Traditional Chinese medicine composition for treating pulmonary nodule

Abstract

The invention discloses a traditional Chinese medicine composition for treating pulmonary nodules. Comprising the following raw material medicines in parts by weight: 12-18 parts of radix scrophulariae, 9-15 parts of Chinese lobelia, 9-15 parts of oldenlandia diffusa, 5-9 parts of stiff silkworm, 5-9 parts of radix bupleuri, 6-10 parts of radix paeoniae alba, 25-35 parts of astragalus membranaceus, 9-15 parts of bighead atractylodes rhizome, 15-25 parts of poria cocos, 8-12 parts of glossy privet fruit, 21-25 parts of salvia miltiorrhiza, 9-15 parts of curcuma zedoary, 6-10 parts of turmeric, 5-9 parts of fructus amomi, 4-6 parts of rhizoma zingiberis, 4-6 parts of jujube, 4-6 parts of platycodon grandiflorum and 4-6 parts of liquorice. The invention is developed on the basis of reexamination of pathogenesis and pathogenesis of pulmonary nodules, and has an expected effect of treating pulmonary nodules.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, and in particular to a traditional Chinese medicine composition for treating pulmonary nodules. Background Technology

[0002] Traditional Chinese medicine (TCM) categorizes pulmonary nodules under the terms "pulmonary accumulation," "accumulation," and "phlegm nodules." TCM theory considers the core pathogenesis of pulmonary nodules to be a complex interplay of "deficiency, phlegm, blood stasis, toxins, and qi stagnation." Based on clinical manifestations and the emphasis on pathogenesis, common classifications include: liver qi stagnation invading the lungs, phlegm-dampness obstruction, phlegm-blood stasis, lung and spleen qi deficiency, and qi and yin deficiency, among others. Corresponding treatment principles include: soothing the liver and regulating qi, promoting lung function and dispersing nodules; strengthening the spleen and eliminating dampness, resolving phlegm and dispersing nodules; promoting blood circulation and removing blood stasis, resolving phlegm and dispersing nodules; tonifying the lungs and spleen, supporting the body's resistance and eliminating pathogenic factors; and nourishing qi and yin, moistening the lungs and dispersing nodules. However, TCM treatment of pulmonary nodules still faces the following challenges: 1. Traditional formulas and commonly used prepared Chinese medicines have a relatively narrow range of indications for treating pulmonary nodules, failing to meet the medication needs of some patients with multiple syndromes (complex syndromes). This is mainly because most classical Chinese medicine formulas and prepared Chinese medicines are designed for single syndrome types, implementing syndrome differentiation and treatment. For patients with multiple syndrome types (complex syndromes) of pulmonary nodules, classical formulas are often modified or prepared Chinese medicines are used in combination. However, combined Chinese medicine treatment has problems such as the use of more drugs, imprecise drug compatibility and dosage ratios, and increased costs. Further innovation is needed in the use of single-herb compound formulas or prepared Chinese medicines to treat the multiple syndrome types (complex syndromes) of pulmonary nodules. 2. The complete regression rate of pulmonary nodules treated with traditional Chinese medicine is still relatively low and needs further improvement.

[0003] In order to overcome the shortcomings of the prior art, the present invention provides a traditional Chinese medicine composition for treating pulmonary nodules, so as to solve the problems mentioned in the background art.

[0004] To achieve the above objectives, the present invention is implemented through the following technical solution.

[0005] This invention combines the theories of TCM (Traditional Chinese Medicine) organ differentiation and the Triple Energizer differentiation with the core pathological mechanisms of Western medicine in treating pulmonary nodules, comprehensively differentiating the etiology and pathogenesis of pulmonary nodules and formulating prescriptions accordingly. Targeting patients with pulmonary nodules exhibiting multiple syndrome types (complex syndromes) including "liver qi stagnation invading the lungs, phlegm-dampness obstruction, phlegm-blood stasis, lung and spleen qi deficiency, and qi and yin deficiency," it integrates the four core pathological mechanisms of Western medicine in treating pulmonary nodules (chronic inflammatory response, fibrosis and abnormal cell proliferation, immune imbalance, oxidative stress and gene mutation). It combines the core pathogenesis mechanisms of TCM and Western medicine in treating pulmonary nodules, carefully selecting raw materials whose pharmacological mechanisms are highly compatible with those of TCM and Western medicine, and fully comply with the principles of TCM syndrome differentiation and medication, to enhance the accuracy and scientific basis of the prescription. This invention focuses on "soothing the liver, strengthening the spleen, and tonifying the kidneys as the root cause, treating pulmonary nodules as the symptom, and promoting the circulation of qi, blood, and body fluids in the Triple Energizer as a supplementary measure," aiming to achieve the goal of "treating both the root cause and symptoms, combining attack and tonification, and holistic conditioning" in treating pulmonary nodules.

[0006] A traditional Chinese medicine composition for treating pulmonary nodules comprises the following raw materials in parts by weight: Scrophularia ningpoensis 12-18 parts, Lobelia chinensis 9-15 parts, Hedyotis diffusa 9-15 parts, Bombyx mori 5-9 parts, Bupleurum chinense 5-9 parts, Paeonia lactiflora 6-10 parts, Astragalus membranaceus 25-35 parts, Atractylodes macrocephala 9-15 parts, Poria cocos 15-25 parts, Ligustrum lucidum 8-12 parts, Salvia miltiorrhiza 21-25 parts, Curcuma zedoaria 9-15 parts, Curcuma longa 6-10 parts, Amomum villosum 5-9 parts, Zingiber officinale 4-6 parts, Ziziphus jujuba 4-6 parts, Platycodon grandiflorus 4-6 parts, Glycyrrhiza uralensis 4-6 parts.

[0007] As a further technical solution of the present invention, the raw materials include the following parts by weight: 12 parts of Scrophularia ningpoensis, 9 parts of Lobelia chinensis, 9 parts of Hedyotis diffusa, 5 parts of Bombyx mori, 5 parts of Bupleurum chinense, 6 parts of Paeonia lactiflora, 25 parts of Astragalus membranaceus, 9 parts of Atractylodes macrocephala, 15 parts of Poria cocos, 8 parts of Ligustrum lucidum, 21 parts of Salvia miltiorrhiza, 9 parts of Curcuma zedoaria, 6 parts of Curcuma longa, 5 parts of Amomum villosum, 4 parts of Zingiber officinale, 4 parts of Ziziphus jujuba, 4 parts of Platycodon grandiflorus, and 4 parts of Glycyrrhiza uralensis.

[0008] As a further technical solution in this regard, the following raw materials are included in parts by weight: 18 parts of Scrophularia ningpoensis, 15 parts of Lobelia chinensis, 15 parts of Hedyotis diffusa, 9 parts of Bombyx mori, 9 parts of Bupleurum chinense, 10 parts of Paeonia lactiflora, 35 parts of Astragalus membranaceus, 15 parts of Atractylodes macrocephala, 25 parts of Poria cocos, 12 parts of Ligustrum lucidum, 25 parts of Salvia miltiorrhiza, 15 parts of Curcuma zedoaria, 10 parts of Curcuma longa, 9 parts of Amomum villosum, 6 parts of Zingiber officinale, 6 parts of Ziziphus jujuba, 6 parts of Platycodon grandiflorus, and 6 parts of Glycyrrhiza uralensis

[0009] The technical solution of this invention is to provide a traditional Chinese medicine composition for treating pulmonary nodules. The composition is prepared by adding excipients required for formulation molding and following conventional methods for preparing formulations.

[0010] Furthermore, the aforementioned traditional Chinese medicine preparations are decoctions, powders, ultrafine powders, pills, granules, tablets, capsules, or oral liquids.

[0011] The beneficial effects of this invention are: The pharmacological effects of each active pharmaceutical ingredient in this invention are as follows: Scrophularia, with a sweet, bitter, and salty taste, and slightly cold in nature; enters the lung, stomach, and kidney meridians. Main functions: clearing heat and cooling blood, nourishing yin and reducing fire, detoxifying and dissipating nodules.

[0012] Lobelia chinensis has a pungent and sweet taste, and is slightly cold in nature; it enters the heart, lung, and small intestine meridians. Its main functions are clearing heat and detoxifying, reducing swelling and promoting diuresis.

[0013] Hedyotis diffusa, sweet and bland in taste, cool in nature; enters the stomach, large intestine, and small intestine meridians. Main functions: clearing heat and detoxifying, promoting diuresis and reducing swelling, invigorating blood and relieving pain.

[0014] Silkworm pupae are salty and pungent in taste, and neutral in nature; they enter the liver, lung, and stomach meridians. Their main functions are: to calm wind and stop spasms, to dispel wind and relieve pain, and to resolve phlegm and dissipate nodules.

[0015] Bupleurum root has a bitter taste and slightly cold properties; it enters the liver and gallbladder meridians. Its main functions are to harmonize the exterior and interior, soothe the liver and relieve depression, and raise yang qi.

[0016] White peony root has a bitter and sour taste, and is slightly cold in nature; it enters the liver and spleen meridians. Its main functions are: nourishing blood and regulating qi, soothing the liver and relieving pain, and calming liver yang.

[0017] Astragalus membranaceus (Huang Qi) is sweet in taste and warm in nature; it enters the lung and spleen meridians. Its main functions are: tonifying qi and raising yang, strengthening the defensive qi and consolidating the exterior, promoting tissue regeneration and detoxification, and promoting diuresis and reducing swelling.

[0018] Atractylodes macrocephala, bitter and sweet in taste, warm in nature; enters the spleen and stomach meridians. Its main functions are: strengthening the spleen and replenishing qi, drying dampness and promoting diuresis, stopping sweating, and calming the fetus.

[0019] Poria cocos is sweet and bland in taste, and neutral in nature; it enters the heart, lung, spleen, and kidney meridians. Its main functions are: promoting diuresis and eliminating dampness, strengthening the spleen and harmonizing the stomach, and calming the mind and soothing the nerves.

[0020] Privet fruit has a sweet and bitter taste and is cool in nature; it enters the liver and kidney meridians. Its main functions are to nourish the liver and kidneys, clear heat, and improve eyesight.

[0021] Salvia miltiorrhiza (danshen) has a bitter taste and slightly cold properties; it enters the heart and liver meridians. Its main functions are: promoting blood circulation and removing blood stasis, regulating menstruation and relieving pain, and nourishing the heart and calming the mind.

[0022] Curcuma zedoaria has a pungent and bitter taste, and is warm in nature; it enters the liver and spleen meridians. Its main functions are to promote qi circulation, break up blood stasis, eliminate stagnation, and relieve pain.

[0023] Turmeric, bitter and pungent in taste, warm in nature; enters the liver meridian. Main functions: breaks up blood stasis, promotes qi circulation, unblocks menstruation, and relieves pain.

[0024] Amomum villosum has a pungent taste and warm properties; it enters the spleen, stomach, and kidney meridians. Its main functions are: to resolve dampness and stimulate appetite, to warm the spleen and stop diarrhea, and to regulate qi and calm the fetus.

[0025] Dried ginger is pungent and hot in nature; it enters the spleen, stomach, kidney, heart, and lung meridians. Its main functions are: warming the middle jiao and dispelling cold, restoring yang and unblocking the meridians, drying dampness and resolving phlegm.

[0026] Jujube, sweet in taste and warm in nature; it enters the spleen and stomach meridians. Main effects: Tonifying qi and strengthening the spleen, nourishing blood and calming the mind, regulating nutrient qi and defensive qi, and alleviating the properties of other drugs.

[0027] Platycodon grandiflorum, bitter and pungent in taste and neutral in nature; it enters the lung meridian. Main effects: Promoting lung qi to resolve phlegm, relieving sore throat and discharging pus.

[0028] Licorice, sweet in taste and neutral in nature; it enters the spleen, stomach, lung and heart meridians. Main effects: Tonifying qi and regulating the middle, eliminating phlegm and relieving cough, clearing heat and detoxifying, alleviating spasm and pain, and coordinating the properties of various drugs.

[0029] For the compatibility of the raw materials of this invention (the monarch, minister, assistant and envoy herbs), the method of selecting and combining traditional Chinese and Western medicines adheres to the principle of "combining the traditional pharmacological mechanisms of traditional Chinese medicine and the pharmacological mechanisms of modern Western medicine, with the pharmacological mechanisms of traditional Chinese medicine as the main and the pharmacological mechanisms of Western medicine as the auxiliary", thereby further improving the accuracy and scientific basis of the drug compatibility of this invention. The traditional Chinese and Western pharmacological mechanisms of each raw material in the composition of this invention are known or publicly available.

[0030] The compatibility (the monarch, minister, assistant and envoy herbs) of this invention and its traditional Chinese and Western pharmacological mechanisms are as follows: Monarch herbs: Scrophularia ningpoensis, Lobelia chinensis, Hedyotis diffusa, and Bombyx batryticatus. Scrophularia ningpoensis clears heat and detoxifies, softens hard masses and disperses nodules, and has the effects of anti-mutation, anti-fibrosis, anti-inflammation and anti-oxidation. Lobelia chinensis clears heat and detoxifies, reduces swelling and promotes diuresis, and has the effects of anti-tumor and anti-fibrosis. Hedyotis diffusa clears heat and detoxifies, activates blood circulation and reduces swelling, and has the effects of inducing apoptosis of tumor cells, anti-inflammation and immune regulation. Bombyx batryticatus dispels wind and relieves pain, resolves phlegm and disperses nodules, and has the effects of immune regulation, anti-fibrosis and anti-virus. The combination of the 4 monarch herbs synergistically resolves the core pathological products (phlegm, stasis, toxin) of lung nodules, directly targeting the pathogenesis of lung accumulation.

[0031] Minister herbs: Bupleurum chinense, Paeonia lactiflora, Astragalus membranaceus, Atractylodes macrocephala, Poria cocos, and Ligustrum lucidum. Bupleurum chinense soothes the liver and relieves depression, and has the effect of inhibiting inflammatory factors. Paeonia lactiflora nourishes blood and softens the liver, and the combination of the two regulates qi movement to assist in dispersing nodules. Astragalus membranaceus tonifies qi and raises yang, promotes the production of muscle and discharges toxin, and has the effect of reducing inflammatory factors. Atractylodes macrocephala strengthens the spleen and replenishes qi, and has the effect of regulating intestinal immunity. Poria cocos strengthens the spleen and harmonizes the middle, promotes diuresis and percolates dampness, and has the effect of regulating intestinal flora and enhancing immune balance. The combination of Astragalus membranaceus, Atractylodes macrocephala and Poria cocos cuts off the source of phlegm-dampness generation. Ligustrum lucidum tonifies the liver and kidney, nourishes yin and moistens dryness, balances the depletion of healthy qi caused by heat-clearing drugs, and has the effect of reversing immune suppression. The combination of the 6 minister herbs resolves the root cause of "deficiency of healthy qi and excess of pathogenic factors" by regulating the functions of the liver, spleen and kidney.

[0032] Adjuvant herbs: Salvia miltiorrhiza, Curcuma zedoaria, Curcuma longa, Amomum villosum, Zingiber officinale, and Ziziphus jujuba. Salvia miltiorrhiza invigorates blood circulation and removes blood stasis, regulating collagen metabolism and synergistically combating fibrosis. Curcuma zedoaria promotes qi circulation, breaks up blood stasis, eliminates stagnation, and relieves pain, with anti-fibrotic effects. Curcuma longa breaks up blood stasis, promotes qi circulation, relieves pain, and has anti-inflammatory and antioxidant effects. The combination of Salvia miltiorrhiza, Curcuma zedoaria, and Curcuma longa assists the principal herbs in invigorating blood circulation, removing blood stasis, promoting qi circulation, and eliminating stagnation. Amomum villosum resolves dampness, stimulates appetite, warms the spleen, stops diarrhea, and promotes gastrointestinal absorption. Zingiber officinale warms the middle jiao, dispels cold, restores yang, unblocks meridians, dries dampness, and eliminates phlegm, improving energy metabolism. Ziziphus jujuba tonifies qi, strengthens the spleen, nourishes blood, calms the mind, harmonizes ying and wei, and enhances immunity. The combination of Amomum villosum, Zingiber officinale, and Ziziphus jujuba assists the adjuvant herbs in improving metabolism and enhancing immunity, while simultaneously protecting the spleen and stomach.

[0033] Guiding herbs: Platycodon grandiflorus and licorice. Platycodon grandiflorus clears the lungs and resolves phlegm, serving as a guiding herb for the lungs. Licorice harmonizes the effects of the other herbs.

[0034] In this invention, the formula comprises: four principal herbs that clear heat and detoxify, resolve phlegm and dissipate nodules, and have anti-inflammatory, anti-fibrotic, immunomodulatory, antioxidant, and anti-oxidative stress effects, specifically targeting the core pathogenesis and pathological products of pulmonary nodules, thus providing symptomatic relief. Six assistant herbs that soothe and soften the liver, strengthen the spleen and dry dampness, tonify the lungs and kidneys, and harmonize the functions of the liver, spleen, and kidneys, thus providing fundamental relief. Six adjuvant herbs that invigorate blood circulation, remove blood stasis, promote qi circulation and eliminate stagnation, resolve dampness and stimulate appetite, dry dampness and eliminate phlegm, tonify qi and strengthen the spleen, and protect the spleen and kidneys. The principal herbs assist the main herbs in promoting blood circulation, removing blood stasis, regulating qi, and eliminating stagnation; the assistant herbs assist the adjuvant herbs in improving metabolism and enhancing immunity. They also have anti-inflammatory, antioxidant, synergistic anti-fibrotic, collagen metabolism-regulating, and immunity-enhancing effects, representing a comprehensive approach to treating both the symptoms and the root cause. Furthermore, the composition of this invention addresses multiple concurrent symptoms of pulmonary nodules (complex syndromes): Bupleurum, White Peony Root, Platycodon, Oldenlandia diffusa, and Lobelia chinensis are combined to treat the "Liver Qi Stagnation Invading the Lung" syndrome; Atractylodes macrocephala, Poria cocos, Bombyx batryticatus, and Scrophularia ningpoensis are combined to treat the "Phlegm-Dampness Obstruction" syndrome; Salvia miltiorrhiza, Curcuma zedoaria, Curcuma longa, Bombyx batryticatus, and Scrophularia ningpoensis are combined to treat the "Phlegm and Blood Stasis Intertwined" syndrome; Astragalus membranaceus, Atractylodes macrocephala, Poria cocos, Platycodon grandiflorus, Bombyx batryticatus, and Scrophularia ningpoensis are combined to treat the "Lung and Spleen Qi Deficiency" syndrome; and Astragalus membranaceus, Atractylodes macrocephala, Poria cocos, Platycodon grandiflorus, Oldenlandia diffusa, and Lobelia chinensis are combined to treat the "Qi and Yin Deficiency" syndrome; thus covering the five major pathogenesis and classifications involved in this invention. Meanwhile, the combination of Bupleurum, Amomum villosum, and Platycodon grandiflorus, the combination of Salvia miltiorrhiza, Curcuma zedoaria, and Curcuma longa, and the combination of Astragalus membranaceus, Atractylodes macrocephala, and Poria cocos, can synergistically treat the imbalance of "qi-blood-water (body fluids)" in the Triple Burner; the combination of Astragalus membranaceus, Atractylodes macrocephala, Ligustrum lucidum, Amomum villosum, dried ginger, jujube, and licorice is a strategy to nourish and protect the internal organs.

[0035] This invention utilizes traditional Chinese medicine pharmacological mechanisms that cover (and align with) the four core pharmacological mechanisms of Western medicine in treating pulmonary nodules. Anti-inflammatory factors: A combination of *Hedyotis diffusa*, *Scrophularia ningpoensis*, and *Curcuma longa*. Anti-fibrotic: A combination of *Salvia miltiorrhiza*, *Curcuma zedoaria*, and *Bombyx batryticatus*. Regulating immune imbalance: A combination of *Astragalus membranaceus*, *Poria cocos*, and *Ligustrum lucidum*. Antioxidant stress and gene mutation: A combination of *Scrophularia ningpoensis*, *Lobelia chinensis*, and *Curcuma longa*.

[0036] The inventiveness of this invention is mainly reflected in the following two aspects: 1. It integrates the five major pathogenesis (subtypes) of pulmonary nodules—"liver qi stagnation invading the lungs, phlegm-dampness obstruction, phlegm-blood stasis, lung and spleen qi deficiency, and qi and yin deficiency"—into a unified treatment framework (complex syndrome). This breaks through the limitations of traditional subtype-based treatment, adapts to complex pathogenesis (complex syndrome), and achieves a new breakthrough in the treatment of pulmonary nodule patients with multiple syndromes and complex pathogenesis (complex syndrome). It realizes the innovation of "a single prescription covering multiple classical and contemporary formulas or multiple types of Chinese patent medicines combined, or multiple types of Western medicines used in combination," reducing the complexity of combined Chinese patent medicines or Western medicines in the treatment of pulmonary nodules, and lowering economic costs and risks. This invention embodies the creative application of the core TCM ideas of "treating both the root cause and the symptoms, combining attack and tonification, and holistic conditioning" and the core TCM treatment principle of "treating multiple syndromes together" in the treatment of pulmonary nodules. 2. This invention innovatively integrates the pathological and pharmacological mechanisms of Traditional Chinese Medicine (TCM) and Western medicine in the treatment of pulmonary nodules (integrating the five major symptom patterns and five major treatment principles of TCM with the four core pathological mechanisms and four core pharmacological mechanisms of Western medicine). This allows the TCM pharmacological mechanism of this invention to cover (match) the entire chain of Western medicine's pharmacological mechanisms for treating pulmonary nodules (four core pharmacological mechanisms), improving the precision and scientific basis of the compound's drug combination. It embodies the creative application of "combining TCM and Western medicine, combining disease and syndrome, and integrating pharmacological mechanisms" in the treatment of pulmonary nodules. 3. This invention, combined with Western medicine, will further improve clinical efficacy, reduce the dosage of Western medicine drugs and treatment side effects, and achieve complementary advantages. 4. It has the advantages of lower economic cost and long-term safe medication. The cost of the TCM compound of this invention is significantly lower than that of biological agents, providing a safer and more economical solution for the treatment of pulmonary nodules, and is more suitable for chronic patients requiring long-term management.

[0037] The individual pharmacological effects of each active pharmaceutical ingredient in the composition of this invention have been clearly recorded in the authoritative document, the Chinese Pharmacopoeia. The formulation and compatibility are all conventional, with clear synergistic effects and uses, directly related to the known uses of each active pharmaceutical ingredient. Therefore, the formulation of this invention is based on the certainty of the known efficacy of the active pharmaceutical ingredients and the synergistic effects of the combination, thus conforming to the theory and principles of traditional Chinese medicine formula compatibility. Furthermore, the pharmacological mechanisms of each active pharmaceutical ingredient in the composition of this invention are known or publicly disclosed in Western medicine. The high degree of compatibility between the pharmacological mechanisms of traditional Chinese medicine and Western medicine helps those skilled in the art to better analyze and understand the regularity and logic of the principles, methods, formulas, and drugs of this invention.

[0038] Furthermore, those skilled in the art, based on the existing technology's disclosed etiology, pathogenesis, treatment principles, the traditional Chinese medicine and Western medicine pharmacological mechanisms of each raw material in this formula, and the certainty of synergistic effects of compatibility, are able to predict that this invention will have the expected effect of treating pulmonary nodules. Detailed Implementation

[0039] Example 1 A traditional Chinese medicine composition for treating pulmonary nodules comprises the following raw materials in parts by weight: Scrophularia ningpoensis 12-18 parts, Lobelia chinensis 9-15 parts, Hedyotis diffusa 9-15 parts, Bombyx mori 5-9 parts, Bupleurum chinense 5-9 parts, Paeonia lactiflora 6-10 parts, Astragalus membranaceus 25-35 parts, Atractylodes macrocephala 9-15 parts, Poria cocos 15-25 parts, Ligustrum lucidum 8-12 parts, Salvia miltiorrhiza 21-25 parts, Curcuma zedoaria 9-15 parts, Curcuma longa 6-10 parts, Amomum villosum 5-9 parts, Zingiber officinale 4-6 parts, Ziziphus jujuba 4-6 parts, Platycodon grandiflorus 4-6 parts, Glycyrrhiza uralensis 4-6 parts.

[0040] Example 2 A traditional Chinese medicine composition for treating pulmonary nodules comprises the following raw materials in parts by weight: 12 parts of Scrophularia ningpoensis, 9 parts of Lobelia chinensis, 9 parts of Hedyotis diffusa, 5 parts of Bombyx mori, 5 parts of Bupleurum chinense, 6 parts of Paeonia lactiflora, 25 parts of Astragalus membranaceus, 9 parts of Atractylodes macrocephala, 15 parts of Poria cocos, 8 parts of Ligustrum lucidum, 21 parts of Salvia miltiorrhiza, 9 parts of Curcuma zedoaria, 6 parts of Curcuma longa, 5 parts of Amomum villosum, 4 parts of Zingiber officinale, 4 parts of Ziziphus jujuba, 4 parts of Platycodon grandiflorus, and 4 parts of Glycyrrhiza uralensis.

[0041] Example 3 A traditional Chinese medicine composition for treating pulmonary nodules comprises the following raw materials in parts by weight: 18 parts of Scrophularia ningpoensis, 15 parts of Lobelia chinensis, 15 parts of Hedyotis diffusa, 9 parts of Bombyx mori, 9 parts of Bupleurum chinense, 10 parts of Paeonia lactiflora, 35 parts of Astragalus membranaceus, 15 parts of Atractylodes macrocephala, 25 parts of Poria cocos, 12 parts of Ligustrum lucidum, 25 parts of Salvia miltiorrhiza, 15 parts of Curcuma zedoaria, 10 parts of Curcuma longa, 9 parts of Amomum villosum, 6 parts of Zingiber officinale, 6 parts of Ziziphus jujuba, 6 parts of Platycodon grandiflorus, and 6 parts of Glycyrrhiza uralensis.

[0042] All features described in the specification and appended claims, whether individually or in any combination thereof, are essential features of this invention.

[0043] Although embodiments of the present invention have been shown and described above, it will be apparent to those skilled in the art that the present invention is not limited to the details of the above embodiments. The above embodiments are exemplary and should not be construed as limiting the present invention. Those skilled in the art can make changes, modifications, substitutions, variations, deletions of features, additions of features, and recombination of features to the above embodiments to form technical solutions without departing from the innovative principles and rules of the present invention. Any simple modifications, equivalent changes, and alterations made to the above embodiments based on the innovative principles of the present invention shall still fall within the scope of the technical solutions of the present invention.

Claims

1. A traditional Chinese medicine composition for treating pulmonary nodules, characterized in that, The raw materials include the following parts by weight: Scrophularia ningpoensis 12-18 parts, Lobelia chinensis 9-15 parts, Hedyotis diffusa 9-15 parts, Bombyx mori 5-9 parts, Bupleurum chinense 5-9 parts, Paeonia lactiflora 6-10 parts, Astragalus membranaceus 25-35 parts, Atractylodes macrocephala 9-15 parts, Poria cocos 15-25 parts, Ligustrum lucidum 8-12 parts, Salvia miltiorrhiza 21-25 parts, Curcuma zedoaria 9-15 parts, Curcuma longa 6-10 parts, Amomum villosum 5-9 parts, Zingiber officinale 4-6 parts, Ziziphus jujuba 4-6 parts, Platycodon grandiflorus 4-6 parts, Glycyrrhiza uralensis 4-6 parts.

2. The traditional Chinese medicine composition for treating pulmonary nodules according to claim 1, characterized in that, The raw materials and their weight parts are as follows: Scrophularia ningpoensis 12 parts, Lobelia chinensis 9 parts, Hedyotis diffusa 9 parts, Bombyx batryticatus 5 parts, Bupleurum chinense 5 parts, Paeonia lactiflora 6 parts, Astragalus membranaceus 25 parts, Atractylodes macrocephala 9 parts, Poria cocos 15 parts, Ligustrum lucidum 8 parts, Salvia miltiorrhiza 21 parts, Curcuma zedoaria 9 parts, Curcuma longa 6 parts, Amomum villosum 5 parts, Zingiber officinale 4 parts, Ziziphus jujuba 4 parts, Platycodon grandiflorus 4 parts, Glycyrrhiza uralensis 4 parts.

3. The traditional Chinese medicine composition for treating pulmonary nodules according to claim 1, characterized in that, The raw materials and their weight parts are as follows: Scrophularia ningpoensis 18 parts, Lobelia chinensis 15 parts, Hedyotis diffusa 15 parts, Bombyx batryticatus 9 parts, Bupleurum chinense 9 parts, Paeonia lactiflora 10 parts, Astragalus membranaceus 35 parts, Atractylodes macrocephala 15 parts, Poria cocos 25 parts, Ligustrum lucidum 12 parts, Salvia miltiorrhiza 25 parts, Curcuma zedoaria 15 parts, Curcuma longa 10 parts, Amomum villosum 9 parts, Zingiber officinale 6 parts, Ziziphus jujuba 6 parts, Platycodon grandiflorus 6 parts, Glycyrrhiza uralensis 6 parts.

4. A traditional Chinese medicine preparation for treating pulmonary nodules, characterized in that, In the traditional Chinese medicine composition according to claims 1-3, excipients required for formulation are added, and the composition is prepared according to conventional methods for preparing formulations.

5. The traditional Chinese medicine preparation according to claim 4, characterized in that, The compound preparation is a decoction, powder, ultrafine powder, pill, granule, tablet, capsule or oral liquid.