Personalized 3D printing hydrogel patch for treating mouth respiration and preparation method thereof

Abstract

The invention discloses a personalized 3D printing hydrogel patch for treating mouth respiration and a preparation method thereof, and relates to the technical field of 3D printing hydrogel patch preparation, and the preparation method comprises the following steps: obtaining three-dimensional surface topography data of a lip region of a user, and constructing a digital model of the personalized hydrogel patch based on the data; designing a three-dimensional structure file with a lip periphery fitting contour according to the digital model; the preparation method comprises the following steps: preparing a prepolymer solution containing gelatin methacryloylation, dopamine methacrylamide, acrylamide, polyethylene glycol diacrylate, a photoinitiator and a skin care type functional additive; injecting the prepolymer solution into photocuring 3D printing equipment, and calling the three-dimensional structure file to perform layer-by-layer exposure printing to form a wet hydrogel patch; placing the wet hydrogel patch in a buffer solution for cleaning so as to remove unreacted components; and performing post-curing treatment on the cleaned hydrogel patch, so that a cross-linked network is fully formed, and a finished patch with moderate adhesion and high toughness is obtained.

Description

Technical Field

[0001] This invention relates to the field of 3D printed hydrogel patch preparation technology, and in particular to a personalized 3D printed hydrogel patch for treating mouth breathing and its preparation method. Background Technology

[0002] Using a photocurable functional hydrogel prepolymer solution as printing ink, combined with a digital model constructed based on individual lip 3D scanning data, a hydrogel patch with personalized geometry, controllable mechanical properties, and built-in skin care functions is precisely molded layer by layer through a photocurable additive manufacturing process. After post-processing steps such as cleaning, post-curing, and sterilization, a complete technical system is obtained for medical device products that can be directly used for clinical intervention of mouth breathing.

[0003] In the field of 3D printing hydrogel patch preparation, existing products mostly use medical tape or pressure-sensitive adhesive patches, which have uncontrollable adhesion. When children or users with sensitive skin remove them, they often cause pain, redness, peeling, or even allergic reactions, which seriously affects user compliance. In addition, mouth breathing itself causes moisture loss from the lips, and traditional adhesive patches are not breathable and do not contain moisturizing ingredients, which further aggravates dryness, peeling, or even cracking of the skin around the lips, forming a vicious cycle of treatment and damage. Summary of the Invention

[0004] In view of the aforementioned existing problems, the present invention is proposed.

[0005] Therefore, this invention provides a personalized 3D-printed hydrogel patch for treating mouth breathing. This solves the problem that existing products mostly use medical tape or pressure-sensitive adhesive patches, which have uncontrollable adhesion. When these patches are removed by children or users with sensitive skin, they often cause pain, redness, peeling, or even allergic reactions, seriously affecting user compliance. Furthermore, mouth breathing itself causes moisture loss from the lips, and traditional adhesive patches are not breathable and do not contain moisturizing ingredients, which further aggravates dryness, peeling, or even cracking of the skin around the lips, creating a vicious cycle of treatment and damage.

[0006] To solve the above-mentioned technical problems, the present invention provides the following technical solution: In a first aspect, the present invention provides a personalized 3D-printed hydrogel patch for treating mouth breathing, comprising: The hydrogel body is made by photopolymerization 3D printing of a prepolymer solution containing matrix polymer material, adhesive functional monomer, photoinitiator, water and functional additives; The three-dimensional shape of the hydrogel patch is personalized based on a 3D scan digital model of the user's lips; The matrix polymer material is gelatin methacrylamide, the adhesive functional monomer is dopamine methacrylamide, and the functional additives include one or more of vitamin C and its derivatives, hyaluronic acid, and glycerin.

[0007] Secondly, the present invention provides a method for preparing a personalized 3D-printed hydrogel patch for treating mouth breathing, comprising: Acquire three-dimensional surface topography data of the user's lip area and construct a digital model of a personalized hydrogel patch based on the data; Design a 3D structural file with a lip-peripheral contour based on the digital model; Prepare a prepolymer solution containing gelatin methacrylamide, dopamine methacrylamide, acrylamide, polyethylene glycol diacrylate, photoinitiator, and skin-care functional additives; The prepolymer solution is injected into the photopolymer 3D printing equipment, and the three-dimensional structure file is called to perform layer-by-layer exposure printing to form a wet hydrogel patch. The wet hydrogel patch was washed in a buffer solution to remove unreacted components; The cleaned hydrogel patch is post-cured to allow the cross-linked network to fully form, resulting in a finished patch with moderate adhesion and high toughness. The finished patch is sterilized and sealed in packaging to obtain a personalized 3D-printed hydrogel patch for treating mouth breathing.

[0008] As a preferred embodiment of the method for preparing a personalized 3D-printed hydrogel patch for treating mouth breathing as described in this invention, the specific steps of acquiring three-dimensional surface morphology data of the user's lip region and constructing a digital model of the personalized hydrogel patch based on the data are as follows: A structured light scanner was used to perform a non-contact scan of the perilip area of ​​the user in a naturally closed lip state to obtain point cloud data; The point cloud data is imported into 3D reconstruction software, and a closed digital model of the lip surface is generated through surface fitting. Offset distance along the normal direction on the outer edge of the lip surface digital model Generate patch boundary contours, where This refers to the patch coverage width parameter; Assign thickness parameters along the direction perpendicular to the lip surface. This forms the initial digital model of the patch.

[0009] As a preferred embodiment of the preparation method of the personalized 3D-printed hydrogel patch for treating mouth breathing described in this invention, the specific steps for preparing the prepolymer solution comprising gelatin methacrylamide, dopamine methacrylamide, acrylamide, polyethylene glycol diacrylate, photoinitiator, and skin-care functional additives are as follows: The gelatin methacrylamide and acrylamide were dissolved together in a buffer solution and stirred under constant temperature until completely dissolved to form the first solution; Add dopamine methacrylamide to the first solution and stir continuously until it is dispersed at the molecular level to form a second solution; Polyethylene glycol diacrylate, photoinitiator, and skin-care functional additives were added sequentially to the second solution, and the mixture was stirred until it became homogeneous and transparent to obtain a prepolymer solution. The molar ratios of the components in the prepolymer solution satisfy the following relationship: ; in, This indicates the molar concentration of dopamine methacrylamide. This indicates the molar concentration of gelatin methacrylylation. The coefficient for regulating the adhesive functional monomer; and These represent the molar concentrations of the crosslinking agent and the comonomer, respectively. This is the network rigidity control coefficient.

[0010] As a preferred embodiment of the method for preparing a personalized 3D-printed hydrogel patch for treating mouth breathing as described in this invention, the specific steps of injecting the prepolymer solution into a photopolymerization 3D printing device and using a three-dimensional structure file for layer-by-layer exposure printing to form a wet hydrogel patch are as follows: The prepolymer solution is injected into the resin tank of a digital light processing (DLP) printing device; Call the initial digital model of the patch, and generate a slice with a layer thickness of... The print path; Controlling the light source to expose each layer, the exposure energy density satisfy: ; in, Light source intensity, For single-layer exposure time; When the cumulative exposure energy reaches the critical gelation threshold Curing is complete at that time; Repeat the above process until all layers are printed to obtain a wet hydrogel patch.

[0011] As a preferred embodiment of the method for preparing a personalized 3D-printed hydrogel patch for treating mouth breathing as described in this invention, the specific steps of performing a post-curing treatment on the cleaned hydrogel patch to fully form a cross-linked network and obtain a finished patch with moderate adhesion and high toughness are as follows: The cleaned wet hydrogel patch was placed under visible light with a wavelength of 405 nanometers for secondary irradiation; During post-curing, the residual double bonds in the system continue to react, increasing the crosslinking density. Evolving over time satisfies: ; in, The theoretical maximum crosslinking density, This is the post-curing reaction rate constant. This refers to the post-curing time; when When the set threshold is reached, the illumination is stopped, and a hydrogel patch with stable mechanical properties is obtained.

[0012] In a preferred embodiment of the method for preparing a personalized 3D-printed hydrogel patch for treating mouth breathing as described in this invention, the release behavior of the skin-care functional additive in the hydrogel network is controlled by diffusion and network relaxation coupling, and its cumulative release fraction satisfies: ; in, To release the amplitude coefficient, For the release index; when 0.5 < When the value is less than 1.0, it indicates that the release process is jointly dominated by polymer chain relaxation and molecular diffusion.

[0013] In a preferred embodiment of the method for preparing a personalized 3D-printed hydrogel patch for treating mouth breathing as described in this invention, the peeling force of the finished patch against the skin is determined by the interfacial adhesion energy W, which is characterized by the following formula: ; in, This refers to the physical wetting energy between the hydrogel and the skin. This represents the increment of the free energy of the reversible chemical interaction between the dopamine group and skin keratin.

[0014] As a preferred embodiment of the preparation method of the personalized 3D printed hydrogel patch for treating mouth breathing described in this invention, wherein: the sterilization and sealing of the finished patch is carried out in a clean environment by placing the patch into a light-proof aluminum-plastic composite bag with a light transmittance of less than 5%, vacuuming it, filling it with inert gas, and then sterilizing it by gamma ray irradiation.

[0015] As a preferred embodiment of the preparation method of the personalized 3D printed hydrogel patch for treating mouth breathing described in this invention, the photoinitiator is a lithium acylphosphine oxide compound, the absorption peak of which matches the wavelength of the printing light source, and it retains some activity in the post-curing stage.

[0016] The beneficial effects of this invention are as follows: By combining precise modeling based on individual 3D lip scanning with a photocurable prepolymer system containing gelatin methacrylamide, dopamine methacrylamide, and functional skin care ingredients, a hydrogel patch that highly conforms to the contours of the lips is prepared using photocurable 3D printing technology. This not only achieves effective physical intervention on mouth breathing behavior but also takes into account moderate adhesion and high toughness, ensuring that the patch can stably close the lips during sleep and can be painlessly removed without damaging the skin when awake. At the same time, the vitamin C derivatives, hyaluronic acid, and glycerin embedded in the patch can slowly release and nourish the skin around the lips, effectively improving the user compliance and comfort of children and sensitive individuals. This overcomes the defects of traditional adhesive tape products, such as easy skin damage, poor adhesion, and lack of care function. Attached Figure Description

[0017] To more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings used in the following description of the embodiments will be briefly introduced. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0018] Figure 1 This is a flowchart of the preparation method of the personalized 3D printed hydrogel patch for treating mouth breathing in Example 1. Detailed Implementation

[0019] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, the specific embodiments of the present invention will be described in detail below with reference to the accompanying drawings.

[0020] Many specific details are set forth in the following description in order to provide a full understanding of the invention. However, the invention may also be practiced in other ways different from those described herein, and those skilled in the art can make similar extensions without departing from the spirit of the invention. Therefore, the invention is not limited to the specific embodiments disclosed below.

[0021] Secondly, the term "one embodiment" or "embodiment" as used herein refers to a specific feature, structure, or characteristic that may be included in at least one implementation of the present invention. The phrase "in one embodiment" appearing in different places in this specification does not necessarily refer to the same embodiment, nor is it a single or selective embodiment that is mutually exclusive with other embodiments.

[0022] Example, refer to Figure 1 This embodiment of the invention provides a personalized 3D-printed hydrogel patch for treating mouth breathing and a method for its preparation, comprising: The hydrogel body is made by photopolymerization 3D printing of a prepolymer solution containing matrix polymer material, adhesive functional monomer, photoinitiator, water and functional additives; The three-dimensional shape of the hydrogel patch is personalized based on a 3D scan digital model of the user's lips; The matrix polymer is gelatin methacrylamide, the adhesive functional monomer is dopamine methacrylamide, and the functional additives include one or more of vitamin C and its derivatives, hyaluronic acid, and glycerin.

[0023] S1. Obtain three-dimensional surface topography data of the user's lip area and construct a digital model of the personalized hydrogel patch based on the data; Furthermore, a structured light scanner is used to perform a non-contact scan of the perilip area when the user's lips are naturally closed to obtain point cloud data. Point cloud data is imported into 3D reconstruction software, and a closed digital model of the lip surface is generated through surface fitting. Offset distance along the normal direction on the outer edge of the lip surface digital model. Generate patch boundary contours, where This refers to the patch coverage width parameter; Assign thickness parameters along the direction perpendicular to the lip surface. This forms the initial digital model of the patch; It should be noted that the natural closed-lip state refers to the physiological posture in which the user's lips close naturally when relaxed and without active biting or facial expressions. This state can truly reflect the lip contour of mouth-breathing patients during nighttime sleep, ensuring that the constructed patch model has good fit and sealing in actual use, and avoiding patch edge lifting or air leakage due to model distortion.

[0024] S2. Design a 3D structural file with a lip-peripheral contour based on the digital model; It should be noted that the 3D structure file not only contains the geometric shape of the patch, but also embeds process parameter information such as printing direction, support structure and interlayer transition curvature, to ensure the forming accuracy of the complex curved surface of the lip during the subsequent photopolymerization printing process, and to prevent structural collapse or loss of details due to gravity or resin flow.

[0025] S3. Prepare a prepolymer solution containing gelatin methacrylamide, dopamine methacrylamide, acrylamide, polyethylene glycol diacrylate, photoinitiator and skin-care functional additives; Furthermore, gelatin methacrylamide and acrylamide are dissolved together in a buffer solution and stirred at a constant temperature until completely dissolved to form the first solution; Add dopamine methacrylamide to the first solution and stir continuously until it is dispersed at the molecular level to form the second solution; Polyethylene glycol diacrylate, photoinitiator, and skin-care functional additives were added sequentially to the second solution, and the mixture was stirred until it became homogeneous and transparent to obtain the prepolymer solution. The molar ratios of the components in the prepolymer solution satisfy the following relationship: ; in, This indicates the molar concentration of dopamine methacrylamide. This indicates the molar concentration of gelatin methacrylylation. The coefficient for regulating the adhesive functional monomer; and These represent the molar concentrations of the crosslinking agent and the comonomer, respectively. This is the network rigidity control coefficient; The release behavior of skincare functional additives in hydrogel networks is controlled by diffusion and network relaxation coupling, and their cumulative release fraction satisfies: ; in, To release the amplitude coefficient, For the release index; when 0.5 < When the value is less than 1.0, it indicates that the release process is jointly dominated by polymer chain relaxation and molecular diffusion. The peel force of the finished patch on the skin is determined by the interfacial adhesion energy W, which is characterized by the following formula: ; in, This refers to the physical wetting energy between the hydrogel and the skin. This represents the increment of the free energy of the reversible chemical interaction between the dopamine group and skin keratin. It should be noted that the stepwise preparation sequence of the prepolymer solution has a decisive influence on the uniformity and performance of the final hydrogel network. If dopamine methacrylamide and crosslinking agent are added at the same time, premature crosslinking or phase separation may occur due to excessively high local concentrations. However, by adopting a strategy of first dissolving the main chain monomer and then introducing the functional components step by step, the molecular-level dispersion of each component can be effectively guaranteed, thereby achieving synergistic optimization of adhesion, toughness and sustained-release performance.

[0026] S4. Inject the prepolymer solution into the photopolymer 3D printing equipment and call the three-dimensional structure file to perform layer-by-layer exposure printing to form a wet hydrogel patch. Furthermore, the prepolymer solution is injected into the resin tank of the digital light processing (DLP) printing equipment; Call the initial digital model of the patch, and generate a slice with a layer thickness of... The print path; Controlling the light source to expose each layer, the exposure energy density satisfy: ; in, Light source intensity, For single-layer exposure time; When the cumulative exposure energy reaches the critical gelation threshold Curing is complete at that time; Repeat the above process until all layers are printed to obtain a wet hydrogel patch. It should be noted that the critical gelation threshold is not a fixed value, but a dynamic parameter that depends on the composition of the prepolymer solution, temperature, and oxygen inhibition effect. By monitoring the curing depth of a single layer in real time and adjusting the exposure time accordingly, it can be ensured that each layer is fully cross-linked without over-curing and embrittlement, thereby obtaining a wet patch with precise dimensions and uniform mechanical properties on a macroscopic scale.

[0027] S5. Place the wet hydrogel patch in a buffer solution to clean it and remove unreacted components; It should be noted that the ionic strength and pH value of the buffer solution should be similar to those of the human physiological environment to prevent the hydrogel from swelling and rupturing or shrinking and deforming due to sudden changes in osmotic pressure during the washing process. At the same time, extending the washing time and changing the buffer solution regularly can remove unreacted monomers and small molecule residues to the maximum extent and reduce the risk of skin irritation during the use of the patch.

[0028] S6. Perform post-curing treatment on the cleaned hydrogel patch to fully form the cross-linked network and obtain a finished patch with moderate adhesion and high toughness. Furthermore, the cleaned wet hydrogel patch was subjected to secondary irradiation under visible light with a wavelength of 405 nanometers. During post-curing, the residual double bonds in the system continue to react, increasing the crosslinking density. Evolving over time satisfies: ; in, The theoretical maximum crosslinking density, This is the post-curing reaction rate constant. This refers to the post-curing time; when When the set threshold is reached, the light exposure is stopped, and a hydrogel patch with stable mechanical properties is obtained. It should be noted that the post-curing treatment not only increases the cross-linking density, but also promotes the further oxidation of dopamine groups to form catechol / quinone structures, enhancing their dynamic reversible bonding ability with skin keratin. The process precisely controls the interfacial adhesion energy without increasing the modulus, making the patch clinically applicable with the characteristics of being stable during sleep and easy to peel off when awake.

[0029] S7. Sterilize and seal the finished patch to obtain a personalized 3D printed hydrogel patch for treating mouth breathing. Furthermore, the finished patches are sterilized and sealed in a clean environment by placing the patches in a light-proof aluminum-plastic composite bag with a light transmittance of less than 5%, vacuuming the bag, filling it with inert gas, and then sterilizing it by gamma irradiation. The photoinitiator is a lithium acylphosphine oxide compound, whose absorption peak matches the wavelength of the printing light source, and retains some activity in the post-curing stage; It should be noted that the light-proof aluminum-plastic composite bag and the inert gas environment can effectively block oxygen, moisture and visible / ultraviolet light, prevent the cross-linking and aging of residual double bonds in the hydrogel, and inhibit the degradation of photosensitive or oxidation-sensitive functional additives such as vitamin C derivatives and hyaluronic acid, ensuring that the product maintains stable mechanical properties, adhesive properties and skin care efficacy during the storage period.

[0030] In summary, this invention combines precise modeling based on individual 3D lip scanning with a photocurable prepolymer system containing gelatin methacrylamide, dopamine methacrylamide, and functional skincare ingredients. Using photocurable 3D printing, a hydrogel patch that closely conforms to the contours of the lips is fabricated. This not only achieves effective physical intervention for mouth breathing but also balances moderate adhesion and high toughness, ensuring the patch stably closes the lips during sleep and can be painlessly removed without damaging the skin upon waking. Furthermore, the embedded vitamin C derivatives, hyaluronic acid, and glycerin provide slow-release nourishment to the skin around the lips, effectively improving user compliance and comfort for children and sensitive individuals. This overcomes the shortcomings of traditional adhesive tape products, such as easy skin damage, poor adhesion, and lack of skincare functions.

[0031] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit it. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention, and all such modifications or substitutions should be covered within the scope of the claims of the present invention.

Claims

1. A personalized 3D printed hydrogel patch for treating mouth breathing, characterized in that: Comprising: a hydrogel body made by photocuring 3D printing from a prepolymer solution containing a base polymer material, an adhesive functional monomer, a photoinitiator, water, and a functional additive; the three-dimensional shape of the hydrogel patch is personalized based on a 3D scanned digital model of the user's lips; wherein the base polymer material is gelatin methacrylation, the adhesive functional monomer is dopamine methacrylamide, and the functional additive includes one or more of vitamin C and its derivatives, hyaluronic acid, and glycerol.

2. A method of manufacturing a personalized 3D printed hydrogel patch for treating mouth breathing, the personalized 3D printed hydrogel patch for treating mouth breathing according to claim 1, characterized in that: Comprising: acquiring three-dimensional surface topography data of the user's lip area, and constructing a digital model of the personalized hydrogel patch based on the data; designing a three-dimensional structure file with a lip contour according to the digital model; preparing a prepolymer solution containing gelatin methacrylation, dopamine methacrylamide, acrylamide, polyethylene glycol diacrylate, a photoinitiator, and a skin-care type functional additive; injecting the prepolymer solution into a photocuring 3D printing device and calling the three-dimensional structure file for layer-by-layer exposure printing to form a wet hydrogel patch; washing the wet hydrogel patch in a buffer solution to remove unreacted components; post-curing the washed hydrogel patch to fully form a cross-linked network, obtaining a finished patch with moderate adhesion and high toughness; sterilizing and sealing the finished patch for packaging, obtaining a personalized 3D printed hydrogel patch for treating oral breathing.

3. The method of producing a personalized 3D printed hydrogel patch for treating mouth breathing according to claim 2, wherein: The specific steps of acquiring three-dimensional surface topography data of the user's lip area, and constructing a digital model of the personalized hydrogel patch based on the data are as follows: using a structured light scanner to non-contact scan the lip contour area of the user in a natural closed lip state to obtain point cloud data; importing the point cloud data into three-dimensional reconstruction software to generate a closed lip surface digital model through surface fitting; offset a distance along the normal outside the lip of the lip surface digital model generating a patch boundary contour, wherein is a patch cover width parameter; Imparting thickness parameters along a direction perpendicular to the labial surface Forming the initial digital model of the patch.

4. The method of producing a personalized 3D printed hydrogel patch for treating mouth breathing according to claim 3, wherein: The specific steps of preparing a prepolymer solution containing gelatin methacrylation, dopamine methacrylamide, acrylamide, polyethylene glycol diacrylate, a photoinitiator, and a skin-care type functional additive are as follows: Dissolve gelatin methacrylation and acrylamide in a buffer solution together, stir to complete dissolution under constant temperature conditions to form a first solution; add dopamine methacrylamide to the first solution, continue to stir until molecular dispersion to form a second solution; add polyethylene glycol diacrylate, a photoinitiator, and a skin-care type functional additive to the second solution in sequence, continue to stir until the system is uniform and transparent to obtain a prepolymer solution; wherein the molar ratio of each component in the prepolymer solution satisfies the following relationship: ； wherein, represents the molar concentration of dopamine methacrylamide, represents the molar concentration of gelatin methacrylation, is the adhesion functional monomer regulation coefficient; with respectively represent the molar concentration of crosslinker and comonomer, is the network rigidity regulation coefficient.

5. The method of producing a personalized 3D printed hydrogel patch for treating mouth breathing according to claim 4, wherein: The specific steps of injecting the prepolymer solution into a photocuring 3D printing device and calling the three-dimensional structure file for layer-by-layer exposure printing to form a wet hydrogel patch are as follows: inject the prepolymer solution into the resin tank of a digital light processing (DLP) printing device; The initial digital model of the patch is called, the slice generation layer thickness is the printing path; The light source is controlled to expose each layer with an exposure energy density satisfies: ； wherein, is the light source intensity, is the single layer exposure time; When the cumulative exposure energy reaches a critical gelation threshold solidification is completed; repeat the above process until all layers are printed to obtain a wet hydrogel patch.

6. The method of producing a personalized 3D printed hydrogel patch for treating mouth breathing according to claim 5, wherein: The specific steps of post-curing the washed hydrogel patch to fully form a cross-linked network, obtaining a finished patch with moderate adhesion and high toughness are as follows: The wet-state hydrogel patch after cleaning is placed under visible light with a wavelength of 405 nm for secondary irradiation; During post-cure, the residual double bonds in the system continue to react and crosslinking density The time evolution satisfies: ； wherein, is the theoretical maximum crosslinking density, is the post-cure reaction rate constant, is the post-cure time; When The light irradiation is terminated when the set threshold is reached, and a hydrogel patch with stable mechanical properties is obtained.

7. The method of producing a personalized 3D printed hydrogel patch for treating mouth breathing according to claim 6, wherein: The release behavior of the skin-care type functional additive in the hydrogel network is controlled by diffusion and network relaxation coupling, and the cumulative release fraction satisfies: ； wherein, is the release amplitude coefficient, is the release exponent; when 0.5 <1.0, indicating that the release process is jointly dominated by polymer chain segment relaxation and molecular diffusion.

8. The method of producing a personalized 3D printed hydrogel patch for treating mouth breathing according to claim 7, characterized in that: The peeling force of the finished patch on the skin is determined by the interfacial adhesion energy W, which is characterized by the following formula: ； wherein, is the physical wetting energy between the hydrogel and the skin, is the free energy increment of the reversible chemical interaction between the dopamine groups and the skin keratin.

9. The method of producing a personalized 3D printed hydrogel patch for treating mouth breathing according to claim 8, wherein: The sterilization and sealed packaging of the finished patch is that the patch is loaded into a light-proof aluminum-plastic composite bag with a transmittance of less than 5% in a clean environment, vacuumized, filled with inert gas, and then sterilized by gamma ray irradiation.

10. The method of producing a personalized 3D printed hydrogel patch for treating mouth breathing according to claim 9, wherein: The photoinitiator is a lithium phosphine oxide compound, the absorption peak matches the wavelength of the printing light source, and part of the activity is still retained in the post-curing stage.

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