Hydrogen peroxide-free whitening oral care compositions

Abstract

Described herein are oral care compositions comprising: an oxidizing agent comprising potassium peroxymonosulfonate, a carrier comprising a polymer fluid, an adhesive, and a flavouring agent; wherein the oxidizing agent is substantially free of a peroxide source, optionally free of a peroxide source.

Description

Cross-references to related applications

[0001] This application claims priority to U.S. Patent Application No. 63 / 586,212, entitled “Oral Care Compositions,” filed September 28, 2023, the contents of which are incorporated herein by reference in their entirety for all purposes. Background Technology

[0002] Oral care products containing whitening agents are frequently used to whiten teeth. For example, traditional oral care products contain hydrogen peroxide and are often used to whiten the tooth surface. While oral care products containing hydrogen peroxide have been proven effective in whitening teeth, the use of hydrogen peroxide is limited. Therefore, there is a need for an improved whitening composition. Summary of the Invention

[0003] An embodiment of the present invention provides a whitening composition comprising: an oxidant comprising potassium caroate; a carrier comprising a polymer fluid; an adhesive; a flavoring agent; and wherein the oxidant is free of hydrogen peroxide.

[0004] Embodiments of the present invention include a whitening composition comprising: a first whitening component comprising: an oxidant comprising potassium peroxide monosulfonate; a carrier comprising a polymer fluid; a flavoring agent; a second whitening component comprising: an alkaline component; and wherein the first whitening component and the second whitening component are present in a weight ratio of about 1:2 to about 2:1.

[0005] In some embodiments, the present invention includes a whitening composition comprising: an oxidant comprising potassium peroxymonosulfonate; a carrier comprising a polymer fluid; a first flavoring agent comprising at least one of sucralose, sodium saccharin, and combinations thereof; and a second flavoring agent comprising a sensate.

[0006] In some embodiments, the present invention includes a method for whitening teeth, comprising: a) dispensing a certain amount of a whitening composition according to any of the aforementioned whitening compositions onto an applicator; b) contacting the whitening composition on the applicator with the teeth for a treatment time.

[0007] In some embodiments, the present invention includes a method of manufacturing a whitening product, comprising: a) mixing an oxidant comprising potassium persulfonate, a carrier comprising a polymer fluid, an adhesive, and a flavoring agent together to form a whitening composition; and b) dispensing a volume of the whitening composition in a package to form a whitening product, wherein the whitening composition in the package is free of hydrogen peroxide.

[0008] The following provides a list of non-limiting exemplary implementations. According to embodiment 1, a whitening composition is provided, comprising: Oxidizing agent, wherein the oxidizing agent comprises potassium peroxymonosulfonate; A carrier comprising a polymer fluid; Adhesive; Flavorings; and The oxidant described herein is substantially free of hydrogen peroxide. Optionally, it does not contain hydrogen peroxide.

[0009] According to embodiment 2, a whitening composition according to embodiment 1 is provided, wherein the oxidant is present in an amount of about 0.1 wt.% to about 15 wt.% based on the total weight of the whitening composition.

[0010] According to embodiment 3, a whitening composition according to any one of embodiments 1 to 2 is provided, wherein the potassium peroxide monosulfonate is present in an amount of about 0.1 wt.% to about 5.0 wt.% based on the total weight of the whitening composition.

[0011] According to embodiment 4, a whitening composition according to any one of embodiments 1 to 3 is provided, wherein the whitening composition is free of hydrogen peroxide.

[0012] According to embodiment 5, a whitening composition according to any one of embodiments 1 to 4 is provided, wherein the polymer fluid comprises a silicone fluid.

[0013] According to embodiment 6, a whitening composition according to embodiment 5 is provided, wherein the silicone fluid is present in an amount of about 20 wt.% to about 60 wt.% based on the total weight of the whitening composition.

[0014] According to embodiment 7, a whitening composition according to any one of embodiments 1 to 6 is provided, wherein the amount of the adhesive present is from about 10.0 wt.% to about 40 wt.% based on the total weight of the whitening composition.

[0015] According to embodiment 8, a whitening composition according to any one of embodiments 1 to 7 is provided, wherein the adhesive comprises one or more of polyvinylpyrrolidone, polyether, and trimethylsiloxane-treated silica.

[0016] According to embodiment 9, a whitening composition according to embodiment 8 is provided, wherein the polyether comprises one or more of polyethylene glycol, polyethylene glycol-polypropylene glycol copolymer, and polyoxypropylene-polyoxyethylene block copolymer.

[0017] According to embodiment 10, a whitening composition according to any one of embodiments 8 to 9 is provided, wherein the polyvinylpyrrolidone is present in an amount of about 1.0 wt.% to about 7.0 wt.% based on the total weight of the whitening composition.

[0018] According to embodiment 11, a whitening composition according to any one of embodiments 8 to 10 is provided, wherein the polyether is present in an amount of about 30.0 wt.% to about 50.0 wt.% based on the total weight of the whitening composition.

[0019] According to embodiment 12, a whitening composition according to any one of embodiments 1 to 11 is provided, which further comprises fumed silica.

[0020] According to embodiment 13, a whitening composition according to embodiment 12 is provided, wherein the fumed silica is present in an amount of about 1.0 wt.% to about 5.0 wt.% based on the total weight of the whitening composition.

[0021] According to embodiment 14, a whitening composition according to any one of embodiments 1 to 11 is provided, which further comprises sodium tripolyphosphate.

[0022] According to embodiment 15, a whitening composition according to embodiment 14 is provided, wherein the sodium tripolyphosphate is present in an amount of about 1.0 wt.% to about 4.0 wt.% based on the total weight of the whitening composition.

[0023] According to embodiment 16, a whitening composition according to any one of embodiments 1 to 15 is provided, wherein the flavoring agent comprises one or more of sodium saccharin, sucralose, and a sensory agent.

[0024] According to embodiment 17, a whitening composition according to any one of embodiments 1 to 16 is provided, wherein the flavoring agent is present in an amount of about 0.1 wt.% to about 2.0 wt.% based on the total weight of the whitening composition.

[0025] According to embodiment 18, a whitening composition is provided, comprising: A first whitening component, the first whitening component comprising: Oxidizing agent, wherein the oxidizing agent comprises potassium peroxymonosulfonate; A carrier comprising a polymer fluid; Flavorings; The second whitening component, the second whitening component comprising: alkaline components; and The first whitening component and the second whitening component are present in a weight ratio of about 1:3 to about 3:1.

[0026] According to embodiment 19, a whitening composition according to embodiment 18 is provided, wherein the first whitening component is substantially free of hydrogen peroxide, optionally, free of hydrogen peroxide.

[0027] According to embodiment 20, a whitening composition according to any one of embodiments 18 to 19 is provided, wherein the second whitening component is substantially free of hydrogen peroxide, and optionally, is free of hydrogen peroxide.

[0028] According to embodiment 21, a whitening composition according to any one of embodiments 18 to 20 is provided, wherein the pH range of the whitening composition is from about 7 to about 9.

[0029] According to embodiment 22, a whitening composition according to any one of embodiments 18 to 21 is provided, wherein the polymer fluid comprises a silicone fluid.

[0030] According to embodiment 23, a whitening composition according to embodiment 22 is provided, wherein the amount of the silicone fluid is about 10.0 wt.% based on the total weight of the first whitening component.

[0031] According to embodiment 24, a whitening composition according to any one of embodiments 16 to 23 is provided, wherein the first whitening component further comprises an adhesive in an amount of about 10.0 wt.% to about 40.0 wt.% based on the total weight of the first whitening component.

[0032] According to embodiment 25, a whitening composition according to embodiment 24 is provided, wherein the adhesive comprises one or more of polyvinylpyrrolidone and polyether.

[0033] According to embodiment 26, a whitening composition according to embodiment 25 is provided, wherein the polyether comprises one or more of polyethylene glycol, polyethylene glycol-polypropylene glycol copolymer, and polyoxypropylene-polyoxyethylene block copolymer.

[0034] According to embodiment 27, a whitening composition according to any one of embodiments 25 to 26 is provided, wherein the polyvinylpyrrolidone is present in an amount of about 1.0 wt.% to about 4.0 wt.% based on the total weight of the first whitening component.

[0035] According to embodiment 28, a whitening composition according to any one of embodiments 25 to 27 is provided, wherein the polyether is present in an amount of about 15.0 wt.% to about 25.0 wt.% based on the total weight of the first whitening component.

[0036] According to embodiment 29, a whitening composition according to any one of embodiments 18 to 28 is provided, which further comprises fumed silica.

[0037] According to embodiment 30, a whitening composition according to embodiment 29 is provided, wherein the fumed silica is present in an amount of about 1.0 wt.% to about 3.0 wt.% based on the total weight of the whitening composition.

[0038] According to embodiment 31, a whitening composition according to any one of embodiments 18 to 30 is provided, which further comprises sodium tripolyphosphate.

[0039] According to embodiment 32, a whitening composition according to embodiment 31 is provided, wherein the sodium tripolyphosphate is present in an amount of about 1.0 wt.% to about 2.0 wt.% based on the total weight of the first whitening component.

[0040] According to embodiment 33, a whitening composition according to any one of embodiments 18 to 32 is provided, wherein the flavoring agent comprises one or more of sodium saccharin, sucralose, and a sensory agent.

[0041] According to embodiment 34, a whitening composition according to any one of embodiments 18 to 33 is provided, wherein the flavoring agent is present in an amount of about 0.1 wt.% to about 2.0 wt.% based on the total weight of the first whitening component.

[0042] According to embodiment 35, a whitening composition according to any one of embodiments 18 to 34 is provided, wherein the alkaline component comprises one or more of sodium bicarbonate and sodium carbonate.

[0043] According to embodiment 36, a whitening composition according to embodiment 35 is provided, wherein the alkaline component comprises sodium bicarbonate and sodium carbonate in a weight ratio of about 6:1 to about 12:1.

[0044] According to embodiment 37, a whitening composition according to embodiment 36 is provided, wherein the alkaline component comprises sodium bicarbonate and sodium carbonate in a weight ratio of about 8:1 to about 9:1.

[0045] According to embodiment 38, a whitening composition according to any one of embodiments 18 to 37 is provided, wherein the weight ratio of the first whitening component to the second whitening component is about 1:1.

[0046] According to embodiment 39, a whitening composition according to any one of embodiments 18 to 38 is provided, wherein the second component further comprises a liquid carrier and a thickener.

[0047] According to embodiment 40, a whitening composition according to embodiment 39 is provided, wherein the liquid carrier comprises water and the thickener comprises sodium carboxymethyl cellulose.

[0048] According to embodiment 41, a whitening composition according to any one of embodiments 39 to 40 is provided, wherein the liquid carrier is present in an amount of about 10.0 wt.% to about 99.0 wt.% based on the total weight of the second whitening component.

[0049] According to embodiment 42, a whitening composition according to any one of embodiments 39 to 41 is provided, wherein the thickener is present in an amount of about 1.0 wt.% to about 8.0 wt.% based on the total weight of the second whitening component.

[0050] According to embodiment 43, a whitening composition is provided, comprising: Oxidizing agent, wherein the oxidizing agent comprises potassium peroxymonosulfonate; A carrier comprising a polymer fluid; A first flavoring agent, comprising at least one of sucralose, sodium saccharin, and combinations thereof; and The second flavoring agent contains a sensory agent.

[0051] According to embodiment 44, a whitening composition according to embodiment 43 is provided, wherein the oxidant is present in an amount of about 0.1 wt.% to about 15 wt.% based on the total weight of the whitening composition.

[0052] According to embodiment 45, a whitening composition according to any one of embodiments 43 to 44 is provided, wherein the potassium peroxide monosulfonate is present in an amount of about 0.1 wt.% to about 5.0 wt.% based on the total weight of the whitening composition.

[0053] According to embodiment 46, a whitening composition according to any one of embodiments 43 to 45 is provided, wherein the oxidant is substantially free of or contains no hydrogen peroxide.

[0054] According to embodiment 47, a whitening composition according to any one of embodiments 43 to 46 is provided, wherein the polymer fluid comprises a silicone fluid.

[0055] According to embodiment 48, a whitening composition according to embodiment 47 is provided, wherein the silicone fluid is present in an amount of about 20 wt.% to about 60 wt.% based on the total weight of the whitening composition.

[0056] According to embodiment 49, a whitening composition according to any one of embodiments 43 to 48 is provided, wherein the amount of the adhesive present is from about 10.0 wt.% to about 40 wt.% based on the total weight of the whitening composition.

[0057] According to embodiment 50, a whitening composition according to any one of embodiments 43 to 49 is provided, wherein the adhesive comprises one or more of polyvinylpyrrolidone and polyether.

[0058] According to embodiment 51, a whitening composition according to embodiment 50 is provided, wherein the polyether comprises one or more of polyethylene glycol, polyethylene glycol-polypropylene glycol copolymer, and polyoxypropylene-polyoxyethylene block copolymer.

[0059] According to embodiment 52, a whitening composition according to any one of embodiments 50 to 51 is provided, wherein the polyvinylpyrrolidone is present in an amount of about 1.0 wt.% to about 7.0 wt.% based on the total weight of the whitening composition.

[0060] According to embodiment 53, a whitening composition according to any one of embodiments 50 to 52 is provided, wherein the polyether is present in an amount of about 30.0 wt.% to about 50.0 wt.% based on the total weight of the whitening composition.

[0061] According to embodiment 54, a whitening composition according to any one of embodiments 43 to 53 is provided, which further comprises fumed silica.

[0062] According to embodiment 55, a whitening composition according to embodiment 54 is provided, wherein the fumed silica is present in an amount of about 1.0 wt.% to about 5.0 wt.% based on the total weight of the whitening composition.

[0063] According to embodiment 56, a whitening composition according to any one of embodiments 43 to 55 is provided, which further comprises sodium tripolyphosphate.

[0064] According to embodiment 57, a whitening composition according to embodiment 56 is provided, wherein the sodium tripolyphosphate is present in an amount of about 1.0 wt.% to about 4.0 wt.% based on the total weight of the whitening composition.

[0065] According to embodiment 58, a whitening composition according to any one of embodiments 43 to 57 is provided, wherein the flavoring agent comprises one or more of sodium saccharin, sucralose, and a sensory agent.

[0066] According to embodiment 59, a whitening composition according to any one of embodiments 43 to 58 is provided, wherein the flavoring agent is present in an amount of about 0.1 wt.% to about 2.0 wt.% based on the total weight of the whitening composition.

[0067] According to embodiment 60, a whitening composition according to any one of embodiments 1 to 59 is provided, wherein the whitening composition is a gel.

[0068] According to embodiment 61, a method for whitening teeth is provided, comprising applying a composition according to any of the foregoing embodiments to the tooth surface of a subject in need of such whitening.

[0069] According to embodiment 62, a method according to embodiment 61 is provided, wherein the composition is applied using an applicator.

[0070] Further applications of the invention will become apparent from the detailed embodiments provided below. It should be understood that while the detailed embodiments and specific examples indicate preferred embodiments of the invention, they are intended for illustrative purposes only and are not intended to limit the scope of the invention. Detailed Implementation

[0071] The following description of preferred embodiments is merely exemplary in nature and is by no means intended to limit the invention, its application, or its use.

[0072] As used throughout, a range is used as a shorthand to describe the individual values ​​within that range. Any value within the range can be chosen as an endpoint of the range. Furthermore, all references cited herein are incorporated herein by reference in their entirety. In the event of any conflict between definitions in this disclosure and definitions in cited references, this disclosure shall prevail.

[0073] Unless otherwise stated, all percentages and quantities expressed herein and elsewhere in the specification should be understood as weight percentages. The quantities given are based on the material's active gravimetric analysis.

[0074] The terms “contains,” “has,” and “includes” are used in their open, non-restrictive sense.

[0075] The compositions and methods disclosed herein may include, consist of, or consist essentially of the essential elements and limitations disclosed herein, as well as any additional or optional ingredients, components, or limitations described herein or otherwise useful.

[0076] The illustrative embodiments of the invention are intended to be read in conjunction with the accompanying drawings, which are considered an integral part of the entire written description. Any references to directions or orientations in the description of the embodiments of the invention disclosed herein are merely for convenience of description and are not intended to limit the scope of the invention in any way.

[0077] Unless otherwise stated, all percentages and quantities expressed herein and elsewhere in the specification should be understood as weight percentages. The quantities given are based on the material's active gravimetric analysis.

[0078] Furthermore, all numerical values ​​are expressed as “approximately” or “about” and take into account experimental errors and variations that would be expected by one of ordinary skill in the art. It should be understood that all numerical values ​​and ranges disclosed herein are approximate values ​​and ranges, whether or not the word “approximately” is used in conjunction with them. It should also be understood that, as used herein, the term “approximately” in conjunction with a number can mean ±0.01% (inclusive), ±0.1% (inclusive), ±0.5% (inclusive), ±1% (inclusive), ±2% (inclusive), ±3% (inclusive), ±5% (inclusive), ±10% (inclusive), or ±15% (inclusive) of the number. It should also be understood that when a numerical range is disclosed herein, any numerical value falling within that range is also specifically disclosed.

[0079] According to this application, the term "substantially free of" is less than about 0.1 wt.%, based on the sum of the mentioned values. According to this application, the term "free of" is 0.0 wt.%, based on the sum of the mentioned values.

[0080] All ranges and values ​​disclosed herein include endpoints and are composable. For example, any value or point falling within the ranges described herein can be used as a minimum or maximum to derive subranges, etc. Furthermore, all ranges provided imply the inclusion of each specific range within a given range as well as combinations of subranges between given ranges. Thus, range 1-5 specifically includes 1, 2, 3, 4, and 5, and subranges such as 2-5, 3-5, 2-3, 2-4, 1-4, etc.

[0081] As used herein, the use of compounds containing several isomers or stereoisomers includes all isomer forms of the compound. When referring to chemical structures and names, the symbols “C,” “H,” and “O” represent carbon, hydrogen, and oxygen, respectively. The symbols “-,” “=", and “≡” represent single, double, and triple bonds, respectively. For readability purposes, chemical functional groups are presented in their adjectival forms; for each adjective, the word “group” is assumed. For example, the adjective “alkyl” without a noun should be read as “alkyl group.”

[0082] As used herein, the expression “at least one” is interchangeable with the expression “one or more”, and thus includes individual components as well as mixtures / combinations.

[0083] As used herein, the term "treatment" (and its grammatical variations) refers to applying the compositions of this disclosure to a surface of skin and / or hair. The term "treatment" (and its grammatical variations) also refers to contacting the skin or hair with the compositions of this disclosure.

[0084] The term "active material" as used in this article, referring to the percentage amount of an ingredient or raw material, means 100% active.

[0085] The term "mixtures thereof" or "blends thereof" does not require that the mixture include all of A, B, C, D, E, and F (although it may include all of A, B, C, D, E, and F). Rather, it means a mixture that may include any two or more of A, B, C, D, E, and F. In other words, it is equivalent to the phrase "one or more elements selected from the group consisting of A, B, C, D, E, F, and mixtures of any two or more of A, B, C, D, E, and F".

[0086] Similarly, the term "a salt thereof" also refers to "salts thereof". Therefore, when this disclosure refers to "an element selected from the group consisting of A, B, C, D, E, F, salts thereof and mixtures thereof", it means that it may include one or more of A, B, C, D and F, one or more of salts of A, B, C, D, E and F, or a mixture of any two of salts of A, B, C, D, E, F, salts of A, B, C, D, E and F.

[0087] Salts mentioned throughout this disclosure may include salts with counterions, such as alkali metal, alkaline earth metal, or ammonium counterions. However, the list of such counterions is not limiting.

[0088] The phrase "stable emulsion" refers to a composition that does not undergo phase separation for at least two weeks at temperatures up to 45°C.

[0089] The expression "including the extreme values" when describing a concentration range means that the limits of the range are included within the defined interval.

[0090] As used herein, the term "weight ratio" or "mass ratio" refers to the proportion of a substance to a mixture containing that substance, and is calculated by dividing the weight of the substance in the mixture by the weight of the mixture containing that substance. For example, in a mixture of A, B, and C, a weight ratio of 0.4 for substance A means that the weight of substance A divided by the total weight of substances A, B, and C is 0.4.

[0091] Some of the components in the defined categories may overlap. In cases where overlap is possible and the composition contains two components (or more than two overlapping components), the overlapping compounds do not represent more than one component. For example, a fatty acid can be characterized as both a nonionic surfactant and a fatty compound. If a particular composition contains both a nonionic surfactant and a fatty compound, then a single fatty acid will either act as a nonionic surfactant only or as a fatty compound only (a single fatty acid does not act as both a nonionic surfactant and a fatty compound).

[0092] As used herein, the term "volatile" refers to a flash point of less than about 100°C. The term "non-volatile" as used herein refers to a flash point of greater than about 100°C.

[0093] The term “polymer” as defined herein includes homopolymers and copolymers formed from at least two different types of monomers.

[0094] All publications and patent applications referenced in this specification are incorporated herein by reference and for any and all purposes, as if each individual publication or patent application were specifically and individually indicated as incorporated by reference. In the event of any inconsistency between this disclosure and any publication or patent application incorporated herein by reference, this disclosure shall prevail.

[0095] Any member of a species list used to exemplify or define a genus may be distinct from, overlap with, be a subset of, be equivalent to, or be nearly identical to, or be the same as any other member of that genus. Furthermore, for example, when listing the Markush group, the species list defining or defining the genus is open-ended and assumes the existence of other species that define or define the genus as well as, or better than, any other species listed, unless explicitly stated otherwise.

[0096] All components and elements positively described in this disclosure may be negatively excluded from the claims. In other words, the personal care compositions of this disclosure may be free of or substantially free of all components and elements positively described throughout this disclosure. In some cases, the personal care compositions of this disclosure may be substantially free of non-accidental amounts of the ingredients or compounds described herein. A non-accidental amount of an ingredient or compound is the amount of an ingredient or compound added alone to the personal care composition. For example, a personal care composition may be substantially free of non-accidental amounts of an ingredient or compound, although such an ingredient or compound may be present as part of a raw material contained as a blend of two or more compounds.

[0097] Some of the components in the defined categories may overlap. In cases where overlap is possible and a personal care composition contains two components (or more than two overlapping components), the overlapping compounds do not represent more than one component. For example, octyl glycol can be characterized as both a humectant and a preservative. If a particular personal care composition contains both a humectant and a preservative, then octyl glycol will act only as a humectant or only as a preservative—not both.

[0098] As used herein, the terms “composition” and “formulation” may be used interchangeably in this specification.

[0099] The compositions disclosed herein may be or include oral care products, oral care compositions, and / or whitening compositions thereof. In one non-limiting embodiment, the composition may be an oral care product or composition comprising a whitening composition, or a whitening composition thereof. In one non-limiting embodiment, the composition may be an oral care product comprising a whitening composition, a whitening composition and a pH enhancer contained separately, or a composition comprising both a whitening composition and a pH enhancer. In one non-limiting embodiment, the composition may be an oral care composition in gel form.

[0100] The following discussion may be directed toward whitening compositions; however, it generally applies to the aforementioned oral care products. The whitening compositions of the present invention contain an oxidizing agent. The whitening compositions may also contain at least one of a carrier and an adhesive. The whitening compositions may also contain at least one flavoring agent.

[0101] The whitening composition may contain a carrier or an orally acceptable excipient. In some embodiments, the oral care product or its whitening composition may be anhydrous or non-aqueous before use. In a non-limiting example, the oral care product or its whitening composition may be anhydrous or substantially anhydrous.

[0102] As used herein, “water-free” or “substantially water-free” can mean that the water content of the composition is less than 10% by weight, less than 8% by weight, less than 5% by weight, less than 3% by weight, less than 1% by weight, less than 0.1% by weight, less than 0.05% by weight, less than 0.01% by weight, less than 0.005% by weight, or less than 0.0001% by weight, based on the total weight of the oral care product or its whitening composition.

[0103] In another embodiment, the oral care product or its whitening composition may have a “low water content” before use. As used herein, “low water content” may mean that the water content of the composition is greater than about 5% by weight or greater than about 10% by weight and less than about 20% by weight, less than about 15% by weight, or less than about 10% by weight, based on the total weight of the oral care product or its whitening composition.

[0104] The whitening composition may be substantially free of hydrogen peroxide. In a preferred embodiment, the whitening composition may be hydrogen peroxide free, i.e., containing 0.0 wt.% hydrogen peroxide based on the total weight of the whitening composition. The oxidant may contain 0.0 wt.% hydrogen peroxide.

[0105] The phrase "hydrogen peroxide free" can refer to both hydrogen peroxide release and components that release hydrogen peroxide when exposed to water. Such components, which may contain hydrogen peroxide or release hydrogen peroxide, include hydrogen peroxide, urea peroxide, calcium peroxide, cross-linked polyvinylpyrrolidone (PVP) hydrogen peroxide complex, sodium percarbonate, and combinations thereof.

[0106] The compositions disclosed herein are preferably substantially free of or free of peroxides. In some embodiments, the compositions disclosed herein may contain about 1 wt.% or less, about 0.5 wt.% or less, about 0.3 wt.% or less, about 0.1 wt.% or less, about 0.05 wt.% or less, about 0.01 wt.% or less, based on the total weight of the composition.

[0107] The oxidant may comprise peroxymonosulfate or persulfate (MPS). In some preferred embodiments, the oxidant consists of peroxymonosulfate or persulfate (MPS). The oxidant may comprise an alkali metal salt of MPS, such as potassium MPS, sodium MPS, ammonium MPS, or any combination thereof. In a preferred embodiment, the oxidant may comprise potassium MPS (also known as potassium peroxymonosulfonate). In some embodiments, the oxidant may be potassium peroxymonosulfonate.

[0108] MPS can be provided as a single molecule, a compound such as a monopersulfate compound or an MPS compound, a complex such as a monopersulfate complex, or any combination thereof. In at least one embodiment, the whitening composition may be or comprises an MPS compound or a mixture of two or more peroxymonosulfates. The MPS compound may be or comprises a mixed salt or a ternary salt, such as (2KHSO5•KHSO4•K2SO4). In some embodiments, the oxidant may comprise potassium peroxymonosulfonate, wherein the amount of potassium peroxymonosulfonate is about 100 wt.%, based on the total weight of the oxidant.

[0109] The oxidant may be present in amounts greater than 0.0 wt.% to about 15 wt.%, based on the total weight of the whitening composition, including all percentages and sub-ranges therein. In non-limiting examples, the amount of oxidant provided may be greater than 0.0 wt%, about 0.5 wt%, about 1 wt%, about 1.5 wt%, about 2 wt%, about 2.5 wt%, about 3 wt%, about 3.5 wt%, about 4 wt%, or about 4.5 wt% to about 5 wt%, about 5.5 wt%, about 6 wt%, about 6.5 wt%, about 7 wt%, about 7.5 wt%, about 8 wt%, about 8.5 wt%, about 9 wt%, about 9.5 wt%, about 10 wt%, about 10.5 wt%, about 11 wt%, about 11.5 wt%, about 12 wt%, or any range or sub-range formed therefrom, based on the total weight of the whitening composition.

[0110] In another example, the amount of oxidant provided may be greater than 0.0 wt%, about 0.1 wt%, about 0.2 wt%, about 0.3 wt%, about 0.4 wt%, about 0.5 wt%, about 0.6 wt%, about 0.7 wt%, about 0.8 wt%, about 0.9 wt%, or about 1.0 wt% to about 1.1 wt%, about 1.2 wt%, about 1.3 wt%, about 1.4 wt%, about 1.5 wt%, about 1.6 wt%, about 1.7 wt%, about 1.8 wt%, about 1.9 wt%, about 2.0 wt%, about 2.1 wt%, about 2.2 wt%, about 2.3 wt%, about 2.4 wt%, about 2.5 wt%, about 2.6 wt%, about 2.7 wt%, about 2.8 wt%, about 2.9 wt%, about 3.0 wt%, about 3.1 wt%, about 3.2 wt%, about 3.3 wt%, about 3.4 wt%, about 3.5 wt%, or any range or subrange thereof, based on the total weight of the whitening composition.

[0111] In another example, the amount of oxidant provided may be greater than 0.0 wt% to about 3.5 wt%, about 0.1 wt% to about 3.4 wt%, about 0.2 wt% to about 3.2 wt%, about 0.3 wt% to about 3.0 wt%, about 0.4 wt% to about 2.8 wt%, about 0.5 wt% to about 2.7 wt%, about 0.9 wt% to about 2.6 wt%, about 1.1 wt% to about 2.5 wt%, about 1.5 wt% to about 2.4 wt%, or about 1.8 wt% to about 2.3 wt%, based on the total weight of the whitening composition.

[0112] Whitening compositions may contain a carrier or an orally acceptable excipient. Together with the orally acceptable excipient or carrier, the resulting whitening composition may form one or more of the following: mouthwash, toothpaste (dental cleaning agent), preventative paste, tooth polish, tooth gel (e.g., whitening gel), chewing gum, lozenges, whitening strips, varnish gels, polishing agents, veneers, gels or pastes applied to an application carrier such as dental floss or a toothbrush (e.g., manual, electric, audible, a combination thereof, or ultrasonic toothbrush), or any combination thereof. In a typical embodiment, the whitening composition may be a whitening gel or a gel whitening composition.

[0113] Orally acceptable excipients may include one or more poloxamers. Poloxamers may be liquids or pastes. The average molecular weight of poloxamers may be less than or equal to about 12,000 Daltons (Da), less than or equal to about 11,000 Da, less than or equal to about 10,000 Da, less than or equal to about 9,000 Da, less than or equal to about 8,000 Da, less than or equal to about 7,000 Da, or less than or equal to about 6,000 Da. Exemplary poloxamers may be, but are not limited to, one or more poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol). In a preferred embodiment, orally acceptable excipients include poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) polymers.

[0114] Orally acceptable excipients may include thickening systems having one or more thickeners. The one or more thickeners may be any orally acceptable thickener or thickening agent configured to control the viscosity of an oral care product or its whitening composition. Exemplary thickeners may be, but are not limited to, colloidal silica, fumed silica, polyvinylpyrrolidone (PVP), cross-linked polyvinylpyrrolidone (PVP) polymers, cross-linked polyvinylpyrrolidone (PVP), etc., or mixtures or combinations thereof.

[0115] In some embodiments, the thickening system includes polyvinylpyrrolidone (PVP), cross-linked polyvinylpyrrolidone (PVP) polymers, or combinations thereof. The thickener may also be, or include but is not limited to, carbomer (e.g., carboxyvinyl polymers), carrageenan derivatives (e.g., but not limited to Irish algae, carrageenan, ι-carrageenan), high molecular weight polyethylene glycol, cellulose polymers, hydroxyethyl cellulose, carboxymethyl cellulose and their salts (e.g., sodium CMC), natural gums (e.g., guilarin, xanthan gum, gum arabic, and tragacanth gum), colloidal magnesium aluminum silicate, etc., or mixtures or combinations thereof.

[0116] The whitening composition may contain from about 1 wt.% to about 30 wt.% of PVP, based on the total weight of the whitening composition—including all percentages and sub-ranges therein. In some embodiments, the whitening composition may contain from about 2.0 wt.% to about 22 wt.% of PVP, based on the total weight of the whitening composition—including all percentages and sub-ranges therein. In some embodiments, the whitening composition may contain about 3.0 wt.% of PVP, based on the total weight of the whitening composition. In some embodiments, the whitening composition may contain about 5.0 wt.% of PVP, based on the total weight of the whitening composition. In some embodiments, the whitening composition may contain about 20.7 wt.% of PVP, based on the total weight of the whitening composition.

[0117] The whitening composition may contain about 0.1 wt.% to about 5 wt.% of fumed silica, based on the total weight of the whitening composition—including all percentages and sub-ranges therein. In some embodiments, the whitening composition may contain about 1.0 wt.% to about 4 wt.% of fumed silica, based on the total weight of the whitening composition—including all percentages and sub-ranges therein. In some embodiments, the whitening composition may contain about 2.5 wt.% of fumed silica, based on the total weight of the whitening composition. In some embodiments, the whitening composition may contain about 1.0 wt.% of fumed silica, based on the total weight of the whitening composition. In some embodiments, the whitening composition may contain about 4.0 wt.% of fumed silica, based on the total weight of the whitening composition. In some embodiments, the whitening composition may contain about 2.5 wt.% of fumed silica, based on the total weight of the whitening composition.

[0118] In a more typical embodiment, the thickening system may include an organic polymer, which may also be configured as an adhesion enhancer. Exemplary organic polymers may be, but are not limited to, hydrophilic polymers such as carbomer, carboxymethylene polymers, acrylic polymers, and acrylic copolymers. Carboxypolymethylene is a weakly acidic vinyl polymer with an active carboxyl group. In a typical embodiment, the thickening system includes carboxypolymethylene.

[0119] The amount or concentration of thickening systems and / or any one or more thickeners present in oral care products or their whitening compositions can vary widely. The amount of thickening systems and / or thickeners present in the whitening composition can be from about 1% by weight to about 99% by weight, based on the total weight of the oral care product or its whitening composition.

[0120] In a non-limiting example, the amount of the thickening system and / or its thickener may be about 1 wt%, about 2 wt%, about 3 wt%, about 4 wt%, about 5 wt%, about 6 wt%, about 7 wt%, about 8 wt%, about 9 wt%, about 10 wt%, about 15 wt%, about 20 wt%, or about 21 wt% to about 22 wt%, about 23 wt%, about 24 wt%, about 25 wt%, about 26 wt%, about 27 wt%, about 28 wt%, about 29 wt%, about 30 wt%, or more, based on the total weight of the oral care product or its whitening composition. In another example, the amount of the thickening system and / or its thickener may be about 1 wt% to about 30 wt%, about 3 wt% to about 29 wt%, about 14 wt% to about 28 wt%, about 15 wt% to about 27 wt%, about 16 wt% to about 26 wt%, about 17 wt% to about 25 wt%, about 18 wt% to about 24 wt%, about 19 wt% to about 23 wt%, or about 20 wt% to about 22 wt%. In a typical implementation, the amount of thickening system and / or thickener present in the oral care product or its whitening composition may be from about 10% to about 20% by weight or from about 1.2% to about 1.8% by weight.

[0121] In at least one embodiment, the total amount of thickener present in the compositions disclosed herein is from about 0.5 to about 7 wt.%, based on the total weight of the compositions disclosed herein. For example, the total amount of thickener in the compositions disclosed herein may be from about 0.5 to about 7 wt.%, from about 0.5 to about 6 wt.%, from about 0.5 to about 5 wt.%, from about 0.5 to about 4 wt.%, from about 0.5 to about 3 wt.%, from about 0.5 to about 2 wt.%; from about 1 to about 7 wt.%, from about 1 to about 6 wt.%, from about 1 to about 5 wt.%, from about 1 to about 4 wt.%, from about 1 to about 3 wt.%, from about 1 to about 2 wt.%; from about 1.5 to about 7 wt.%, from about 1.5 to about 6 wt.%, from about 1.5 to about 5 wt.%, from about 1.5 to about 4 wt.%, from about 1.5 to about 3 wt.%; from about 2 to about 7 wt.%, from about 2 to about 6 wt.%, from about 2 to about 5 wt.%, from about 2 to about 4 wt.%, from about 0.5 to about 3 wt.%, from about 0.5 to about 2 wt.%; from about 3 to about 7 wt.%, from about 3 to about 6 wt.%, from about 3 to about 5 wt.%; ... wt.%, or any range or subrange thereof, based on the total weight of the composition (e.g., whitening composition).

[0122] Orally acceptable excipients may include one or more thickeners that are building blocks. Building blocks are capable of or configured to form gels or gel structures through self-assembly. Building blocks are capable of or formulated to form gels with other building blocks and / or orally acceptable excipients by interacting with one or more components of other building blocks and / or orally acceptable excipients via any one or more intermolecular forces (e.g., van der Waals forces, dipole-dipole forces, hydrogen bonds, covalent bonds, etc.).

[0123] In some embodiments, the building agent may be or includes a polymer. In some instances, the building agent may be or includes an amphiphilic copolymer, wherein the amphiphilic copolymer comprises two or more monomers, wherein at least one monomer is hydrophilic (e.g., vinylpyrrolidone) and wherein at least one monomer is hydrophobic (e.g., vinyl acetate). It should be understood that the amphiphilic copolymer is capable of or can be configured to interact with both hydrophilic and hydrophobic components, substances, and liquids. In at least one embodiment, the building agent may be, or includes, poloxamer as described above, crosslinked polymers such as crosslinked polyvinylpyrrolidone (“PVP”), polyvinylpyrrolidone copolymers, polyvinylpyrrolidone vinyl acetate copolymers, or any combination thereof.

[0124] Exemplary structural builders may be, but are not limited to, N-vinyllactam-based polymers and copolymers. Monomers used to prepare the vinyllactam-based polymers or copolymers of this application include any monomer having 3 to 8 atoms in a heterocycle, which contains a carbonyl carbon atom and heteroatoms (such as N, S, O) in its vinyl moiety. Suitable monomers include, but are not limited to, N-vinyl-2-pyrrolidone, N-vinyl-2-piperidone, N-vinyl-3-methylpyrrolidone, N-vinyl-3-methylpiperidone, N-vinyl-3-methylcaprolactam, N-vinyl-4-methylpyrrolidone, N-vinyl-4-methyl-2-pyrrolidone, N-vinyl-4-methylpiperidone, N-vinyl-4-methylcaprolactam, N-vinyl-5-methylpyrrolidone, N-vinyl-5-ethyl-2-pyrrolidone, N-vinyl-4-methylpiperidone, N-vinyl-3-ethylpyrrolidone, N-vinyl-4,5-dimethylpyrrolidone, and N-vinyl-5,5-dimethylpyrrolidone. N-Vinyl-3,3,5-trimethylpyrrolidone, N-Vinyl-5-methyl-5-ethylpyrrolidone, N-Vinyl-3,4,5-trimethyl-3-ethylpyrrolidone, N-Vinyl-6-methyl-2-piperidinone, N-Vinyl-6-ethyl-2-piperidinone, N-Vinyl-3,5-dimethyl-2-piperidinone, N-Vinyl-4,4-dimethyl-2-piperidinone, N-Vinyl-2-caprolactam, N-Vinyl-7-methyl -Caprolactam, N-vinyl-7-ethylcaprolactam, N-vinyl-3,5-dimethylcaprolactam, N-vinyl-4,6-dimethylcaprolactam, N-vinyl-3,5,7-trimethylcaprolactam, N-vinyl-2-valeractam, N-vinyl-hexahydro-2-azacycloheptanone, N-vinyl-octahydro-2-azacyclooctanone, N-vinyloctahydro-2-azacyclononone, N-vinyldecahydro-2-azacyclodecanone, etc., or combinations thereof.

[0125] The amount or concentration of any one or more structural building agents present in an oral care product or its whitening composition can vary widely. The amount of any one or more structural building agents present in an oral care product or its whitening composition can be from about 1% by weight to about 99% by weight, based on the total weight of the oral care product or its whitening composition.

[0126] In a non-limiting example, the amount of the thickening system and / or its thickener may be about 1 wt%, about 2 wt%, about 3 wt%, about 4 wt%, about 5 wt%, about 6 wt%, about 7 wt%, about 8 wt%, about 9 wt%, about 10 wt%, about 15 wt%, about 20 wt%, or about 21 wt% to about 22 wt%, about 23 wt%, about 24 wt%, about 25 wt%, about 26 wt%, about 27 wt%, about 28 wt%, about 29 wt%, about 30 wt%, or more, based on the total weight of the oral care product or its whitening composition. In another example, the amount of any one or more structural building blocks may be about 1 wt% to about 99 wt%, about 3 wt% to about 90 wt%, about 14 wt% to about 80 wt%, about 15 wt% to about 80 wt%, about 16 wt% to about 70 wt%, about 17 wt% to about 60 wt%, 18 wt% to about 50 wt%, about 19 wt% to about 40 wt%, or about 20 wt% to about 30 wt%. In a typical embodiment, the amount of any one or more structural building blocks present in the oral care product or its whitening composition may be from about 10% to about 20% by weight, more typically from about 1.2% to about 1.8% by weight, or more typically from about 1.5% by weight.

[0127] In some embodiments, oral care products or their orally acceptable excipients may include hydrophobic components. The hydrophobic component may be or includes hydrophobic polymers, such as silicone polymers. The term "hydrophobic" or "water-insoluble" used with respect to polymers refers herein to a substantially non-aqueous organic polymer whose water solubility at 25°C is less than 1 g / 100 g water.

[0128] In some embodiments, the hydrophobic polymers suitable for use in this invention may relate to siloxane polymers, white petrolatum, or combinations thereof. Siloxane polymers may generally refer to "silicone" polymers. In some embodiments, the hydrophobic polymers may include those in which a whitening agent can be dispersed. In preferred embodiments, the hydrophobic polymers may be, or include, silicone-based hydrophobic polymers, such as polyorganosiloxanes, particularly polydimethylsiloxanes.

[0129] In some embodiments, the siloxane polymer, which may be part of the hydrophobic component, is in fluid form. Polysiloxane fluids (also known as silicone fluids) that can be used as hydrophobic silicone material components herein include those with viscosities of about 1 centipoise (cP) to about 1000 cP, or about 2 cP to about 500 cP, or about 20 cP to about 400 cP, measured at 25°C.

[0130] The polysiloxane fluids used herein can be linear or cyclic and can be substituted with various substituents. Substituents can be, but are not limited to, methyl, ethyl, phenyl substituents, or mixtures thereof. Suitable polysiloxane fluids may include linear polysiloxane polymers, such as polydimethylsiloxane and other low-viscosity analogs of polysiloxane materials with a viscosity of about 200 cP or less, as well as cyclic polydimethylsiloxane and other cyclic siloxanes with a viscosity of about 200 cP or less. Other fluids include polysiloxane polyether copolymers and hydroxyl-terminated polydimethylsiloxane fluids. High molecular weight silicone resins having polysiloxane blends may also be used, including powdered trimethylsiloxysilicate.

[0131] In some embodiments, the hydrophobic component may be or includes a silicone fluid, white petrolatum, or a combination thereof. In some embodiments, the silicone fluid may be or includes a siloxane polymer.

[0132] The compositions disclosed herein may include one or more silicone fluids in amounts of about 15 to about 70 wt.%, based on the total weight of the composition. For example, a whitening composition may contain one or more silicone fluids in amounts of about 40 to about 65 wt.%, about 40 to about 60 wt.%, about 40 to about 55 wt.%, about 40 to about 50 wt.%, about 45 to about 65 wt.%, about 45 to about 60 wt.%, about 45 to about 55 wt.%, about 45 to about 50 wt.%, about 50 to about 65 wt.%, about 50 to about 60 wt.%, or any range or subrange thereof, based on the total weight of the whitening composition (e.g., without a pH enhancer). In other cases, the composition may comprise a whitening composition and a pH enhancer, and the total amount of the silicone fluid is about 15 to about 40 wt.%, about 15 to about 35 wt.%, about 15 to about 30 wt.%, about 15 to about 25 wt.%, about 20 to about 40 wt.%, about 20 to about 35 wt.%, about 20 to about 30 wt.%, about 25 to about 40 wt.%, about 25 to about 35 wt.%, about 25 to about 30 wt.%, or any range or subrange thereof, based on the total weight of the composition containing the mixture and / or combination of the whitening composition and the pH enhancer composition.

[0133] The amount of hydrophobic components in an oral care product or its whitening composition may be from about 10% to about 95% by weight, from about 10% to about 80% by weight, from about 10% to about 60% by weight, from about 10% to about 40% by weight, or from about 10% to about 30% by weight, based on the total weight of the oral care product or its whitening composition.

[0134] Whitening compositions may contain one or more adhesives or adhesion enhancers. In some embodiments, the whitening composition may optionally contain one or more adhesives configured to improve, maintain, and / or promote the adhesion of the oral care product or its whitening composition to oral surfaces. The one or more adhesives may also be configured to increase the hydrophobicity of the film formed by the oral care product or its whitening composition, thereby allowing the film to withstand external challenges such as abrasion, friction, or brushing.

[0135] Exemplary adhesives may be, but are not limited to, alkyd resins, polyvinyl acetal, polyvinyl alcohol, polyvinyl acetate, poly(ethylene oxide), polyacrylate, ketone resins, polyvinylpyrrolidone, polyvinylpyrrolidone / vinyl acetate copolymers, polyethylene glycol with a molecular weight of 200 to 1000, polyoxyethylene / polyoxypropylene block copolymers (Polyox), silicone resins, and mixtures or combinations thereof. In at least one embodiment, the one or more adhesives may include siloxane polymers, which are commonly referred to in the art as "silicone" polymers. Exemplary silicone-based hydrophobic polymers may be, but are not limited to, polyorganosiloxanes, polydiorganosiloxanes, and combinations thereof. In at least one embodiment, the adhesion enhancer includes at least one silicone pressure-sensitive adhesive (PSA). This PSA may be a pressure-sensitive hydrophobic polymer specifically designed for pharmaceutical applications and is permeable to many pharmaceutical compounds and applicable to transdermal applications of various compounds. In some embodiments, the silicone polymer is a copolymer product of a silanol-terminated polydiorganosiloxane (such as polydimethylsiloxane) and a silanol-containing silicone resin, wherein the silanol groups of the polydiorganosiloxane and the silanol groups of the silicone resin undergo a condensation reaction, causing the polydiorganosiloxane to be slightly crosslinked through the silicone resin (i.e., the polydiorganosiloxane chains are linked together by the resin molecules, resulting in chain branching and entanglement and / or a small amount of network characteristics) to form a silicone hydrophobic polymer.

[0136] Changing the ratio of silicone resin to polydiorganosiloxane alters the adhesive properties of the polymer. The ratio of silicone resin to polydiorganosiloxane can range from about 70:30 to about 50:50—inclusive of all ratios and subranges therebetween. Non-limiting examples of silicone resin to polydiorganosiloxane ratios include 65:35 (low tack), 60:40 (medium tack), and 55:45 (high tack). This polyorganosiloxane PSA can be obtained in the form of a solution dissolved in ethyl acetate or polydimethylsiloxane.

[0137] The amount of one or more adhesives or adhesion enhancers present in the oral care product or its whitening composition may be from about 10% to about 80% by weight, from about 10% to about 60% by weight, from about 10% to about 50% by weight, from about 10% to about 40% by weight, or from about 10% to about 30% by weight, based on the total weight of the oral care product or its whitening composition.

[0138] Preferably, the whitening composition may be substantially water-free or water-free. In some embodiments, the whitening composition may have about 3% by weight or less, about 2% by weight or less, about 1% by weight or less, about 0.5% by weight or less, about 0.1% by weight or less, based on the total weight of the whitening composition.

[0139] The whitening composition may contain one or more flavoring agents. Exemplary flavoring agents may include, but are not limited to, essential oils and various flavoring aldehydes, esters, alcohols, etc. Flavoring agents may also include, but are not limited to, sweeteners, sucralose, glucose, polydextrose, sucrose, maltose, dextrin, dried invert sugar, mannose, xylose, ribose, fructose, levulose, galactose, corn syrup (including high fructose corn syrup and corn syrup solids), partially hydrolyzed starch, hydrogenated starch hydrolysate, sorbitol, mannitol, xylitol, maltitol, isomaltitol, aspartame, neotame, saccharin and its salts (e.g., sodium saccharin), dipeptide-based potent sweeteners, cyclohexylsulfamic acid salts, dihydrochalcone, etc., or mixtures thereof.

[0140] Examples of essential oils include spearmint oil, peppermint oil, wintergreen oil, sassafras oil, clove oil, sage oil, eucalyptus oil, marjoram oil, cinnamon oil, lemon oil, lime oil, grapefruit oil, and orange oil. In another example, flavoring agents may include menthol, carvone, and anethole. In a preferred embodiment, flavoring agents include peppermint and spearmint. In a more preferred embodiment, flavoring agents include Firmenich Newman Flavor.

[0141] The amount of any one or more flavoring agents in the oral care product or its whitening composition may be less than 1.0% by weight, less than 0.9% by weight, less than 0.8% by weight, or less than 0.7% by weight. For example, the amount of flavoring agent in the oral care product or its whitening composition may be from about 0.0% by weight to about 1.0% by weight, from about 0.5% by weight to about 0.9% by weight, or from about 0.7% by weight to about 0.8% by weight. In a preferred embodiment, the amount of flavoring agent in the oral care product or its whitening composition is from about 0.01% by weight to about 0.4% by weight, preferably from about 0.1% by weight to about 0.3% by weight, or about 0.2% by weight.

[0142] Whitening compositions may contain one or more additional ingredients. Those skilled in the art will understand that oral care products and / or their whitening compositions may contain other additional ingredients / components. For example, oral care products and / or their whitening compositions may contain anti-caries agents, desensitizing agents, viscosity modifiers, diluents, mouthfeeling agents, colorants, preservatives, etc., or combinations or mixtures thereof. Those skilled in the art will also understand that while the general properties of each of the above material categories may differ, some common properties may exist, and any given material may be used for multiple purposes in two or more such material categories.

[0143] In at least one embodiment, the additional ingredients / components may include one or more active materials configured to prevent and / or treat one or more oral conditions and / or ailments. For example, the one or more active materials may be configured to prevent and / or treat one or more conditions and / or ailments of the hard and / or soft tissues of the oral cavity. The active materials may also be configured to prevent and / or treat one or more physiological conditions and / or ailments, and / or provide cosmetic benefits to the oral cavity.

[0144] In at least one embodiment, the oral care product and / or its whitening composition may contain an anti-tartar agent. Typically, anti-tartar agents may be incompatible with some whitening compositions; however, embodiments of this disclosure can incorporate an anti-tartar agent and a whitening composition into a single-phase oral care product. Exemplary anti-tartar agents may include, but are not limited to, phosphates and polyphosphates (e.g., pyrophosphates), polyaminopropanesulfonic acid (AMPS), hexametaphosphate, zinc citrate trihydrate, peptides, polyolefin sulfonates, polyolefin phosphates, and bisphosphonates. In typical embodiments, anti-tartar agents include calcium pyrophosphate, tetrasodium pyrophosphate (TSPP), sodium tripolyphosphate (STPP), or combinations thereof.

[0145] Oral care products and / or their whitening compositions may optionally contain one or more antimicrobial agents and / or one or more preservatives, such as methylisothiazolinone (MIT), sodium benzoate, potassium sorbate, benzyl alcohol, etc., or combinations thereof. In another example, the oral care composition may contain one or more antimicrobial agents selected from halogenated diphenyl ethers (e.g., triclosan), herbal extracts and essential oils (e.g., rosemary extract, tea extract, magnolia extract, thymol, menthol, eucalyptol, geraniol, carvacrol, citral, hinokitol, catechin, methyl salicylate, epigallocatechin gallate, epigallocatechin gallate, gallic acid, miswakextract, sea buckthorn extract), biguanide antimicrobial agents (e.g., chlorhexidine, alexiconidine, or oteninidine), quaternary ammonium compounds (e.g., cetylpyridine chloride (CPC), benzalkonium chloride, tetradecylpyridine chloride (TPC)). The following are considered antimicrobial agents: N-tetradecyl-4-ethylpyridine chloride (TDEPC), phenolic antimicrobial agents, hexetidine, ostinidine, sanguisorbin, povidone-iodine, dimopistol, salifluor, other metal ions (e.g., stannous salts, copper salts, iron salts), sanguisorbin, propolis, and oxidizing agents (e.g., hydrogen peroxide, buffered sodium perborate, or sodium percarbonate), phthalic acid and its salts, monoperthalicacid and its salts and esters, ascorbic acid stearate, oleoylsarcosine, alkyl sulfates, dioctyl sulfosuccinate, salicylaniline, domiphen bromide, dimopistol, octapinol, and other piperidinyl derivatives, nicin preparations, chlorites; or any mixture of the foregoing. In a typical embodiment, the antimicrobial agent includes hexadecylpyridine chloride (CPC). For example, all biphasic mouthwash compositions disclosed herein may contain CPC as an antimicrobial agent.

[0146] Oral care products and / or their whitening compositions may contain antioxidants. Any oral-acceptable antioxidant may be used, including but not limited to butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), vitamin A, carotenoids, vitamin E, flavonoids, polyphenols, ascorbic acid, herbal antioxidants, chlorophyll, melatonin, etc., or combinations or mixtures thereof.

[0147] The amount or concentration of any one or more additional ingredients / components present in an oral care product or its whitening composition can vary widely. The amount of any one or more additional ingredients / components present in an oral care product or its whitening composition can be from about 1% by weight to about 99% by weight, based on the total weight of the oral care product or its whitening composition.

[0148] In a non-limiting example, the amount of any one or more additional ingredients / components may be about 1 wt%, about 2 wt%, about 3 wt%, about 4 wt%, about 5 wt%, about 6 wt%, about 7 wt%, about 8 wt%, about 9 wt%, about 10 wt%, about 15 wt%, about 20 wt%, or about 21 wt% to about 22 wt%, about 23 wt%, about 24 wt%, about 25 wt%, about 26 wt%, about 27 wt%, about 28 wt%, about 29 wt%, about 30 wt%, or more, based on the total weight of the oral care product or its whitening composition. In another example, the amount of any one or more additional ingredients / components may be about 1 wt% to about 99 wt%, about 3 wt% to about 90 wt%, about 14 wt% to about 80 wt%, about 15 wt% to about 80 wt%, about 16 wt% to about 70 wt%, about 17 wt% to about 60 wt%, about 18 wt% to about 50 wt%, about 19 wt% to about 40 wt%, or about 20 wt% to about 30 wt%. In a typical implementation, the amount of any one or more additional ingredients / components in the oral care product or its whitening composition may be from about 10% to about 20% by weight, more typically from about 1.2% to about 1.8% by weight, or more typically from about 1.5% by weight.

[0149] The whitening compositions of the present invention can exhibit a pH of about 6 to 8—including all pH values ​​and subranges therebetween. For example, the pH of the whitening compositions can preferably be about 6.5 to 8, about 7 to 8; about 6 to about 7.5, about 6.5 to about 7.5, about 6 to about 7, or any range or subrange thereof.

[0150] The present invention also provides a two-part whitening composition comprising a first whitening component and a second whitening component, the second whitening component typically being a pH-raising composition / formulation. The first whitening component may be one of the whitening compositions discussed earlier. The two-part whitening composition may comprise a first whitening component and a second whitening component contained separately from the first whitening component. In some embodiments, the two-part whitening composition comprises a first whitening component and a second whitening component, wherein the first whitening component is contained in the same container. For example, the first and second whitening components may be uniformly mixed together, may be in a two-phase form with a single-phase interface between the two phases, and / or may be in the form of an emulsion. Preferably, the two-part whitening composition consists of a first whitening component and a second whitening component.

[0151] The second whitening component may contain alkaline components and / or alkaline earth metal components.

[0152] The first whitening component and the second whitening component may be present in a weight ratio of about 1.0:2.0 to about 2.0:1.0—inclusive of all ratios and subranges therein. For example, in some embodiments, a composition comprising the first whitening component and the second whitening component is provided, wherein the weight ratio of the first whitening component to the second whitening component is about 1 to about, about 1.3 to about 2, about 1.5 to about 2, about 1 to about 1.7, or about 1 to about 1.5. In some embodiments, the weight ratio of the first whitening component to the second whitening component may be about 1:1.

[0153] The alkaline component may comprise one or more of sodium bicarbonate and sodium carbonate. Other examples of the alkaline component include potassium carbonate, potassium bicarbonate, calcium carbonate, and / or calcium bicarbonate. The alkaline component may comprise sodium bicarbonate and sodium carbonate in a weight ratio ranging from about 6:1 to about 12:1—reduced to about 8:1 to about 9:1. The amount of the alkaline component in the second whitening component may be about 1 to about 5 wt.%, about 2 to about 5 wt.%, about 3 to about 5 wt.%; about 1 to about 4 wt.%, about 2 to about 4 wt.%, about 3 to about 4 wt.%; about 1 to about 3 wt.%, about 2 to about 3 wt.%, or any range or subrange thereof, based on the total weight of the second whitening component.

[0154] Preferably, the second whitening component is free of alkalis other than sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate, calcium carbonate, and calcium bicarbonate. Furthermore, the first whitening component is preferably free of alkalis other than sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate, calcium carbonate, and calcium bicarbonate. In some preferred embodiments, the two-part composition (e.g., both the first and second whitening components) is free of sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate, calcium carbonate, and calcium bicarbonate.

[0155] The pH of the second whitening component can be from 8 to about 11 – including all pH values ​​and sub-ranges therein. For example, the pH of the second whitening component can preferably be from 8.5 to about 11, from about 9 to about 11, from about 10 to about 11; from 8.5 to about 10, from about 9 to about 10, or any range or sub-range thereof.

[0156] The second whitening component may also include a liquid carrier and a thickener. The liquid carrier may be aqueous. The liquid carrier may contain one or more of glycerol, water, and combinations thereof. The liquid carrier may contain water. The amount of water present in the second whitening component may be from about 50 to about 80 wt.%, based on the total weight of the second whitening component. For example, the total amount of water in the second whitening component may be from about 50 to about 70 wt.%, from about 50 to about 65 wt.%, from about 50 to about 60 wt.%, from about 55 to about 70 wt.%, from about 55 to about 65 wt.%, from about 60 to about 70 wt.%, or any range or subrange thereof, based on the total weight of the second whitening component.

[0157] The thickener of the second whitening component may comprise or consist of any thickener described above with respect to the whitening composition (e.g., the first whitening composition). The thickener of the second whitening component may comprise sodium carboxymethyl cellulose.

[0158] The liquid carrier may be present in an amount from about 10 wt.% to about 99 wt.% based on the total weight of the second whitening component. The water may be present in an amount from about 30 wt.% to about 90 wt.% based on the total weight of the second whitening component. The glycerol may be present in an amount from about 10 wt.% to about 50 wt.% based on the total weight of the second whitening component.

[0159] The amount of thickener present can be from about 1 wt.% to about 8 wt.%, based on the total weight of the second whitening component.

[0160] When the first whitening component and the second whitening component are combined, the resulting blend may have a pH of 8 to about 11 – including all pH values ​​and subranges therein. For example, the pH of the composition obtained by combining the first whitening component and the second whitening component may preferably be 8.5 to about 11, about 9 to about 11, about 10 to about 11; 8.5 to about 10, about 9 to about 10, or any range or subrange thereof.

[0161] All ingredients used in the compositions described herein should be orally acceptable. As used herein, “orally acceptable” means that an ingredient present in the composition in the stated amount and form will not render the composition unsafe for use in the oral cavity.

[0162] This disclosure also provides a method for whitening human teeth, or a method for whitening human teeth using the oral care products and / or whitening compositions disclosed herein. The method may include contacting the oral care product, whitening composition, or a hydrogen peroxide source thereof with water to initiate the formation of hydrogen peroxide. The method may also include contacting the oral care product or its whitening composition with oral surfaces such as tooth surfaces.

[0163] In some embodiments, contacting the tooth surface with an oral care product or its whitening composition may include applying the oral care product or whitening composition directly to the teeth using a delivery device, such as a pen-like device or a liquid stick with an applicator (e.g., a felt head, a brush, a roller, a nonwoven pad, etc.). In another embodiment, contacting the tooth surface with an oral care product or its whitening composition may include placing the oral care product or its whitening composition in a dental tray (e.g., a tray reservoir) and placing the tray around the teeth.

[0164] Oral care products or whitening compositions may be applied to teeth and remain in place for at least 2 minutes, at least 5 minutes, typically at least 10 minutes, or more typically at least 30 minutes. After each treatment with the whitening composition, the teeth may be treated with a tooth desensitizing agent. Exemplary desensitizing agents may contain potassium nitrate, citric acid, citrate, strontium chloride, etc.

[0165] Oral care products and / or their whitening compositions may be applied to and / or contacted with the tooth surface at predetermined intervals. For example, once daily, at least once a day, for several days, or every other day. In another example, oral care products and / or their whitening compositions may be applied to and / or contacted with the tooth surface at least once daily, at least once every two days, at least once every three days, at least once every five days, at least once a week, at least once every two weeks, or at least once a month. Oral care products and / or their whitening compositions may be used for up to 2 weeks, up to 3 weeks, up to 4 weeks, up to 6 weeks, up to 8 weeks, or longer.

[0166] Dental trays can be of any conventional form and can be formed from commonly used polymers, such as thermoplastic polymers. Thermosetting polymers can also be used. Therefore, dental trays can range from highly flexible to lowly flexible. Thermoplastic polymers are typically used. Exemplary thermoplastic polymers can be, or include, polyethylene and polypropylene polymers, their derivatives and copolymers, silicone elastomers, polyurethanes and their derivatives, polycaprolactam, polystyrene and its derivatives, polybutadiene and its derivatives, polyisoprene and its derivatives, and polymethacrylates and their derivatives, or combinations thereof.

[0167] All ingredients used in the compositions described herein should be orally acceptable. As used herein, “orally acceptable” can mean any ingredient present in the composition in the described amount and form that would not make the composition unsafe for use in the oral cavity.

[0168] The present invention also provides a method for manufacturing a personal care product with viscosity control. The method includes: blending a viscosity control composition with a personal care ingredient to form a personal care composition. Subsequently, the method includes adding a predetermined volume of the personal care composition to a container to form a personal care product. Example

[0169] The following experiments tested the effect of combining emulsifiers / dispersants with the UV filters and emollients of this invention on stability. These examples used the following formulation details.

[0170] Oxidizing agent: Potassium peroxymonosulfonate

[0171] Carrier 1: Trimethylsiloxysilicate / polydimethylsiloxane crosspolymer and polydimethylsiloxane

[0172] Carrier 2: White Vaseline

[0173] Carrier 3: Polyethylene glycol 600, poloxamer 105 and PEG / PPG-116 / 66 copolymer

[0174] PVP: Polyvinylpyrrolidone

[0175] Flavoring agent 1: One or more of sodium saccharin and sucralose

[0176] Flavoring agent 2: one or more peppermint oils Example 1

[0177] The first experiment was conducted to determine the whitening efficacy of the whitening compositions of the present invention. Four non-limiting example whitening compositions (Examples 1-4) were prepared according to aspects of this disclosure. A comparative composition (Comparative Example 1) was also prepared for comparison with Example Compositions 1-4. The formulations of Example Compositions 1-4 and Comparative Composition 1 are shown in Table 1. Each formulation was prepared by blending the ingredients together, and each oral care composition was applied to the surface of stained teeth for the same duration, with multiple identical treatments performed. The teeth were stained by coffee and tea. Subsequently, after the treatment cycle was completed, the color value (L*a*b) of each tooth was measured and recorded, and compared with the initial recorded color value of each tooth before the start of treatment. Whiteness was reported as ΔW*. W* = (a*2 + b*2 + (L* - 100)2)1 / 2 ΔW* = Processed W* – Baseline W*

[0178] Regarding ΔW, the more negative the value, the closer the teeth are to white. The results are listed in Table 1 below. Table 1

[0179] As shown in Table 1, the addition of MPS provides an effective teeth whitening composition—as confirmed by color change values, showing a ΔW* of at least -7.8 (Example 3) up to a ΔW* exceeding -10 (Example 1). Furthermore, the formulations were determined to be stable by exhibiting storage stability over a period of time, indicative of the shelf-stable life required for commercial whitening products. Example 2

[0180] A second experiment was conducted to determine the whitening efficacy of the pH-raising agent in combination with the whitening composition of the present invention. The pH-raising formulation was prepared as shown in Table 2. Table 2

[0181] Subsequently, two non-limiting example compositions (Examples 5 and 6) and a placebo were prepared and subjected to a tooth whitening test similar to that of Experiment 1, except that the whitening was performed on artificially stained bovine teeth with tobacco—the formulation of Example 6 was combined with a pH-raising agent in a 1:1 weight ratio, while the formulation of Example 5 was not combined with a pH-raising agent. The results are listed in Table 3 below. Table 3

[0182] As shown in Table 4, it has been surprisingly found that the addition of a pH enhancer in combination with MPS oxidant produced a significant improvement in whitening effect—even without flavoring agent 2.

[0183] While the invention has been described with reference to specific examples including the currently preferred mode for implementing the invention, those skilled in the art will understand that many variations and arrangements of the above-described systems and techniques exist. It should be understood that other embodiments can be used, and structural and functional modifications can be made, without departing from the scope of the invention. Therefore, the spirit and scope of the invention should be interpreted broadly as set forth in the appended claims.

Claims

1. A whitening composition comprising: Oxidizing agent, wherein the oxidizing agent comprises potassium peroxymonosulfonate; A carrier comprising a polymer fluid; Adhesives; and Seasoning, The oxidant mentioned therein does not contain hydrogen peroxide.

2. The whitening composition according to claim 1, wherein the potassium peroxide monosulfonate is present in an amount of about 0.1 wt.% to about 5.0 wt.% based on the total weight of the whitening composition.

3. The whitening composition according to claim 1 or claim 2, wherein the polymer fluid comprises a silicone fluid.

4. The whitening composition according to claim 3, wherein the silicone fluid is present in an amount of about 20 wt.% to about 60 wt.% based on the total weight of the whitening composition.

5. The whitening composition according to any one of claims 1 to 4, wherein the adhesive is present in an amount of about 10 wt.% to about 40 wt.% based on the total weight of the whitening composition.

6. The whitening composition according to any one of claims 1 to 5, wherein the adhesive comprises one or more of polyvinylpyrrolidone, polyether, or trimethylsiloxane-treated silica.

7. The whitening composition according to claim 6, wherein the polyether comprises one or more of polyethylene glycol, polyethylene glycol-polypropylene glycol copolymer, or polyoxypropylene-polyoxyethylene block copolymer.

8. The whitening composition according to claim 6 or claim 7, wherein the polyvinylpyrrolidone is present in an amount of about 1.0 wt.% to about 7.0 wt.% based on the total weight of the whitening composition.

9. The whitening composition according to any one of claims 6 to 8, wherein the polyether is present in an amount of about 30 wt.% to about 50 wt.% based on the total weight of the whitening composition.

10. The whitening composition according to any one of claims 1 to 9, further comprising fumed silica.

11. The whitening composition of claim 10, wherein the fumed silica is present in an amount of about 1 wt.% to about 5 wt.% based on the total weight of the whitening composition.

12. The whitening composition according to any one of claims 1 to 11, further comprising sodium tripolyphosphate.

13. The whitening composition of claim 12, wherein the sodium tripolyphosphate is present in an amount of about 1 wt.% to about 4 wt.% based on the total weight of the whitening composition.

14. The whitening composition according to any one of claims 1 to 13, wherein the flavoring agent comprises one or more of sodium saccharin, sucralose, and a sensory agent.

15. The whitening composition according to any one of claims 1 to 14, wherein the flavoring agent is present in an amount of about 0.1 wt.% to about 2 wt.% based on the total weight of the whitening composition.

16. A whitening composition comprising: A first whitening component, the first whitening component comprising: Oxidizing agent, wherein the oxidizing agent comprises potassium peroxymonosulfonate; A carrier comprising a polymer fluid; Flavorings; The second whitening component, the second whitening component comprising: alkaline components; and The first whitening component and the second whitening component are present in a weight ratio of about 1:3 to about 3:

1.

17. The whitening composition of claim 16, wherein the second whitening component is substantially free of hydrogen peroxide, optionally, free of hydrogen peroxide.

18. The whitening composition according to claim 16 or claim 18, wherein the pH range of the whitening composition is from 8 to about 11.

19. The whitening composition according to any one of claims 16 to 18, further comprising an adhesive, wherein the adhesive comprises one or more of polyvinylpyrrolidone and polyether.

20. The whitening composition of claim 19, wherein the polyether is present in an amount of about 15 wt.% to about 25 wt.% based on the total weight of the first whitening component.

21. The whitening composition according to any one of claims 16 to 20, wherein the alkaline component comprises one or more of sodium bicarbonate and sodium carbonate, wherein the alkaline component comprises sodium bicarbonate and sodium carbonate in a weight ratio of about 6:1 to about 12:1, preferably about 8:1 to about 9:

1.

22. The whitening composition according to any one of claims 16 to 21, wherein the weight ratio of the first whitening component to the second whitening component is about 1:1.

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