A ternary micro-nano copolymer salt, a preparation method and application thereof
The ternary micro-nano copolymer salts prepared by the invention solve the problems of thinning and graying hair, achieving safe and effective hair growth and dyeing effects, and avoiding the health risks of chemical hair dyeing.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- NANNING ZAIXIAN BIOTECHNOLOGY CO LTD
- Filing Date
- 2026-02-11
- Publication Date
- 2026-05-29
Smart Images
Figure CN122103224A_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the fields of hair growth and hair dyeing technology, and in particular to a ternary micro / nano copolymer salt, its preparation method, and its application. Background Technology
[0002] Graying hair and thinning hair due to hair loss are common phenomena among middle-aged and elderly people. At the same time, due to various reasons, the phenomenon of graying hair and hair loss is becoming increasingly common among younger people, with many young adults also experiencing these issues.
[0003] To address the aforementioned hair loss problems, researchers have developed various hair regrowth methods, such as topical medications, oral medications, biotechnology, and surgical transplantation. However, these methods generally suffer from delayed effects, significant individual variability, high costs, or unverified safety profiles. More importantly, existing hair regrowth methods do not have the effect of dyeing hair black, and therefore cannot solve the problem of graying hair in middle-aged and elderly people and young people.
[0004] To address the issue of graying hair, people often resort to hair dyeing. While hair dyeing has become a common way to change one's appearance, it primarily relies on chemical dyes. The core principle is to open the hair cuticle with chemicals and allow pigment to deposit. However, this process carries significant health risks, specifically the harmful effects of the chemicals and allergic reactions. Furthermore, current hair dyeing methods do not promote hair growth and cannot solve the problem of thinning hair.
[0005] In conclusion, existing hair regrowth and dyeing methods can only solve the problem of dyeing hair to blacken it or the problem of hair loss, and they bring many new problems. Moreover, they cannot solve both of these problems at the same time. Summary of the Invention
[0006] In view of this, the present invention provides a ternary micro-nano copolymer salt, its preparation method and application. The ternary micro-nano copolymer salt provided by the present invention has the functions of dyeing and blackening hair and promoting hair growth.
[0007] The present invention provides a ternary micro / nano copolymer salt comprising tannic acid, p-phenylenediamine linked to the tannic acid via a Schiff base reaction, and salicylic acid linked to the p-phenylenediamine via a Schiff base reaction.
[0008] Preferably, the individual molecule size of the ternary micro / nano copolymer salt is 3.5~4.3 nanometers.
[0009] This invention also provides a method for preparing the ternary micro / nano copolymer salt described above, comprising the following steps: (1) Tannic acid and p-phenylenediamine are mixed and subjected to a first Schiff base reaction to obtain p-phenylenediamine tannic acid salt; (2) The tannic acid p-phenylenediamine salt and salicylic acid are mixed and subjected to a second Schiff base reaction to obtain the ternary micro-nano copolymer salt.
[0010] Preferably, the mass ratio of tannic acid to p-phenylenediamine is 0.8~1.2:1; the mass ratio of tannic acid to salicylic acid is 0.8~1.2:1.
[0011] Preferably, the temperature of the first Schiff base reaction is 80-85 degrees Celsius, and the holding time is 30-60 minutes; the first Schiff base reaction is carried out under stirring conditions; the first Schiff base reaction is carried out under solvent conditions.
[0012] Preferably, the temperature of the second Schiff base reaction is 80-85 degrees Celsius, and the holding time is 30-60 minutes; the second Schiff base reaction is carried out under stirring conditions; the second Schiff base reaction is carried out under solvent conditions.
[0013] The present invention also provides the application of the ternary micro-nano copolymer salt described in the above-described scheme or the ternary micro-nano copolymer salt obtained by the preparation method described in the above-described scheme in the preparation of hair growth products, hair dyeing products or hair growth and hair dyeing products.
[0014] The present invention also provides a hair growth and blackening liquid, comprising the following raw materials in parts by weight: 1-3 parts of ternary micro-nano copolymer salt, 0.3-0.5 parts of hair extract, 0.5-1.5 parts of alkalinity regulator, 15-25 parts of ethanol, and 65-78 parts of water; wherein the ternary micro-nano copolymer salt is the ternary micro-nano copolymer salt described in the above scheme or the ternary micro-nano copolymer salt obtained by the preparation method described in the above scheme; wherein the hair extract comprises tyrosine, cystine, and tryptophan.
[0015] Preferably, the total mass fraction of the components in the hair growth and blackening liquid is 100 parts.
[0016] This invention also provides a method for preparing the hair growth and blackening liquid described above, comprising the following steps: (1) Hair, sodium hydroxide and water were mixed and boiled, acidified and precipitated and then separated into solid and liquid to obtain hair extract; (2) The hair extract is mixed with ternary micro-nano copolymer salt, alkaline regulator, water and ethanol to obtain the hair growth and blackening liquid.
[0017] This invention provides a ternary micro / nano copolymer salt. The ternary micro / nano copolymer salt provided by this invention is a micro / nano copolymer salt of tannic acid, p-phenylenediamine, and salicylic acid, possessing both hair dyeing / darkening and hair growth functions. The main principles involved are as follows: (1) The reaction principle that the mixture of ternary micro-nano copolymer salts appears dark black: Under alkaline conditions, the ternary copolymer salt molecules of the present invention contain multiple conjugated benzene rings, forming extra-large conjugated π bonds. These extra-large conjugated π bond molecules containing benzene rings appear black under alkaline conditions.
[0018] (2) Hair growth principle: Ternary micro-nano copolymer salt and hair extract can be transferred to hair follicles through diffusion movement, providing nutrients for hair growth and thus promoting the growth of new hair.
[0019] (3) Hair-darkening principle: The ternary micro-nano copolymer salt molecules contain active hydrogen ions, thus exhibiting a certain positive charge. This positive charge gives it a strong adsorption force on the negatively charged hair, allowing it to adhere firmly to the hair surface. Simultaneously, under the action of an alkaline aqueous solution, the ternary micro-nano copolymer salt appears black, thus enabling it to dye and blacken hair. Furthermore, the ternary micro-nano copolymer salt provided by this invention can diffuse from the surface of the hair into the hair shaft and hair follicle. This diffusion keeps the newly grown hair roots black for a certain period, achieving the effect of turning white hair black.
[0020] This invention also provides a method for preparing the ternary micro / nano copolymer salt described above. The preparation method provided by this invention is simple in steps, convenient in operation, safe, and highly stable.
[0021] This invention also provides the application of the ternary micro-nano copolymer salt described in the above-described scheme or the ternary micro-nano copolymer salt obtained by the preparation method described in the above-described scheme in the preparation of hair growth products, hair dyeing products, or hair growth and hair dyeing products. The ternary micro-nano copolymer salt provided by this invention has both hair dyeing and hair-darkening functions, which can well meet the needs of hair growth and hair dyeing, and is suitable for use in hair growth agents, hair dyes, and hair growth and hair dyeing products.
[0022] This invention also provides a hair growth and blackening liquid, comprising the ternary micro-nano copolymer salt described in the above-described scheme or the ternary micro-nano copolymer salt obtained by the preparation method described in the above-described scheme. The hair growth and blackening liquid provided by this invention is deep black and simultaneously possesses both hair growth and blackening functions, thereby promoting new hair growth and, within a certain period of time, turning previously dyed white hair sections black while keeping newly grown hair roots black, achieving a white-to-black effect. Compared with existing hair dyes, this invention uses a ternary micro-nano copolymer salt to replace free p-phenylenediamine, greatly reducing the content of free p-phenylenediamine in the product, thus reducing the chemical hazards during the hair care process. This invention uses salicylic acid biomass raw material with anti-allergic properties, which can greatly reduce the probability of allergic reactions. The hair growth and blackening liquid provided by this invention does not use oxidants, avoiding damage to hair caused by oxidants.
[0023] The hair growth and blackening liquid provided by this invention was tested in 20 cases. The test results showed that: 1) it had a significant hair dyeing and blackening effect in 20 cases, with an effectiveness rate of 100%; 2) the hair roots did not turn white within 15 days and remained black or grayish-black in 18 cases, with an effectiveness rate of 90%; 3) new hair growth was found in 12 cases within 30 days, with an effectiveness rate of 60%; 4) new hair growth was found in 17 cases within 60 days, with an effectiveness rate of 85%.
[0024] This invention also provides a method for preparing the hair growth and blackening liquid described in the above-mentioned scheme. This invention uses ternary micro / nano copolymer salt as the base material, hair extract as a nutrient, water and ethanol as solvents, and adds an alkaline regulator to obtain a liquid hair care product that simultaneously promotes hair growth and blackens hair. Attached Figure Description
[0025] To more clearly illustrate the technical solutions of this invention, the accompanying drawings used in the embodiments of this invention or in the prior art are briefly described below. For those skilled in the art, other drawings can be derived from the following drawings without creative effort, and all such drawings are within the protection scope of this invention.
[0026] Figure 1 A process flow diagram for preparing hair growth and blackening liquid provided by the present invention; Figure 2 A schematic diagram of the molecular structure of the ternary micro / nano copolymer salt provided by the present invention; reference numerals: TA is tannic acid molecule, PPDA is p-phenylenediamine molecule, SA is salicylic acid molecule; Figure 3 A physical image of the ternary micro / nano copolymer salt provided by this invention; Figure 4 A photograph of the hair growth and blackening liquid provided by this invention; Detailed Implementation
[0027] The present invention provides a ternary micro / nano copolymer salt comprising tannic acid, p-phenylenediamine linked to the tannic acid via a Schiff base reaction, and salicylic acid linked to the p-phenylenediamine via a Schiff base reaction.
[0028] The structure of the ternary micro / nano copolymer salt provided by this invention is as follows: Figure 2 As shown, the molecular structure of the ternary micro / nano copolymer salt provided by this invention consists of three layers from the inside out: a central layer of tannic acid (molar mass 1701.2 g / mol), a middle layer of grafted p-phenylenediamine (molar mass 108.41 g / mol), and an outer layer of salicylic acid (molar mass 138.0 g / mol) molecules connected to the outer end of the p-phenylenediamine. The molecular weight of the ternary micro / nano copolymer salt provided by this invention varies with the amount of grafted p-phenylenediamine and salicylic acid.
[0029] In this invention, the particle size of a single ternary micro / nano copolymer salt is preferably 3.5–4.3 nanometers, more preferably 3.8–4 nanometers. Multiple ternary micro / nano copolymer salt molecules can aggregate to form larger nano and micron particles.
[0030] This invention also provides a method for preparing the ternary micro / nano copolymer salt described above, comprising the following steps: (1) Tannic acid and p-phenylenediamine are mixed and subjected to a first Schiff base reaction to obtain p-phenylenediamine tannic acid salt; (2) The tannic acid p-phenylenediamine salt and salicylic acid are mixed and subjected to a second Schiff base reaction to obtain the ternary micro-nano copolymer salt.
[0031] In this invention, tannic acid and p-phenylenediamine are mixed (denoted as the first mixture) and subjected to a first Schiff base reaction to obtain p-phenylenediamine tannic acid salt. In this invention, the mass ratio of tannic acid to p-phenylenediamine is preferably 0.8~1.2:1, more preferably 1:1.
[0032] In this invention, the temperature of the first Schiff base reaction is preferably 80-85 degrees Celsius, more preferably 81-84 degrees Celsius, and even more preferably 82-83 degrees Celsius; the holding time is preferably 30-60 minutes, more preferably 40-50 minutes; the first Schiff base reaction is preferably carried out under stirring conditions; the first Schiff base reaction is preferably carried out under solvent conditions; the solvent conditions preferably include water; the solvent conditions preferably also include ethanol.
[0033] In this invention, when the first Schiff base reaction is carried out under solvent conditions, the first mixing preferably includes the following steps: mixing tannic acid and solvent to obtain a tannic acid suspension, and then mixing the tannic acid suspension with an aqueous solution of p-phenylenediamine.
[0034] In this invention, the solid content of the tannic acid suspension is preferably 1-6 wt%; the concentration of the p-phenylenediamine aqueous solution is preferably 1-6 wt%.
[0035] In this invention, the volume ratio of the tannic acid suspension to the p-phenylenediamine aqueous solution is preferably 1:1.
[0036] After obtaining p-phenylenediamine tannic acid salt, the present invention mixes the p-phenylenediamine tannic acid salt and salicylic acid (denoted as the second mixture) and performs a second Schiff base reaction to obtain the ternary micro / nano copolymer salt. In the present invention, the mass ratio of tannic acid to salicylic acid is preferably 0.8~1.2:1, more preferably 1:1.
[0037] In this invention, the temperature of the second Schiff base reaction is preferably 80-85 degrees Celsius, more preferably 81-84 degrees Celsius, and even more preferably 82-83 degrees Celsius; the holding time is preferably 30-60 minutes, more preferably 40-50 minutes; the second Schiff base reaction is preferably carried out under stirring conditions; the second Schiff base reaction is preferably carried out under solvent conditions; the solvent conditions preferably include water; the solvent conditions preferably also include ethanol.
[0038] In this invention, when the second Schiff base reaction is carried out under solvent conditions, the second mixing preferably includes the following steps: mixing the reaction solution obtained from the first Schiff base reaction with a salicylic acid solution.
[0039] In this invention, the concentration of the salicylic acid solution is preferably 1 to 6 wt%.
[0040] In this invention, the volume ratio of the salicylic acid solution to the tannic acid suspension is preferably 1:1.
[0041] In the preparation method provided by this invention, during the reaction of tannic acid and p-phenylenediamine, due to the steric hindrance effect of the tannic acid molecule, only one of the two amino groups at both ends of the p-phenylenediamine molecule can undergo a Schiff base reaction with the phenolic hydroxyl group in the tannic acid molecule, generating an amino-phenolic hydroxyl cross-linked group through hydrogen bonding. The other (outer) amino group remains in a free state. This free amino group can continue to undergo a Schiff base reaction with the carboxyl hydroxyl group of salicylic acid, generating a second amino-carboxyl hydroxyl cross-linked group through hydrogen bonding, thus generating a ternary micro / nano copolymer, namely, a copolymer salt of tannic acid-p-phenylenediamine-salicylic acid.
[0042] The present invention also provides the application of the ternary micro-nano copolymer salt described in the above-described scheme or the ternary micro-nano copolymer salt obtained by the preparation method described in the above-described scheme in the preparation of hair growth products, hair dyeing products or hair growth and hair dyeing products.
[0043] The present invention also provides a hair growth and blackening liquid, comprising the following raw materials in parts by weight: 1-3 parts of ternary micro-nano copolymer salt, 0.3-0.5 parts of hair extract, 0.5-1.5 parts of alkalinity regulator, 15-25 parts of ethanol, and 65-78 parts of water; wherein the ternary micro-nano copolymer salt is the ternary micro-nano copolymer salt described in the above scheme or the ternary micro-nano copolymer salt obtained by the preparation method described in the above scheme; wherein the hair extract comprises tyrosine, cystine, and tryptophan.
[0044] The raw materials of the hair growth and blackening liquid provided by the present invention, by weight, include 1 to 3 parts of ternary micro-nano copolymer salt, preferably 2 parts.
[0045] Based on the mass fraction of the ternary micro-nano copolymer salt, the raw materials of the hair growth and blackening liquid provided by the present invention include 0.3 to 0.5 parts of hair extract, preferably 0.4 parts.
[0046] Based on the mass fraction of the ternary micro-nano copolymer salt, the raw materials of the hair growth and blackening liquid provided by the present invention include 0.5 to 1.5 parts of alkaline regulator, preferably 0.8 to 1.2 parts, and more preferably 1 part.
[0047] In this invention, the alkalinity regulator preferably includes sodium carbonate.
[0048] Based on the mass fraction of the ternary micro-nano copolymer salt, the raw materials of the hair growth and blackening liquid provided by the present invention include 15-25 parts of ethanol, preferably 18-23 parts, and more preferably 19-20 parts.
[0049] Based on the mass fraction of the ternary micro-nano copolymer salt, the raw materials of the hair growth and blackening liquid provided by the present invention include 65-78 parts of water, preferably 67-76 parts, more preferably 69-74 parts, and even more preferably 71 parts.
[0050] In this invention, the total mass fraction of the components of the hair growth and blackening liquid is preferably 100 parts.
[0051] This invention also provides a method for preparing the hair growth and blackening liquid described above, comprising the following steps: (1) Hair, sodium hydroxide and water were mixed and boiled, acidified and precipitated and then separated into solid and liquid to obtain hair extract; (2) The hair extract is mixed with ternary micro-nano copolymer salt, alkaline regulator, water and ethanol to obtain the hair growth and blackening liquid.
[0052] The preparation process of the hair growth and blackening liquid provided by this invention is as follows: Figure 1 As shown. In this invention, hair, sodium hydroxide, and water are mixed and sequentially subjected to boiling, acidification precipitation, and solid-liquid separation to obtain a hair extract. In this invention, the hair is preferably human hair.
[0053] In this invention, the mass ratio of hair to sodium hydroxide is preferably 10:3~4, more preferably 10:3.5.
[0054] In this invention, the mass ratio of hair to water is preferably 1:10.
[0055] In this invention, the preferred temperature for steaming is 130-140 degrees Celsius, more preferably 135 degrees Celsius; the preferred pressure is 0.3-0.4 MPa, more preferably 0.35 MPa; and the preferred holding time is 30-60 minutes, more preferably 40 minutes. This invention dissolves hair through steaming.
[0056] In this invention, the cooking process preferably includes cooling the resulting product and then separating the solid and liquid components to obtain a cooking filtrate; the cooling is preferably natural cooling to room temperature; and the solid-liquid separation is preferably filtration.
[0057] In this invention, the acidifying agent used for the acidification precipitation preferably includes one or more of hydrochloric acid, sulfuric acid, acetic acid and citric acid; the target pH value of the acidification precipitation is preferably 3.
[0058] In this invention, the solid-liquid separation is preferably performed by filtration.
[0059] After obtaining the hair extract, the present invention mixes the hair extract with a ternary micro / nano copolymer salt, an alkaline regulator, water, and ethanol (denoted as the third mixture) to obtain the hair growth and blackening liquid. In the present invention, the third mixture preferably includes the following steps: mixing an aqueous solution of the ternary micro / nano copolymer salt with the hair extract and the alkaline regulator to obtain a premix, and then diluting the premix with ethanol.
[0060] In this invention, the concentration of the aqueous solution of the ternary micro-nano copolymer salt is preferably 3-6 wt%, more preferably 4-5 wt%.
[0061] In this invention, the ternary micro-nano copolymer salt is preferably obtained by diluting the ternary micro-nano copolymer salt with water.
[0062] In this invention, the third mixing is preferably stirred mixing; the temperature of the third mixing is preferably room temperature, and the mixing time is preferably 30-60 minutes, more preferably 40-50 minutes.
[0063] To further illustrate the present invention, the technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings and embodiments.
[0064] Example 1 (1) Preparation of tannic acid p-phenylenediamine salt liquid: Prepare a tannic acid suspension with a concentration of 6wt%, gradually add an equal volume and concentration of p-phenylenediamine aqueous solution, heat to 83 degrees Celsius, stir thoroughly, and react continuously for 50 minutes to allow the tannic acid to react completely, and obtain a yellow tannic acid p-phenylenediamine salt liquid with a concentration of 6wt%.
[0065] (2) Preparation of ternary micro / nano copolymer salt: A salicylic acid solution of equal volume and concentration to the tannic acid suspension prepared in step (1) is gradually added to the liquid containing p-phenylenediamine tannic acid. The reaction temperature is maintained at 85 degrees Celsius, and the mixture is stirred continuously for 50 minutes to ensure complete reaction and dissolution of the salicylic acid, resulting in a yellow suspension of ternary micro / nano copolymer salt with a solids concentration of 6 wt%. Figure 3 As shown.
[0066] (3) Preparation of hair extract: Weigh 1 part by mass of hair, put it into a pressure reactor, add 10 parts by mass of water, and then add 0.3 parts by mass of sodium hydroxide solid powder; heat to 130 degrees Celsius, corresponding to a gauge pressure of 0.4 MPa, keep warm for 60 minutes, and then cool naturally to room temperature; filter to obtain cooking filtrate; add hydrochloric acid to cooking filtrate according to the mass ratio of cooking filtrate to hydrochloric acid of 1:3 to make the pH value reach 3, so that the hair extract precipitates; filter and dry to obtain hair extract solid powder.
[0067] (4) Dilute the prepared ternary micro / nano copolymer salt suspension with water three times to obtain an aqueous solution of ternary micro / nano copolymer salt with a content of 2wt%. Then add 0.5wt% hair extract solid and 1.0wt% sodium carbonate solid, and stir thoroughly for 60 minutes to obtain a dark black aqueous solution. Then add 25wt% ethanol to obtain a hair growth and blackening solution, such as... Figure 4 As shown.
[0068] Effect Test: This example involved a trial test on 20 cases. The test results showed that: 1) 20 cases achieved significant hair dyeing and blackening effects, with a success rate of 100%; 2) 18 cases showed no white hair roots within 15 days, remaining black or grayish-black, with a success rate of 90%; 2 cases showed white hair roots within 15 days, with a failure rate of 10%; 3) 12 cases showed new hair growth within 30 days, with a success rate of 60%; 8 cases showed no new hair growth within 30 days, with a failure rate of 40%; 4) 17 cases showed new hair growth within 60 days, with a success rate of 85%; 3 cases showed no new hair growth within 60 days, with a failure rate of 15%.
[0069] Example 2 (1) Preparation of tannic acid and p-phenylenediamine salt liquid: Prepare a tannic acid suspension with a concentration of 3wt%, gradually add an equal volume and concentration of p-phenylenediamine aqueous solution, heat to 80 degrees Celsius, stir thoroughly, and react continuously for 60 minutes to allow the tannic acid to react completely, and obtain a yellow tannic acid p-phenylenediamine salt liquid with a concentration of 3wt%.
[0070] (2) Preparation of ternary micro-nano copolymer salt: Add salicylic acid solution of the same volume and concentration as tannic acid suspension to the tannic acid p-phenylenediamine salt liquid prepared in step (1), maintain the reaction temperature at 83 degrees Celsius, stir thoroughly, and react continuously for 40 minutes to completely dissolve the salicylic acid and obtain a yellow ternary micro-nano copolymer salt with a solid concentration of 3wt%.
[0071] (3) Preparation of hair extract: Weigh 1 part by mass of hair, put it into a pressure reactor, add 10 parts by mass of water, and then add 0.4 parts by mass of sodium hydroxide solid powder; heat to 140 degrees Celsius, corresponding to a gauge pressure of 0.3 MPa, keep warm for 40 minutes, and then cool naturally to room temperature; filter to obtain cooking filtrate; add hydrochloric acid to the cooking filtrate according to the mass ratio of cooking filtrate to hydrochloric acid of 1:3 to make the pH value reach 3, so that the hair extract precipitates; filter and dry to obtain hair extract solid powder.
[0072] (4) Dilute the suspension of the prepared ternary micro-nano copolymer salt with water by 3 times to obtain an aqueous solution of ternary micro-nano copolymer salt with a content of 1wt%. Then add 0.3wt% hair extract solid and 0.5wt% sodium carbonate solid, stir and react for 40 minutes to obtain a dark black aqueous solution. Then add 20wt% ethanol to obtain hair growth and blackening solution.
[0073] Effect Test: This example involved a trial test on 20 cases. The test results showed that: 1) 20 cases achieved significant hair dyeing and blackening effects, with a success rate of 100%; 2) 17 cases showed no white hair roots within 15 days, remaining black or grayish-black, with a success rate of 85%; 3 cases showed white hair roots within 15 days, with a failure rate of 15%; 3) 13 cases showed new hair growth within 30 days, with a success rate of 65%; 7 cases showed no new hair growth within 30 days, with a failure rate of 35%; 4) 16 cases showed new hair growth within 60 days, with a success rate of 80%; 4 cases showed no new hair growth within 60 days, with a failure rate of 20%.
[0074] Example 3 (1) Preparation of tannic acid and p-phenylenediamine salt liquid: Prepare a tannic acid suspension with a concentration of 4.5 wt%, gradually add an equal volume and concentration of p-phenylenediamine aqueous solution, heat to 85 degrees Celsius, stir thoroughly, and react continuously for 30 minutes to allow the tannic acid to react completely, and obtain a yellow tannic acid p-phenylenediamine liquid with a concentration of 4.5 wt%.
[0075] (2) Preparation of ternary micro-nano copolymer salt: Add salicylic acid solution of the same volume and concentration as tannic acid solution to the tannic acid p-phenylenediamine salt liquid prepared in step (1), maintain the reaction temperature at 80 degrees Celsius, stir thoroughly, and react continuously for 60 minutes to completely dissolve the salicylic acid and obtain a yellow ternary micro-nano copolymer salt with a solid concentration of 4.5 wt%.
[0076] (3) Preparation of hair extract: Weigh 1 part by mass of hair, put it into a pressure reactor, add 10 parts by mass of water, and then add 0.3 parts by mass of sodium hydroxide solid powder; heat to 140 degrees Celsius, corresponding to a gauge pressure of 0.4 MPa, keep warm for 30 minutes, and then cool naturally to room temperature; filter to obtain cooking filtrate; add hydrochloric acid to the cooking filtrate according to the mass ratio of cooking filtrate to hydrochloric acid of 1:3 to make the pH value reach 3, so that the hair extract precipitates; filter and dry to obtain hair extract solid powder.
[0077] (4) Dilute the suspension of the prepared ternary micro-nano copolymer salt with water by 3 times to obtain an aqueous solution of ternary micro-nano copolymer salt with a content of 1.5wt%; then add 0.4wt% hair extract solid and 0.8wt% sodium carbonate solid, stir and react for 50 minutes to obtain a dark black aqueous solution; then add 15wt% ethanol to obtain hair growth and blackening solution.
[0078] Effect Test: This example involved a trial test on 20 cases. The test results showed that: 1) 20 cases achieved significant hair dyeing and blackening effects, with a success rate of 100%; 2) 19 cases showed no white hair roots within 15 days, remaining black or grayish-black, with a success rate of 95%; 1 case showed white hair roots within 15 days, with a failure rate of 5%; 3) 15 cases showed new hair growth within 30 days, with a success rate of 75%; 5 cases showed no new hair growth within 30 days, with a failure rate of 25%; 4) 18 cases showed new hair growth within 60 days, with a success rate of 90%; 2 cases showed no new hair growth within 60 days, with a failure rate of 20%.
[0079] As can be seen from the above embodiments, the hair growth and blackening liquid prepared by the ternary micro-nano copolymer salt provided by the present invention has good hair growth and blackening effects, with ideal overall results and no allergic reactions, and has broad application prospects.
[0080] The embodiments of the present invention have been described above; however, these embodiments are for illustrative purposes only and are not intended to limit the scope of the invention. All other embodiments obtained by those skilled in the art based on the above embodiments of the present invention without inventive effort are within the protection scope of the present invention.
Claims
1. A ternary micro / nano copolymer salt, characterized in that, It includes tannic acid, p-phenylenediamine linked to the tannic acid via a Schiff base reaction, and salicylic acid linked to the p-phenylenediamine via a Schiff base reaction.
2. The ternary micro / nano copolymer salt according to claim 1, characterized in that, The individual molecular particle size of the ternary micro / nano copolymer salt is 3.5~4.3 nanometers.
3. The method for preparing the ternary micro / nano copolymer salt according to any one of claims 1 to 2, characterized in that, Includes the following steps: (1) Tannic acid and p-phenylenediamine are mixed and subjected to a first Schiff base reaction to obtain p-phenylenediamine tannic acid salt; (2) The tannic acid p-phenylenediamine salt and salicylic acid are mixed and subjected to a second Schiff base reaction to obtain the ternary micro-nano copolymer salt.
4. The preparation method according to claim 3, characterized in that, The mass ratio of tannic acid to p-phenylenediamine is 0.8~1.2:1; The mass ratio of tannic acid to salicylic acid is 0.8~1.2:
1.
5. The preparation method according to claim 3 or 4, characterized in that, The temperature for the first Schiff base reaction is 80-85 degrees Celsius, and the holding time is 30-60 minutes; The first Schiff base reaction was carried out under stirring conditions; The first Schiff base reaction is carried out under solvent conditions.
6. The preparation method according to claim 3 or 4, characterized in that, The temperature for the second Schiff base reaction is 80-85 degrees Celsius, and the holding time is 30-60 minutes; The second Schiff base reaction was carried out under stirring conditions; The second Schiff base reaction is carried out under solvent conditions.
7. The application of the ternary micro-nano copolymer salt according to any one of claims 1 to 2 or the ternary micro-nano copolymer salt obtained by the preparation method according to any one of claims 3 to 6 in the preparation of hair growth products, hair dyeing products or hair growth and hair dyeing products.
8. A hair growth and blackening liquid, characterized in that, The raw materials include the following parts by weight: 1-3 parts of ternary micro-nano copolymer salt, 0.3-0.5 parts of hair extract, 0.5-1.5 parts of alkalinity regulator, 15-25 parts of ethanol and 65-78 parts of water; The ternary micro-nano copolymer salt is the ternary micro-nano copolymer salt according to any one of claims 1 to 2 or the ternary micro-nano copolymer salt obtained by the preparation method according to any one of claims 3 to 6; The hair extract includes tyrosine, cystine, and tryptophan.
9. The hair growth and blackening liquid according to claim 8, characterized in that, The total mass fraction of the components in the hair growth and blackening liquid is 100 parts.
10. The method for preparing the hair growth and blackening liquid according to any one of claims 8 to 9, characterized in that, Includes the following steps: (1) Hair, sodium hydroxide and water were mixed and boiled, acidified and precipitated and then separated into solid and liquid to obtain hair extract; (2) The hair extract is mixed with ternary micro-nano copolymer salt, alkaline regulator, water and ethanol to obtain the hair growth and blackening liquid.