Radiotherapy injury repair injection hydrogel and preparation method thereof

By preparing a radiotherapy damage repair injectable hydrogel, an anti-inflammatory traditional Chinese medicine formula is encapsulated in PLGA microspheres and cross-linked with gelatin and sodium oxidized alginate to form an injectable hydrogel. This solves the treatment problem of radiotherapy damage to deep organs and achieves local slow release and efficient repair of the anti-inflammatory traditional Chinese medicine formula.

CN121868432APending Publication Date: 2026-04-17HEBEI PROVINCE CANGZHOU HOSPITAL OF INTEGRATED TRADITIONAL & WESTERN MEDICINE
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Patent Information

Application Number
CN202610107878.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-01-27
Publication Date
2026-04-17

AI Technical Summary

Technical Problem

Existing Chinese herbal compound components cannot effectively treat radiation damage to deep organs such as the abdominal cavity and pelvic cavity through topical application, especially complications such as radiation proctitis, radiation cystitis, and inflammation, ulceration, and fibrosis of the cervix and vaginal mucosa caused by radiotherapy.

Method used

An injectable hydrogel for radiotherapy damage repair was prepared by encapsulating an anti-inflammatory traditional Chinese medicine formula in PLGA microspheres and mixing it with gelatin and sodium alginate solution to form an injectable hydrogel, thereby achieving localized slow release of the anti-inflammatory traditional Chinese medicine formula. Controlled sustained release was achieved by utilizing the cross-linking reaction between gelatin and sodium alginate.

Benefits of technology

This method achieves highly effective local treatment of radiotherapy-induced damage to deep organs using anti-inflammatory traditional Chinese medicine formulas, alleviating inflammatory responses, promoting tissue repair, and avoiding the limitations of topical application. It is suitable for treating radiotherapy-induced damage to deep organs such as the abdominal cavity and pelvis.

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Abstract

The invention relates to the technical field of biomedical materials, in particular to radiotherapy injury repair injection hydrogel and a preparation method thereof, and the preparation method comprises the following steps: S1, preparing PLGA wrapped anti-inflammatory traditional Chinese medicine formula microspheres by taking an anti-inflammatory traditional Chinese medicine formula, a polylactic acid-glycolic acid copolymer and polyvinyl alcohol as raw materials; s2, dispersing the PLGA coated anti-inflammatory traditional Chinese medicine formula microspheres in a gelatin solution to obtain a solution A; s3, mixing the solution A with an oxidized sodium alginate solution to obtain the radiotherapy injury repair injection hydrogel. The preparation method comprises the following steps: embedding an anti-inflammatory traditional Chinese medicine formula in PLGA microspheres, dispersing the microspheres in an amino group-containing solution such as gelatin, mixing with an oxidized sodium alginate solution, and carrying out a Schiff base reaction on the amino group of the gelatin and the oxidized sodium alginate to form the imine bond dynamic crosslinking injectable hydrogel. Therefore, local slow release of the anti-inflammatory traditional Chinese medicine formula is realized, and the purpose of efficiently repairing radiotherapy injury is achieved.
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