2-methyl-5-trifluoromethylfuran and process for its preparation
By using the tandem reaction of trifluoroacetone with 1-chloro-2-methylethylene oxide, the problems of cumbersome preparation steps and low yield in the existing technology of 2-methyl-5-trifluoromethylfuran are solved, and an efficient and mild preparation method is realized, which is suitable for industrial production.
CN122010876BActive Publication Date: 2026-07-24ZIBO FEIYUAN CHEM CO LTD
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Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- ZIBO FEIYUAN CHEM CO LTD
- Filing Date
- 2026-04-14
- Publication Date
- 2026-07-24
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Figure CN122010876B_ABST
Abstract
The present application belongs to the technical field of organic chemical preparation, and particularly relates to 2-methyl-5-trifluoromethyl furan and a preparation method thereof. The preparation method comprises the following steps: adding a solvent into trifluoroacetone, adding a base under ice bath condition, adding 1-chloro-2-methyl epoxide, reacting at room temperature, adding an acid, completing a dehydration reaction under the condition of 40-60 DEG C, then adding a base for aromatization, continuously completing an aromatization reaction, extracting the reaction system by adding water, taking an organic phase, and rectifying to obtain 2-methyl-5-trifluoromethyl furan. The 2-methyl-5-trifluoromethyl furan and the preparation method thereof have the advantages of mild reaction condition, simple steps, high yield of the prepared 2-methyl-5-trifluoromethyl furan, and suitability for industrial production.
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