Drug sustained-release device for cervical HPV (human papillomavirus) infection

Abstract

The invention discloses a medicine slow-release device for cervical HPV infection, which comprises a cylinder, the top of the cylinder is hermetically connected with an end, the end is provided with medicine outlets at equal angles, and the middle of the bottom surface of the cylinder is connected with a piston rod in a penetrating manner; a protective cover is hinged to the top of the barrel at equal angles, the protective cover covers the outer side of the end, a regulation and control mechanism is arranged on the inner side of the bottom of the barrel, the regulation and control mechanism drives the protective cover to rotate in an opening and closing mode in a meshing rotation mode, and meanwhile the protective cover is used for protecting the end; an installation locking mechanism is arranged on the cylinder body, and the installation locking mechanism is used for firmly connecting the end heads in a rotating connection mode. According to the medicine slow release device for cervical HPV infection, the cleanliness of the medicine delivery end can be kept, the medicine delivery end does not make contact with the external environment, the end can be conveniently and firmly connected and rapidly disassembled and assembled, then disinfection treatment is convenient, meanwhile, the medicine delivery speed can be controlled, and medicine delivery is uniform.

Description

Technical Field

[0001] This invention relates to the field of tumor drug treatment equipment technology, specifically a drug release device for cervical HPV infection. Background Technology

[0002] HPV, transmitted through close skin contact, is the primary cause of cervical cancer. Humans are the only host for the HPV virus. After entering the skin and mucous membranes, HPV mainly lies dormant among the basal cells of the epidermis. Once the time is right, it will cause disease. Most infected individuals can clear the virus through their body's immune system within 1-2 years. Those who cannot clear the virus and remain infected have a significantly increased chance of developing precancerous lesions of the cervix. Currently, the commonly used traditional treatments for HPV mainly include surgery, laser therapy, and topical medications. Topical medications act directly on the lesions and are highly targeted, but require continuous use, generally for 3-4 months as a course of treatment. However, the cervix is ​​special, and medication is inconvenient, requiring patients to go to the hospital for medication by a doctor, which brings great inconvenience to their lives. Therefore, there is a need for cervical HPV infection drug sustained-release devices. A drug release device for cervical HPV infection disclosed in publication number CN201911257886.7 involves placing the vertical part of the drug-carrying device in the installation chamber of the drug delivery device. After bending the two horizontal extensions of the drug-carrying device inward along their vertical central axis, the entire drug delivery device is gradually pressed into the installation chamber. The push rod moves downward. After the entire drug delivery device is delivered into the installation chamber, the cylindrical slot is then fastened to the push rod to prevent it from slipping. The patient then gradually inserts the end of the release device into the cervix. After the patient feels the end of the release device enter the uterus, the cylindrical slot on the push rod is removed, and the push rod is pushed out of the installation chamber. The two horizontal parts of the drug-carrying device gradually unfold until the entire drug-carrying device is pushed out. The drug delivery device is then retrieved and can be reused after disinfection. A drug release device for cervical HPV infection disclosed in publication number CN202222043991.4 has a piston block located inside the sprayer near the spray nozzle. When drug application is required, the patient inserts the end of the infusion tube away from the sprayer into a container containing the drug solution and opens the valve. The patient then activates the air pump, which draws air out of the rubber tube and moves the piston block away from the spray nozzle. A one-way valve located inside the sprayer near the spray nozzle prevents external air from entering the sprayer. The movement of the piston block creates a negative pressure in the space above the piston block inside the sprayer, drawing the medicine into the sprayer through the infusion tube. After the medicine is drawn in, the patient closes the valve and controls the air pump to stop inhaling. Then, the patient can insert one end of the spray nozzle into the cervix. Both the rubber tube and the infusion tube are flexible, making it easy for the patient to move the sprayer. Once the patient feels that one end of the spray nozzle has entered the uterus, the patient controls the air pump to deliver air into the rubber tube. Under the action of air pressure, the piston block inside the sprayer moves towards the spray nozzle. During this process, the medicine in the sprayer is slowly sprayed onto the affected area. However, the above-mentioned solution still has the following problems in use: During use, the drug delivery mechanism needs to be installed on the sustained-release device or integrated into the end of the sustained-release device, which is in contact with the external environment, making it easy to cause infection. It is not convenient to safely and hygienically place and use the drug delivery mechanism. After use, the drug delivery mechanism needs to be removed and disinfected for the next use. The connection between the existing sustained-release device drug delivery mechanism and the sustained-release device is a direct sleeve, which is not very stable and is prone to slippage, thus affecting the drug delivery operation.

[0003] Therefore, we propose a drug release device for cervical HPV infection to address the problems mentioned above. Summary of the Invention

[0004] The purpose of this invention is to provide a sustained-release device for cervical HPV infection, addressing the problems mentioned in the background section regarding existing sustained-release devices for cervical HPV infection. These devices require the drug delivery mechanism to be installed on or integrated into the end of the device, exposing it to the external environment, which increases the risk of infection. Furthermore, they are inconvenient for safe and hygienic placement and use. After use, the drug delivery mechanism needs to be removed and disinfected for future use. Additionally, the connection between the drug delivery mechanism and the device in existing sustained-release devices is a direct sleeve, which is unstable and prone to slippage, thus affecting the drug delivery process.

[0005] To achieve the above objectives, the present invention provides the following technical solution: a drug release device for cervical HPV infection, comprising a cylinder, wherein the top of the cylinder is sealed with an end, and the end is provided with a drug outlet at an equal angle, and a piston rod is connected through the middle of the bottom surface of the cylinder. It also includes: a protective cover is hinged at an equal angle to the top of the cylinder, and the protective cover covers the outside of the end. An adjustment mechanism is provided on the inner side of the bottom of the cylinder. The adjustment mechanism drives the protective cover to open and close by meshing and rotating. At the same time, the protective cover is used to protect the end and prevent it from being directly exposed to the external environment and causing pollution. The cylinder is equipped with a locking mechanism, and the locking mechanism securely connects the end head by rotation.

[0006] Preferably, the piston rod is configured with an "I" shaped structure, and the piston rod slides in close contact with the cylinder. The left end of the cylinder is connected to an injection tube, and a one-way valve is installed at the connection between the injection tube and the cylinder, as well as at the connection between the cylinders. The flow directions of the two one-way valves are opposite.

[0007] Preferably, the piston rod has symmetrically formed grooves on its outer side, and protrusions are engaged and slidably connected in the grooves. The protrusions are symmetrically fixed to the inner wall of the sleeve, and the sleeve bearing is connected to the bottom inner side of the cylinder.

[0008] Preferably, the control mechanism is provided with a rotating ring, and the middle part of the rotating ring is connected to the top outer side of the sleeve through a first ratchet assembly. A wave groove is provided on the outer side of the rotating ring, and a sliding plate is connected in the wave groove.

[0009] Preferably, the outer end of the slide plate is slidably connected to the limiting groove, and the limiting groove is set as a rectangular structure. The limiting groove is opened at equal angles on the inner wall of the bottom of the cylinder, and the slide plate forms an up-and-down moving structure through the wave groove and the limiting groove.

[0010] Preferably, a pull rope is fixed to the outer end of the slide plate, and the top of the pull rope is connected to the hinge of the protective cover and the cylinder. A torsion spring is installed at the hinge of the protective cover and the cylinder. The protective cover forms an opening and closing rotation structure through the pull rope and the torsion spring. When the protective cover is closed, it is a hemispherical structure.

[0011] Preferably, the mounting and locking mechanism is provided with a large gear, which is connected to the bottom outer side of the sleeve through a second ratchet assembly, and a small gear is meshed with the outer side of the large gear. Both the large gear and the small gear are bearing-connected to the bottom inner side of the cylinder.

[0012] Preferably, a locking rod is integrally installed in the center of the top surface of the pinion, and the locking rod is set as a "T" shaped structure. The top of the locking rod is connected through to the top of the cylinder, and the top of the locking rod is connected through to a rectangular slot. The slot is opened at the same angle around the bottom of the end.

[0013] Preferably, crossbars are symmetrically fixed on the front and rear sides of the cylinder, and a sliding sleeve is connected to the outside of the crossbars by a spring. The end of the hemispherical sliding sleeve is slidably engaged with the groove of the hemispherical body, and the grooves are equally spaced on the front and rear sides of the piston rod.

[0014] Compared with existing technologies, the beneficial effects of the cervical HPV infection drug sustained-release device of the present invention are as follows: During use, the protective shield protects the infusion tip from direct exposure to the external environment. The protective shield also facilitates the insertion of the sustained-release device tip into the body and allows for convenient and secure installation, preventing loosening. Furthermore, the inclusion of a speed control mechanism allows for precise control of the infusion rate, ensuring even application of the drug to the cervix. Specific details are as follows: 1. After the piston rod is pulled out and moved, a negative pressure is formed inside the cylinder, which then draws the medicine into the cylinder through the injection tube. After the piston rod is pulled out and moved, the medicine will be injected into the end. Then the cylinder is inserted into the cervix. After the protective cover is opened, the end outputs the medicine through the medicine outlet and then applies it to the lesion on the cervix. 2. After the piston rod rotates, it will drive the rotating ring to rotate through the first ratchet assembly. After the rotating ring rotates, it will drive the slide plate to move through the wave groove. The slide plate will be subject to the limit groove, which will cause the slide plate to move up and down. After the slide plate moves, it will drive the protective cover to rotate through the pull rope. After the protective cover rotates, it will open, making it easy to open inside the body. This ensures that the end is inside the protective cover before use, avoiding contact with the external environment. Furthermore, as the skateboard moves down, the pull rope is released, and the torsion spring will cause the protective cover to close, thus protecting the end again, and then it will be removed from the body for easy use next time. 3. After the piston rod reverses, it drives the large gear to rotate via the second ratchet assembly. The rotation of the large gear drives the small gear to rotate, which in turn drives the locking rod to rotate synchronously. After the locking rod rotates, it will be in a state parallel to the slot. Then, the slot on the end is inserted into the locking rod. The locking rod continues to rotate, thereby firmly connecting the locking rod and the slot, thus improving the firmness of the end installation and preventing loosening. 4. When the piston rod moves to deliver the drug, the sliding sleeve will intermittently engage with the groove, thereby intermittently compressing the spring. This causes the piston rod to experience intermittent resistance during movement, thus allowing the drug to be pushed out evenly. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the overall cross-sectional structure of the present invention; Figure 2 For the present invention Figure 1 Enlarged structural diagram at point A in the middle; Figure 3 This is a top-section schematic diagram of the connection structure between the piston rod, sleeve, and swivel ring of the present invention; Figure 4 This is a top-section schematic diagram of the connection structure of the piston rod, sleeve, large gear and small gear of the present invention; Figure 5 For the present invention Figure 1 Enlarged structural diagram at point B; Figure 6 This is a top view schematic diagram of the connection between the protective cover, pull rope, and torsion spring of the present invention; Figure 7 This is a schematic diagram of the overall side profile of the present invention; Figure 8 For the present invention Figure 7 Enlarged structural diagram at point C.

[0016] In the diagram: 1. Cylinder; 2. End; 3. Discharge port; 4. Protective cover; 5. Piston rod; 6. Injection tube; 7. One-way valve; 8. Sleeve; 9. Protrusion; 10. Slide groove; 11. First ratchet assembly; 12. Wave groove; 13. Slide plate; 14. Limiting groove; 15. Pull rope; 16. Torsion spring; 17. Second ratchet assembly; 18. Large gear; 19. Small gear; 20. Locking rod; 21. Slot; 22. Crossbar; 23. Slide sleeve; 24. Spring; 25. Groove; 26. Rotary ring. Detailed Implementation

[0017] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0018] Please see Figures 1-8 The present invention provides the following technical solution: Example 1: To address the issue of infection caused by contact between the infusion tip 2 and the external environment during use of existing sustained-release devices, the following solution is proposed. Please refer to the following for details. Figure 1 and Figure 7As shown, the device includes a cylinder 1, with an end 2 sealed to the top of the cylinder 1. An outlet 3 is provided at an equal angle on the end 2. A piston rod 5 is connected through the center of the bottom surface of the cylinder 1. The device also includes a protective cover 4 hinged at an equal angle to the top of the cylinder 1, covering the outside of the end 2. A control mechanism is provided on the inner side of the bottom of the cylinder 1, which drives the protective cover 4 to open and close by meshing and rotating. The protective cover 4 protects the end 2 from direct exposure to the external environment and prevents contamination. The piston rod 5 is designed in an "I" shape and slides close to the cylinder 1. An injection tube 6 is connected to the left end of the cylinder 1. The connection between the injection tube 6 and the cylinder 1, as well as the connection between the cylinder 1 and the end 2, are also included. One-way valves 7 are installed at the connection points of the body 1. The flow directions of the two one-way valves 7 are opposite. When in use, the piston rod 5 in the body 1 is pulled. After the piston rod 5 moves, the inside of the body 1 will be in a negative pressure state. The injection tube 6 is connected to the external medicine box, which will draw the medicine into the inside of the body 1. Then, the one-way valve 7 at the injection tube 6 only allows inflow and not outflow. Then, the end of the entire slow-release device is inserted into the body. The protective cover 4 can protect the end 2, so that it is separated from the external environment before use to avoid contamination. After being inserted into the lesion at the cervix, the protective cover 4 is opened and the piston rod 5 is pushed. The piston rod 5 will inject the medicine inside the body 1 into the end 2 through another one-way valve 7. The end 2 will output through the medicine outlet 3, thereby applying the medicine to the cervix. Combination Figures 1-3 and Figures 5-7As shown, the piston rod 5 has symmetrically arranged grooves 10 on its outer side, and protrusions 9 are slidably connected in the grooves 10. The protrusions 9 are symmetrically fixed to the inner wall of the sleeve 8. The sleeve 8 is bearing-connected to the inner bottom of the cylinder 1. The control mechanism is provided with a rotating ring 26, and the middle part of the rotating ring 26 is connected to the outer top of the sleeve 8 through the first ratchet assembly 11. The outer side of the rotating ring 26 has a wave groove 12, and a sliding plate 13 is connected in the wave groove 12. The outer end of the sliding plate 13 is slidably connected to the limiting groove 14. The limiting groove 14 is a rectangular structure and is opened at equal angles on the inner wall of the bottom of the cylinder 1. The sliding plate 13 forms a vertical movement structure through the wave groove 12 and the limiting groove 14. A pull rope 15 is fixed to the outer end of the sliding plate 13, and the top of the pull rope 15 is connected to the hinge between the protective cover 4 and the cylinder 1. A torsion spring 16 is installed at the hinge between the protective cover 4 and the cylinder 1. Furthermore, the protective cover 4 forms an opening and closing rotating structure through the pull rope 15 and the torsion spring 16. When the protective cover 4 is closed, it is a hemispherical structure. When the piston rod 5 is rotated, the piston rod 5 will drive the sleeve 8 to rotate through the protrusion 9 and the slide groove 10. After the sleeve 8 rotates, it will drive the rotating ring 26 to rotate through the first ratchet assembly 11. After the rotating ring 26 rotates, it will drive the slide plate 13 to move through the wave groove 12. The slide plate 13 will be limited by the limiting groove 14, thus causing the slide plate 13 to move up and down. When the slide plate 13 moves down, it will pull the pull rope 15, which will drive the protective cover 4 to rotate, and then reverse the torsion spring 16. After the protective cover 4 rotates, the end 2 will output the liquid medicine. When the slide plate 13 moves up, the pull rope 15 will be released, and the torsion spring 16 will drive the protective cover 4 to rotate and close, protecting the end 2 again, isolating the end 2 from the outside world and keeping it clean.

[0019] Example 2: To improve the stability and ease of assembly and disassembly between the drug delivery end 2 and the cylinder 1, the following solution is proposed. Please refer to the following for details. Figures 1-2 , Figures 4-5 and Figure 7As shown, a locking mechanism is provided on the cylinder 1, and the locking mechanism is firmly connected to the end 2 by a rotatable connection. The locking mechanism is provided with a large gear 18, which is connected to the outer bottom of the sleeve 8 through a second ratchet assembly 17. A small gear 19 is meshed with the outer side of the large gear 18. Both the large gear 18 and the small gear 19 are bearing connected to the inner bottom of the cylinder 1. A locking rod 20 is integrally installed in the center of the top surface of the small gear 19. The locking rod 20 is set with a "T"-shaped structure, and the top of the locking rod 20 is connected to the top of the cylinder 1. The top of the locking rod 20 is connected to a rectangular slot 21, which is opened at equal angles around the bottom of the end 2. The piston rod 5 rotates in the opposite direction. After the movement, the sleeve 8 will rotate synchronously in reverse. After the sleeve 8 rotates, it will drive the large gear 18 to rotate through the second ratchet assembly 17. After the large gear 18 rotates, it will drive the outer small gear 19 to rotate synchronously. After the small gear 19 rotates, it will drive the locking rod 20 to rotate. The top of the locking rod 20 will rotate to a state parallel to the slot 21 on the end 2. Then, the end 2 is placed on the top of the cylinder 1, and the locking rod 20 is inserted into the slot 21. After the locking rod 20 continues to rotate, its top will rotate to a state perpendicular to the slot 21, thus connecting the end 2 to the cylinder 1 conveniently and firmly. When disassembling later, the above operation can be repeated. When the top of the locking rod 20 is parallel to the slot 21, the end 2 can be separated and cleaned.

[0020] Example 3: To address the issue of drug delivery uniformity at the infusion end 2, the following solution is proposed. Please refer to the following for details. Figure 1 and Figures 7-8 As shown, crossbars 22 are symmetrically fixed on the front and rear sides inside the cylinder 1, and a sliding sleeve 23 is connected to the outside of the crossbar 22 by a spring 24. The end of the hemispherical sliding sleeve 23 is slidably engaged with the groove 25 of the hemispherical body. The grooves 25 are evenly spaced on the front and rear sides of the piston rod 5. During the process of pushing the piston rod 5, the sliding sleeve 23 on the crossbar 22 will intermittently misalign with the groove 25 on the outside of the piston rod 5, thereby compressing the spring 24. When the sliding sleeve 23 engages with the groove 25, the spring 24 will extend, so that the piston rod 5 is in an intermittent and uniform state when moving, so that the medicine can be evenly applied to the cervix.

[0021] The contents not described in detail in this specification are existing technologies known to those skilled in the art.

[0022] Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A drug release device for cervical HPV infection, comprising a cylinder (1), wherein the top of the cylinder (1) is sealed with an end (2), and the end (2) is provided with a drug outlet (3) at an equal angle, and a piston rod (5) is connected through the middle of the bottom surface of the cylinder (1). Its features are: Also includes: The top of the cylinder (1) is hinged at an equal angle to a protective cover (4), and the protective cover (4) covers the outside of the end (2). The bottom inner side of the cylinder (1) is provided with an adjustment mechanism, and the adjustment mechanism drives the protective cover (4) to open and close by meshing and rotating. At the same time, the protective cover (4) is used to protect the end (2) to avoid direct exposure to the external environment and pollution. The cylinder (1) is provided with a locking mechanism, and the locking mechanism is used to securely connect the end (2) by means of rotation.

2. The drug release device for cervical HPV infection according to claim 1, characterized in that: The piston rod (5) is configured as an "I" shaped structure, and the piston rod (5) slides in close contact with the cylinder (1). The left end of the cylinder (1) is connected to the injection tube (6), and a one-way valve (7) is installed at the connection between the injection tube (6) and the cylinder (1) and at the connection between the cylinder (1) and the cylinder (1). At the same time, the flow directions of the two one-way valves (7) are opposite.

3. The drug release device for cervical HPV infection according to claim 1, characterized in that: The piston rod (5) has symmetrically provided grooves (10) on its outer side, and a protrusion (9) is engaged and slidably connected in the groove (10). The protrusion (9) is symmetrically fixed on the inner wall of the sleeve (8), and the sleeve (8) is connected to the bottom inner side of the cylinder (1) by a bearing.

4. A drug release device for cervical HPV infection according to claim 1, characterized in that: The control mechanism is provided with a rotating ring (26), and the middle part of the rotating ring (26) is connected to the top outer side of the sleeve (8) through the first ratchet assembly (11). A wave groove (12) is provided on the outer side of the rotating ring (26), and a sliding plate (13) is connected in the wave groove (12).

5. A drug release device for cervical HPV infection according to claim 4, characterized in that: The outer end of the slide plate (13) is slidably connected to the limiting groove (14), and the limiting groove (14) is set as a rectangular structure. The limiting groove (14) is opened at equal angles on the inner wall of the bottom of the cylinder (1). The slide plate (13) forms an up-and-down moving structure through the wave groove (12) and the limiting groove (14).

6. A drug release device for cervical HPV infection according to claim 5, characterized in that: The outer end of the slide (13) is fixed with a pull rope (15), and the top of the pull rope (15) is connected to the hinge of the protective cover (4) and the cylinder (1). A torsion spring (16) is installed at the hinge of the protective cover (4) and the cylinder (1). The protective cover (4) forms an opening and closing rotation structure through the pull rope (15) and the torsion spring (16). When the protective cover (4) is closed, it is a hemispherical structure.

7. A drug release device for cervical HPV infection according to claim 1, characterized in that: The installation locking mechanism is provided with a large gear (18), and the large gear (18) is connected to the bottom outer side of the sleeve (8) through the second ratchet assembly (17). The outer side of the large gear (18) is meshed with a small gear (19), and both the large gear (18) and the small gear (19) are bearing connected to the bottom inner side of the cylinder (1).

8. A drug release device for cervical HPV infection according to claim 7, characterized in that: The pinion (19) has a locking rod (20) integrally installed in the middle of its top surface. The locking rod (20) is set as a "T" shaped structure. The top of the locking rod (20) is connected to the top of the cylinder (1). The top of the locking rod (20) is connected to a rectangular slot (21). The slot (21) is opened at the same angle around the bottom of the end (2).

9. A drug release device for cervical HPV infection according to claim 1, characterized in that: The cylinder (1) has crossbars (22) fixed symmetrically on the front and back sides inside, and the crossbars (22) are connected to the outer side by springs (24) with a sliding sleeve (23). The end of the hemispherical sliding sleeve (23) is slidably engaged with the groove (25) of the hemispherical body, and the grooves (25) are equally spaced on the front and back sides of the piston rod (5).

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