Antibacterial material for root canal therapy based on fluorine titanium oxide as well as preparation method and application of antibacterial material

Abstract

The invention discloses an antibacterial material for root canal therapy based on fluorine titanium oxide and a preparation method and application of the antibacterial material, and belongs to the technical field of oral medical materials, and the antibacterial material for root canal therapy is fluorine titanium oxide nanoparticles; the fluorine titanium oxide nanoparticles are fluorine-doped titanium oxide; the fluorine titanium oxide nanoparticles can absorb infrared radiation of a human body and generate surface electromagnetic oscillation, so that a bacterial membrane structure is destroyed through a charge polarization effect. A continuous antibacterial field is excited on the surfaces of the fluorine titanium oxide nanoparticles by utilizing human body infrared radiation, the antibacterial effect of destroying a bacterial membrane by charge polarization is realized, and the method has the advantages of long-acting antibacterial effect, no chemical release, avoidance of cytotoxicity and the like; in addition, when the antibacterial material fluorine titanium oxide nanoparticles are prepared into antibacterial coating liquid, the operation process can be simplified, and the antibacterial coating liquid is suitable for clinical root canal flushing instruments.

Description

Technical Field

[0001] This invention relates to the field of oral medical materials technology, specifically to an antibacterial material for root canal treatment based on fluorine-titanium oxide, its preparation method, and its application. Background Technology

[0002] Root canal treatment is an effective treatment for diseases such as pulpitis and periapical periodontitis. Its core goal is to thoroughly remove infected material from the root canal system and prevent reinfection through meticulous filling. In this process, root canal disinfection is a crucial step in determining the success of the treatment. Ideal root canal disinfection materials should possess highly effective and broad-spectrum antibacterial capabilities, good biocompatibility, no damage to tooth tissue, and the ability to maintain an antibacterial environment for a certain period to promote the healing of periapical tissues.

[0003] Currently, in root canal treatment, commonly used root canal disinfection materials mainly rely on the bactericidal or bacteriostatic effects of chemical drugs. However, they have significant limitations in terms of effectiveness, safety, and operability. For example, sodium hypochlorite irrigator, a commonly used root canal irrigator, relies on the strong oxidizing properties of released chlorine to achieve rapid sterilization; however, high concentrations (usually >5%) of sodium hypochlorite irrigator have the following problems: it easily corrodes dentin, reducing the mechanical strength of teeth; overflow from the apical foramen can cause tissue necrosis, and some patients experience allergies; its action time is short (≤1 hour), and it cannot maintain a long-term antibacterial environment. Calcium hydroxide paste, as a classic intracanal medication, although having relatively good biocompatibility, has problems such as requiring an alkaline environment for sterilization, being biocorrosive, easily absorbing CO2 to form calcium carbonate and becoming ineffective, being difficult to clean, and not being able to effectively inhibit drug-resistant bacteria for a long time. EDTA lubricant is mainly used to remove the smear layer from the root canal wall and soften dentin; however, EDTA lubricant itself has weak antibacterial ability, and in clinical practice, it needs to be used alternately with sodium hypochlorite, which is cumbersome. Some EDTA lubricants (such as those containing citric acid) are acidic, and long-term exposure may lead to dentin demineralization and reduce the bonding strength of dental restorations.

[0004] In summary, current root canal disinfection techniques generally rely on chemicals (such as OH disinfectants). - ,ClO - Traditional root canal disinfectants share common problems, including plasma release posing a risk of tissue toxicity, insufficient durability (unable to maintain a long-term sterile environment in the root canal), and complex operation or cleaning difficulties (calcium hydroxide paste forms calcium carbonate which is difficult to remove, and sodium hypochlorite + EDTA two-step irrigation increases treatment time). Therefore, there is an urgent need to develop a chemical-free, safe, long-lasting, and easy-to-use antibacterial material to replace traditional root canal disinfectants. Summary of the Invention

[0005] The purpose of this invention is to provide an antibacterial material for root canal treatment based on fluorotitanium oxide, its preparation method and application, so as to solve the problems mentioned in the background art.

[0006] To achieve the above objectives, the present invention provides the following technical solution:

[0007] An antibacterial material for root canal treatment based on fluorinated titanium oxide is fluorinated titanium oxide nanoparticles; the fluorinated titanium oxide nanoparticles are fluorine-doped titanium oxides; the fluorinated titanium oxide nanoparticles can absorb infrared radiation from the human body and generate surface electromagnetic oscillations, thereby destroying the bacterial membrane structure through charge polarization.

[0008] Furthermore, the fluorotitanium oxide nanoparticles are prepared by a solvothermal reaction of tetrabutyl titanate and ammonium fluoride.

[0009] Furthermore, the amount of ammonium fluoride used is 0.5wt%-5wt% of tetrabutyl titanate, which is used to optimize the infrared absorption efficiency in the 9.35μm band.

[0010] Furthermore, the particle size of the fluorotitanium oxide nanoparticles is 50-100 nm.

[0011] Another object of the present invention is to provide a method for preparing the above-mentioned antibacterial material for root canal treatment based on fluorotitanium oxide, comprising the following steps:

[0012] Tetrabutyl titanate and ammonium fluoride were added to a solvent and stirred, and the pH was adjusted to 2.5-3.5 to form a sol.

[0013] The sol was heated to 170-190℃ to react and the product was obtained.

[0014] The product was centrifuged and washed, and then vacuum dried to obtain the antibacterial material.

[0015] Furthermore, the solvent is ethanol.

[0016] Furthermore, acetic acid was used to adjust the pH.

[0017] Furthermore, the vacuum drying temperature is 50-70℃.

[0018] Another object of the present invention is to provide the application of the above-mentioned fluorotitanium oxide-based antibacterial material for root canal treatment in the preparation of antibacterial coating solution for root canal treatment.

[0019] Another object of the present invention is to provide an antibacterial coating solution for root canal treatment, comprising the following components by mass percentage: 5%-10% of the above-mentioned fluorotitanium oxide-based antibacterial material for root canal treatment, 1%-3% of hydroxyethyl cellulose, 3%-7% of glycerin, and the balance being deionized water.

[0020] This invention provides an antibacterial material for root canal treatment based on fluorotitanium oxide. It utilizes human infrared radiation (37°C, 9.35μm) to excite a continuous antibacterial field on the surface of fluorotitanium oxide nanoparticles, achieving an antibacterial effect by disrupting the bacterial membrane through charge polarization. It has the advantages of long-lasting antibacterial effect, no chemical release, and avoidance of cytotoxicity. In addition, the antibacterial material fluorotitanium oxide nanoparticles can be made into an antibacterial coating solution, which can simplify the operation process and is compatible with clinical root canal irrigation instruments. Attached Figure Description

[0021] Figure 1 This is a schematic diagram illustrating the antibacterial mechanism of the fluorotitanium oxide-based antibacterial material for root canal treatment provided in an embodiment of the present invention.

[0022] Figure 2 This is a transmission electron microscope (TEM) image of the fluorine-titanium oxide nanoparticles prepared in Example 1.

[0023] Figure 3 This is a SEM image of the biofilm in the fluorine-titanium oxygen experimental group.

[0024] Figure 4 The image shows a SEM image of dentinal tubules. In the image, A represents the antibacterial coating treatment group, which showed no demineralization; B represents the sodium hypochlorite solution treatment group, which showed collapse.

[0025] Figure 5 FTIR absorption spectra of antibacterial materials prepared with different ammonium fluoride doping amounts. Detailed Implementation

[0026] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0027] like Figure 1 As shown, in one embodiment of the present invention, an antibacterial material for root canal treatment based on fluorotitanium oxide is provided, which is fluorotitanium oxide nanoparticles; the fluorotitanium oxide nanoparticles are fluorine-doped titanium oxides; the fluorotitanium oxide nanoparticles can absorb infrared radiation from the human body and generate surface electromagnetic oscillations, thereby destroying the bacterial membrane structure through charge polarization. This antibacterial material does not require chemical release and can avoid tissue toxicity.

[0028] In this embodiment of the invention, the fluorotitanium oxygen nanoparticles absorb infrared radiation energy from the human body (37°C, especially at a wavelength of 9.35 μm), and the lattice micro-oscillation generates a local surface electromagnetic field, which induces charge polarization of the bacterial membrane phospholipid bilayer, destroys the integrity of the bacterial membrane, and stimulates a continuous antibacterial field, achieving long-lasting antibacterial effect (≥7 days) without ion release. It has the advantages of avoiding cytotoxicity, and can replace traditional disinfectants and solve the problem of root canal infection control.

[0029] Preferably, the fluorotitanium oxide nanoparticles are prepared by a solvothermal reaction of tetrabutyl titanate and ammonium fluoride. The amount of ammonium fluoride used as doping is 0.5wt%-5wt% of tetrabutyl titanate, used to optimize the infrared absorption efficiency in the 9.35μm band. The particle size of the fluorotitanium oxide nanoparticles is 50-100nm.

[0030] In another embodiment of the present invention, a method for preparing the above-mentioned fluorine-titanium oxide-based antibacterial material for root canal treatment is also provided, comprising the following steps:

[0031] S1. Add tetrabutyl titanate and ammonium fluoride to a solvent such as ethanol and stir magnetically for 20-40 minutes. Then, add acetic acid dropwise to adjust the pH to 2.5-3.5 to form a transparent sol.

[0032] S2. Transfer the above sol to a polytetrafluoroethylene reactor and heat it to 170-190℃ for 10-14 hours to obtain the product.

[0033] S3. The above product is centrifuged (6000-10000 rpm, 5-15 min), and the precipitate is washed several times with deionized water. Then, it is vacuum dried at 50-70℃ for 10-14 h to obtain fluorotitanium oxide nanoparticles with a particle size of 50-100 nm, which is the antibacterial material. The transmission electron microscope image of the fluorotitanium oxide nanoparticles is shown below. Figure 2 As shown.

[0034] In another embodiment of the present invention, the application of the above-mentioned fluorotitanium oxide-based antibacterial material for root canal treatment is also provided in the antibacterial treatment of root canals.

[0035] Specifically, during root canal treatment, this antibacterial varnish can be injected, using a 25G root canal irrigation needle. Specifically, the antibacterial varnish is injected into the root canal through the 25G root canal irrigation needle, forming a thin film that covers the root canal wall, achieving long-lasting antibacterial effect for 7 days or more.

[0036] In another embodiment of the present invention, an antibacterial coating solution for root canal treatment is also provided, comprising the following components by mass percentage: 5%-10% of the above-mentioned fluorotitanium oxide-based antibacterial material for root canal treatment, 1%-3% of hydroxyethyl cellulose, 3%-7% of glycerin, and the balance being deionized water.

[0037] Example 1: This example provides an antibacterial material and antibacterial coating solution for root canal treatment based on fluorotitanium oxide. The preparation method includes the following steps:

[0038] S1. Add 3.4g tetrabutyl titanate and 0.17g ammonium fluoride (5wt%) to 40mL anhydrous ethanol and stir magnetically for 30min. Add acetic acid dropwise to adjust the pH to 3 to form a transparent sol.

[0039] S2. Transfer the above sol to a polytetrafluoroethylene reactor and heat it to 180°C for 12 hours to obtain the product.

[0040] S3. The above product is centrifuged (8000 rpm, 12 min), and the precipitate is washed three times with deionized water. Then it is vacuum dried at 60°C for 12 h to obtain fluorotitanium oxide nanoparticles (powder), which is an antibacterial material.

[0041] S4. Take 2.5g of fluorotitanium oxide nanoparticles, 1g of hydroxyethyl cellulose, 2.5g of glycerol, and 44g of deionized water, mix them, and ultrasonically disperse them for 30min. Then, autoclave them at 121℃ for 20min to obtain the antibacterial coating solution, which can be dispensed into sterile syringes.

[0042] Example 2: This example provides an antibacterial material and antibacterial coating solution for root canal treatment based on fluorotitanium oxide. The preparation method includes the following steps:

[0043] S1. Add 3.4g tetrabutyl titanate and 0.085g ammonium fluoride (2.5wt%) to 40mL anhydrous ethanol and stir magnetically for 30min. Add acetic acid dropwise to adjust the pH to 3 to form a transparent sol.

[0044] S2. Transfer the above sol to a polytetrafluoroethylene reactor and heat it to 180°C for 12 hours to obtain the product.

[0045] S3. The above product is centrifuged (8000 rpm, 12 min), and the precipitate is washed three times with deionized water. Then it is vacuum dried at 60°C for 12 h to obtain fluorotitanium oxide nanoparticles, which are antibacterial materials.

[0046] S4. Take 2.5g of fluorotitanium oxide nanoparticles, 1g of hydroxyethyl cellulose, 2.5g of glycerol, and 44g of deionized water, mix them, and ultrasonically disperse them for 30min. Then, autoclave them at 121℃ for 20min to obtain the antibacterial coating solution, which can be dispensed into sterile syringes.

[0047] Example 3: This example provides an antibacterial material and antibacterial coating solution for root canal treatment based on fluorotitanium oxide. The preparation method includes the following steps:

[0048] S1. Add 3.4g tetrabutyl titanate and 0.034g ammonium fluoride (1wt%) to 40mL anhydrous ethanol and stir magnetically for 30min. Then add acetic acid dropwise to adjust the pH to 3 to form a transparent sol.

[0049] S2. Transfer the above sol to a polytetrafluoroethylene reactor and heat it to 180°C for 12 hours to obtain the product.

[0050] S3. The above product is centrifuged (8000 rpm, 12 min), and the precipitate is washed three times with deionized water. Then it is vacuum dried at 60°C for 12 h to obtain fluorotitanium oxide nanoparticles, which are antibacterial materials.

[0051] S4. Take 2.5g of fluorotitanium oxide nanoparticles, 1g of hydroxyethyl cellulose, 2.5g of glycerol, and 44g of deionized water, mix them, and ultrasonically disperse them for 30min. Then, autoclave them at 121℃ for 20min to obtain the antibacterial coating solution, which can be dispensed into sterile syringes.

[0052] Example 4: This example provides an antibacterial material and antibacterial coating solution for root canal treatment based on fluorotitanium oxide. The preparation method includes the following steps:

[0053] S1. Add 3.4g tetrabutyl titanate and 0.017g ammonium fluoride (0.5wt%) to 40mL anhydrous ethanol and stir magnetically for 30min. Add acetic acid dropwise to adjust the pH to 3 to form a transparent sol.

[0054] S2. Transfer the above sol to a polytetrafluoroethylene reactor and heat it to 180°C for 12 hours to obtain the product.

[0055] S3. The above product is centrifuged (8000 rpm, 12 min), and the precipitate is washed three times with deionized water. Then it is vacuum dried at 60°C for 12 h to obtain fluorotitanium oxide nanoparticles, which are antibacterial materials.

[0056] S4. Take 2.5g of fluorotitanium oxide nanoparticles, 1g of hydroxyethyl cellulose, 2.5g of glycerol, and 44g of deionized water, mix them, and ultrasonically disperse them for 30min. Then, autoclave them at 121℃ for 20min to obtain the antibacterial coating solution, which can be dispensed into sterile syringes.

[0057] Example 5: This example provides an antibacterial material and antibacterial coating solution for root canal treatment based on fluorotitanium oxide. The preparation method includes the following steps:

[0058] S1. Add 3.4g tetrabutyl titanate and 0.068g ammonium fluoride to 30mL anhydrous ethanol and stir magnetically for 20min. Then add acetic acid dropwise to adjust the pH to 2.5 to form a transparent sol.

[0059] S2. Transfer the above sol to a polytetrafluoroethylene reactor and heat it to 170°C for 10 hours to obtain the product.

[0060] S3. After centrifuging the above product (6000 rpm, 5 min) and washing the precipitate three times with deionized water, the product is then vacuum dried at 50°C for 10 h to obtain fluorotitanium oxide nanoparticles, which are antibacterial materials.

[0061] S4. Take 2.5g of fluorotitanium oxide nanoparticles, 0.5g of hydroxyethyl cellulose, 1.5g of glycerol, and 40g of deionized water, mix them, and ultrasonically disperse them for 30min. Then, autoclave them at 121℃ for 20min to obtain the antibacterial coating solution, which can be dispensed into sterile syringes.

[0062] Example 6: This example provides an antibacterial material and antibacterial coating solution for root canal treatment based on fluorotitanium oxide. The preparation method includes the following steps:

[0063] S1. Add 3.4g tetrabutyl titanate and 0.102g ammonium fluoride to 50mL anhydrous ethanol and stir magnetically for 40min. Then add acetic acid dropwise to adjust the pH to 3.5 to form a transparent sol.

[0064] S2. Transfer the above sol to a polytetrafluoroethylene reactor and heat it to 190°C for 14 hours to obtain the product;

[0065] S3. After centrifuging the above product (10000 rpm, 15 min) and washing the precipitate three times with deionized water, vacuum dry it at 70°C for 14 h to obtain fluorotitanium oxide nanoparticles, which are antibacterial materials.

[0066] S4. Take 2.5g of fluorotitanium oxide nanoparticles, 0.75g of hydroxyethyl cellulose, 1.75g ​​of glycerol, and 22.75g of deionized water, mix them, and ultrasonically disperse them for 30min. Then, autoclave them at 121℃ for 20min to obtain the antibacterial coating solution, which can be dispensed into sterile syringes.

[0067] Example 7: This example provides an antibacterial material and antibacterial coating solution for root canal treatment based on fluorotitanium oxide. The preparation method includes the following steps:

[0068] S1. Add 3.4g tetrabutyl titanate and 0.17g ammonium fluoride to 40mL anhydrous ethanol and stir magnetically for 30min. Add acetic acid dropwise to adjust the pH to 3 to form a transparent sol.

[0069] S2. Transfer the above sol to a polytetrafluoroethylene reactor and heat it to 180°C for 12 hours to obtain the product.

[0070] S3. The above product is centrifuged (8000 rpm, 12 min), and the precipitate is washed three times with deionized water. Then it is vacuum dried at 60°C for 12 h to obtain fluorotitanium oxide nanoparticles, which are antibacterial materials.

[0071] S4. Take 3g of fluorotitanium oxide nanoparticles, 1g of hydroxyethyl cellulose, 2g of glycerol, and 44g of deionized water, mix them, and ultrasonically disperse them for 30min. Then, autoclave them at 121℃ for 20min to obtain the antibacterial coating solution, which can be dispensed into sterile syringes.

[0072] Comparative Example 1: This comparative example provides undoped titanium oxide nanoparticles, the preparation method of which includes the following steps:

[0073] S1. Add 3.4g of tetrabutyl titanate to 40mL of anhydrous ethanol and stir magnetically for 30min. Then add acetic acid to adjust the pH to 3 to form a transparent sol.

[0074] S2. Transfer the above sol to a polytetrafluoroethylene reactor and heat it to 180°C for 12 hours to obtain the product.

[0075] S3. After centrifuging the above product (8000 rpm, 12 min) and washing the precipitate three times with deionized water, vacuum dry it at 60°C for 12 h to obtain undoped titanium oxide nanoparticles.

[0076] Experimental Example: I. Verification of the antibacterial effect of an in vitro biofilm model:

[0077] 1. Biofilm model construction: 2 mL of Enterococcus faecalis was inoculated into isolated root canals (ATCC 19433, 10). 8 CFU / mL), anaerobic culture for 21 days;

[0078] 2. Treatment groups: The fluorotitanium oxygen experimental group was injected with 0.05 mL of the 5 wt% antibacterial coating solution prepared in Example 1; the control group consisted of four groups, each injected with 0.05 mL of 5 wt% sodium hypochlorite solution, 20 wt% calcium hydroxide paste, 15 wt% EDTA lubricant, and physiological saline, respectively.

[0079] 3. Experimental results are as follows Figure 3 As shown in Table 1: the CFU count in the fluorine-titanium-oxygen experimental group decreased by 99.2% (SEM showed complete detachment of the biofilm, as detailed in Table 1). Figure 3(As shown), lasting for 7 days or more. In the control group, the CFU count decreased by 92% in the sodium hypochlorite group, lasting for less than 1 hour; the CFU count decreased by 40% in the calcium hydroxide paste group, lasting for less than 24 hours; the CFU count decreased by 92% in the EDTA lubricant group, lasting for less than 1 hour; and the CFU count in the saline group did not decrease, and there was no duration of antibacterial activity.

[0080] Table 1

[0081] Material Antibacterial rate Duration of action Dentin damage Cytotoxicity Sodium hypochlorite solution (5wt%) 92% ≤1h Small tube collapse high Calcium hydroxide paste (20wt%) 40% ≤24h none Low EDTA lubricant (15wt%) 92% ≤1h Small tube collapse high physiological saline – – none none Antibacterial coating solution (5wt%) 99.2% ≥7d none none

[0082] II. Verification of dentin damage:

[0083] 1. Dentin damage test method:

[0084] Sample preparation was as follows: Healthy extracted premolars (n=12) were collected and longitudinally split in half along the buccal-lingual direction to expose the dentin plane; the dentin surface was polished with 600-grit silicon carbide sandpaper to form a standardized smear layer; the samples were randomly divided into 2 groups (12 samples in each group) and treated as follows.

[0085] 2. Treatment groups: These included an antibacterial coating solution treatment group (experimental group) and a sodium hypochlorite solution treatment group (control group). The antibacterial coating solution treatment group was treated with 5wt% antibacterial coating solution prepared in Example 1 for 10 min; the sodium hypochlorite solution treatment group was treated with 5wt% sodium hypochlorite solution prepared in Example 1 for 10 min. The procedure was as follows: Each group of samples was immersed in the corresponding treatment solution (at a constant temperature of 37℃); after treatment, the samples were rinsed three times with deionized water and fixed with glutaraldehyde for 24 h; then dehydrated in a gradient manner (ethanol concentration 30%-100%), sputter-coated with gold, and observed by scanning electron microscopy (SEM).

[0086] 3. Experimental results are as follows Figure 4 As shown: the dentinal tubules in the antibacterial coating group were intact, while the dentinal tubules in the sodium hypochlorite solution treatment group collapsed.

[0087] III. Verification of Infrared Absorption Characteristics:

[0088] 1. FTIR test sample preparation: Take 15 μg each of the fluorinated titanium oxide nanoparticles prepared in Examples 1-4 and the undoped titanium oxide nanoparticles prepared in Comparative Example 1, and press them into tablets with 200 μg of potassium bromide to obtain samples.

[0089] 2. Perform FTIR testing on the sample, and the results are as follows: Figure 5 As shown: The fluorinated titanium oxide nanoparticles prepared in Example 1 of the present invention have an absorption peak intensity at 9.35 μm that is 72 times that of the undoped titanium oxide nanoparticles.

[0090] In summary, the antibacterial materials and antibacterial coating solutions provided in the embodiments of the present invention have the following advantages:

[0091] 1. Long-lasting effect: The infrared radiation from the human body provides continuous energy, maintaining the antibacterial field for more than 7 days;

[0092] 2. Safety: Because there is no ion release, it does not damage dentinal tubules and has no cytotoxicity;

[0093] 3. Convenience: Avoids the formation of carbonates from calcium hydroxide paste, which are difficult to clean, and is a single-component alternative to the two-step rinsing process of sodium hypochlorite + EDTA.

[0094] Based on the above-described preferred embodiments of the present invention, and through the foregoing description, those skilled in the art can make various changes and modifications without departing from the inventive concept. The technical scope of this invention is not limited to the contents of the specification.

Claims

1. A fluorotitanium oxide-based antibacterial material for root canal treatment, characterized in that, The nanoparticles are fluorine-doped titanium oxides; the nanoparticles are fluorine-doped titanium oxides; the nanoparticles can absorb infrared radiation from the human body and generate surface electromagnetic oscillations, thereby destroying the bacterial membrane structure through charge polarization.

2. The antibacterial material for root canal treatment based on fluorotitanium oxide according to claim 1, characterized in that, The fluorinated titanium oxide nanoparticles were prepared by a solvothermal reaction of tetrabutyl titanate and ammonium fluoride.

3. The antibacterial material for root canal treatment based on fluorotitanium oxide according to claim 2, characterized in that, The amount of ammonium fluoride used is 0.5wt%-5wt% of tetrabutyl titanate, used to optimize the infrared absorption efficiency in the 9.35μm band.

4. The antibacterial material for root canal treatment based on fluorotitanium oxide according to claim 1 or 2, characterized in that, The particle size of the fluorotitanium oxide nanoparticles is 50-100 nm.

5. A method for preparing a fluorotitanium oxide-based antibacterial material for root canal treatment as described in any one of claims 1-4, characterized in that, Includes the following steps: Tetrabutyl titanate and ammonium fluoride were added to a solvent and stirred, and the pH was adjusted to 2.5-3.5 to form a sol. The sol was heated to 170-190℃ to react and the product was obtained. The product was centrifuged and washed, and then vacuum dried to obtain the antibacterial material.

6. The method for preparing the fluorotitanium oxide-based antibacterial material for root canal treatment according to claim 5, characterized in that, The solvent is ethanol.

7. The method for preparing the fluorotitanium oxide-based antibacterial material for root canal treatment according to claim 5, characterized in that, Acetic acid was used to adjust the pH.

8. The method for preparing the antibacterial material for root canal treatment based on fluorotitanium oxide according to claim 5, characterized in that, The temperature for vacuum drying is 50-70℃.

9. The use of a fluorotitanium oxide-based antibacterial material for root canal treatment as described in any one of claims 1-4 in the preparation of an antibacterial coating solution for root canal treatment.

10. An antibacterial coating solution for root canal treatment, characterized in that, It comprises the following components by weight percentage: 5%-10% of the fluorotitanium oxide-based antibacterial material for root canal treatment according to any one of claims 1-4, 1%-3% of hydroxyethyl cellulose, 3%-7% of glycerin, and the balance being deionized water.

Images