary materials comprise a variety of components such as moisturizing agents, abrasives and surfactants. The composition can synergistically collapse the structure of dental plaque, has the characteristics of strong bacteriostasis, anti-inflammation and mild gingival protection, has excellent dental plaque removal rate, has a bacteriostasis rate of oral pathogenic bacteria of more than 99%, has no mucous membrane irritation risk, is suitable for preparing oral care products for inhibiting and removing dental plaque, can effectively solve the problems of single action, incomplete removal and easy damage to flora balance of existing products, and has significant practical value and market prospect.

Description

Technical Field

[0001] This invention relates to the field of oral care technology, and more specifically, to a composition for effectively removing dental plaque and a method for preparing the same. Background Technology

[0002] Dental plaque is a complex three-dimensional structure composed of various bacterial microbial cells from the oral cavity, including Streptococcus, Lactobacillus, and Actinomycetes, and an extracellular polymeric matrix. It adheres to and colonizes the tooth surface, forming a typical bacterial biofilm (BF). Dental plaque consists of a matrix and bacterial cells, containing inorganic, organic, and functional components. The formation of dental plaque is a complex and dynamic process, which can be roughly divided into three stages: acquired film formation (salivary proteins adsorb onto the tooth surface), bacterial adhesion and aggregation (selective adsorption of oral microorganisms onto the acquired film on the tooth surface), and plaque maturation.

[0003] Dental plaque can cause a variety of oral problems, including swollen and bleeding gums, cavities, bad breath, and yellowing teeth. Gum problems caused by dental plaque are also linked to systemic diseases such as diabetes and heart disease. Dental plaque not only affects oral health but also has a certain relationship with cardiovascular disease, diabetes, and systemic diseases such as premature birth and low birth weight. Therefore, controlling plaque growth is of great significance for the prevention and treatment of dental caries and periodontal disease.

[0004] Dental plaque control methods mainly encompass mechanical and chemical approaches. Mechanical removal primarily involves using toothbrushes, toothpaste, toothpicks, dental floss, and professional scaling to remove plaque biofilm. Chemical methods mainly utilize substances with antibacterial or bactericidal properties. Examples include cationic surfactants, cetylpyridinium chloride (CPC), and heavy metal salt antibacterial agents, all of which work by killing bacteria to combat plaque. These agents are primarily effective against early-stage plaque formation, but less so against mature plaque. The complex three-dimensional structure of mature plaque and the presence of extracellular polysaccharides create resistance for the antibacterial agents to reach the inner bacterial community.

[0005] Therefore, developing a plaque removal composition that has a synergistic effect in breaking down plaque, while also effectively inhibiting bacteria and inflammation and gently protecting gums, and with advanced technology and stable efficacy, has become an urgent problem to be solved in the field of oral care, and has important practical application value and market prospects. Summary of the Invention

[0006] To address the shortcomings of existing technologies, the present invention aims to provide a plaque removal composition that has a synergistic effect in breaking down plaque, while also effectively inhibiting bacteria and inflammation and gently protecting gums, and is characterized by advanced technology and stable efficacy.

[0007] To achieve the above objectives, the present invention discloses the following technical solutions:

[0008] In a first aspect, the present invention provides a composition for effectively removing dental plaque, comprising a core active ingredient and excipients;

[0009] The core active ingredients, by weight percentage, include: α-glucanase 0.01–0.6%, glucose oxidase 0.01–0.5%, magnolia bark extract 0.01–3%, cherry blossom extract 0.01–2%, and calendula extract 0.01–2%.

[0010] This invention controls dental plaque through a combination of anti-adhesion and anti-pathogenic bacteria methods. The adhesion of bacteria to the acquired membrane on the tooth surface is a key process in the formation of biofilm. For example, dextran, as an extracellular polysaccharide, provides the material basis for the metabolism of dental plaque biofilm, mediates the adhesion of bacteria to the tooth surface and bacterial co-aggregation. Structurally, the bacterial community in dental plaque is surrounded by EPS matrix (extracellular polysaccharide).

[0011] Effective control of dental plaque involves the decomposition of extracellular polysaccharides and the killing of bacteria. For example, the extracellular polysaccharides synthesized by glucosyltransferases (GTFs) in Streptococcus mutans mainly consist of three types: glucans rich in α-1,6 glycosidic chains, glucans rich in α-1,3 glycosidic chains, and a water-soluble glucan. Water-soluble glucans are easily soluble in water and can be removed by ordinary oral hygiene methods such as rinsing and brushing. α-glucanase specifically hydrolyzes α-(1,6) and α-(1,3) glycosidic bonds, while glucose oxidase catalyzes the production of gluconic acid and hydrogen peroxide from β-D-glucose. α-glucanase and glucose oxidase form a synergistic enzymatic system, disrupting the structural stability of dental plaque.

[0012] Magnolia officinalis extract is rich in active substances such as magnolol and honokiol, which have the effects of inhibiting the growth of oral pathogens and reducing oral inflammation. The products of glucose oxidase after glucose decomposition can synergistically inhibit oral pathogens with Magnolia officinalis extract. The combination of the three can effectively control dental plaque and achieve the goal of eliminating dental plaque from the root.

[0013] Cherry blossom extract and calendula extract work synergistically to soothe the oral mucosa, reducing the potential irritation of other toothpaste ingredients. The flavonoids in cherry blossom extract help inhibit plaque adhesion, while the anti-inflammatory properties of calendula extract further strengthen oral mucosal protection.

[0014] Preferably, the core active ingredients, by mass percentage, include: 0.01-0.2% α-glucanase, 0.01-0.2% glucose oxidase, 0.01-0.3% magnolia bark extract, 0.01-0.2% cherry blossom extract, and 0.01-0.2% calendula extract.

[0015] Preferably, the excipients include one or more of the following: humectants, abrasives, surfactants, stabilizers, preservatives, taste modifiers, flavorings, thickeners, appearance modifiers, and solvents.

[0016] Preferably, the α-glucanase activity is ≥10000 U / g, and the glucose oxidase activity is ≥10000 U / g.

[0017] More preferably, the moisturizer is selected from at least one of sorbitol, glycerin, propylene glycol, and polyethylene glycol;

[0018] The abrasive is selected from at least one of hydrated silica, dicalcium phosphate, and dicalcium phosphate dihydrate.

[0019] The surfactant is selected from at least one of sodium lauryl sulfate, sodium lauroyl sarcosinate, cocamidopropyl betaine, lauryl glucoside, sodium lauroyl glutamate, potassium cocoyl glycinate, sodium cocoyl glycinate, sodium cocoyl glutamate, decanyl glucoside, sodium methyl cocoyl taurate, sodium polyaspartate, rhamnolipid, Sapindus mukorossi extract, and soapberry extract.

[0020] The thickener is selected from at least one of xanthan gum, cellulose gum, hydroxypropyl guar gum, carbomer, chondrus crispus polysaccharide, and hydroxyethyl cellulose;

[0021] The stabilizer is selected from at least one of sodium pyrophosphate, sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium carbonate, and sodium bicarbonate.

[0022] The taste improver is selected from at least one of sodium saccharin, trichlorogalactosyl xylitol, stevioside, and sodium chloride;

[0023] The appearance modifier is selected from at least one of titanium dioxide, natural pigments, synthetic pigments, synthetic lakes, colored silica, and pearlescent pigments;

[0024] The fragrance is selected from at least one of the following: floral fragrance, floral-fruity fragrance, mint fragrance, spearmint fragrance, wintergreen fragrance, fruit fragrance, tea fragrance, medicinal fragrance, natural essential oil, and other distinctive fragrances.

[0025] The solvent is distilled water.

[0026] In a second aspect, the present invention provides a method for preparing the composition described in the first aspect, the method comprising the following steps:

[0027] (1) Add the abrasive and thickener to the mixer and stir at room temperature for 3-5 minutes to obtain mixture A;

[0028] (2) Mix α-glucanase, glucose oxidase, magnolia bark extract, cherry blossom extract, calendula extract with solvent and humectant to obtain mixture B;

[0029] (3) Add distilled water, stabilizer, preservative and taste modifier to the reaction vessel and stir at room temperature for 10-15 minutes until dissolved to obtain mixture C;

[0030] (4) Mixing and preparing the paste: Mix mixture C with mixture A and stir for 25-30 minutes. Then add the appearance improver solution, surfactant and fragrance in sequence and stir for 15-20 minutes. Finally add mixture B and stir for 3-5 minutes to prepare the paste.

[0031] (5) Transfer the paste into a vacuum degasser and degas it for 10 to 15 minutes under a vacuum of ≤-0.092 MPa to obtain the composition.

[0032] Preferably, the mixer speed in step (1) is 300-500 rpm.

[0033] Preferably, the stirring speed of the reaction vessel in step (3) is 600-800 rpm.

[0034] Preferably, in step (4), mixture C and mixture A are mixed and stirred at 1800-2000 rpm for 25-30 min;

[0035] Add appearance improver solution, surfactant, and fragrance, and stir at 1200-1500 rpm for 15-20 minutes;

[0036] Add mixture B and stir at 1200-1500 rpm for 3-5 minutes to form a paste.

[0037] Thirdly, the present invention provides the use of the composition described in the first aspect in the preparation of oral care products having the function of inhibiting and removing dental plaque.

[0038] The beneficial effects of this invention are:

[0039] 1. The α-glucanase and glucose oxidase provided by this invention can respectively target and decompose glucan and glucose in the core matrix of dental plaque, thereby structurally disintegrating the plaque skeleton. The products of glucose decomposition by glucose oxidase can work synergistically with Magnolia officinalis extract to help destroy plaque adhesion. Cherry blossom extract and Calendula officinalis extract have a stable removal effect, effectively solving the core problems of single efficacy and large amount of plaque residue in the prior art.

[0040] 2. The composition of this invention has a strong inhibitory effect on common oral pathogens, with an inhibition rate of ≥99% against bacteria such as Porphyromonas gingivalis and Streptococcus mutans, and an inhibition rate of ≥99% against fungi such as Candida albicans. The α-glucanase, glucose oxidase and Magnolia officinalis extract form a synergistic plaque-removing mechanism, avoiding the drawbacks of traditional chemical antibacterial agents, and can maintain a healthy oral microenvironment for a long time, preventing gingivitis, periodontitis and dental caries. Detailed Implementation

[0041] To better illustrate the objectives, technical solutions, and advantages of this invention, the invention will be further described below with reference to specific embodiments. Those skilled in the art should understand that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

[0042] Unless otherwise specified, the test methods used in the examples and comparative examples are conventional methods; the materials and reagents used are commercially available unless otherwise specified; and the percentages mentioned in the examples and comparative examples are mass percentages unless otherwise specified.

[0043] In this invention

[0044] α-Glucanase: Enzyme activity 10000 U / g;

[0045] Glucose oxidase: Enzyme activity 10000U / g.

[0046] Preparation of toothpaste composition

[0047] The toothpaste composition preparation method includes the following steps:

[0048] (1) Add the abrasive and thickener to the mixer and stir at room temperature and 300-500 rpm for 3-5 minutes to obtain mixture A;

[0049] (2) First, dissolve α-glucanase, glucose oxidase, magnolia bark extract, cherry blossom extract, and calendula extract in distilled water to obtain solutions B1, B2, B3, B4, and B5. Then add them to a mixing tank with a humectant and stir for 5 to 8 minutes to obtain mixture B.

[0050] (3) Add distilled water, stabilizer, preservative and taste modifier to the reaction vessel and stir at room temperature and 600-800 rpm for 10-15 minutes until dissolved to obtain mixture C;

[0051] (4) Mixing and preparing the paste: Mix mixture C and mixture A at 1800-2000 rpm for 25-30 min, then add appearance improver, surfactant and fragrance in sequence and stir at 1200-1500 rpm for 15-20 min, finally add mixture B and stir at 1200-1500 rpm for 3-5 min to obtain the paste;

[0052] (5) Transfer the paste into a vacuum degasser and degas it for 10 to 15 minutes under a vacuum of ≤-0.092 MPa to obtain the composition.

[0053] The raw material mass percentages for Examples 1-3 are shown in Table 1:

[0054] Table 1 (Unit: %)

[0055]

[0056] The raw material mass percentages of Comparative Examples 1-5 and the matrix group are shown in Table 2:

[0057] Table 2 (Unit: %)

[0058]

[0059] Note: " / " in the table indicates no addition.

[0060] Performance testing

[0061] The compositions of Examples 1-3, Comparative Examples 1-5, and the matrix group were subjected to laboratory evaluation of plaque removal efficacy (according to T / COCIA 36-2024 standard), quantitative antibacterial test of carrier immersion (according to 5.1.2 of WS / T 650-2019), and mucosal irritation test to verify their efficacy and safety.

[0062] 1. Laboratory evaluation of plaque removal efficacy

[0063] 1.1 Experimental Principle

[0064] Hydroxyapatite tablets (HAP tablets) were used to simulate teeth. Dental plaque biofilm models were constructed using Streptococcus mutans (ATCC25175), Actinomyces viscous (GDMCC1.381), and Streptococcus sanguinis (GDMCC1.1558). After treatment with toothpaste slurry, the amount of biofilm was measured using the crystal violet staining method, the plaque removal rate was calculated, and the removal efficacy was evaluated.

[0065] 1.2 Instruments and Reagents

[0066] Level 2 biosafety cabinet, multi-functional microplate reader, microplate shaker (≥1500rpm); brain and heart extract broth (BHI broth), artificial saliva (pH 7.4, ISO / TR10271-2020), 1% crystal violet, 33% glacial acetic acid, physiological saline (0.9% NaCl); HAP slides (12-13mm in diameter, 1.0-1.3mm in thickness), 12-well cell culture plates.

[0067] 1.3 Experimental Procedure

[0068] 1) Preparation of HAP tablets: Autoclave at 121℃ for 20 minutes, then set aside.

[0069] 2) Strain activation: Inoculate the three strains into BHI broth and incubate aerobically at 37±1℃ for 18-24 hours. Frozen strains need to be activated for more than 3 generations until they are stable.

[0070] 3) Preparation of bacterial suspension: Take the bacterial suspension in the logarithmic growth phase, adjust the OD600nm absorbance value to 0.45-0.55, mix them in a 1:1:1 ratio, vortex mix for 20 seconds, and use immediately after preparation;

[0071] 4) Culture medium preparation: Mix BHI broth and artificial saliva at a ratio of 3:1, add sucrose (final concentration 0.5%) and porcine gastric mucoprotein (final concentration 0.25%), and sterilize at 121℃ for 20 min;

[0072] 5) Dental plaque modeling and grouping: Sterile HAP sheets were placed in 12-well plates and divided into blank group, model group, and experimental group (Examples 1-3, Comparative Examples 1-5, and substrate group), with 3 replicates for each group; 1.8 mL of culture medium + 0.2 mL of mixed bacterial solution was added to the model group / experimental group, and 2 mL of culture medium was added to the blank group; after incubation at 37±1℃ for 24 h, the bacterial solution was aspirated, and 2 mL of culture medium was added to continue incubation for another 24 h to complete the modeling;

[0073] 6) Toothpaste slurry preparation: Under aseptic conditions, weigh 10g of toothpaste sample, add 20g of physiological saline (1:2 mass ratio), and homogenize with a beater until completely dispersed;

[0074] 7) Sample preparation: Transfer the HAP plates after modeling to a new 12-well plate (without inverting). Add 1.5 mL of toothpaste slurry to the experimental group and 1.5 mL of physiological saline to the model group / blank group. After sealing the plate, shake at 1300 rpm for 10 min.

[0075] 8) Washing and fixation: Transfer HAP slides to new well plates, add 1.5 mL of physiological saline, wash twice at 1500 rpm (5 min each time); after removing the saline, add 0.5 mL of methanol for fixation for 5 min, and air dry in a biosafety cabinet for 2 min;

[0076] 9) Staining and destaining: Add 50 μL of 1% crystal violet for staining for 5 min; add 2.5 mL of physiological saline and shake at 400 rpm for 2 min to wash away unbound staining solution, repeat 4 times; add 2.5 mL of 33% glacial acetic acid and shake at 400 rpm for 20 min to destain;

[0077] 10) Biofilm assay: Add 100 μL of decolorizing solution to a 96-well plate, measure the OD570nm value using an ELISA reader, and calculate the plaque removal rate according to the following formula.

[0078] C=(A2-A1) / (A2-A0)×100%

[0079] Where A0 represents the mean OD value of the blank group;

[0080] A1 — Mean OD value of the experimental group;

[0081] A2 — the mean OD of the model group.

[0082] 1.4 Results and Analysis

[0083] As shown in Table 3.

[0084] Table 3. Results of plaque removal rate test

[0085] Group Plaque removal rate (C, %) Example 1 56.3 Example 2 72.1 Example 3 89.7 Comparative Example 1 33.6** Comparative Example 2 29.8** Comparative Example 3 27.3** Comparative Example 4 34.1** Comparative Example 5 32.4** matrix 7.0***

[0086] Note: * indicates a significant difference compared to Example 2, P < 0.05; **P < 0.01; ***P < 0.001.

[0087] 1.5 Results Analysis:

[0088] Examples 1-3 showed clearance rates of 56.3%-89.7%, significantly higher than the comparative example and the matrix group; Example 3 showed the best effect due to the highest content of the core active ingredient.

[0089] Comparative Examples 1–3 (lacking the dual enzymes or Magnolia officinalis extract) showed a clearance rate of only 27.3%–33.6%, a decrease of 38.5%–44.8% compared to Example 2, demonstrating that the dual enzymes (α-glucanase + glucose oxidase) and Magnolia officinalis extract are the core components for breaking down plaque. Comparative Examples 4–5 (lacking cherry blossom / calendula extract) still showed a certain decrease in clearance rate, indicating that soothing ingredients can also help improve clearance stability.

[0090] 2. Quantitative antibacterial test by carrier immersion

[0091] 2.1 Experimental Principle

[0092] Using 10mm×10mm defatted white plain cloth as a carrier, common oral pathogens (Staphylococcus aureus, Streptococcus mutans, and Candida albicans) were inoculated. After being soaked in toothpaste samples, the number of surviving bacteria on the carrier was measured, the antibacterial rate was calculated, and the antibacterial efficacy was evaluated.

[0093] 2.2 Instruments and Reagents

[0094] Biosafety cabinet (level 2), microplate shaker, constant temperature water bath; 0.03 mol / L phosphate buffer (PBS, pH 7.2–7.4), nutrient agar (for bacteria), Sabouraud agar (for fungi); defatted white plain weave cloth (10 mm × 10 mm, sterilized at 121°C for 20 min), 12-well cell culture plates.

[0095] Experimental strains: Staphylococcus aureus (ATCC6538), Streptococcus mutans (ATCC25175), and Candida albicans (ATCC10231), purchased from Guangdong Provincial Microbial Culture Collection Center.

[0096] 2.3 Experimental Procedure

[0097] 1) Preparation of bacterial suspension: Take 24-hour fresh slant culture, wash with PBS and dilute, adjusting the concentration: bacteria (Staphylococcus aureus, Streptococcus mutans) 5.0 × 10⁻⁶ 6 ~5.0×10 7 CFU / mL, fungus (Candida albicans) 5.0 × 10⁻⁶ 5 ~5.0×10 6 CFU / mL;

[0098] 2) Preparation of bacterial carrier: Add 10 μL of bacterial suspension to a sterile cloth using a micropipette, dry at 36±1℃ (or air dry at room temperature), and set aside for later use;

[0099] 3) Sample preparation: Weigh toothpaste samples (Examples 1-3, Comparative Examples 1-5, and matrix group) at a rate of 5g / piece into a sterile Petri dish and incubate in a water bath at 20±1℃ for 5min; use sterile tweezers to completely immerse the stained cloth in the sample, start timing immediately, and allow it to act for 10min.

[0100] 4) Bacterial elution and counting: Transfer the treated cloth to a test tube containing 5.0 mL PBS, shake for 1 min to elute the bacteria; take 1.0 mL of elution buffer (or 10-fold serial dilution) to inoculate 2 petri dishes, pour in 40-45℃ culture medium, and incubate at 36±1℃ (48 h for bacteria, 72 h for Candida albicans), and count the number of colonies;

[0101] 5) Control setup: The positive control was prepared by soaking the contaminated cloth strip in PBS from the same batch instead of the toothpaste sample;

[0102] 6) Calculation of antibacterial rate: Calculated according to the formula "X=(A0-A1) / A1×100%", where A0 is the average number of colonies in the positive control (CFU / tablet) and A1 is the average number of colonies in the experimental group (CFU / tablet); Result judgment: antibacterial rate ≥50%~90% is considered to have antibacterial effect, and ≥90% is considered to have strong antibacterial effect.

[0103] 2.4 Results and Analysis

[0104] As shown in Table 4.

[0105] Table 4 Results of quantitative antibacterial test of carrier immersion (antibacterial rate, %)

[0106] Group Porphyromonas gingivalis Streptococcus mutans Candida albicans Example 1 99.8 99.5 92.3 Example 2 ＞99.9 ＞99.9 96.7 Example 3 ＞99.9 ＞99.9 ＞99.9 Comparative Example 1 90.5 88.7 75.2 Comparative Example 2 89.2 87.3 72.5 Comparative Example 3 76.5 72.8 48.9 Comparative Example 4 98.2 97.5 85.6 Comparative Example 5 97.8 96.9 84.3 matrix 72.3 70.5 35.7

[0107] Examples 1-3 showed significantly higher inhibition rates against the three strains than the control group and the substrate group, with inhibition rates of ≥99% against bacteria (strong inhibition) and ≥90% against Candida albicans (strong inhibition).

[0108] Comparative Example 3 (lacking Magnolia officinalis extract) showed an inhibition rate of only 48.9% against Candida albicans, demonstrating that Magnolia officinalis extract is key to inhibiting oral fungi.

[0109] The antibacterial rate of comparative examples 1 and 2 decreased by 9.4% to 12.6% compared with example 2, which verified that there is a synergistic antibacterial effect between the dual enzymes and the Magnolia officinalis extract.

[0110] 3. Oral mucosal irritation test

[0111] 3.1 Subject population

[0112] 54 healthy volunteers (aged 18-35) were divided into 6 groups, excluding those with oral mucosal diseases and allergies.

[0113] 3.2 Experimental Methods

[0114] Each group of volunteers brushed their teeth twice a day, once in the morning and once in the evening, using 1.5g of toothpaste per brushing, for 21 days. The occurrence of mucosal irritation symptoms was recorded, and the toothpaste was discontinued when an irritation reaction occurred.

[0115] 3.3 Results and Analysis

[0116] As shown in Table 5.

[0117] Table 5 Number of people experiencing oral mucosal irritation

[0118] Group Number of people responding to the stimulus Symptom description Example 1 0 No redness, swelling, or stinging Example 2 0 No redness, swelling, or stinging Example 3 0 No redness, swelling, or stinging Comparative Example 1 0 No redness, swelling, or stinging Comparative Example 2 0 No redness, swelling, or stinging Comparative Example 3 0 No redness, swelling, or stinging Comparative Example 4 1 Mild mucosal stinging (relieved after 1 week) Comparative Example 5 1 Mild mucosal stinging (relieved after 1 week) matrix 0 No redness, swelling, or stinging

[0119] The results show that the toothpaste composition provided by the present invention is safe and non-irritating, suitable for use by sensitive groups, and has a wide range of applications.

[0120] Finally, it should be noted that the above descriptions are merely preferred embodiments of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A composition for effectively removing dental plaque, characterized in that, The composition consists of a core active ingredient and excipients; The core active ingredients, by weight percentage, include: α-glucanase 0.01–0.2%, glucose oxidase 0.01–0.2%, magnolia bark extract 0.01–0.3%, cherry blossom extract 0.01–0.2%, and calendula extract 0.01–0.2%. The α-glucanase activity is ≥10000U / g, and the glucose oxidase activity is ≥10000U / g.

2. The composition according to claim 1, characterized in that, The excipients include one or more of the following: humectants, abrasives, surfactants, stabilizers, preservatives, flavor modifiers, fragrances, thickeners, appearance modifiers, and solvents; The stabilizer is selected from at least one of sodium pyrophosphate, sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium carbonate, and sodium bicarbonate.

3. The composition according to claim 2, characterized in that, The moisturizer is selected from at least one of sorbitol, glycerin, propylene glycol, and polyethylene glycol; The abrasive is selected from at least one of hydrated silica, dicalcium phosphate, and dicalcium phosphate dihydrate. The surfactant is selected from at least one of sodium lauryl sulfate, sodium lauroyl sarcosinate, cocamidopropyl betaine, lauryl glucoside, sodium lauroyl glutamate, potassium cocoyl glycinate, sodium cocoyl glycinate, sodium cocoyl glutamate, decanyl glucoside, sodium methyl cocoyl taurate, sodium polyaspartate, rhamnolipid, Sapindus mukorossi extract, and soapberry extract. The thickener is selected from at least one of xanthan gum, cellulose gum, hydroxypropyl guar gum, carbomer, chondrus crispus polysaccharide, and hydroxyethyl cellulose; The taste improver is selected from at least one of sodium saccharin, trichlorogalactose, xylitol, stevioside, and sodium chloride; The appearance modifier is selected from at least one of natural pigments and synthetic pigments; The fragrance is selected from at least one of the following: floral fragrance, mint fragrance, spearmint fragrance, wintergreen fragrance, fruit fragrance, and tea fragrance. The solvent is distilled water.

4. The composition according to claim 2, characterized in that, The appearance improver is a synthetic lake.

5. The composition according to claim 2, characterized in that, The appearance improver is selected from at least one of titanium dioxide and colored silicon dioxide.

6. The composition according to claim 2, characterized in that, The appearance modifier is selected from pearlescent pigments.

7. The composition according to claim 2, characterized in that, The fragrance is a pharmaceutical fragrance.

8. The composition according to claim 2, characterized in that, The fragrance is a natural essential oil.

9. The composition according to claim 2, characterized in that, The fragrance is a compound fragrance.

10. The use of the composition according to any one of claims 1-9 in the preparation of an oral care product having the function of inhibiting and removing dental plaque.

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