Molecularly imprinted polymer membrane based on microfluidic confinement as well as preparation method and application of molecularly imprinted polymer membrane

By using microfluidic confinement technology to prepare molecularly imprinted polymer films, the selectivity and sensitivity issues of detecting multiple substances on microfluidic chips were solved, and uniform control and efficient detection of multi-template molecular imprints were achieved.

CN121944818APending Publication Date: 2026-05-01SUN YAT SEN UNIV
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Patent Information

Application Number
CN202511890295.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-12-15
Publication Date
2026-05-01

AI Technical Summary

Technical Problem

Existing technologies struggle to achieve high selectivity and sensitivity for detecting a variety of substances on microfluidic chips, and the thickness control of traditional molecularly imprinted polymer films is uneven, affecting detection performance.

Method used

Molecularly imprinted polymer films were prepared using microfluidic confinement technology. By carrying out a prepolymerization reaction in a microfluidic channel, a uniform molecularly imprinted polymer film was formed using a silane coupling agent, template molecules, crosslinking agent, and catalyst, enabling simultaneous imprinting of multiple template molecules.

Benefits of technology

It enables the simultaneous detection of multiple substances, and features high selectivity, high sensitivity, good repeatability and stability. It also boasts fast detection speed, low reagent consumption, and a small and portable microfluidic chip.

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Abstract

The invention provides a molecularly imprinted polymer membrane based on microfluidic confinement and a preparation method and application thereof, the preparation method comprises the following steps: taking a base material, and arranging a microchannel on the base material; adding the prepolymerization solution into the microchannel; the prepolymerization solution comprises a silane coupling agent, template molecules, a cross-linking agent and a catalyst; and carrying out polymerization reaction on the prepolymerization solution under a confinement condition to prepare the molecularly imprinted polymer membrane. The microchannel is used for providing a confinement environment for in-situ growth of the molecularly imprinted polymer film, simultaneous imprinting of multiple template molecules is achieved, the obtained molecularly imprinted polymer film is uniform and controllable in thickness and matched with a detection probe, simultaneous detection of multiple substances can be achieved, the preparation method is simple, and preparation conditions are mild. According to the invention, high-integration-level detection of MIPs and NIPs is realized on the same chip, and the chip is simultaneously applied to simultaneous identification, separation, enrichment and detection of simultaneous detection of various substances.
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