Preparation method of methyl 3, 4-diaminobenzoate

By combining metal catalysts and ligand catalysts, the preparation process of methyl 3,4-diaminobenzoate was simplified, solving the problems of cumbersome routes and the use of precious metals in existing technologies, and realizing industrial production with high yield and high purity.

CN121471094APending Publication Date: 2026-02-06JINAN CARBOTANG BIOTECH CO LTD
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Patent Information

Application Number
CN202511587127.2
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-10-31
Publication Date
2026-02-06

AI Technical Summary

Technical Problem

The existing preparation route for methyl 3,4-diaminobenzoate is complicated, involves dangerous reactions and the use of precious metal catalysts, making industrial production difficult, and the raw materials are hard to obtain and costly.

Method used

3,4-Diaminobenzoic acid was prepared from 3,4-dichlorobenzoic acid using a metal catalyst and a ligand catalyst. Then, methyl 3,4-diaminobenzoate was prepared from 3,4-diaminobenzoic acid. The product was obtained by reflux reaction in methanol with sulfuric acid, followed by pH adjustment, concentration, filtration and drying.

Benefits of technology

This invention provides a preparation method that uses readily available raw materials, involves a simple process, requires no hazardous reactions, and does not use precious metal catalysts. It achieves yields and product purity comparable to or higher than existing technologies, making it suitable for industrial production.

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Abstract

The invention provides a method for preparing 3, 4-diaminobenzoic acid methyl ester, which comprises the following steps: preparing 3, 4-diaminobenzoic acid from 3, 4-dichlorobenzoic acid by using a metal catalyst and a ligand catalyst; and preparing methyl 3, 4-diaminobenzoate by using the 3, 4-diaminobenzoic acid. The method provided by the invention has the advantages of easily available raw materials, simple process route, no dangerous reaction, no use of expensive heavy metal catalysts, yield and product purity which are equivalent to or superior to those in the prior art, and easiness in large-scale production.
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