Rapid skull growth marker and application thereof

By detecting the expression levels of FAK, Twist1, and related bone growth factors, the problem of inaccurate timing of pediatric cranial defect repair surgery was solved, enabling precise cranial repair and postoperative management, and improving the success rate and safety of the surgery.

CN121852527APending Publication Date: 2026-04-14THE FIRST AFFILIATED HOSPITAL OF BAOTOU MEDICAL COLLEGE OF INNER MONGOLIA UNIV OF SCI & TECH
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Patent Information

Application Number
CN202511927717.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-12-19
Publication Date
2026-04-14

AI Technical Summary

Technical Problem

Current technologies lack key biomarkers based on the pressure/dura mater FAK-Twist1 pathway, leading to inaccurate timing of pediatric skull defect repair surgery, which may affect skull growth and development and increase the risk of complications.

Method used

FAK, Twist1, and related soluble bone growth factors (such as BMP-2 and TGF-β1) were used as markers of rapid skull growth. By detecting their mRNA and protein expression levels, the growth and development status of the skull was assessed, guiding the appropriate timing of repair and postoperative monitoring.

Benefits of technology

It has improved the success rate and safety of cranial defect repair surgery, reduced complications, provided personalized treatment plans and postoperative prognostic assessments, and reduced reliance on imaging equipment and physician experience.

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Abstract

The invention belongs to the technical field of medicine, discloses a skull rapid growth marker and application thereof, and provides a skull rapid growth marker based on a pressure / dura mater FAK-Twist1 pathway and an application method of the marker in child skull defect repair. By detecting the expression level of the marker, the growth and development state of the pediatric skull can be accurately judged, and a scientific basis is provided for clinical doctors to select proper skull repair opportunities, so that the success rate and safety of pediatric skull defect repair operations are improved, and postoperative complications are reduced. The rapid skull growth markers determined by the invention are closely related to the growth and development mechanism of the child skull based on a pressure / dura mater FAK-Twist1 pathway, and the growth state of the skull can be accurately reflected by detecting the expression level of the markers, so that a reliable diagnostic basis is provided for opportunity selection of a child skull defect repair operation.
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