An antibacterial anti-inflammatory and antipruritic traditional Chinese medicine composition, a preparation method and application thereof

Abstract

The application relates to the technical field of traditional Chinese medicine, and provides an antibacterial anti-inflammatory and antipruritic traditional Chinese medicine composition as well as a preparation method and application thereof. The traditional Chinese medicine composition is mainly prepared from the following weight parts of traditional Chinese medicinal materials: 8-12 parts of grass red vine; 3-6 parts of parsnip; 4-6 parts of houttuynia cordata; 9-11 parts of honeysuckle; 0.8-1.2 parts of purple grass; 0.6-0.9 parts of xuchangqing; 1.5-3.5 parts of cicada shell; and 1.5-2.5 parts of broad dried tangerine or orange peel. Coldness is mainly used, and pungent-warm herbs are used to regulate qi, so that the compatibility characteristics of 'clearness without condensation and dispersion without consumption' are formed.

Description

[0001] A traditional Chinese medicine composition with antibacterial, anti-inflammatory, and antipruritic properties, its preparation method, and its application. Technical Field

[0002] This application belongs to the field of traditional Chinese medicine technology, and in particular relates to a traditional Chinese medicine composition with antibacterial, anti-inflammatory and antipruritic properties, its preparation method and application. Background Technology

[0003] As people's living standards improve, their dietary habits are also changing, and skin condition is affected by the surrounding environment and dietary habits. Acne-prone skin is becoming increasingly common, causing distress for many. Summary of the Invention

[0004] The purpose of this application is to provide a traditional Chinese medicine composition with antibacterial, anti-inflammatory and antipruritic properties, its preparation method and application, aiming to solve the life problems caused by acne-prone skin.

[0005] To achieve the above-mentioned objectives, the technical solution adopted in this application is as follows: In the first aspect, this application provides a traditional Chinese medicine composition for antibacterial, anti-inflammatory and antipruritic purposes, mainly made from the following traditional Chinese medicinal materials in parts by weight: 8-12 parts of *Caulis Scutellariae*; 3-6 parts of *Herba Patriniae*; 4-6 parts of *Herba Houttuyniae*; 9-11 parts of *Flos Lonicerae*; 0.8-1.2 parts of *Radix Lithospermi*; 0.6-0.9 parts of *Radix Cynanchi*; 1.5-3.5 parts of *Fructus Cicadae*; and 1.5-2.5 parts of *Pericarpium Citri Reticulatae*.

[0006] As a preferred embodiment, the traditional Chinese medicine composition is mainly made from the following traditional Chinese medicinal materials in parts by weight: 8-10 parts of *Smilax glabra*; 3-5 parts of *Patrinia scabiosifolia*; 4-5 parts of *Houttuynia cordata*; 9-10 parts of honeysuckle; 0.8-1 part of *Lithospermum erythrorhizon*; 0.6-0.8 parts of *Cynanchum paniculatum*; 1.5-3 parts of cicada slough; and 1.5-2 parts of dried tangerine peel.

[0007] As a more preferred method, the traditional Chinese medicine composition is mainly made from the following traditional Chinese medicinal materials in parts by weight: 10 parts of *Caulis Scutellariae*; 5 parts of *Patrinia scabiosifolia*; 5 parts of *Houttuynia cordata*; 10 parts of *Lonicera japonica*; 1 part of *Lithospermum erythrorhizon*; 0.8 parts of *Cynanchum paniculatum*; 3 parts of *Cicada slough*; and 2 parts of *Citrus reticulata*.

[0008] Secondly, this application provides a method for preparing an antibacterial, anti-inflammatory, and antipruritic traditional Chinese medicine composition, comprising the following steps: Mix together herbs such as *Caulis Amaranthus praecox*, *Houttuynia cordata*, honeysuckle, *Radix Lithospermum*, *Cynanchum paniculatum*, cicada slough, and dried tangerine peel, then soak and simmer in water.

[0009] One possible method is to soak for 20 to 25 minutes.

[0010] One possible method is to simmer for 25 to 30 minutes.

[0011] The beneficial effects of this invention are as follows: I. Principal Drug (Leading Drug, targeting the primary disease / symptom) 1. Red vine Functions: Clears heat and detoxifies, promotes blood circulation and reduces swelling Position: It has the largest dosage and is used to target the core pathogenesis of heat toxicity stagnation, carbuncles, sores, and other similar conditions.

[0012] 2. Honeysuckle Functions: Clears heat and detoxifies, disperses wind-heat Status: Together with *Caulis Scutellariae*, it serves as the principal herb, enhancing the ability to clear heat and detoxify, and is particularly adept at dissipating heat through the skin.

[0013] II. Assistant herbs (those that assist the principal herbs and enhance their therapeutic effect) 1. Patrinia scabiosifolia Functions: Clears heat and detoxifies, drains pus and breaks up blood stasis, assists the principal drug in eliminating carbuncles and dissipating nodules.

[0014] 2. Houttuynia cordata Functions: Clears heat and promotes diuresis, detoxifies and reduces swelling, with a focus on clearing damp-heat in the lungs and lower abdomen.

[0015] Synergistic effect: The two herbs assist the principal herb in eliminating heat and toxins, enhancing the therapeutic effect through different pathways of the three jiaos (upper jiao lung, middle and lower jiao damp heat).

[0016] III. Adjuvant drugs (to treat secondary symptoms or mitigate side effects) 1. Lithospermum Functions: Cools the blood and promotes blood circulation, detoxifies and promotes rash eruption, targeting rashes and eczema caused by heat entering the blood.

[0017] 2. Xu Changqing Functions: dispels wind and relieves pain, invigorates blood and detoxifies, and helps relieve pain or itching caused by heat toxicity.

[0018] 3. Cicada skin Functions: Disperses wind-heat, soothes the throat and promotes rash eruption; it has a light and upward-moving effect, helping honeysuckle to expel pathogens from the surface.

[0019] 4. Guangchenpi (dried tangerine peel) Functions: Regulates Qi and strengthens the spleen, dries dampness and resolves phlegm, counteracts the stomach irritation caused by cold and cooling medicines, and prevents stagnation of Qi.

[0020] IV. Guiding herbs (or harmonizing other herbs) Guangchenpi (dried tangerine peel) also serves as an adjuvant: its pungent and aromatic properties can guide other medicines into the spleen and stomach, harmonize the cold and cooling properties of other medicines, and prevent damage to the yang qi of the middle jiao (middle burner).

[0021] Cicada slough: It also has the function of guiding medicine upwards to the head, face, and throat.

[0022] V. Synergistic Mechanism 1. Primarily focused on clearing heat and detoxifying: The principal herbs (Caulis Spatholobi and Lonicera japonica) and the assistant herbs (Herba Patriniae and Herba Houttuyniae) form a core heat-clearing and detoxifying network, covering heat toxins in the Qi and Blood levels.

[0023] 2. Emphasizing both blood circulation and surface penetration: Purple gromwell and Cynanchum paniculatum promote blood circulation and prevent stagnation, while cicada slough and honeysuckle expel pathogens and prevent internal heat toxins from accumulating.

[0024] 3. Protect the spleen and stomach's Qi mechanism: Guangchenpi (dried tangerine peel) regulates qi and strengthens the spleen, harmonizing the stimulation of the gastrointestinal tract by a large amount of cold and cooling medicines, ensuring the long-lasting absorption of the medicine's effects.

[0025] 4. Multi-target synergy: The upper burner (cicada slough, houttuynia cordata), middle burner (dried tangerine peel), and lower burner (patrinia scabiosaefolia) are used to eliminate pathogenic factors; pathogenic factors are expelled through multiple pathways such as expelling pathogens from the surface, promoting diuresis, and activating blood circulation.

[0026] The formula is mainly based on cold and cooling properties, supplemented with pungent and warm properties to regulate qi, forming a formula that is "clear without stagnation and dispersing without depletion". Detailed Implementation

[0027] To make the technical problems, technical solutions, and beneficial effects of this application clearer, the following detailed description is provided in conjunction with embodiments. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the scope of this application.

[0028] In this application, the term "and / or" describes the relationship between related objects, indicating that three relationships can exist. For example, A and / or B can represent: A existing alone, A and B existing simultaneously, or B existing alone. A and B can be singular or plural. The character " / " generally indicates that the preceding and following related objects have an "or" relationship.

[0029] It should be understood that in the various embodiments of this application, the order of the above processes does not imply the order of execution. Some or all steps may be executed in parallel or sequentially. The execution order of each process should be determined by its function and internal logic, and should not constitute any limitation on the implementation process of the embodiments of this application.

[0030] The terminology used in the embodiments of this application is for the purpose of describing particular embodiments only and is not intended to be limiting of this application. The singular forms “a,” “the,” and “the” used in the embodiments of this application and the appended claims are also intended to include the plural forms unless the context clearly indicates otherwise.

[0031] The weights of the relevant components mentioned in the embodiments of this application can refer not only to the specific content of each component, but also to the proportional relationship between the weights of the components. Therefore, any scaling up or down of the content of the relevant components according to the embodiments of this application is within the scope disclosed in the embodiments of this application. Specifically, the mass described in the embodiments of this application can be a well-known unit of mass in the chemical industry, such as µg, mg, g, or kg.

[0032] The following description is based on specific embodiments.

[0033] Example 1 This embodiment discloses a traditional Chinese medicine composition for antibacterial, anti-inflammatory and antipruritic purposes, which is made from the following traditional Chinese medicinal materials in parts by weight: 8 parts of *Caulis Scutellariae*; 3 parts of *Herba Patriniae*; 4 parts of *Herba Houttuyniae*; 9 parts of *Flos Lonicerae*; 0.8 parts of *Radix Lithospermi*; 0.6 parts of *Radix Cynanchi*; 1.5 parts of *Periostracum Cicadae*; and 1.5 parts of *Pericarpium Citri Reticulatae*.

[0034] This embodiment also discloses a method for preparing an antibacterial, anti-inflammatory, and antipruritic traditional Chinese medicine composition, including the following steps: Mix together the following herbs: *Caulis Amaranthus praecox*, *Houttuynia cordata*, honeysuckle, *Radix Lithospermum*, *Radix Cynanchi*, cicada slough, and dried tangerine peel. Add water and soak and simmer for 20 minutes and 25 minutes respectively.

[0035] Example 2 This embodiment discloses a traditional Chinese medicine composition for antibacterial, anti-inflammatory and antipruritic purposes, which is made from the following traditional Chinese medicinal materials in parts by weight: 12 parts of *Caulis Scutellariae*; 6 parts of *Herba Patriniae*; 6 parts of *Herba Houttuyniae*; 11 parts of *Flos Lonicerae*; 1.2 parts of *Radix Lithospermi*; 0.9 parts of *Radix Cynanchi*; 3.5 parts of *Periostracum Cicadae*; and 2.5 parts of *Pericarpium Citri Reticulatae*.

[0036] This embodiment also discloses a method for preparing an antibacterial, anti-inflammatory, and antipruritic traditional Chinese medicine composition, including the following steps: Mix together the following herbs: *Caulis Amaranthus praecox*, *Caulis Patriniae*, *Houttuynia cordata*, honeysuckle, *Radix Lithospermum*, *Radix Cynanchi*, cicada slough, and dried tangerine peel. Add water and soak and simmer for 25 minutes and 30 minutes respectively.

[0037] Example 3 This embodiment discloses a traditional Chinese medicine composition with antibacterial, anti-inflammatory and antipruritic properties, which is made from the following traditional Chinese medicinal materials in parts by weight: 10 parts of *Caulis Scutellariae*; 5 parts of *Herba Patriniae*; 5 parts of *Herba Houttuyniae*; 10 parts of *Flos Lonicerae*; 1 part of *Radix Lithospermi*; 0.8 parts of *Radix Cynanchi*; 3 parts of *Periostracum Cicadae*; and 2 parts of *Pericarpium Citri Reticulatae*.

[0038] This embodiment also discloses a method for preparing an antibacterial, anti-inflammatory, and antipruritic traditional Chinese medicine composition, including the following steps: Mix together the following herbs: *Caulis Amaranthus praecox*, *Caulis Patriniae*, *Houttuynia cordata*, honeysuckle, *Radix Lithospermum*, *Radix Cynanchi*, cicada slough, and dried tangerine peel. Add water and soak and simmer for 23 minutes and 28 minutes respectively.

[0039] Comparative Example 1 Compared with Example 1, the differences are as follows: A traditional Chinese medicine composition is made from the following traditional Chinese medicinal materials in parts by weight: Patrinia scabiosifolia 3 parts; Houttuynia cordata 4 parts; Lonicera japonica 9 parts; Lithospermum erythrorhizon 0.8 parts; Cynanchum paniculatum 0.6 parts; Cicadae periostracum 1.5 parts; Citrus reticulata 1.5 parts.

[0040] Comparative Example 2 The differences compared to Example 1 are as follows: A traditional Chinese medicine composition is made from the following traditional Chinese medicinal materials in parts by weight: 8 parts of *Smilax glabra*; 4 parts of *Houttuynia cordata*; 9 parts of honeysuckle; 0.8 parts of *Lithospermum erythrorhizon*; 0.6 parts of *Cynanchum paniculatum*; 1.5 parts of cicada slough; and 1.5 parts of dried tangerine peel.

[0041] Comparative Example 3 The differences compared to Example 1 are as follows: A traditional Chinese medicine composition is made from the following traditional Chinese medicinal materials in parts by weight: 8 parts of *Caulis Scutellariae*; 3 parts of *Herba Patriniae*; 9 parts of *Flos Lonicerae*; 0.8 parts of *Radix Lithospermi*; 0.6 parts of *Radix Cynanchi*; 1.5 parts of *Periostracum Cicadae*; and 1.5 parts of *Pericarpium Citri Reticulatae*.

[0042] Comparative Example 4 The differences compared to Example 1 are as follows: A traditional Chinese medicine composition is made from the following traditional Chinese medicinal materials in parts by weight: 8 parts of *Caulis Scutellariae*; 3 parts of *Herba Patriniae*; 4 parts of *Herba Houttuyniae*; 0.8 parts of *Radix Lithospermi*; 0.6 parts of *Radix Cynanchi*; 1.5 parts of *Periostracum Cicadae*; and 1.5 parts of *Pericarpium Citri Reticulatae*.

[0043] Comparative Example 5 The differences compared to Example 1 are as follows: A traditional Chinese medicine composition is made from the following traditional Chinese medicinal materials in parts by weight: 8 parts of *Caulis Scutellariae*; 3 parts of *Herba Patriniae*; 4 parts of *Herba Houttuyniae*; 9 parts of *Flos Lonicerae*; 0.6 parts of *Radix Cynanchi*; 1.5 parts of *Periostracum Cicadae*; and 1.5 parts of *Pericarpium Citri Reticulatae*.

[0044] Comparative Example 6 The differences compared to Example 1 are as follows: A traditional Chinese medicine composition is made from the following traditional Chinese medicinal materials in parts by weight: 8 parts of *Smilax glabra*; 3 parts of *Patrinia scabiosifolia*; 4 parts of *Houttuynia cordata*; 9 parts of honeysuckle; 0.8 parts of *Lithospermum erythrorhizon*; 1.5 parts of cicada slough; and 1.5 parts of dried tangerine peel.

[0045] Comparative Example 7 The differences compared to Example 1 are as follows: A traditional Chinese medicine composition is made from the following traditional Chinese medicinal materials in parts by weight: 8 parts of *Caulis Scutellariae*; 3 parts of *Herba Patriniae*; 4 parts of *Herba Houttuyniae*; 9 parts of *Flos Lonicerae*; 0.8 parts of *Radix Lithospermi*; 0.6 parts of *Radix Cynanchi*; and 1.5 parts of *Pericarpium Citri Reticulatae*.

[0046] Comparative Example 8 The differences compared to Example 1 are as follows: A traditional Chinese medicine composition is made from the following traditional Chinese medicinal materials in parts by weight: 8 parts of *Caulis Scutellariae*; 3 parts of *Herba Patriniae*; 4 parts of *Herba Houttuyniae*; 9 parts of *Flos Lonicerae*; 0.8 parts of *Radix Lithospermi*; 0.6 parts of *Radix Cynanchi*; and 1.5 parts of *Fructus Cicadae*.

[0047] 220 patients with facial acne were recruited and divided into 11 groups, each using the traditional Chinese medicine compositions of Examples 1-3 and Comparative Examples 1-8 respectively.

[0048] The main symptoms of acne are: raised lesions on the face that are not broken, redness, swelling and pain, or scabs that have formed but are still red and painful around the scabs.

[0049] Each group of patients drank 150 ml three times a day, morning, noon and evening, for one month as one course of treatment. The results are shown in Table 1.

[0050] Table 1

[0051] Note: The effectiveness of the plaster is mainly determined by the degree of pain and the area of ​​redness and swelling. The percentages in Table 1 are obtained by comparing the situation with the condition before treatment.

[0052] The above description is merely a preferred embodiment of this application and is not intended to limit this application. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of this application should be included within the protection scope of this application.

Claims

1. A traditional Chinese medicine composition with antibacterial, anti-inflammatory, and antipruritic properties, characterized in that, The traditional Chinese medicine composition is mainly made from the following traditional Chinese medicinal materials in parts by weight: 8-12 parts of *Smilax glabra*; 3-6 parts of *Patrinia scabiosifolia*; 4-6 parts of *Houttuynia cordata*; 9-11 parts of *Lonicera japonica*; and 0.8-1.2 parts of *Lithospermum erythrorhizon*. Xu Changqing 0.6~0.9 parts; Cicada slough 1.5~3.5 parts; Guangchenpi 1.5~2.5 parts.

2. The antibacterial, anti-inflammatory, and antipruritic traditional Chinese medicine composition according to claim 1, characterized in that, The traditional Chinese medicine composition is mainly made from the following traditional Chinese medicinal materials in parts by weight: 8-10 parts of *Caulis Scutellariae*; 3-5 parts of *Herba Patriniae*; 4-5 parts of *Herba Houttuyniae*; 9-10 parts of *Flos Lonicerae*; and 0.8-1 part of *Radix Lithospermi*. Xu Changqing 0.6~0.8 parts; Cicada slough 1.5~3 parts; Guangchenpi 1.5~2 parts.

3. The antibacterial, anti-inflammatory, and antipruritic traditional Chinese medicine composition according to claim 1, characterized in that, The traditional Chinese medicine composition is mainly made from the following traditional Chinese medicinal materials in parts by weight: 10 parts of *Caulis Scutellariae*; 5 parts of *Herba Patriniae*; 5 parts of *Herba Houttuyniae*; 10 parts of *Flos Lonicerae*; 1 part of *Radix Lithospermi*; 0.8 parts of *Radix Cynanchi*; 3 parts of *Periostracum Cicadae*; and 2 parts of *Pericarpium Citri Reticulatae*.

4. A method for preparing the antibacterial, anti-inflammatory, and antipruritic traditional Chinese medicine composition according to any one of claims 1-3, characterized in that, The manufacturing method includes the following steps: Mix together herbs such as *Caulis Amaranthus praecox*, *Houttuynia cordata*, honeysuckle, *Radix Lithospermum*, *Cynanchum paniculatum*, cicada slough, and dried tangerine peel, then soak and simmer in water.

5. The method for preparing the antibacterial, anti-inflammatory, and antipruritic traditional Chinese medicine composition according to claim 4, characterized in that, Soaking time is 20-25 minutes.

6. The method for preparing the antibacterial, anti-inflammatory, and antipruritic traditional Chinese medicine composition according to claim 4, characterized in that, The cooking time is 25-30 minutes.

7. An acne treatment drug, characterized in that, The acne-removing drug is the antibacterial, anti-inflammatory, and antipruritic traditional Chinese medicine composition according to any one of claims 1-3.

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