Method for continuously preparing 2, 4-dichloro-5-isopropoxy phenylhydrazine hydrochloride

By enhancing the reduction reaction using microchannel technology, the heat and mass transfer problems of batch reactions and the cost and stability problems of continuous reactions have been solved, enabling efficient and stable continuous production of 2,4-dichloro-5-isopropoxyphenylhydrazine hydrochloride.

CN122010770APending Publication Date: 2026-05-12SHENYANG RES INST OF CHEM IND
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Patent Information

Application Number
CN202610406183.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-03-31
Publication Date
2026-05-12

AI Technical Summary

Technical Problem

Existing batch reactions suffer from poor heat and mass transfer, low production efficiency, uncontrollable reaction process, and large accumulation of diazonium salts; while existing continuous reactions suffer from high cost and poor stability.

Method used

Microchannel technology is used to enhance the reduction reaction. The microchannel reactor makes the solid phenylhydrazine hydrochloride more uniformly dispersed and reduces the particle size. The high specific surface area and short heat conduction path of the microchannel are used to control the reaction temperature, so as to achieve continuous production.

Benefits of technology

It improves reaction speed and product selectivity, reduces viscosity, avoids clogging, achieves high yield and stable continuous production, simplifies the process, and reduces production costs.

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Abstract

The invention belongs to the technical field of preparation of oxadiazon intermediates, and particularly discloses a method for continuously preparing 2, 4-dichloro-5-isopropoxy phenylhydrazine hydrochloride. The method comprises the following steps: respectively precooling a 2, 4-dichloro-5-isopropoxy chlorobenzene diazonium salt solution and a stannous chloride aqueous solution, introducing into a microchannel reactor after precooling, mixing, and reacting to obtain the 2, 4-dichloro-5-isopropoxy phenylhydrazine hydrochloride. The mixing effect of the diazonium salt and the reducing agent stannous chloride is enhanced by utilizing a micro-reaction technology, the reaction speed is increased, the mass transfer and heat transfer effects are improved, and the problems of poor heat and mass transfer effects, low production efficiency, uncontrollable reaction process and accumulation of a large amount of diazonium salt in the existing intermittent reaction are solved; and the existing continuous reaction has the problems of high cost and poor stability.
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