Traditional Chinese medicine formula for regulating comprehensive metabolism, tea drink and preparation method

Abstract

The invention relates to the technical field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine formula for regulating comprehensive metabolism, a tea drink and a preparation method. The formula consists of dried orange peel, rose, Chinese angelica, prepared rehmannia root, corn stigma, fragrant solomonseal rhizome, white paeony root, fried malt, cassia seed, vinegar bupleurum chinense, turmeric root-tuber, dried ginger, medlar, tuckahoe, madder, dwarf lilyturf tuber, immature bitter orange, astragalus root, hemp seed, coix seed and dahurian angelica root according to a specific weight ratio. The traditional Chinese medicine organically combines treatment methods of soothing liver and regulating qi, tonifying spleen and clearing damp, nourishing yin and blood, relaxing bowel and the like, and systematic regulation of sugar, fat and energy metabolism of a human body is realized through synergistic compatibility of monarch, minister, assistant and guide. Compared with the prior art, the tea not only can effectively assist in reducing fat and improving glycolipid metabolism indexes, but also can synchronously promote intestinal tract movement, improve sleep rhythm and internally regulate so as to improve skin gloss and color, and a safe and convenient tea drink solution with comprehensive conditioning benefits is provided.

Description

TECHNICAL FIELD

[0001] The present application belongs to the field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine formula, tea and preparation method for regulating comprehensive metabolism. BACKGROUND

[0002] With the change of modern lifestyle, metabolic syndrome characterized by obesity, glucose and lipid metabolism disorder, insulin resistance, etc. has become a global health problem. Modern medical research has confirmed that metabolic abnormalities do not exist in isolation, and are closely related to intestinal flora imbalance, chronic low-grade inflammation, autonomic nervous dysfunction and sleep disorders, etc., forming a complex pathological network. For example, the intestine, as an important metabolic and immune organ, its dysfunction not only affects nutrient absorption and waste excretion, but also can exacerbate systemic metabolic abnormalities and skin problems (such as dull skin, acne) through the "gut-liver axis", "gut-brain axis" and other pathways. At the same time, long-term mental stress and sleep deprivation can disrupt the hypothalamic-pituitary-adrenal axis and melatonin secretion rhythm, further increasing metabolic burden and affecting skin health.

[0003] In terms of intervention strategies, the current mainstream methods are mostly "point-to-point" interventions targeting a single target or symptom. For example, using hypoglycemic drugs to control blood glucose, using lipid-lowering drugs to regulate blood lipids, using hypnotics to improve sleep, using external whitening products to treat skin problems, etc. However, this segmented treatment model often ignores the integrity and relevance of the human metabolic system, making it difficult to fundamentally break the vicious cycle of "metabolic disorder-intestinal imbalance-poor sleep-dull skin". In addition, long-term use of chemical drugs may have side effects and cannot provide comprehensive health benefits. SUMMARY

[0004] To solve the above technical problems, the present application provides a traditional Chinese medicine formula, tea and preparation method for regulating comprehensive metabolism, to solve the problem that there is no traditional Chinese medicine formula in the prior art that can simultaneously improve glucose and lipid metabolism, intestinal health, sleep quality and skin condition.

[0005] A traditional Chinese medicine formula for regulating comprehensive metabolism, consisting of the following raw materials by weight:

[0006] Chenpi 30-50 parts, rose flower 8-12 parts, Angelica sinensis 4-8 parts, Radix Rehmanniae Preparata 2-4 parts, corn silk 6-10 parts, Polygonatum 2-4 parts, white peony root 3-5 parts, fried wheat germ 6-10 parts, Cassia obtusifolia 15-25 parts, vinegar Bupleurum 2-4 parts, Curcuma 1-3 parts, dried ginger 1-3 parts, Fructus Lycii 2-4 parts, Poria cocos 30-50 parts, madder 1-3 parts, Ophiopogon 4-8 parts, Citrus aurantium 3-5 parts, Astragalus 2-4 parts, Cannabis sativa L. 4-8 parts, Coix 25-35 parts, Bai Zhi 1-3 parts.

[0007] Preferably, the following raw materials by weight are used:

[0008] Chenpi 40 parts, rose 10 parts, angelica 6 parts, rehmannia 3 parts, corn silk 8 parts, polygonatum 3 parts, white peony root 4 parts, fried wheat 8 parts, cassia seed 20 parts, vinegar north 3 parts, radix notopterygii 2 parts, dried ginger 2 parts, medlar 3 parts, tuckahoe 40 parts, madder 2 parts, ophiopogon 6 parts, bitter orange 4 parts, milk vetch 3 parts, seed of fructus cannabis 6 parts, seed of fructus chrysanthemi 30 parts, white anise 2 parts.

[0009] Preferably, the group party is used to prepare tea with regulating comprehensive metabolism function.

[0010] A tea for regulating comprehensive metabolism, which is prepared by water extraction of the above-mentioned traditional Chinese medicine group party.

[0011] A preparation method of the tea for regulating comprehensive metabolism as described above, comprising the following steps:

[0012] S1. Weighing: weighing each raw material according to the proportion;

[0013] S2. Soaking and decocting: placing all the weighed raw materials into a decocting container, adding water in an amount of 8-12 times the total weight of the raw materials, soaking for 10-30 minutes, and then heating to boiling;

[0014] S3. Filtering and taking liquid: maintaining the boiling or micro-boiling state for 10-30 minutes, filtering, and pouring out the decocting liquid to obtain the tea.

[0015] Preferably, in step S2, the added water is 10 times the total weight of the raw materials.

[0016] Preferably, in step S2, the soaking time is 20 minutes.

[0017] Preferably, in step S3, the decocting time is 15-20 minutes.

[0018] Compared with the prior art, the present application has the following beneficial effects:

[0019] Through the combination design of dispersing liver and regulating qi, invigorating spleen and eliminating dampness, nourishing yin and blood, and moistening intestines and defecation, the synergistic and systematic regulation of human body sugar metabolism, lipid metabolism, energy metabolism, intestinal microecology and skin metabolism function is realized;

[0020] The group party can not only effectively reduce weight and improve body fat distribution, but also simultaneously promote intestinal peristalsis and improve defecation quality. At the same time, by regulating endocrine rhythm and improving liver and spleen function, sleep quality is significantly improved, and skin nutrition and pigment metabolism are improved from the inside, so that skin luster is improved and color spots are faded, finally achieving the organic unity of multiple health benefits such as weight loss, defecation, tranquilization and skin beautification, which reflects the unique advantages of TCM holistic regulation. BRIEF DESCRIPTION OF DRAWINGS

[0021] Figure 1 The preparation process of the components of the present application is shown in the schematic diagram. DETAILED DESCRIPTION

[0022] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative work fall within the scope of protection of the present application.

[0023] As Figure 1 shown:

[0024] The present application provides Example 1:

[0025] The present embodiment provides a traditional Chinese medicine formula for regulating comprehensive metabolism and a preparation method of tea beverage thereof.

[0026] 1. Formula raw materials (by weight):

[0027] Chenpi 30 parts, rose 8 parts, angelica 4 parts, radix rehmanniae preparata 2 parts, corn silk 6 parts, polygonatum 2 parts, white peony root 3 parts, fried wheat germ 6 parts, cassia seed 15 parts, vinegar north radix bupleuri 2 parts, curcuma 1 part, dried ginger 1 part, medlar 2 parts, tuckahoe 30 parts, madder 1 part, ophiopogon 4 parts, citron fruit 3 parts, radix astragali 2 parts, hemp seed 4 parts, coix seed 25 parts, white fang 1 part.

[0028] 2. Tea beverage preparation method:

[0029] S1. Weighing: accurately weigh each raw material according to the above ratio, mix uniformly, and obtain a traditional Chinese medicine composition.

[0030] S2. Soaking and decocting: put the mixed raw materials into a ceramic or stainless steel decocting pot, add 8 times the weight of the total raw materials of pure water (for example, if the total weight of the raw materials is 100g, add 800ml of water). Soak at room temperature for 30 minutes.

[0031] S3. Filtering liquid: after soaking, cover the pot with a lid, heat to boiling with strong fire. After boiling, turn to low heat to maintain a state of slight boiling, continue to decoct for 30 minutes. After decocting, filter with a 100 mesh screen while hot, pour out all the decocting liquid, and naturally cool to a suitable drinking temperature to obtain a tea beverage for regulating comprehensive metabolism.

[0032] Example 2:

[0033] The present embodiment provides a traditional Chinese medicine formula for regulating comprehensive metabolism and a preparation method of tea beverage thereof.

[0034] 1. Formulation raw materials (by weight):

[0035] Pericarpium Citri Reticulatae 40 parts, rose 10 parts, Angelica sinensis 6 parts, Radix Rehmanniae Preparata 3 parts, corn silk 8 parts, Polygonatum 3 parts, Radix Paeoniae Alba 4 parts, Fried wheat germ 8 parts, Cassia seed 20 parts, vinegar Bupleurum 3 parts, Curcuma 2 parts, dried ginger 2 parts, Fructus Lycii 3 parts, Poria 40 parts, madder 2 parts, Ophiopogon 6 parts, Citrus aurantium 4 parts, Astragalus 3 parts, Hemp seed 6 parts, Coix seed 30 parts, Bai Zhi 2 parts.

[0036] 2. Tea preparation method:

[0037] S1. Weighing: accurately weigh each raw material according to the above optimal ratio, mix uniformly, and obtain a traditional Chinese medicine composition.

[0038] S2. Soaking and decocting: place all the mixed raw materials into a decocting container, add 10 times the weight of the total raw materials of drinking water. Soak at room temperature for 20 minutes.

[0039] S3. Filtering and taking liquid: after soaking is complete, heat to boiling. After boiling, adjust the heat to maintain a state of gentle boiling, continue to decoct for 20 minutes. After decoction is complete, filter with gauze or a filter screen, and pour out the clear decoction liquid to obtain the tea drink for adjusting comprehensive metabolism. This embodiment is the most explicit and stable implementation of the technical effect of the present application.

[0040] Example 3:

[0041] The present embodiment provides a traditional Chinese medicine formula for adjusting comprehensive metabolism and a preparation method of its tea drink.

[0042] 1. Formulation raw materials (by weight):

[0043] Pericarpium Citri Reticulatae 50 parts, rose 12 parts, Angelica sinensis 8 parts, Radix Rehmanniae Preparata 4 parts, corn silk 10 parts, Polygonatum 4 parts, Radix Paeoniae Alba 5 parts, Fried wheat germ 10 parts, Cassia seed 25 parts, vinegar Bupleurum 4 parts, Curcuma 3 parts, dried ginger 3 parts, Fructus Lycii 4 parts, Poria 50 parts, madder 3 parts, Ophiopogon 8 parts, Citrus aurantium 5 parts, Astragalus 4 parts, Hemp seed 8 parts, Coix seed 35 parts, Bai Zhi 3 parts.

[0044] 2. Tea preparation method:

[0045] S1. Weighing: accurately weigh each raw material according to the above ratio, mix uniformly, and obtain a traditional Chinese medicine composition.

[0046] S2. Soaking and decocting: place all the mixed raw materials into a decocting container, add 12 times the weight of the total raw materials of pure water. Soak at room temperature for 10 minutes.

[0047] S3. Filtering the liquid: after the soaking is completed, heat to boiling and maintain the boiling state, decoct for 10 minutes. After the decoction is completed, immediately filter and pour out the decocted liquid, to obtain the tea drink for adjusting comprehensive metabolism.

[0048] Experimental Example: Improvement of the comprehensive metabolism and skin and intestinal health of rats with metabolic syndrome model by the Chinese medicine formula

[0049] 1. Experimental purpose

[0050] The comprehensive effects of the Chinese medicine formula in the present application in reducing body fat, improving glucose and lipid metabolism disorder, promoting intestinal health, improving sleep quality and skin appearance (whitening and gloss), etc. are verified, and the comparison experiments are verified.

[0051] 2. Experimental materials

[0052] Experimental animals: 60 healthy male C57BL / 6J mice, weighing 18-22 g, were adaptively fed for one week.

[0053] Test drug: same as before, the formula (Example 2) of the present application is concentrated to 1.0 g / mL.

[0054] Main reagents and instruments: high-fat high-sugar feed, small animal metabolism cage system (monitoring activity and sleep), mouse electronic scale, body composition analyzer, blood glucose meter, full-automatic biochemical analyzer, ELISA kit (melatonin, inflammatory factor, tight junction protein), ultraviolet spectrophotometer (melanin), histopathology equipment, etc.

[0055] 3. Experimental scheme

[0056] Model and grouping: high-fat high-sugar feed was used to feed for 8 weeks to establish an obesity metabolic syndrome model. The successfully modeled mice were randomly divided into 6 groups, 10 mice in each group:

[0057] Blank control group: ordinary feed + distilled water.

[0058] Model control group: high-fat high-sugar feed + distilled water.

[0059] Positive control A group (lipid-lowering): high-fat high-sugar feed + orlistat gavage.

[0060] Positive control B group (anxiolytic): high-fat high-sugar feed + melatonin gavage.

[0061] Formula group of the present application (Example 2): high-fat high-sugar feed + the liquid medicine of the present application (10 g crude drug / kg / d).

[0062] Comparative example group (simplified formula): a simplified formula containing only five kinds of core dampness-removing and bowel-moving medicinal materials, i.e. “Pericarpium Citri Reticulatae, Poria cocos, Cassia seed, Coix seed and Fried wheat”, which is gavaged in the same amount of crude drug.

[0063] Dosing and endpoint detection: continuous gavage for 6 weeks.

[0064] Whole body metabolism and body fat: weight every week; at the end of the experiment, body fat rate was measured by body composition analyzer; Lee's Index was calculated.

[0065] Glycolipid metabolism: at the end of the experiment, fasting blood glucose (FBG), insulin (FINS), HOMA-IR index were measured; serum TC, TG, LDL-C, HDL-C were measured.

[0066] Intestinal health and defecation:

[0067] Defecation: record the average daily defecation particles and fecal character score (1-5 points, the higher the score, the closer to normal) in the last week.

[0068] Intestinal barrier function: colon tissue was taken to detect the mRNA expression level of tight junction proteins (ZO-1, Occludin).

[0069] Sleep quality:

[0070] Autonomic activity monitoring: in the last week, the mice were placed in a metabolic cage, and the circadian rhythm was continuously monitored for 72 hours, and the total activity at night (active period) and the proportion of resting time during the day (resting period) were counted.

[0071] Biochemical indicators: at the end of the experiment, blood was taken to detect the serum melatonin (MT) level.

[0072] Skin improvement (whitening and luster):

[0073] Melanin determination: after the end of the administration, the skin tissue of the fixed area on the back of the mouse was taken, homogenized, and the melanin content was measured.

[0074] Histological observation: the skin on the back was taken to make HE staining sections, and the epidermal thickness, dermal collagen fiber arrangement and hair follicle state were observed.

[0075] Skin luster: blind evaluation was made by animal hair scoring system (0-5 points, the higher the score, the smoother the hair).

[0076] 4. Experimental results

[0077] Table 1: Comparison of whole body metabolism, body fat and intestinal function indicators of mice in each group

[0078] Group Body weight gain (g) Body fat rate (%) Lee's Index HOMA-IR Average daily defecation number Fecal character score Blank control group 5.2 15.3 300 2.1 28 4.5 Model control group 12.8 32.5 345 8.5 15 2.0 Positive control group A 8.5 25.1 328 5.2 18 2.8 Example 2 group 7.0 21.8 318 3.8 30 4.2 Comparative example group 10.2 29.4 338 6.8 25 3.5

[0079] Table 2: Comparison of blood lipid, sleep and skin related indicators of mice in each group

[0080] Group TG (mmol / L) Night activity amount (counts) Daytime resting time ratio (%) Serum melatonin (pg / mL) Skin melanin (OD value) Hair luster score Blank control group 0.72 4500 75 45.2 0.15 4.0 Model control group 1.95 2800 50 28.5 0.32 2.0 Positive control group B 1.82 3600 68 40.1 0.30 2.3 Example 2 group 0.95 4200 70 42.8 0.20 3.8 Comparative example group 1.60 3200 58 32.0 0.28 2.5

[0081] Molecular biology and histology results:

[0082] Intestinal barrier: The mRNA expression of colon ZO-1 and Occludin in Example 2 group was significantly higher than that in model group and comparative example group, close to the level of blank group.

[0083] Skin histology: HE staining showed that the epidermis of model group mice was thickened, and the collagen in the dermis was arranged in disorder. The skin structure of Example 2 group mice was close to normal, the epidermis was moderate in thickness, the collagen fibers were arranged in order, and the hair follicles were healthy. The improvement of comparative example group was limited.

[0084] 5. Comprehensive analysis of experimental results

[0085] The prescription group (Example 2) of the present application performed well in reducing fat (body weight, body fat rate), improving sugar metabolism (HOMA-IR), and regulating blood lipids (TG), and the effect was better than that of single-function positive drug A (orlistat), which proved that it had the advantages of "multiple targets and overall regulation".

[0086] The prescription group (Example 2) of the present application could significantly improve the night activity and the ratio of daytime rest time, and increase the serum melatonin level, indicating that it improved the sleep quality by regulating endocrine rhythm. The improvement of sleep helped to correct metabolic disorders, forming a virtuous cycle.

[0087] The prescription group (Example 2) of the present application significantly reduced the content of skin melanin, and the histological examination and glossiness score confirmed that the skin health was significantly improved. This was due to the liver-soothing and depression-relieving, dampness-removing and pus-removing, and liver and kidney tonifying effects of rose, Bai Zhi, Yiyiren, and Gouqi in the prescription, which regulated the skin metabolism from the inside to the outside.

[0088] The prescription group (Example 2) of the present application performed best in the number and properties of defecation and intestinal barrier function indicators, which reflected the synergistic effect of hemp seeds, cassia seeds, fried wheat, and dried tangerine or orange peel in regulating the intestine, removing stagnation, and regulating qi, ensuring the effective discharge of metabolic waste.

[0089] The comparative example verified the integrity of the prescription: the comparative example group (simplified prescription) had certain effect on defecation, but was significantly inferior to the complete prescription of the present application in reducing fat, improving sleep, and whitening skin, etc.

[0090] 6. Experimental conclusion

[0091] This experiment proved that the traditional Chinese medicine prescription (represented by Example 2) of the present application not only effectively reduced fat and regulated sugar and lipid metabolism, but also simultaneously improved sleep quality, whitened and improved skin gloss, promoted intestinal health and regular defecation, achieving overall and synergistic improvement of "comprehensive metabolism" and related skin, nervous system, and digestive system.

[0092] In the description of the specification, the description of the terms "one embodiment", "some embodiments", "an example", "a specific example" or "some examples" etc. means that the specific features, structures, materials or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present application. In the specification, the illustrative description of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any appropriate manner in any one or more embodiments or examples. In addition, those skilled in the art can combine and combine the different embodiments or examples described in the specification and the features of the different embodiments or examples without contradiction.

[0093] In the drawings of the embodiments of the present application, only the structures related to the embodiments of the present disclosure are involved, and other structures can refer to the general design. In the case of no conflict, the same embodiment and different embodiments of the present application can be combined with each other.

[0094] Although the present application has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions recorded in the foregoing embodiments, or make equivalent replacements for part of the technical features, and any modification, equivalent replacement, improvement, etc. made within the spirit and principles of the present application shall be included in the protection scope of the present application.

Claims

1. A traditional Chinese medicine formula for regulating overall metabolism, characterized in that, It consists of the following raw materials in parts by weight: 30-50 parts dried tangerine peel, 8-12 parts rose petals, 4-8 parts angelica root, 2-4 parts prepared rehmannia root, 6-10 parts corn silk, 2-4 parts polygonatum rhizome, 3-5 parts white peony root, 6-10 parts roasted malt, 15-25 parts cassia seed, 2-4 parts vinegar-processed bupleurum root, 1-3 parts turmeric, 1-3 parts dried ginger, 2-4 parts wolfberry, 30-50 parts poria cocos, 1-3 parts madder root, 4-8 parts ophiopogon root, 3-5 parts immature bitter orange, 2-4 parts astragalus root, 4-8 parts hemp seed, 25-35 parts coix seed, 1-3 parts angelica dahurica root.

2. The traditional Chinese medicine formula according to claim 1, characterized in that, It consists of the following raw materials in parts by weight: 40 parts dried tangerine peel, 10 parts rose petals, 6 parts angelica root, 3 parts prepared rehmannia root, 8 parts corn silk, 3 parts polygonatum rhizome, 4 parts white peony root, 8 parts roasted malt, 20 parts cassia seed, 3 parts vinegar-processed bupleurum root, 2 parts turmeric, 2 parts dried ginger, 3 parts wolfberry, 40 parts poria cocos, 2 parts madder root, 6 parts ophiopogon root, 4 parts immature bitter orange, 3 parts astragalus root, 6 parts hemp seed, 30 parts coix seed, 2 parts angelica root.

3. The traditional Chinese medicine formula according to claim 1 or 2, characterized in that, The formula is used to prepare a tea beverage with the function of regulating overall metabolism.

4. A tea beverage for regulating overall metabolism, characterized in that, It is prepared by water extraction from the traditional Chinese medicine formula described in any one of claims 1-3.

5. A method for preparing a tea beverage for regulating overall metabolism as described in claim 4, characterized in that, Includes the following steps: S1. Weighing: Weigh each raw material according to the proportions; S2. Soaking and decocting: Place all weighed ingredients into a decoction container, add water to 8-12 times the total weight of the ingredients, soak for 10-30 minutes, and then heat to boiling. S3. Filtration and liquid collection: Simmer for 10-30 minutes at a constant boil or simmering temperature, filter, and pour out the decoction to obtain the tea.

6. The preparation method according to claim 5, characterized in that, In step S2, the amount of water added is 10 times the total weight of the raw materials.

7. The preparation method according to claim 5, characterized in that, In step S2, the soaking time is 20 minutes.

8. The preparation method according to any one of claims 5-7, characterized in that, In step S3, the simmering time is 15-20 minutes.

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