Honeycomb scaffold bioreactor for mass cell production
By using a support structure with a solid outer wall and multiple inner walls in the bioreactor, the back pressure problem caused by insufficient mechanical strength of the scaffold in high-density cell culture was solved, thus achieving a stable cell growth environment and a simplified production process.
Patent Information
- Application Number
- CN202480058649.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Priority Date
- 2023-09-13
- Filing Date
- 2024-09-11
- Publication Date
- 2026-04-10
AI Technical Summary
Existing scaffolds lack sufficient mechanical strength in large-scale or commercial cell production, leading to increased back pressure during perfusion culture, causing scaffold compaction, stacking, and collapse, which affects cell growth and nutrient supply.
The support structure employs a solid outer wall and multiple inner walls to form multiple channels to accommodate the polymer scaffold, providing physical support and uniformly distributing cells. The inner walls can be porous to guide fluid flow. The support structure can withstand high pressure without deformation and can be a modular or independent structure.
Maintaining the stability of the scaffold structure under high cell density reduces back pressure, ensures uniform fluid distribution and cell growth environment, simplifies large-scale production processes, and reduces capital investment and processing time.