Mitral valve gripping system

Abstract

The invention discloses a mitral valve clamping system. The mitral valve clamping system comprises a clamping component, an operation control component and a conveying rod. The gripping member is configured to grip the mitral valve in a first direction. The operation control component is detachably connected with the near end of the clamping component and the far end of the clamping component, and the operation control component comprises a conveying rod. And a conveying rod. Comprising a main body part, a first blocking part and a second blocking part, the first blocking part and the second blocking part are arranged at the far end of the main body part and connected with the far end of the main body part, and the first blocking part and the second blocking part are arranged in a spaced mode in the second direction and jointly define a containing space used for containing at least part of the clamping component. The first direction is perpendicular to the second direction, and the axial direction of the conveying rod is perpendicular to each other. The first blocking part and the second blocking part are arranged on the different sides of the clamping part, and the chordae tendineae can be prevented from entering the clamping area of the clamping part.

Description

Technical Field

[0001] This application relates to the field of medical device technology, specifically to a mitral valve clamping system. Background Technology

[0002] like Figure 1 As shown, the mitral valve is part of the heart, located between the left atrium and the left ventricle. Blood is pumped from the left atrium into the left ventricle. When the left ventricle contracts to pump blood throughout the body, the mitral valve closes to prevent blood from being pumped back into the left atrium.

[0003] Mitral regurgitation is one of the most common valvular diseases today, mainly caused by mitral annular dilatation, chordae tendineae insufficiency, mitral myxomatosis, leaflet prolapse, rheumatic valvular heart disease, and ischemic lesions. The most common method to repair damaged mitral valve function is through surgical valve replacement or repair. However, because surgery requires cardiopulmonary bypass, it is quite invasive, and for elderly patients and those with multiple comorbidities, there is a significantly high incidence of complications and mortality.

[0004] Minimally invasive surgery is now a better option for treating most heart valve diseases. The main treatment methods include artificial chordae tendineae implantation, mitral valve annuloplasty, and mitral valve clipping. Among them, mitral valve clipping is mainly used to treat mitral regurgitation caused by mitral regurgitation.

[0005] One approach to mitral valve clamping is to insert an implantable clamp through the apex of the heart to the vicinity of the mitral valve, clamping and fixing the free edges of the anterior and posterior leaflets. During systole, the mitral valve changes from a large single orifice to a small double orifice, allowing the leaflets to close properly at the end of systole and reducing regurgitation.

[0006] In existing technologies, transapical mitral valve clamping uses a clamp made of a metal alloy with a biocompatible material on its surface. The clamp enters the heart through the apex and clamps the diseased mitral valve area (such as the anterior and posterior leaflets). This causes the mitral valve to change from a large single orifice to a small double orifice during systole, resulting in tighter leaflet closure and reducing blood regurgitation from the ventricle to the left atrium. The procedure involves capturing and clamping the leaflets while the heart is still beating. This capture and clamping process requires the clamp to operate within the ventricle. The ventricle contains numerous chordae tendineae, and traditional valve clamping devices are prone to snagging or becoming entangled in these chordae tendineae during movement, positioning, and clamping within the ventricle, requiring a high level of surgical skill. Summary of the Invention

[0007] In view of the above problems, this application provides a mitral valve clamping system, which can prevent the chordae tendineae from entering the clamping area of ​​the clamping component through a first blocking part and a second blocking part, so as to prevent the clamping component from clamping the chordae tendineae during the clamping process of the clamping component clamping the mitral valve.

[0008] According to the embodiments of the present application, a mitral valve clamping system is provided, comprising: a clamping component configured to clamp the mitral valve along a first direction; an operation control component detachably connected with the proximal end of the clamping component and the distal end of the clamping component respectively, the operation control component comprising a delivery rod; the delivery rod comprising a main body, a first blocking portion and a second blocking portion, the first blocking portion and the second blocking portion being respectively arranged at and connected with the distal end of the main body, the first blocking portion and the second blocking portion being spaced apart along a second direction and jointly defining a receiving space for receiving at least part of the clamping component, the first direction, the second direction and the axial direction of the delivery rod being perpendicular to each other.

[0009] In the technical solution, the first blocking portion and the second blocking portion are arranged at different sides of the clamping component, and when the clamping component clamps the valve of the mitral valve, the chordae tendineae can be blocked from entering the clamping area of the clamping component. In addition, the proximal end of the clamping component is detachably connected with the operation control component, and the distal end of the clamping component is detachably connected with the delivery rod, which can simplify the separation operation of the clamping component and enable the clamping component to be more stably fixed during clamping, thereby facilitating the clamping component to more accurately clamp the valve.

[0010] In some embodiments of the present application, the delivery rod further comprises an adapter arranged at the distal end of the first blocking portion, the second blocking portion is spaced apart from the adapter along the second direction, the proximal end of the adapter is hung with the distal end of the clamping component, the adapter has a release rod delivery channel, the distal end of the clamping component is provided with a limiting hole in communication with the release rod delivery channel, and the operation control component further comprises a release rod, the release rod is in sliding fit with the release rod delivery channel, the distal end of the release rod is configured to be arranged in the limiting hole, and the proximal end of the release rod is arranged to be driven so that the distal end of the release rod can be withdrawn into the release rod delivery channel.

[0011] In some embodiments of the present application, the release rod delivery channel extends to the distal end of the first blocking portion and extends from the distal end of the first blocking portion to the proximal end of the main body along the axial direction of the delivery rod, and the proximal end of the release rod passes out from the proximal end of the main body.

[0012] In some embodiments of the present application, the operation control component further comprises a release operation component and a housing connected with the proximal end of the main body, the release operation component is in sliding connection with the housing along the axial direction of the delivery rod, the release operation component has a limiting position and a release position on the housing, and the proximal end of the release rod is connected with the release operation component; In the limiting position, the distal end of the release rod is arranged in the limiting hole; In the release position, the distal end of the release rod is arranged in the release rod delivery channel.

[0013] In some embodiments of the present application, the clamping component comprises: a support comprising a rod body and a seat body, the rod body being arranged at a distal end of the seat body, the distal end of the rod body being hingedly connected to a proximal end of the adapter, and the distal end of the rod body being provided with a limiting hole; a clamping arm assembly, each of the two sides of the seat body along the first direction being provided with a clamping arm assembly, and the clamping arm assembly being configured to clamp the mitral valve; a fixing member, each of the two clamping arm assemblies being rotatably connected to the fixing member; the operation control component comprises an adjusting rod, the adjusting rod being arranged at one side of a proximal end of the fixing member along an axial direction of the delivery rod, the proximal end of the fixing member being detachably connected to a distal end of the adjusting rod, and the adjusting rod being configured to drive the fixing member to move relative to the seat body along the axial direction of the delivery rod to adjust an opening angle of the clamping arm assemblies on the two sides of the seat body along the first direction.

[0014] In some embodiments of the present application, the clamping arm assembly comprises: a clamping arm, a proximal end of the clamping arm being rotatably connected to the seat body about a first axis; an adjusting arm, a distal end of the adjusting arm being rotatably connected to the proximal end of the clamping arm about a second axis, and a proximal end of the adjusting arm being rotatably connected to the fixing member about a third axis, the first axis, the second axis and the third axis being parallel to each other.

[0015] In some embodiments of the present application, the distal end of the adjusting rod is threadedly connected to the proximal end of the fixing member.

[0016] In some embodiments of the present application, the clamping arm assembly comprises: a clamping arm, a proximal end of the clamping arm being rotatably connected to the seat body about a first axis; an adjusting arm, a distal end of the adjusting arm being connected to the clamping arm, and a proximal end of the adjusting arm being connected to the fixing member, the adjusting arm being an arm body with elasticity, and an elastic force of the adjusting arm having a tendency to close the clamping arm.

[0017] In some embodiments of the present application, the distal end of the adjusting arm is rotatably connected to the clamping arm, and an axis about which the distal end of the adjusting arm rotates relative to the clamping arm is parallel to the first axis, and the connection between the proximal end of the adjusting arm and the fixing member is one of integral forming, bonding and welding; or, the distal end of the adjusting arm is one of integral forming, bonding and welding with the clamping arm, the connection between the proximal end of the adjusting arm and the fixing member is rotatable connection, and an axis about which the proximal end of the adjusting arm rotates relative to the fixing member is parallel to the first axis.

[0018] In some embodiments of the present application, the clamping component further comprises a slot rod connected to the fixing member, a proximal end of the rod body is provided with a plug hole, the slot rod and the plug hole being slidably fitted along an axial direction of the slot rod, and an outer peripheral surface of the slot rod is provided with a plurality of clamping grooves arranged at intervals along the axial direction of the slot rod. The clamping component further comprises an elastic sheet connected with the fixing member or the seat body, the elastic sheet is arranged between the fixing member and the seat body, the elastic sheet is provided with a mounting hole, the distal end of the slot rod is arranged through the mounting hole, and the elastic sheet has a first state of being clamped with the clamping groove and a second state of being separated from the clamping groove. The operation control component further comprises an unlocking wire, a distal end of the unlocking wire is connected with the elastic sheet, and the unlocking wire is configured to provide a pulling force to the elastic sheet to switch the elastic sheet from the first state to the second state. In some embodiments of the present application, the mounting hole comprises a first mounting hole and a second mounting hole, the distal end of the slot rod is arranged through the first mounting hole and the second mounting hole in sequence, the elastic sheet comprises a first sheet body, a second sheet body and a third sheet body, two ends of the second sheet body are connected with the first sheet body and the third sheet body respectively and are arranged at an angle with the first sheet body and the third sheet body respectively, the third sheet body is connected with the fixing member or the seat body, the first sheet body is located on a side of the third sheet body away from the fixing member and is connected with the unlocking wire, the first mounting hole penetrates through the third sheet body, a hole wall of the first mounting hole is located outside the clamping groove, and the second mounting hole penetrates through the first sheet body. In the first state, the first sheet body is arranged at an obtuse angle with the second sheet body, and part of the hole wall of the second mounting hole is located in the clamping groove. In the second state, the first sheet body moves out to the outside of the clamping groove.

[0019] In some embodiments of the present application, the operation control component further comprises an unlocking wire operation component and a shell, the unlocking wire operation component is slidingly connected with the shell in the axial direction of the conveying rod, and the unlocking wire operation component is connected with a proximal end of the unlocking wire. When the unlocking wire operation component moves towards the proximal end of the shell, the unlocking wire pulls the elastic sheet to switch from the first state to the second state.

[0020] In some embodiments of the present application, the main body part has an unlocking wire channel penetrating through both ends thereof, and part of the unlocking wire is located in the unlocking wire channel. And / or, the main body part has an adjusting rod conveying channel penetrating through both ends thereof, and part of the adjusting rod is located in the adjusting rod conveying channel.

[0021] In some embodiments of the present application, the operation control component further comprises a shell, an adjusting rod fixing component and an adjusting sleeve, the adjusting rod fixing component is arranged at a proximal end of the shell and is slidingly connected with the shell in the axial direction of the conveying rod, a proximal end of the adjusting rod is connected with the adjusting rod fixing component, the adjusting sleeve is sleeved on the adjusting rod fixing component and is threadedly connected with the adjusting rod fixing component, and the adjusting sleeve is rotationally connected with the shell.

[0022] In some embodiments of the present application, the adjusting rod fixing component comprises: The screw rod has a receiving cavity passing through the proximal end of the screw rod and the distal end of the screw rod, the adjusting sleeve is sleeved on the outer peripheral surface of the screw rod and threadedly cooperates with the screw rod, and the distal end of the adjusting rod passes through the distal end of the screw rod and slidably cooperates with the screw rod in the axial direction of the delivery rod; The proximal connector is partially arranged in the receiving cavity, and the proximal connector is connected with the proximal end of the adjusting rod; The proximal connector is detachably connected with the screw rod through the unlocking member, and after the proximal connector is separated from the screw rod, the proximal connector can rotate relative to the screw rod to separate the distal end of the adjusting rod from the proximal end of the fixing member.

[0023] In some embodiments of the present application, the proximal connector comprises a first rod part and a second rod part, the first rod part and the second rod part are both arranged in the receiving cavity, the first rod part is arranged at the distal end of the second rod part, and the diameter of the first rod part is smaller than the diameter of the second rod part, the outer peripheral surface of the second rod part is provided with a limiting groove, the limiting groove comprises a first groove part extending in the axial direction of the second rod part and a second groove part extending in the circumferential direction of the second rod part, and the first groove part passes through the distal end of the second rod part and forms a moving outlet; The unlocking member is slidably connected with the shell in the circumferential direction of the adjusting sleeve, the unlocking member is provided with a limiting part, the limiting part is arranged in the limiting groove, the limiting part can move in the second groove part in the circumferential direction of the second rod part to the proximal end of the first groove part and move from the proximal end of the first groove part to the outside of the moving outlet.

[0024] In some embodiments of the present application, the clip arm assembly further comprises: The elastic arm is connected with the seat body at the proximal end, the elastic arm is arranged between the rod body and the clip arm, the elastic force of the elastic arm has a tendency to rotate towards the clip arm, so that the elastic arm and the clip arm jointly clamp the mitral valve.

[0025] In some embodiments of the present application, the distal end of the delivery rod is provided with a wire passing hole, the distal end of the elastic arm of any clip arm assembly is provided with a wire passing hole, and the operation control part comprises a control wire which respectively passes through the wire passing hole and the wire passing hole; When the control wire is pulled, the distal end of each clip arm assembly can move towards the receiving space and be in a closed state; When the control wire is released, the elastic arm moves towards the clip arm under the action of its own elastic force.

[0026] In some embodiments of the present application, the surface of the elastic arm facing the clip arm is provided with at least one barb structure, the barb structure has a fixed end and a free end, and the free end is closer to the proximal end of the elastic arm than the fixed end.

[0027] In some embodiments of the present application, the main body part has a control wire delivery channel, and part of the control wire is arranged in the control wire delivery channel; And / or, the operation control component further comprises a housing and a first locking wire part, an outer surface of the housing is provided with a second locking wire part, a proximal end of the control wire passes out of the second locking wire part, the second locking wire part is threadedly matched with the first locking wire part, and part of the control wire is arranged between the threadedly matched surfaces of the second locking wire part and the first locking wire part.

[0028] In some embodiments of the present application, a distal end of the adapter is provided with a guide cone, the guide cone, the adapter and the main body are all provided with a guide wire channel, the operation control component further comprises a housing and a guide wire arranged in the guide wire channel, the adjustment rod fixing component is arranged at a proximal end of the housing, a distal end of the guide wire passes out of an end of the guide cone, and the guide wire passes through the clamping component, and a proximal end of the guide wire is configured to pass out of the housing.

[0029] The above description is only a summary of the technical solutions of the present application. In order to enable the technical means of the present application to be more clearly understood, and to be implemented according to the content of the description, and in order to enable the above and other purposes, characteristics and advantages of the present application to be more apparent and easy to understand, the following specific embodiments of the present application are described in detail. BRIEF DESCRIPTION OF DRAWINGS

[0030] Various other advantages and benefits will become apparent to those of ordinary skill in the art upon reading the following detailed description of the preferred embodiments. The accompanying drawings are intended to further assist in understanding the preferred embodiments and are not intended to limit the application. Moreover, like reference numerals designate like parts throughout the several views in the drawings. In the drawings: Figure 1 A diagram of the structure of a heart; Figure 2 An axonometric view of a mitral valve clamping system according to some embodiments of the present application; Figure 3 A close-up view of I in Figure 2 Figures 4A-4D An axonometric view of a mitral valve clamping system according to different embodiments of the present application, with the clamping component in an open state; Figure 5 A partial structural view of a mitral valve clamping system according to some embodiments of the present application, from a first perspective; Figure 6 A partial cross-sectional view of a mitral valve clamping system according to some embodiments of the present application, passing through the axis of the limiting hole and the delivery channel of the release rod; Figure 7 A partial structural view of a mitral valve clamping system according to some embodiments of the present application, from a second perspective when the clamping arms of the clamping component are open; Figure 8 A partial structural view of a mitral valve clamping system according to some embodiments of the present application, from a second perspective when the clamping arms of the clamping component are closed; Figure 9 ​for Figure 8 A magnified view of section II; Figure 10 This is a partial structural diagram from a second perspective of a clamping component in a mitral valve clamping system according to some embodiments of this application, when the clamping arm is open. Figure 11 for Figure 10 A magnified view of section III; Figure 12 This is an isometric view of an elastic sheet in a mitral valve clamping system according to some embodiments of this application; Figure 13 This is a partial structural diagram of a mitral valve clamping system according to some embodiments of this application; Figure 14 This is a partial axial cross-sectional view of an adjusting sleeve in a mitral valve clamping system according to some embodiments of this application. Figure 15 for Figure 14 A magnified view of section IV; Figure 16 This is a partial structural diagram of the proximal connector in a mitral valve clamping system according to some embodiments of this application; Figure 17 This is a partial axial cross-sectional view of an adjusting sleeve in a mitral valve clamping system according to some embodiments of this application. Figure 18 This is a partial cross-sectional view of a mitral valve clamping system through a guidewire channel, according to some embodiments of this application. Figure 19 A partial cross-sectional view of the axis passing through the first locking element and the adjusting sleeve in a mitral valve clamping system according to some embodiments of this application; Figure 20 This is a partial exploded view of the connection between the fixing member and the adjusting member in a mitral valve clamping system according to some embodiments of this application; Figure 21 for Figure 20 Structural diagram of the connecting sleeve; Figure 22 This is a partial structural diagram of a clamping component capturing the mitral valve in a mitral valve clamping system according to some embodiments of this application; Figure 23 This is a partial structural diagram of a mitral valve clamping system according to some embodiments of this application, showing the clamping component clamping the mitral valve. Figure 24 This is a partial structural diagram of the mitral valve clamping system according to some embodiments of this application, showing the clamping component inside the heart after clamping the mitral valve.

[0031] The reference numerals in the detailed embodiments are as follows: 10. Mitral valve; 11. Chords of tendinos; 100, Mitral valve clamping system; 20, operation control component; 21, delivery rod; 211, main body; 2111, unlocking line channel; 2112, adjustment rod delivery channel; 2113, control line delivery channel; 2114, guide wire channel; 212, first blocking part; 213, second blocking part; 214, adapter; 2141, release rod delivery channel; 215, guide cone; 216, wire passing hole; 22, release rod; 23, shell; 231, ring groove; 24, release operation component; 25, adjustment rod; 251, stop groove; 26, unlocking line; 27, unlocking line operation component; 271, clamping knob; 272, lock cap; 28, adjustment rod fixing component; 281, screw rod; 282, proximal end connector; 2821, first rod part; 2822, second rod part; 28221, limiting groove; 28222, first groove part; 28223, second groove part; 283, unlocking piece; 2831, limiting part; 29, adjustment sleeve; 291, annular protrusion; 201, first locking line piece; 202, second locking line piece; 203, control line; 204, set screw; 205, guide wire; 30, clamping component; 31, support piece; 311, seat body; 312, rod body; 3121, hook body structure; 3122, insertion hole; 32, clamping arm assembly; 321, clamping arm; 322, adjustment arm; 323, elastic arm; 3231, wire passing hole; 3232, barb structure; 33, fixing piece; 331, connecting sleeve; 332, notch; 333, elastic sheet; 334, protrusion; 34, slot rod; 341, clamping groove; 35, elastic sheet; 351, first sheet body; 3511, second mounting hole; 3512, connecting hole; 352, second sheet body; 3521, clamping protrusion; 353, third sheet body; 3531, first mounting hole; 354, mounting hole; 301, limiting hole; X, first direction; Y, second direction; Z, axial direction. DETAILED DESCRIPTION

[0032] The embodiments of the technical solution of the present application will be described in detail below with reference to the drawings. The following embodiments are only used to more clearly illustrate the technical solution of the present application, and therefore only serve as examples, and cannot limit the protection scope of the present application.

[0033] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs; the terms used herein are only for the purpose of describing specific embodiments and are not intended to limit the present application; the terms "include" and "have" and any variations thereof in the specification and claims of the present application and the above description of drawings are intended to cover non-exclusive inclusion.

[0034] In the description of the embodiments of the present application, the technical terms "first", "second" and the like are only used to distinguish different objects, and cannot be understood as indicating or implying relative importance or implicitly indicating the number, specific order or primary and secondary relationship of the indicated technical features. In the description of the embodiments of the present application, the meaning of "multiple" is more than two, unless otherwise explicitly specified and limited.

[0035] Reference herein to "embodiments" means that the particular features, structures, or characteristics described in connection with the embodiments can be included in at least one embodiment of the present application. The appearance of this phrase in various places in the specification does not necessarily all refer to the same embodiment, nor is it necessarily independent or alternative to other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described herein can be combined with other embodiments.

[0036] In the description of the embodiments of the present application, the term "and / or" is only a description of the association relationship of the associated objects, which means that there can be three relationships, for example, A and / or B, which can represent the three cases of A alone, A and B together, and B alone. In addition, the character " / " herein generally represents an "or" relationship between the front and rear associated objects.

[0037] In the description of the embodiments of the present application, the term "multiple" refers to more than two (including two), and similarly, "multiple groups" refers to more than two groups (including two groups), and "multiple pieces" refers to more than two pieces (including two pieces).

[0038] In the description of the embodiments of the present application, the technical terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, which is only for the convenience of describing the embodiments of the present application and simplifying the description, and does not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the embodiments of the present application.

[0039] In the description of the embodiments of the present application, unless otherwise explicitly specified and limited, the technical terms "mounting", "connection", "connection", "fixing" and the like should be understood in a broad sense, for example, it can be fixedly connected, or it can be detachably connected, or it can be integrated; it can be mechanical connection, or it can be electrical connection; it can be directly connected, or it can be indirectly connected through an intermediate medium; it can be the internal communication of two elements or the interaction relationship between two elements. For those skilled in the art, the specific meaning of the above terms in the embodiments of the present application can be understood according to the specific circumstances.

[0040] In the present application, the proximal end refers to the end close to the operator, and the distal end refers to the end away from the operator.

[0041] According to the embodiments of the present application, please refer to Figures 2-4A , a mitral valve clamping system 100 is provided, which comprises a clamping component 30, an operation control component 20 and a delivery rod 21. The clamping component 30 is configured to clamp the mitral valve 10 along a first direction X. The operation control component 20 is detachably connected with the proximal end of the clamping component 30 and the distal end of the clamping component 30 respectively, and the operation control component 20 comprises the delivery rod 21. The delivery rod 21 comprises a main body part 211, a first blocking part 212 and a second blocking part 213, the first blocking part 212 and the second blocking part 213 are respectively arranged at and connected with the distal end of the main body part 211, the first blocking part 212 and the second blocking part 213 are arranged at intervals along a second direction Y, and the first blocking part 212 and the second blocking part 213 jointly define an accommodation space for accommodating at least part of the clamping component 30. The first direction X, the second direction Y and the axial direction Z of the delivery rod 21 are perpendicular to each other.

[0042] The structures of the first blocking part 212 and the second blocking part 213 can be the same or different.

[0043] The first blocking part 212 and the second blocking part 213 can be fixed between the main body part 211 by welding, bonding or threaded connection, etc.

[0044] In the technical solution, the first blocking part 212 and the second blocking part 213 are arranged on different sides of the clamping component 30, and when the clamping component 30 clamps the valve of the mitral valve 10, the chordae tendineae 11 can be blocked from entering the clamping area of the clamping component 30. In addition, the proximal end of the clamping component 30 is detachably connected with the operation control component 20, and the distal end of the clamping component 30 is detachably connected with the delivery rod 21, which can simplify the separation operation of the clamping component 30, and the clamping component 30 can be more stably fixed during clamping, which is beneficial to the clamping component 30 to clamp the valve more accurately.

[0045] In some embodiments of the present application, please refer to Figures 4A-6The conveying rod 21 further comprises an adapter 214 arranged at the distal end of the first blocking part 212, the second blocking part 213 is arranged at the adapter 214 in the second direction Y, the proximal end of the adapter 214 is hingedly connected with the distal end of the clamping component 30, the adapter 214 is provided with a release rod conveying channel 2141, the distal end of the clamping component 30 is provided with a limiting hole 301 in communication with the release rod conveying channel 2141, the operation control component 20 further comprises a release rod 22, the release rod 22 is slidably arranged in the release rod conveying channel 2141, and the distal end of the release rod 22 is arranged in the limiting hole 301, and the proximal end of the release rod 22 is arranged to be driven so that the distal end of the release rod 22 can be withdrawn into the release rod conveying channel 2141.

[0046] The adapter 214 can be part of the first blocking part 212, or can be a separate piece connected with one or both of the first blocking part 212 and the second blocking part 213.

[0047] The release rod conveying channel 2141 can be arranged only in the adapter 214, in which case a part of the release rod 22 is located outside the first blocking part 212 and the main body part 211. The release rod conveying channel 2141 can also be arranged in both the adapter 214 and the first blocking part 212, i.e. the release rod conveying channel 2141 extends from the adapter 214 to the first blocking part 212. The release rod conveying channel 2141 can also be arranged in the interiors of the adapter 214, the first blocking part 212 and the main body part 211 at the same time, in which case the release rod 22 is completely hidden.

[0048] The release rod 22 can be made of nickel-titanium alloy or stainless steel.

[0049] The proximal end of the adapter 214 and the distal end of the clamping component 30 are both provided with hook structures 3121, and the hooks of the two define avoidance spaces, and the hook structures 3121 of the two are arranged in the avoidance spaces of each other, and the mutually matched outer contour lines thereof are approximately S-shaped or Z-shaped when viewed from the clamping area of the clamping component 30.

[0050] In an example, the conveying rod 21 further comprises a guide cone 215 arranged at the distal end of the adapter 214, the distal end of the guide cone 215 has a smaller diameter than the proximal end, and the guide cone 215 can be connected with the first blocking part 212, or can be connected with the second blocking part 213, or can be connected with both the first blocking part 212 and the second blocking part 213.

[0051] When the clamping component 30 clamps the valve, the clamping component 30 needs to be separated from the operation control component 20, and the clamping component 30 is retained at the valve. First, the proximal end of the clamping component 30 is detached from the operation control component 20, and then the release rod 22 is withdrawn by operating the release rod 22 at the proximal end of the operation control component 20, so that the distal end of the release rod 22 is withdrawn into the release rod delivery channel 2141, the release rod 22 is released from the limiting cooperation with the limiting hole 301, at this time, the proximal end of the adapter 214 and the distal end of the clamping component 30 are only in a hanging state, and the distal end of the clamping component 30 and the proximal end of the adapter 214 can be separated by moving the delivery rod 21 in the radial direction. The separation operation of the distal end of the clamping component 30 and the proximal end of the adapter 214 is realized by withdrawing the release rod 22. On the one hand, the adapter 214 can provide support for the clamping component 30 during clamping to reduce the shaking of the clamping component 30 during clamping, which is conducive to improving the accuracy and reliability of clamping. On the other hand, the separation operation of the clamping component 30 and the adapter component is simple and convenient, which is conducive to reducing the difficulty of surgical operation. In some embodiments of the present application, please refer to Figure 6 The release rod delivery channel 2141 extends to the distal end of the first blocking portion 212, and extends from the distal end of the first blocking portion 212 to the proximal end of the main body portion 211 in the axial direction Z of the delivery rod 21, and the proximal end of the release rod 22 passes out from the proximal end of the main body portion 211.

[0052] In an example, the release rod delivery channel 2141 has a curved section in the adapter 214, and the first blocking portion 212 and the main body portion 211 can be straight sections extending in the axial direction Z of the delivery rod 21, at this time, the release rod 22 is bent in the adapter 214.

[0053] Therefore, the release rod 22 can not be exposed outside the delivery rod 21, which is conducive to reducing the occupied space of the release rod 22, facilitating surgical operation, and avoiding interference caused by the release rod 22 during clamping, facilitating clamping operation of the clamping component 30.

[0054] In another embodiment of the present application, the distal end of the clamping component 30 is a rod-shaped structure, the rod-shaped structure can be inserted and matched with the release rod delivery channel 2141 in the axial direction Z of the delivery rod 21, the distal end of the release rod 22 is connected with the rod-shaped structure, and the distal end of the release rod 22 is provided with a weak portion, which can be a groove or a notch. By providing a withdrawal force to the release rod 22, the distal end of the release rod 22 is disconnected from the connection position of the rod-shaped structure, at this time, the rod-shaped structure of the clamping component 30 can be withdrawn from the distal end of the release rod delivery channel 2141 by only pushing the delivery rod 21 forward, and the separation operation is completed. By using this connection mode, the distal end of the clamping component 30 can be firmly fixed during clamping.

[0055] In some embodiments of the present application, please refer to Figure 6 and Figure 14 The operation control component 20 further comprises a release operation component 24 and a shell 23 connected to the proximal end of the main body 211, the release operation component 24 is slidingly connected to the shell 23 along the axial direction Z of the delivery rod 21, the release operation component 24 has a limit position and a release position on the shell 23, and the proximal end of the release rod 22 is connected to the release operation component 24. In the limit position, the distal end of the release rod 22 is arranged in the limit hole 301. In the release position, the distal end of the release rod 22 is arranged in the release rod delivery channel 2141.

[0056] The shell 23 and the proximal end of the main body 211 can be fixed by welding, bonding, screw connection or clamping.

[0057] In an example, the shell 23 has a movable cavity extending along the axial direction Z of the delivery rod 21, a part of the release operation component 24 is arranged in the movable cavity and can move along the axial direction Z of the delivery rod 21, the limit position of the release operation component 24 moving distally in the movable cavity is the limit position, and the limit position of the release operation component 24 moving proximally in the movable cavity is the release position (withdrawal), the proximal end of the release operation component 24 is fixedly connected to the release rod 22, which can be fixed by screw connection, welding or bonding. Another part of the release operation component 24 is located outside the shell 23, which facilitates the push-pull operation of the operator. In order to facilitate the release operation component 24 to be installed in the shell 23, the shell 23 can be divided into two parts, and the two parts are buckled to form the shell 23.

[0058] The release operation component 24 can be one piece or a whole piece connected by multiple pieces By operating the release operation component 24, compared with directly pulling the release rod 22 by human, the operation is convenient, and by observing the moving position of the release operation component 24, it is easier to determine whether the release rod 22 is in the release position when withdrawing, so as to reduce the operation difficulty.

[0059] In some embodiments of the present application, please refer to Figure 4AThe clamping component 30 comprises a support 31, a clamping arm assembly 32 and a fixing member 33. The support 31 comprises a rod body 312 and a seat body 311. The rod body 312 is arranged at the distal end of the seat body 311. The distal end of the rod body 312 is hingedly connected to the proximal end of the adapter 214. The distal end of the rod body 312 is provided with a limiting hole 301. The seat body 311 is provided with the clamping arm assembly 32 on both sides along the first direction X. The clamping arm assembly 32 is configured to clamp the mitral valve 10. Either of the clamping arm assemblies 32 is rotationally connected to the fixing member 33. The operation control component 20 comprises an adjusting rod 25. The adjusting rod 25 is arranged on one side of the proximal end of the fixing member 33 along the axial direction Z of the delivery rod 21. The proximal end of the fixing member 33 is detachably connected to the distal end of the adjusting rod 25. The adjusting rod 25 drives the fixing member 33 to move relative to the seat body 311 along the axial direction Z of the delivery rod 21, so as to adjust the opening angle of the clamping arm assemblies 32 on both sides of the seat body 311 along the first direction X.

[0060] The rod body 312 and the seat body 311 can be integrally formed or fixed by welding or bonding.

[0061] The limiting hole 301 can pass through the proximal end of the seat body 311 along the length direction of the rod body 312.

[0062] The fixing member 33 can be a fixed plate, a fixed block or an irregularly shaped structure.

[0063] Thus, the distal end and the proximal end of the clamping component 30 can be fixed and detached. When clamping, the shaking of the clamping component 30 can be reduced, so that the clamping component 30 can more stably clamp the valve of the mitral valve 10. When separating the clamping component 30, the adjusting rod 25 and the release rod 22 are only needed to be withdrawn and rotated, so that the separation operation of the clamping component 30 can be completed, and the operation is convenient.

[0064] In some embodiments of the present application, please refer to Figure 4A The clamping arm assembly 32 comprises a clamping arm 321 and an adjusting arm 322. The proximal end of the clamping arm 321 is rotationally connected to the seat body 311 about a first axis. The distal end of the adjusting arm 322 is rotationally connected to the proximal end of the clamping arm 321 about a second axis. The proximal end of the adjusting arm 322 is rotationally connected to the fixing member 33 about a third axis. The first axis, the second axis and the third axis are parallel.

[0065] In this scheme, the adjusting arms 322 on both sides of the seat body 311 along the first direction X, the clamping arms 321, the fixing member 33 and the seat body 311 constitute a four-bar linkage mechanism. The fixing member 33 is driven to move relative to the seat body 311 by the adjusting rod 25, so that the clamping arms 321 on both sides of the seat body 311 along the first direction X can be opened or closed. In the closed state, the clamping component 30 can be conveniently delivered to a predetermined position. Then, the clamping arms 321 are opened, so that the valve can be conveniently clamped.

[0066] In other embodiments, the adjusting arm 322 can not be provided, and the clamping arm assembly 32 comprises clamping arms 321 and adapter rods, the proximal end of each clamping arm 321 being rotatably connected to the distal end of an adapter rod about a second axis parallel to the first axis. The proximal end of each adapter rod is threadedly connected to an adjusting rod 25, and axial movement of the adjusting rod 25 drives the clamping arm 321 to rotate about the first axis, thereby adjusting the angle between the clamping arm 321 and the axis of the conveying rod 21.

[0067] In some embodiments of the present application, the distal end of the adjusting rod 25 is threadedly connected to the proximal end of the fixing member 33.

[0068] The distal end of the adjusting rod 25 can be provided with a threaded hole, and the proximal end of the fixing member 33 is provided with an externally threaded rod; or the distal end of the adjusting rod 25 is provided with a threaded rod, and the proximal end of the fixing member 33 is provided with a threaded hole. The threaded rod and the threaded hole are threadedly engaged.

[0069] Through the threaded connection, on the one hand, the connection can be more reliable, and on the other hand, the disassembly operation is facilitated.

[0070] In other embodiments of the present application, please refer to Figure 20 and Figure 21 The connection between the proximal end of the fixing member 33 and the distal end of the adjusting rod 25 can be a threaded connection, and the two can also be fixed by clamping. For example, the fixing member 33 comprises a connecting sleeve 331, the proximal end of the connecting sleeve 331 is inserted into the distal end of the adjusting rod 25, and the proximal end of the connecting sleeve 331 is provided with a plurality of notches 332 spaced along the axial direction of the connecting sleeve 331, and a spring piece 333 is formed between adjacent two notches 332, the spring piece 333 has a rebound force inward along the radial direction of the connecting sleeve 331, a plurality of spring pieces 333 clamps and fixes the adjusting rod 25 under the action of the spring force, and the outer peripheral surface close to the distal end of the adjusting rod 25 is provided with a stop groove 251, and the spring piece 333 has a convex part 334, and the convex part 334 is located in the stop groove 251. When disengaging, the adjusting rod 25 is simply withdrawn to overcome the clamping force of the spring piece 333 and the stop groove 251, and the separation of the adjusting rod 25 and the fixing member 33 can be realized.

[0071] In some embodiments of the present application, please refer to Figures 4B-4D The clamping arm assembly 32 comprises clamping arms 321 and adjusting arms 322. The proximal end of the clamping arm 321 is rotatably connected to the seat body 311 about the first axis. The distal end of the adjusting arm 322 is connected to the clamping arm 321, and the proximal end of the adjusting arm 322 is connected to the fixing member 33. The adjusting arm 322 is an arm body with elasticity, and the elastic force of the adjusting arm 322 has a tendency to close the clamping arm 321.

[0072] The adjusting arm 322 can be a spring structure, and the adjusting arm 322 can be fixedly connected with at least one of the clamping arm 321 and the fixing member 33. The fixedly connected means that the latter cannot move relative to the former. The adjusting arm 322 can be fixed to at least one of the clamping arm 321 and the fixing member 33 by welding, integral molding or adhesion.

[0073] Figure 4B The proximal end of the adjusting arm 322 is rotationally connected with the fixing member 33, and the distal end of the adjusting arm 322 is fixedly connected with the clamping arm 321.

[0074] Figure 4C The distal end of the adjusting arm 322 is rotationally connected with the clamping arm 321, and the proximal end of the adjusting arm 322 is fixedly connected with the fixing member 33.

[0075] Figure 4D The distal end of the adjusting arm 322 is fixedly connected with the clamping arm 321, and the proximal end of the adjusting arm 322 is fixedly connected with the fixing member 33.

[0076] The clamping arm 321 in the closed state means that the clamping arm 321 is not unfolded.

[0077] The adjusting arm 322 can be made of a shape memory alloy, and specifically can be made of a nickel-titanium alloy.

[0078] The adjusting arm 322 can make the clamping arm 321 have a closing tendency. After the clamping arm 321 captures the mitral valve 10, the clamping arm 321 can exert a clamping force on the mitral valve 10, so as to improve the reliability of the clamping assembly 30 in clamping the mitral valve 10.

[0079] In some embodiments of the present application, please refer to Figure 4C The distal end of the adjusting arm 322 is rotationally connected with the clamping arm 321, and the proximal end of the adjusting arm 322 is fixedly connected with the fixing member 33. Figure 4D The distal end of the adjusting arm 322 is rotationally connected with the clamping arm 321, and the proximal end of the adjusting arm 322 is fixedly connected with the fixing member 33.

[0080] The adjusting arm 322 can be fixedly connected with at least one of the clamping arm 321 and the fixing member 33, so that the adjusting arm 322 can store elastic potential energy and release the elastic potential energy to the clamping arm 321, and the clamping arm 321 has a closing tendency.

[0081] In some embodiments of the present application, please refer toFigures 6-13 The clamping component 30 further comprises a slot rod 34 connected with the fixing member 33, the proximal end of the rod body 312 is provided with a insertion hole 3122, the slot rod 34 is in sliding fit with the insertion hole 3122 along the axial direction of the slot rod 34, and the outer peripheral surface of the slot rod 34 is provided with a plurality of clamping grooves 341 which are arranged at intervals along the axial direction of the slot rod 34. The clamping component 30 further comprises an elastic sheet 35 connected with the fixing member 33 or the seat body 311, the elastic sheet 35 is arranged between the fixing member 33 and the seat body 311, the elastic sheet 35 is provided with a mounting hole 354, the distal end of the slot rod 34 is arranged through the mounting hole 354, and the elastic sheet 35 has a first state of clamping with the clamping grooves 341 and a second state of being separated from the clamping grooves 341; the operation control component 20 further comprises an unlocking wire 26, the distal end of the unlocking wire 26 is connected with the elastic sheet 35, and the unlocking wire 26 is configured to provide a pulling force to the elastic sheet 35 so that the elastic sheet 35 is switched from the first state to the second state. The elastic sheet 35 can be a shape memory alloy material, and specifically can be a nickel-titanium alloy.

[0082] The slot rod 34 and the fixing member 33 can be connected through welding, bonding or a screw and the like.

[0083] In the first state, the elastic sheet 35 is in a state of partially or completely releasing elastic force, at this time, the edge of the mounting hole 354 is clamped into the clamping groove 341.

[0084] The elastic sheet 35 can be fixed to the fixing member 33 or the seat body 311 through a screw, bonding or welding and the like.

[0085] The unlocking wire 26 can be a metal wire, such as a nickel-titanium wire, a stainless steel wire and the like. The unlocking wire 26 can also be a high polymer wire, such as a polypropylene wire, a polyethylene terephthalate wire and the like.

[0086] Optionally, the seat body 311 has a placement space for accommodating the elastic sheet 35, and the elastic sheet 35 is arranged in the placement space.

[0087] When the elastic sheet 35 is not pulled by the unlocking wire 26, the elastic sheet 35 always keeps the clamping state with the clamping groove 341, at this time, the fixing member 33 cannot move along the axial direction Z of the conveying rod 21 relative to the seat body 311, and the clamping arm 321 cannot rotate relative to the seat body 311. When the clamping arm 321 is in the closed state, that is, the included angle between the clamping arm 321 and the axis of the conveying rod 21 is 0°, it is convenient to convey the clamping component 30 to the predetermined position, and then the elastic sheet 35 is deformed by pulling the elastic sheet 35 through the unlocking wire 26, so that the elastic sheet 35 is separated from the clamping groove 341, at this time, the clamping arm 321 is unfolded by pushing the adjusting rod 25, and it is convenient for subsequent clamping operation of the valve. When the valve is clamped, the unlocking wire 26 can be released, so that the clamping arm 321 keeps the predetermined clamping position to provide support, so that the clamping component 30 keeps the clamping state of clamping the valve.

[0088] In some embodiments of the present application, please refer to Figures 6-12 The mounting hole 354 includes a first mounting hole 3531 and a second mounting hole 3511, the distal end of the slot rod 34 is arranged in sequence through the first mounting hole 3531 and the second mounting hole 3511, the elastic sheet 35 includes a first sheet body 351, a second sheet body 352 and a third sheet body 353, the two ends of the second sheet body 352 are connected with the first sheet body 351 and the third sheet body 353 respectively, and are arranged at an angle with the first sheet body 351 and the third sheet body 353 respectively, the third sheet body 353 is connected with the fixing member 33 or the seat body 311, the first sheet body 351 is located on the side of the third sheet body 353 away from the fixing member 33 and is connected with the unlocking line 26, the first mounting hole 3531 penetrates through the third sheet body 353, the hole wall of the first mounting hole 3531 is arranged outside the clamping groove 341, and the second mounting hole 3511 penetrates through the first sheet body 351. In the first state, the first sheet body 351 and the second sheet body 352 are arranged at an obtuse angle, and part of the hole wall of the second mounting hole 3511 is located in the clamping groove 341. In the second state, the first sheet body 351 moves out to the outside of the clamping groove 341.

[0089] When the first sheet body 351 is clamped into the clamping groove 341, the angle between the first sheet body 351 and the second sheet body 352 can be about 45°.

[0090] The first sheet body 351, the second sheet body 352 and the third sheet body 353 can be an integrally formed structure, and can be made by bending when the elastic sheet 35 is made. The first sheet body 351, the second sheet body 352 and the third sheet body 353 can also be connected by welding. When the elastic sheet 35 is pulled to the compressed state by the unlocking line 26, the elastic sheet 35 is generally in a U-shaped structure.

[0091] The diameter of the first mounting hole 3531 and the diameter of the second mounting hole 3511 are both greater than the outer diameter of the slot rod 34.

[0092] The cross-sectional profile shape of the clamping groove 341 can be, but is not limited to, rectangular, U-shaped, V-shaped or semicircular arc-shaped, etc.

[0093] As an example, the end of the first sheet body 351 away from the second sheet body 352 is provided with a connecting hole 3512, one end of the unlocking line 26 is withdrawn to one side of the operation control component 20 after penetrating through the connecting hole 3512, and both ends of the unlocking line 26 are located on one side of the operator during the operation process. Before the two ends of the clamping component 30 are separated from the operation control component 20, the operator can pull one end of the unlocking line 26 to make the unlocking line 26 withdrawn from the connecting hole 3512, and complete the separation operation of the unlocking line 26 and the clamping component 30.

[0094] When the elastic sheet 35 is in the first state, the axis of the second mounting hole 3511 intersects with the axis of the slot rod 34, and the two are not parallel. In the second state, by pulling the unlocking line 26, the axis of the second mounting hole 3511 is substantially parallel to the axis of the slot rod 34, so that the second mounting hole 3511 is completely outside the clamping groove 341, so that the slot rod 34 can slide relative to the rod body 312, realizing the movement of the fixing part 33 relative to the seat body 311, and further realizing the adjustment of the angle between the clamping arm 321 and the axis of the conveying rod 21. Through the clamping of the first sheet body 351 and the clamping groove 341, if the unlocking line 26 is not pulled, the part of the first sheet body 351 clamped in the clamping groove 341 is not easy to be separated from the clamping groove 341, so that the clamping is more reliable, that is, the clamping arm 321 provides support for the valve, and after clamping, the valve is not easy to be separated from the clamping part 30, which is beneficial to improve the success rate of the operation.

[0095] In some embodiments of the present application, please refer to Figure 13 , the elastic sheet 35 can be an L-shaped elastic sheet, that is, the elastic sheet 35 only includes the first sheet body 351 and the second sheet body 352. In the embodiment in which the clamping part 30 includes the adjusting arm 322, the first sheet body 351 is fixed to the fixing part 33 or the seat body 311, the second sheet body 352 can be arranged between the adjusting arm 322 and the slot rod 34, and the surface of the second sheet body 352 facing the slot rod 34 is provided with a clamping protrusion 3521. The second sheet body 352 has a rebounding force towards the clamping groove 341, so that the clamping protrusion 3521 can be clamped and matched with the clamping groove 341. The unlocking line 26 can be connected with the second sheet body 352 through the adjusting arm 322. When the unlocking line 26 is pulled, the second sheet body 352 can be separated from the clamping groove 341, realizing unlocking.

[0096] In some embodiments of the present application, please refer to Figure 14 , the operation control part 20 further includes an unlocking line operation part 27 and a housing 23. The unlocking line operation part 27 is slidably connected with the housing 23 along the axial direction Z of the conveying rod 21, and the unlocking line operation part 27 is connected with the proximal end of the unlocking line 26. When the unlocking line operation part 27 moves towards the proximal end of the housing 23, the unlocking line 26 pulls the elastic sheet 35, so that it is switched from the first state to the second state.

[0097] In an example, the unlocking line operation component 27 includes a clamping knob 271 and a lock cap 272, the clamping knob 271 is slidingly connected with the shell 23 along the axial direction Z of the delivery rod 21, the clamping knob 271 has a column located outside the shell 23, the lock cap 272 is threadedly connected with the column, and the unlocking line 26 is clamped between the threadedly connected fitting surfaces of the lock cap 272 and the column. The retracted position of the clamping knob 271 on the shell 23 can be used as an unlocking position, in which the unlocking line 26 is retracted to make the elastic sheet 35 disengage from the clamping groove 341 to complete the unlocking of the slot rod 34, and at this time, the clamping knob 271 is clamped and fitted with the shell 23 to maintain the unlocking state. Specifically, the clamping knob 271 can be provided with a clamping protrusion, and the shell 23 is provided with a clamping groove, and in the unlocking position, the clamping protrusion is clamped and fitted with the clamping groove. When it is needed to clamp and fit the elastic sheet 35 with the clamping groove 341 of the slot rod 34, the lock cap 272 can be manually pushed to the distal end direction of the delivery rod 21 to make the clamping protrusion disengage from the clamping groove.

[0098] Through the setting of the unlocking line operation component 27, the problem that the operator is easily cut by the unlocking line 26 when pulling the unlocking line 26 can be avoided, and compared with the unlocking mode of directly pulling the unlocking line 26, the problem that the unlocking line 26 slips on the hand and cannot be pulled to the position can be avoided, and the operation is facilitated.

[0099] In some embodiments of the present application, please refer to Figure 10 The main body 211 has an unlocking line passage 2111 penetrating through both ends thereof, and part of the unlocking line 26 is located in the unlocking line passage 2111. The main body 211 has an adjusting rod delivery passage 2112 penetrating through both ends thereof, and part of the adjusting rod 25 is located in the adjusting rod delivery passage 2112.

[0100] In the above example in which the unlocking line operation component 27 includes the clamping knob 271 and the lock cap 272, the clamping knob 271 has a cavity, the cavity is in communication with the unlocking line passage 2111, and the proximal end of the unlocking line 26 sequentially passes through the unlocking line passage 2111 and the cavity and is drawn out from the cavity. In other examples, the clamping knob 271 can also not be provided with a cavity, and an exit hole (not shown in the figure) is arranged on the shell 23, and the unlocking line 26 is directly drawn out from the exit hole of the shell 23.

[0101] Through the setting of the unlocking line passage 2111, the unlocking line 26 is hidden in the delivery rod 21, and the problem that the unlocking line 26 is entangled on the clamping component 30 during the clamping of the valve can be avoided, so as to reduce the difficulty of the operation.

[0102] In some embodiments of the present application, please refer to Figures 14-16The operation control component 20 further comprises a housing 23, an adjusting rod fixing component 28 and an adjusting sleeve 29. The adjusting rod fixing component 28 is arranged at the proximal end of the housing 23 and is in sliding connection with the housing 23 along the axial direction Z of the delivery rod 21. The proximal end of the adjusting rod 25 is connected with the adjusting rod fixing component 28. The adjusting sleeve 29 is sleeved on the adjusting rod fixing component 28 and is in threaded connection with the adjusting rod fixing component 28. The adjusting sleeve 29 is in rotational connection with the housing 23.

[0103] In an example, the inner surface of the side wall of the housing 23 is provided with a guide groove extending along the circumference of the delivery rod 21, the guide groove penetrating through the proximal end of the housing 23. The outer circumferential surface of the adjusting rod fixing component 28 is provided with a guide protrusion. The guide groove is in sliding connection with the guide protrusion to limit the rotation of the adjusting rod fixing component 28 itself. The adjusting sleeve 29 functions as a limiting part for the guide protrusion to prevent the adjusting rod fixing component 28 from moving out of the proximal end of the housing 23 along the axial direction Z of the delivery rod 21.

[0104] The inner circumferential surface of the side wall of the housing 23 is provided with a ring groove 231. The distal end of the adjusting sleeve 29 is provided with a ring protrusion 291. The ring protrusion 291 is in cooperation with the ring groove 231 and can rotate relative to the ring groove 231. The ring protrusion 291 and the ring groove 231 are both arranged around the axis of the delivery rod 21.

[0105] By rotating the adjusting sleeve 29, the adjusting rod fixing component 28 can move relative to the delivery rod 21 along the axial direction Z of the delivery rod 21, so that the adjusting rod 25 moves relative to the delivery rod 21. Since the rod body 312 of the clamping component 30 is detachably connected with the adapter 214, the rod body 312 is connected with the seat body 311, i.e. the seat body 311 is fixed relative to the delivery rod 21, the fixing part 33 can move relative to the seat body 311 along the axial direction Z of the delivery rod 21, so that the fixing part 33 drives the adjusting arm 322 to rotate relative to the clamping arm 321, and finally the angle adjustment between the clamping arm 321 and the axis of the delivery rod 21 is realized. By this adjustment mode, on the one hand, the adjustment is more convenient. On the other hand, the threaded cooperation has a self-locking function, so that the clamping arm 321 can be kept at a predetermined angle, which is convenient for other operations in the surgical process, such as valve capturing and position adjustment of the clamping arm 321.

[0106] In other embodiments of the present application, the adjusting sleeve 29 can be omitted, the adjusting rod fixing member 28 is arranged at the proximal end side of the housing 23, the adjusting rod fixing member 28 is a single rod member, and the adjusting rod fixing member 28 is slidably fitted with the side wall of the housing 23 in the axial direction Z of the conveying rod 21, and is rotationally fitted with the side wall of the housing 23 in the circumferential direction of the conveying rod 21, that is, the adjusting rod fixing member 28 can slide relative to the housing 23 and rotate relative to the housing 23, that is, the above-mentioned embodiments do not provide a guide groove on the side wall of the housing 23, and do not provide a guide protrusion on the outer circumferential surface of the adjusting rod fixing member 28. Through this operation, on the one hand, the opening angle of the clamping arm 321 can be adjusted, and on the other hand, by rotating the adjusting rod fixing member 28, in the embodiment in which the adjusting rod 25 is threadedly connected with the fixing member 33, the adjusting rod 25 can be rotated relative to the fixing member 33, so as to realize the separation of the two, that is, the disassembly and separation of the proximal end of the clamping member 30 and the adjusting rod 25.

[0107] In some embodiments of the present application, please refer to Figure 15 and Figure 16 , the adjusting rod fixing member 28 includes a screw rod 281, a proximal end connecting member 282, and an unlocking member 283. The screw rod 281 has a receiving cavity passing through the proximal end of the screw rod 281 and the distal end of the screw rod 281, the adjusting sleeve 29 is sleeved on the outer circumferential surface of the screw rod 281 and threadedly cooperates with the screw rod 281, and the distal end of the adjusting rod 25 passes through the distal end of the screw rod 281 and is slidably fitted with the screw rod 281 in the axial direction Z of the conveying rod 21. Part of the proximal end connecting member 282 is arranged in the receiving cavity, and the proximal end connecting member 282 is connected with the proximal end of the adjusting rod 25. The proximal end connecting member 282 is detachably connected with the screw rod 281 through the unlocking member 283, after the proximal end connecting member 282 is separated from the screw rod 281, the proximal end connecting member 282 can rotate relative to the screw rod 281, so as to separate the distal end of the adjusting rod 25 from the proximal end of the fixing member 33. The proximal end of the adjusting rod 25 passes through the hole of the distal end of the receiving cavity into the receiving cavity, and can be fixedly connected with the proximal end connecting member 282, which can be fixed by bonding, welding or screw connection, etc.

[0108] The proximal connecting member 282 is in a cylindrical or rod shape. The proximal connecting member 282 is detachably connected with the screw rod 281 through the unlocking member 283. When the proximal connecting member 282 is not detached, the proximal connecting member 282 moves together with the screw rod 281 along the axial direction Z of the delivery rod 21. When the rotation adjusting sleeve 29 is rotated, the adjusting rod 25 is driven to move along the axial direction of the adjusting rod 25, so as to change the opening angle of the clamping arms 321. When the unlocking member 283 detaches the proximal connecting member 282 from the screw rod 281, the proximal connecting member 282 can rotate relative to the screw rod 281. In the embodiment in which the adjusting rod 25 is threadedly connected with the fixing member 33, the proximal connecting member 282 is twisted to separate the adjusting rod 25 from the fixing member 33. Therefore, the unlocking member 283 is arranged to facilitate the adjustment of the opening angle of the clamping arms 321 during the clamping of the valve by the clamping member 30, and facilitates the detachment of the proximal end of the clamping member 30 after the clamping.

[0109] In some embodiments of the present application, please refer to Figure 15 and Figure 16 The proximal connecting member 282 comprises a first rod portion 2821 and a second rod portion 2822. The first rod portion 2821 and the second rod portion 2822 are located in the accommodating cavity. The first rod portion 2821 is arranged at the distal end of the second rod portion 2822, and the diameter of the first rod portion 2821 is smaller than that of the second rod portion 2822. The outer circumferential surface of the second rod portion 2822 is provided with a limiting groove 28221. The limiting groove 28221 comprises a first groove portion 28222 extending along the axial direction of the second rod portion 2822 and a second groove portion 28223 extending along the circumferential direction of the second rod portion 2822. The first groove portion 28222 penetrates the distal end of the second rod portion 2822 and forms a moving outlet.

[0110] The unlocking member 283 is slidably connected with the shell 23 along the circumferential direction of the adjusting sleeve 29. The unlocking member 283 is provided with a limiting portion 2831 located in the limiting groove 28221. The limiting portion 2831 can move in the second groove portion 28223 along the circumferential direction of the second rod portion 2822 to the proximal end of the first groove portion 28222, and move from the proximal end of the first groove portion 28222 to the outside of the moving outlet.

[0111] The first rod portion 2821 and the second rod portion 2822 can be an integral structure, or can be fixed by welding or threaded connection, etc. The first rod portion 2821 and the second rod portion 2822 can be coaxially arranged.

[0112] The shell 23 is provided with a long slot hole extending along the circumferential direction of the adjusting sleeve 29. The unlocking member 283 is slidably connected with the long slot hole along the circumferential direction of the adjusting sleeve 29.

[0113] The second groove portion 28223 can be an annular groove extending along the circumference of the second rod portion 2822 for one turn, or can be an arc-shaped groove extending along the circumference of the second rod portion 2822 for less than one turn. The first groove portion 28222 is in communication with the second groove portion 28223. By rotating the unlocking member 283, the limiting portion 2831 is moved from the second groove portion 28223 to the first groove portion 28222, and then the adjusting sleeve 29 is rotated to move the proximal end connecting member 282 relative to the screw rod 281, so that the limiting portion 2831 is moved out of the first groove portion 28222 to the moving-out position, to release the connection between the proximal end connecting member 282 and the screw rod 281. The proximal end connecting member 282 can be rotated relative to the screw rod 281 to realize the separation of the adjusting rod 25 and the fixing member 33. Through the cooperation of the limiting portion 2831 and the first groove portion 28222 and the second groove portion 28223 of the limiting groove 28221, the proximal end connecting member 282 and the screw rod 281 can be disassembled, and the rotation of the proximal end connecting member 282 relative to the housing 23 is realized.

[0114] In some embodiments of the present application, please refer to Figure 17 The unlocking member 283 can be a nut and a set screw 204. The outer circumferential surface of the proximal end connecting member 282 and the outer circumferential surface of the screw rod 281 are connected by the nut to limit the movement of the proximal end connecting member 282 relative to the screw rod 281 in the axial direction of the adjusting sleeve 29. An abutting plane is arranged on the outer circumferential surface of the proximal end connecting member 282, and the cylindrical surface of the outer circumferential surface of the proximal end connecting member 282 is a threaded structure. The nut is threadedly connected with the set screw 204, and the end of the set screw 204 abuts against the abutting plane. The set screw 204 plays a role of preventing the nut from loosening. When it is necessary to disassemble the fixing member 33 and the adjusting rod 25 (threaded connection), the set screw 204 and the nut are disassembled in sequence, and then the proximal end connecting member 282 is rotated to drive the adjusting rod 25 to rotate.

[0115] In some embodiments of the present application, please refer to Figure 4A The clamping arm assembly 32 further comprises a resilient arm 323. The proximal end of the resilient arm 323 is connected with the seat body 311. The resilient arm 323 is arranged between the rod body 312 and the clamping arm 321. The elastic force of the resilient arm 323 has a tendency to rotate the resilient arm 323 towards the clamping arm 321, so that the resilient arm 323 and the clamping arm 321 jointly clamp the mitral valve 10.

[0116] The resilient arm 323 can be connected with the seat body 311 by welding, or can be made into an integrated structure with the seat body 311 by removing material.

[0117] The resilient arm 323 can be made of a memory alloy material, and specifically can be made of a nickel-titanium alloy.

[0118] The elastic arms 323 are in an open state in a natural state, and the elastic arms 323 can jointly hold the valve with the clamping arms 321 in the natural state. The elastic arms 323 can hold the valve after the clamping component 30 is separated, thereby preventing the mitral valve 10 from causing mitral valve regurgitation due to incomplete closure.

[0119] In the above embodiment in which the adjusting arm 322 is an elastic arm, the clamping arm 321 and the elastic arm 323 jointly hold the valve, that is, the adjusting arm 322 provides elastic force for the clamping arm 321, so that the clamping arm 321 rotates towards the elastic arm 323, and the elastic arm 323 rotates towards the clamping arm 321 in the process of releasing elastic force. The free ends of the two arms move towards each other when the elastic force is released, and jointly provide clamping force for the mitral valve 10. In this way, the mitral valve 10 can be further prevented from slipping out of the clamping arm 321 and the elastic arm 323, thereby improving the success rate of the operation.

[0120] In some embodiments of the present application, please refer to Figure 4A The distal end of the delivery rod 21 is provided with a wire passing hole 216, and the distal end of the elastic arm 323 of any clamping arm assembly 32 is provided with a wire passing hole 3231. The operation control component 20 includes a control wire 203, and the control wire 203 passes through the wire passing hole 216 and the wire passing hole 3231, respectively.

[0121] The control wire 203 can be a metal wire, such as a nickel-titanium wire, a stainless steel wire, etc. The control wire 203 can also be a polymer wire, such as a polypropylene wire, a polyethylene terephthalate wire, etc.

[0122] When the control wire 203 is pulled, the distal end of each clamping arm assembly 32 can move towards the accommodating space and be in a closed state; When the control wire 203 is released, the elastic arm 323 moves towards the clamping arm 321 under the action of its own elastic force.

[0123] The wire passing hole 216 can be one or more.

[0124] The wire passing hole 216 can be arranged on the above-mentioned first blocking portion 212, the above-mentioned second blocking portion 213, or the above-mentioned adapter portion 214.

[0125] The control wire 203 can also be one or more.

[0126] In an example, the number of the wire passing holes 216 is one, the control line 203 is one, one end of the control line 203 respectively passes through the wire passing hole 216 and the wire passing hole 3231 of the different elastic arm 323, and is led out from the side of the proximal end of the operation control component 20, and the other end of the control line 203 is also led out from the side of the proximal end of the operation control component 20, that is, the control line 203 is led out from the same side of the proximal end of the operation control component 20. When the valve is clamped by the valve capturing and releasing elastic arm 323, before the clamping component 30 is separated from the operation control component 20, one end of the control line 203 can be withdrawn, so that the control line 203 is withdrawn from the wire passing hole 216 and the wire passing hole 3231, and then the clamping component 30 is disassembled and separated. The clamping component can also be disassembled and separated first, and then the control line 203 is withdrawn from the wire passing hole 216 and the wire passing hole 3231.

[0127] By arranging the control line 203, the opening angle of the elastic arm 323 can be changed, and in the delivery process, the elastic arm 323 can be closed, that is, the included angle between the elastic arm 323 and the axis of the delivery rod 21 is substantially kept at 0°, so as to reduce the volume of the clamping component 30 in the delivery process. When clamping is needed, the elastic arm 323 can be released by releasing the control line 203, and at this time, the elastic arm 323 clamps the valve together with the clamping arm 321. Therefore, by arranging the control line 203, the wire passing hole 3231 and the wire passing hole 216, the delivery of the clamping component 30 and the clamping operation of the valve are facilitated.

[0128] In some embodiments of the present application, please refer to Figure 7 The surface of the elastic arm 323 facing the clamping arm 321 is provided with at least one barb structure 3232, and the barb structure 3232 has a fixed end and a free end, and the free end is closer to the proximal end of the elastic arm 323 than the fixed end.

[0129] When the barb structure 3232 is multiple, the barb structures 3232 can be arranged at intervals along the direction from the proximal end to the distal end of the elastic arm 323.

[0130] The free end of the barb structure 3232 can be a thorn structure.

[0131] The barb structure 3232 and the elastic arm 323 can be an integrally formed structure, or can be fixed to the elastic arm 323 by welding.

[0132] When the elastic arm 323 abuts against the valve, the barb structure 3232 can be stabbed into the valve, so as to prevent the elastic arm 323 from sliding out of the valve after the valve is clamped by the elastic arm 323 and the clamping arm 321, and improve the clamping reliability.

[0133] In some embodiments of the present application, the wire passing hole 216 includes a first wire passing hole and a second wire passing hole, the distal end of the first blocking part 212 or the adapter part 214 is provided with the first wire passing hole, and the distal end of the second blocking part 213 is provided with the second wire passing hole.

[0134] The first wire passing hole and the second wire passing hole can pass through one control wire 203, and the control wire 203 is one. That is, the opening angle of the elastic arm 323 of the two clamping arm assemblies 32 is controlled by one control wire 203, and compared with the control of each elastic arm 323 by using multiple control wires 203, the operation can be simplified by one control wire 203.

[0135] The above-mentioned control wire 203 can also be two, one control wire 203 passes through the first wire passing hole, and the other control wire 203 passes through the second wire passing hole, and the opening angle of the elastic arm 323 is controlled by operating the two control wires 203 respectively.

[0136] In this way, the first wire passing hole and the second wire passing hole are convenient to set, and by withdrawing the control wire 203, a pulling force of the elastic arm 323 towards the distal end of the conveying rod 21 can be provided, the opening angle of the elastic arm 323 can be reduced by actively operating the control wire 203, and the operation is convenient.

[0137] In some embodiments of the present application, please refer to Figure 4A and Figure 7 The control wire 203 includes a first control wire and a second control wire, the first control wire passes through the first wire passing hole and the wire passing hole 3231 of one elastic arm 323 respectively, and the second control wire passes through the second wire passing hole and the wire passing hole 3231 of the other elastic arm 323 respectively.

[0138] In this way, by withdrawing or releasing the first control wire and the second control wire respectively, the opening angle of each elastic arm 323 can be controlled individually, and during clamping, the opening angle of each elastic arm 323 can be flexibly adjusted according to the actual operation process, and the flexibility of the operation is improved.

[0139] In some embodiments of the present application, the main body part 211 has a control wire conveying channel 2113, and part of the control wire 203 is arranged in the control wire conveying channel 2113.

[0140] The control wire conveying channel 2113 can be one or two. In the above-mentioned embodiment in which the control wire 203 includes a first control wire and a second control wire, taking the case of two control wire conveying channels 2113, part of the first control wire can be arranged in one control wire conveying channel 2113, and part of the second control wire can be arranged in the other control wire conveying channel 2113. When the control wire conveying channel 2113 is one, part of the first control wire and part of the second control wire are arranged in the control wire conveying channel 2113.

[0141] By setting the control line conveying channel 2113, the part of the control line 203 exposed outside the conveying rod 21 can be reduced, so as to reduce the risk of the control line 203 being entangled in the process of conveying and clamping the clamping component 30, and the success rate of the operation is improved.

[0142] In some embodiments of the present application, please refer to Figure 4A and Figure 19 The operation control component 20 further comprises a housing 23 and a first wire locking part 201, the outer surface of the housing 23 is provided with a second wire locking part 202, the proximal end of the control line 203 is arranged to pass out of the second wire locking part 202, the second wire locking part 202 is threadedly matched with the first wire locking part 201, and part of the control line 203 is arranged between the threadedly matched surfaces of the second wire locking part 202 and the first wire locking part 201.

[0143] The second wire locking part 202 can be a separate part connected with the housing 23, or can be integrally formed with the housing 23. In an example, the outer peripheral surface of the second wire locking part 202 is provided with threads, the first wire locking part 201 is provided with a threaded hole, and the first wire locking part 201 is threadedly matched with the second wire locking part 202. In another example, the inner peripheral surface of the second wire locking part 202 is provided with threads, the first wire locking part 201 is provided with external threads, and the external threads of the first wire locking part 201 are matched with the internal threads of the second wire locking part 202. When it is needed to release the control line 203 to release the elasticity of the elastic arm 323 and jointly clamp the valve with the clamping arm 321, the first wire locking part 201 can be simply disassembled from the second wire locking part 202.

[0144] By setting the second wire locking part 202 and the first wire locking part 201, the adjustment of the opening angle of the elastic arm 323 and the release of the elastic arm 323 can be facilitated, and the operation difficulty is reduced.

[0145] In some embodiments of the present application, please refer to Figure 18 The distal end of the adapter 214 is provided with a guide cone 215, the guide cone 215, the adapter 214 and the main body 211 are all provided with a guide wire channel 2114, the operation control component 20 further comprises a housing 23 and a guide wire 205 arranged in the guide wire channel 2114, the proximal end of the adjusting rod fixing component 28 is arranged at the proximal end of the housing 23, the distal end of the guide wire 205 is arranged to pass out of the end of the guide cone 215, the guide wire 205 passes through the clamping component 30, and the proximal end of the guide wire 205 is arranged to pass out of the housing 23.

[0146] By setting the guide cone 215 and the guide wire 205, the guide wire 205 can play a guiding role in the process of conveying the clamping component 30 to the heart.

[0147] The operation process is as follows: Please refer to Figure 4A , Figure 15 , Figures 18-24, the guide wire 205 is previously guided to the position of the left atrium of the heart, and the clamping component 30 is always in the closed state during the guide wire 205 guiding the delivery process. The clamping component 30 enters the left ventricle from the apex of the heart, and then enters the left atrium. When the unlocking line operation component 27 is operated to move towards the proximal end of the shell 23, the unlocking line 26 pulls the elastic sheet 35 to complete the unlocking of the slot rod 34, the rotating adjusting sleeve 29 pushes the slot rod 34 to move axially, so that the fixing part 33 moves towards the seat body 311, the clamping arm 321 is opened, the clamping arm 321 is opened to about 120°, the position of the clamping arm 321 is adjusted, the clamping arm 321 is moved to the position of the valve, the adjusting control line 203 is adjusted to adjust the opening angle of the elastic arm 323, so as to realize the capture of the valve. After the valve is captured, the opening angle of the elastic arm 323 and the clamping arm 321 is adjusted to be smaller, so that the mitral valve is closed, the clamping and fixing are completed, finally the control line 203 and the unlocking line 26 are released, and the elastic arm 323 and the clamping arm 321 are kept in the preset clamping state under the action of the clamping of the elastic sheet 35 and the clamping groove 341. Finally, the control line 203 and the unlocking line 26 are withdrawn, and the distal end and the proximal end of the clamping component 30 are separated from the operation control component 20, so that the clamping component 30 is implanted in the position of the heart valve.

[0148] Finally, it should be noted that: the above embodiments are only used to illustrate the technical solutions of the present application, but not to limit them; although the present application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that: it can still modify the technical solutions recorded in the foregoing embodiments, or make equivalent replacement for part or all of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the present application, and they should be covered in the scope of the claims and the description of the present application. Especially, as long as there is no structural conflict, each technical feature mentioned in each embodiment can be combined in any way. The present application is not limited to the specific embodiments disclosed in the text, but includes all technical solutions falling within the scope of the claims.

Claims

1. A mitral valve clipping system, characterized by, The application relates to a device for clamping a mitral valve, comprising: a clamping component configured to clamp the mitral valve along a first direction; an operation control component detachably connected with a proximal end of the clamping component and a distal end of the clamping component respectively, the operation control component comprising a delivery rod; the delivery rod comprising a main body, a first blocking part and a second blocking part, the first blocking part and the second blocking part being arranged on and connected with the distal end of the main body respectively, the first blocking part and the second blocking part being arranged along a second direction and defining a containing space for containing at least part of the clamping component, the first direction, the second direction and an axial direction of the delivery rod being perpendicular to each other. The delivery rod further comprises an adapter arranged on the distal end of the first blocking part, the second blocking part being arranged along the second direction and spaced apart from the adapter, the proximal end of the adapter being hinged to the distal end of the clamping component, the adapter having a release rod delivery channel, the distal end of the clamping component being provided with a limiting hole communicated with the release rod delivery channel; the operation control component further comprises a release rod, the release rod being slidably matched with the release rod delivery channel, and the distal end of the release rod being arranged in the limiting hole, the proximal end of the release rod being arranged to be driven so that the distal end of the release rod can be withdrawn into the release rod delivery channel. The release rod delivery channel extends to the distal end of the first blocking part and extends from the distal end of the first blocking part to the proximal end of the main body along the axial direction of the delivery rod, and the proximal end of the release rod is arranged to pass out of the proximal end of the main body. The operation control component further comprises a release operation component and a shell connected with the proximal end of the main body, the release operation component being slidably connected with the shell along the axial direction of the delivery rod, the release operation component having a limiting position and a release position on the shell, and the proximal end of the release rod being connected with the release operation component; in the limiting position, the distal end of the release rod is arranged in the limiting hole; in the release position, the distal end of the release rod is arranged in the release rod delivery channel.

2. The mitral valve clipping system of claim 1, wherein, The clamping component comprises: a support comprising a rod body and a seat body, the rod body being arranged on the distal end of the seat body, the distal end of the rod body being hinged to the proximal end of the adapter, and the distal end of the rod body being provided with the limiting hole; a clamping arm assembly, the seat body being provided with the clamping arm assembly on both sides along the first direction, the clamping arm assembly being configured to clamp the mitral valve; a fixing member, each clamping arm assembly being rotatably connected with the fixing member; the operation control component comprises an adjusting rod, the adjusting rod being arranged on one side of the proximal end of the fixing member along the axial direction of the delivery rod, the proximal end of the fixing member being detachably connected with the distal end of the adjusting rod, and the adjusting rod driving the fixing member to move relative to the seat body along the axial direction of the delivery rod so as to adjust the opening angle of the clamping arm assembly on both sides of the seat body along the first direction. The clamping arm assembly comprises: a clamping arm, the proximal end of the clamping arm being rotatably connected with the seat body about a first axis; 3. The mitral valve clipping system of claim 2, wherein, ​ 4. The mitral valve clipping system of claim 3, wherein, ​ ​ ​ 5. The mitral valve clipping system of claim 2, wherein, ​ ​ ​ ​ ​ 6. The mitral valve clipping system of claim 5, wherein, ​ ​ An adjusting arm, a distal end of the adjusting arm is rotatably connected with a proximal end of the clamping arm around a second axis, a proximal end of the adjusting arm is rotatably connected with the fixing member around a third axis, the first axis, the second axis and the third axis are parallel to each other.

7. The mitral valve clipping system of claim 5, wherein, A distal end of the adjusting rod is threadedly connected with a proximal end of the fixing member.

8. The mitral valve clipping system of claim 6, wherein, The clamping arm assembly comprises: A clamping arm, a proximal end of the clamping arm is rotatably connected with the seat body around a first axis; An adjusting arm, a distal end of the adjusting arm is connected with the clamping arm, a proximal end of the adjusting arm is connected with the fixing member, the adjusting arm is an arm body with elasticity, an elastic force of the adjusting arm has a tendency to close the clamping arm.

9. The mitral valve clipping system of claim 8, wherein, A distal end of the adjusting arm is rotatably connected with the clamping arm, and an axis of rotation of the distal end of the adjusting arm relative to the clamping arm is parallel to the first axis, and the connection of the proximal end of the adjusting arm with the fixing member is integrally formed, bonded or welded; or, The distal end of the adjusting arm is integrally formed, bonded or welded with the clamping arm, and the connection of the proximal end of the adjusting arm with the fixing member is rotatable, and an axis of rotation of the proximal end of the adjusting arm relative to the fixing member is parallel to the first axis.

10. The mitral valve clipping system according to any one of claims 5-9, characterized in that, The clamping member further comprises a slot rod connected with the fixing member, a proximal end of the rod body is provided with a insertion hole, along an axial direction of the slot rod, the slot rod is slidably fitted with the insertion hole, an outer peripheral surface of the slot rod is provided with a plurality of clamping grooves which are spaced apart along the axial direction of the slot rod; The clamping member further comprises an elastic sheet connected with the fixing member or the seat body, the elastic sheet is arranged between the fixing member and the seat body, the elastic sheet is provided with a mounting hole, a distal end of the slot rod is arranged through the mounting hole, the elastic sheet has a first state of clamping with the clamping grooves and a second state of being separated from the clamping grooves; The operation control member further comprises an unlocking wire, a distal end of the unlocking wire is connected with the elastic sheet, the unlocking wire is configured to provide a pulling force to the elastic sheet to switch the elastic sheet from the first state to the second state.

11. The mitral valve clipping system of claim 10, wherein, The mounting hole comprises a first mounting hole and a second mounting hole, a distal end of the slot rod is arranged through the first mounting hole and the second mounting hole in sequence, the elastic sheet comprises a first sheet body, a second sheet body and a third sheet body, two ends of the second sheet body are connected with the first sheet body and the third sheet body respectively and are arranged at an angle with the first sheet body and the third sheet body respectively, the third sheet body is connected with the fixing member or the seat body, the first sheet body is located on a side of the third sheet body away from the fixing member and is connected with the unlocking wire, the first mounting hole penetrates through the third sheet body, a hole wall of the first mounting hole is located outside the clamping grooves, and the second mounting hole penetrates through the first sheet body; In the first state, the first sheet body and the second sheet body are arranged at an obtuse angle, and a part of a hole wall of the second mounting hole is located inside the clamping grooves; In the second state, the first sheet body moves out to outside of the clamping grooves.

12. The mitral valve clipping system of claim 10, wherein, The operation control component further comprises an unlocking wire operation component and a housing, the unlocking wire operation component is connected with the proximal end of the unlocking wire in a sliding manner along the axial direction of the delivery rod; When the unlocking wire operation component moves towards the proximal end of the housing, the unlocking wire pulls the elastic sheet to switch from the first state to the second state.

13. The mitral valve clipping system of claim 10, wherein, The main body has an unlocking wire channel passing through both ends of the main body, and part of the unlocking wire is located in the unlocking wire channel. And / or, the main body has an adjustment rod delivery channel passing through both ends of the main body, and part of the adjustment rod is located in the adjustment rod delivery channel.

14. The mitral valve clipping system of claim 9, wherein, The operation control component further comprises a housing, an adjustment rod fixing component and an adjustment sleeve, the adjustment rod fixing component is arranged at the proximal end of the housing and connected with the housing in a sliding manner along the axial direction of the delivery rod, the proximal end of the adjustment rod is connected with the adjustment rod fixing component, the adjustment sleeve is sleeved on the adjustment rod fixing component and connected with the adjustment rod fixing component in a threaded manner, and the adjustment sleeve is connected with the housing in a rotating manner.

15. The mitral valve clipping system of claim 14, wherein, The adjustment rod fixing component comprises: a screw rod having a receiving cavity passing through the proximal end and the distal end of the screw rod, the adjustment sleeve is sleeved on the outer peripheral surface of the screw rod and connected with the screw rod in a threaded manner, and the distal end of the adjustment rod passes through the distal end of the screw rod and connected with the screw rod in a sliding manner along the axial direction of the delivery rod; a proximal end connector, part of the proximal end connector is arranged in the receiving cavity, and the proximal end connector is connected with the proximal end of the adjustment rod; an unlocking piece, the proximal end connector is connected with the screw rod in a detachable manner through the unlocking piece, and after the proximal end connector is separated from the screw rod, the proximal end connector can rotate relative to the screw rod to separate the distal end of the adjustment rod from the proximal end of the fixing component.

16. The mitral valve clipping system according to claim 15, wherein, The proximal end connector comprises a first rod portion and a second rod portion, both of which are located in the receiving cavity, the first rod portion is arranged at the distal end of the second rod portion, and the diameter of the first rod portion is smaller than that of the second rod portion, the outer peripheral surface of the second rod portion is provided with a limiting groove, the limiting groove comprises a first groove portion extending along the axial direction of the second rod portion and a second groove portion extending along the circumferential direction of the second rod portion, and the first groove portion passes through the distal end of the second rod portion and forms a moving outlet; The unlocking piece is connected with the housing in a sliding manner along the circumferential direction of the adjustment sleeve, the unlocking piece has a limiting portion located in the limiting groove, the limiting portion can move in the second groove portion along the circumferential direction of the second rod portion to the proximal end of the first groove portion and from the proximal end of the first groove portion to the outside of the moving outlet.

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