A traditional Chinese medicine tea drink for preventing or treating upper respiratory tract infection and a preparation method and application thereof

Abstract

This application provides a traditional Chinese medicine tea for the prevention or treatment of upper respiratory tract infections, its preparation method, and its application. The tea is made from the following raw materials in parts by weight: 2-4 parts of Scrophularia ningpoensis, 2-4 parts of Ophiopogon japonicus, 1-3 parts of Adenophora stricta, 2-4 parts of Adenophora stricta, 2-4 parts of Scutellaria baicalensis, 0.5-1.5 parts of Platycodon grandiflorus, 0.5-1.5 parts of Belamcanda chinensis, 0.5-1.5 parts of Lonicera japonica, 0.5-1.5 parts of Oroxylum indicum, and 1-3 parts of Glycyrrhiza uralensis. The raw materials in this application are formulated and the components of the traditional Chinese medicine are quantified and proportioned through precise cutting parameters, and the preservation of the precisely cut herbs is controlled. This allows the tea to: nourish Yin and moisten dryness, replenish Qi and generate fluids, clear heat from the upper burner, treat dry and itchy throat, sore throat, dry cough, and prevent upper respiratory tract infections.

Description

Technical Field

[0001] This application relates to the field of traditional Chinese medicine technology, specifically to a traditional Chinese medicine tea for the prevention or treatment of upper respiratory tract infections, its preparation method, and its application. Background Technology

[0002] In recent years, influenza viruses have been prevalent, especially during the autumn and winter flu season, with influenza A, influenza B, and COVID-19 viruses often co-occurring, leading to a sharp increase in the workload of emergency rooms, pediatric departments, and fever clinics in traditional Chinese medicine (TCM) hospitals. TCM treatment of influenza has its unique advantages. It is generally believed that the pathogenic factor of dryness is related to factors such as geographical environment, seasonal climate, lifestyle habits, and constitution. The characteristic of dryness-related illness is the depletion of body fluids, and the treatment principle is to generate fluids and moisten dryness. Therefore, the determination of TCM treatment needs to be based on a comprehensive assessment of individual constitution and geographical location. However, because TCM is usually taken through conventional decoction methods, it is not suitable for modern lifestyles, and the decoctions are bitter, hindering the promotion of TCM treatment. Summary of the Invention

[0003] To achieve the above objectives, this application adopts the following technical solution: Based on the Xuanmai Ganjie Decoction, and considering the local characteristics of prevalent summer heat and dampness, strong autumn dryness, and susceptibility to dryness-induced lung invasion, this classic formula is supplemented with North and South American ginseng, Scutellaria baicalensis, Belamcanda chinensis, Lonicera japonica, and Oroxylum indicum. The combined effects of these herbs nourish yin and moisten dryness, replenish qi and generate fluids, resist dryness-induced pathogens, protect the first line of defense of the respiratory system, clear the upper burner, and prevent upper respiratory tract infections. Simultaneously, carefully selected and precisely cut Chinese medicinal herbs are blended in a specific ratio to prepare herbal tea bags for easy extraction of active ingredients. One dose is taken daily, steeped in hot water for 10 minutes, and drunk as tea.

[0004] The inventive point of this application is to provide a traditional Chinese medicine tea for the prevention or treatment of upper respiratory tract infections, made from the following raw materials in parts by weight: 2-4 parts of Scrophularia ningpoensis, 2-4 parts of Ophiopogon japonicus, 1-3 parts of Adenophora stricta, 2-4 parts of Adenophora stricta, 2-4 parts of Scutellaria baicalensis, 0.5-1.5 parts of Platycodon grandiflorus, 0.5-1.5 parts of Belamcanda chinensis, 0.5-1.5 parts of Lonicera japonica, 0.5-1.5 parts of Oroxylum indicum, and 1-3 parts of Glycyrrhiza uralensis.

[0005] In this herbal tea, Scrophularia ningpoensis is sweet, bitter, and salty, and slightly cold in nature. It enters the lung, stomach, and kidney meridians, and excels at clearing heat and cooling blood, detoxifying and resolving lumps, and nourishing yin and generating fluids. It is effective in treating yin deficiency caused by febrile diseases, steaming cough due to bone fever, red eyes and sore throat, and carbuncles and boils. Ophiopogon japonicus is sweet, slightly bitter, and slightly cold in nature, and enters the lung, stomach, and heart meridians. It nourishes yin and generates fluids, moistens dryness, and clears deficiency heat. It is effective in treating stomach yin deficiency, fluid depletion caused by febrile diseases, dry cough due to yin deficiency, and heart yin deficiency. For irritability and insomnia; North and South American ginseng nourish yin and clear the lungs, benefit the stomach and generate fluids, resolve phlegm and benefit qi; Scutellaria baicalensis clears the upper burner; Platycodon grandiflorus is bitter and pungent in taste and neutral in nature, enters the lung meridian, and is good at ventilating the lungs and stopping cough; Belamcanda chinensis eliminates phlegm and fire and benefits the throat; Lonicera japonica clears heat and detoxifies; Oroxylum indicum clears the lungs and benefits the throat, soothes the liver and harmonizes the stomach. The combined effects of these herbs nourish yin and moisten dryness, benefit qi and generate fluids, and resist dryness; Glycyrrhiza uralensis is sweet in taste and neutral in nature, and can tonify the spleen and benefit qi, resolve phlegm and stop cough, clear heat and detoxify, and harmonize the effects of the herbs.

[0006] The above-mentioned components are scientifically and rationally combined according to the unique compatibility principles of traditional Chinese medicine, with the principal, assistant, adjuvant, and guide herbs in the formula. Scrophularia and Ophiopogon japonicus are the principal herbs, clearing heat and detoxifying, nourishing yin and generating fluids, cooling blood and dispersing stagnation; Adenophora stricta and Glehnia littoralis nourish yin and clear the lungs, benefit the stomach and generate fluids, resolve phlegm and benefit qi, strengthening the principal herbs' yin-nourishing and fluid-generating effects, and also benefiting qi and resolving phlegm, thus serving as assistant herbs; Platycodon grandiflorus promotes lung function and stops cough; Scutellaria baicalensis clears the upper burner; Belamcanda chinensis eliminates phlegm and fire, and benefits the throat; Lonicera japonica clears heat and detoxifies; Oroxylum indicum clears the lungs and benefits the throat, soothes the liver and harmonizes the stomach. The five herbs combined not only assist the principal and assistant herbs in clearing heat and resolving phlegm, but also clear the upper burner, promote lung function, and benefit the throat, thus serving as adjuvant herbs.

[0007] Licorice harmonizes the effects of other herbs, relieves cough and alleviates urgency, serving as the guiding herb. When used together, these herbs work synergistically to clear heat, nourish yin, soothe the throat, and eliminate phlegm, protecting the first line of defense for the respiratory system. They also clear the upper burner and prevent upper respiratory tract infections.

[0008] In response to the characteristics of hot and humid climates, strong autumn dryness, and susceptibility to lung dryness, this invention presents a traditional Chinese medicine tea with a strict combination of principal, assistant, adjuvant, and guide herbs, which complement each other and are scientifically prepared. It has stable quality, good efficacy, and has achieved very good technical results in clinical trials.

[0009] Optionally, it is made from the following ingredients in parts by weight: 3 parts Scrophularia, 3 parts Ophiopogon japonicus, 2 parts Adenophora stricta, 3 parts Adenophora buergeriana, 3 parts Scutellaria baicalensis, 1 part Platycodon grandiflorus, 1 part Belamcanda chinensis, 1 part Lonicera japonica, 1 part Oroxylum indicum, and 2 parts Glycyrrhiza uralensis.

[0010] The ingredients of this tea are mostly medicinal and edible herbs, which are used in small doses, have high safety in treatment, and are inexpensive. In addition, the small doses, low cost, good taste, and convenient consumption make it more acceptable to patients.

[0011] Another inventive point of this application is to provide a method for preparing the Chinese herbal tea beverage as described above, comprising: (1) selecting each raw material; (2) slicing some of the raw materials; and (3) under specific conditions, preparing and packaging each raw material into a bag according to the above proportions.

[0012] The selection criteria are as follows: Among them, Scrophularia: flat and black in color; Ophiopogon japonicus: 15-20mm long and 5-6mm in diameter, flattened and whole; Platycodon grandiflorus: flat and whole in color, yellowish-white in color; Glycyrrhiza uralensis: yellowish-white in color and firm in texture; Adenophora stricta: yellowish-white in color, flat, loose and whole in slices; Adenophora stricta: 3-5mm long and 5-8mm in diameter; Scutellaria baicalensis: yellowish-brown or yellowish-green in color; Belamcanda chinensis: bright yellow in color; Lonicera japonica: 2-3cm long and yellowish-white or greenish-white in color; Oroxylum indicum: whole slices, light yellowish-white in color, with translucent wings and a silky luster.

[0013] Because the quality and specifications of Chinese medicinal herbs are higher than those of herbs used in decoctions, it is necessary to carefully select each raw material.

[0014] Optionally, in step (2), the Scrophularia, Adenophora, Scutellaria, Platycodon, Belamcanda, and Glycyrrhiza are sliced; the slices include very thin slices, thin slices, or thick slices; wherein, the thickness of the very thin slices is less than 0.5 mm; the thickness of the thin slices is 1~2 mm; and the thickness of the thick slices is 2~4 mm.

[0015] Optionally, the following slices may be used: Scrophularia ningpoensis sliced ​​thinly or very thinly; Platycodon grandiflorus sliced ​​thinly or very thinly; Glycyrrhiza uralensis sliced ​​thickly; Adenophora stricta sliced ​​thickly; Scutellaria baicalensis sliced ​​thinly; Belamcanda chinensis sliced ​​thinly.

[0016] Using different slicing specifications makes it easier to extract the effective components of each raw material.

[0017] Optionally, the specifications of each raw material in step (3) are as follows: Scrophularia: 0.5-1mm thick, flat and black in color; Ophiopogon japonicus: 15-20mm long and 5-6mm in diameter, flattened and whole; Platycodon grandiflorus: 0.5-1mm thick, flat and whole in color, yellowish-white in color; Glycyrrhiza uralensis: 2-3mm thick, yellowish-white in color, and solid in texture; Adenophora stricta: 2-4mm thick, yellowish-white in color, flat and whole in slice; Adenophora stricta: 3-5mm long and 5-8mm in diameter; Scutellaria baicalensis: 0.8-1.5mm thick, yellowish-brown or yellowish-green in color; Belamcanda chinensis: 1-2mm thick and bright yellow in color; Lonicera japonica: 2-3cm long and yellowish-white or greenish-white in color; Oroxylum indicum: whole slice, light yellowish-white in color, with translucent wings and a silky luster.

[0018] Traditional Chinese medicine (TCM) is prone to loss of active ingredients after formulation, especially after precise cutting. This application achieves quantitative and proportional control of TCM components and preservation of precisely cut herbs by adjusting the precision cutting parameters. This can achieve the following effects: nourishing yin and moistening dryness, replenishing qi and promoting body fluids, clearing the upper burner, and preventing and treating upper respiratory tract infections.

[0019] The specific storage conditions are: temperature 15℃~20℃; excessively high or low temperatures will affect the stability of the effective components of traditional Chinese medicine, leading to reduced efficacy or ineffectiveness. The humidity should be between 15% and 50%. Too high a humidity level can easily lead to mold growth and the production of toxic substances, while too low a humidity level may cause a large loss of moisture from the Chinese medicine, resulting in reduced efficacy.

[0020] Keep away from light.

[0021] Optionally, the above preparation method further includes: soaking each raw material in alcohol, then soaking it in water, and then freeze-drying it to obtain freeze-dried raw materials.

[0022] Optionally, the alcohol concentration is 15% to 30%; the alcohol soaking time is 0.5 to 2 hours; after soaking in alcohol, the product is dried.

[0023] Alcohol concentration: refers to the ratio of alcohol to the total volume of the solution; for example, 15% alcohol means that every 100 ml of solution contains 15 ml of pure alcohol (ethanol) and the remaining 85 ml is water.

[0024] The choice of alcohol concentration and soaking time reduces the degree of structural damage to Chinese medicinal materials, allowing them to maintain their complete tissue structure; at the same time, it allows water to penetrate into the interior of the Chinese medicinal materials.

[0025] The drying temperature is 0℃~30℃; low-temperature drying allows the alcohol to evaporate, avoiding the loss of the effective components of the Chinese medicinal materials.

[0026] After soaking in alcohol, soaking in water further dilutes the alcohol, reducing its residue in the medicinal herbs. It also allows the alcohol to penetrate deeper into the herbs, preparing them for subsequent freeze-drying.

[0027] The soaking time in water is 1 hour to 5 hours; it can be 1 hour, 2 hours, 3 hours, 4 hours or 5 hours.

[0028] Optionally, multiple soakings can be performed, that is, repeated alcohol soaking, drying, and water soaking operations; the preferred number of times is 1 to 5.

[0029] Freeze-drying refers to freezing water-containing Chinese medicinal materials below the freezing point, turning the water into ice, and then turning the ice into vapor under a high vacuum to remove the moisture.

[0030] This method ensures that the volume of dried Chinese medicinal materials remains unchanged and that they are loose and porous; after being soaked in water again, the effective components can be dissolved in the water to the greatest extent, and the dissolution rate is relatively fast.

[0031] Another inventive point of this application is to provide the use of any of the above-described Chinese herbal teas in the preparation of drugs for the prevention or treatment of upper respiratory tract infections.

[0032] Optionally, the herbal tea can be steeped in hot water.

[0033] Compared with the prior art, this application has the following advantages: (1) This application requires higher quality and specifications for the Chinese herbal tea than for general decoctions. The carefully selected and finely cut Chinese herbal slices are mixed in a certain proportion to prepare Chinese herbal tea bags that are easy to extract the effective ingredients. One dose is taken daily and can be drunk after being steeped in hot water. It is used to prevent or treat upper respiratory tract infections.

[0034] (2) The herbal teas formulated in this application are low-cost, have a good taste, do not require decoction, are easy to take and carry, and have a sweet taste that is easily accepted by patients. In addition, the tea formulations mostly use medicinal and edible herbs, which are low-cost, have high safety in diagnosis and treatment, and are low in cost; the effects are long-lasting, making them more suitable for the prevention of upper respiratory tract infections. Detailed Implementation

[0035] To make the objectives, technical solutions, and advantages of this application clearer, a more detailed description is provided below. However, it should be understood that the description herein is merely for explaining this application and is not intended to limit its scope.

[0036] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the scope of this application. All reagents and instruments used herein are commercially available, and the characterization methods involved can be found in relevant descriptions in the prior art, and will not be repeated here.

[0037] To further understand this application, the following detailed description is provided in conjunction with the preferred embodiments.

[0038] Tea culture is a quintessential representation of Chinese culture. The practice of incorporating medicinal ingredients into tea, and vice versa, has a long history. Tea-based medicinal formulas draw upon the traditional Chinese medicine decoction method, preparing medicinal herbs into easily extractable forms, with the effective components dissolving at a rate similar to decoction after steeping in hot water. Tea-based medicinal formulas, which can prevent seasonal colds, not only combine the characteristics of both medicine and tea, adapt to Chinese tea-drinking habits and culture, but also conform to the medicinal properties, formulation principles, and taste characteristics of traditional Chinese medicine for seasonal health maintenance, disease prevention, and treatment.

[0039] Xuanmai Ganjie Decoction is based on the Platycodon Decoction (Platycodon grandiflorus and Glycyrrhiza uralensis) recorded in the Treatise on Cold Damage, with the addition of Scrophularia ningpoensis and Ophiopogon japonicus. It is often used to treat throat ailments caused by Shaoyin heat or deficiency heat, and is described in the Handbook of Chinese Materia Medica Preparations (edited by the Institute of Chinese Materia Medica, Chinese Academy of Medical Sciences, Ministry of Health, 1965, Beijing). However, Xuanmai Ganjie Decoction is not suitable for those with a cold constitution or those prone to diarrhea.

[0040] This application, based on the Xuanmai Ganju Decoction, uses a herbal tea to prevent and treat upper respiratory tract infections such as sore throat and cough, while reducing harm to those with a cold constitution or prone to diarrhea, and making the effects gentler. In initial applications, it received considerable praise for both its efficacy and taste. With further standardized preparation, it is expected to become one of the distinctive projects of our hospital's traditional Chinese medicine department.

[0041] Example 1 By weight, take 3 parts of Scrophularia, 3 parts of Ophiopogon japonicus, 3 parts of Adenophora stricta, 3 parts of Adenophora nigra, 3 parts of Scutellaria baicalensis, 1 part of Platycodon grandiflorus, 1 part of Belamcanda chinensis, 1 part of Lonicera japonica, 1 part of Oroxylum indicum, and 2 parts of Glycyrrhiza uralensis Use a shredder-type herb cutter and sorting machine to prepare and clean the following Chinese medicinal herbs, and mix them according to the above proportions.

[0042] Among them, Scrophularia: sliced ​​thinly, 0.5-1mm thick, with a flat, black cut surface; Ophiopogon japonicus: medium-sized pieces, 15-20mm long, 5-6mm in diameter, flattened, whole pieces; Platycodon grandiflorus: sliced ​​thinly to very thinly, 0.5-1mm thick, with a flat, whole cut surface, yellowish-white; Glycyrrhiza uralensis: sliced ​​thickly, 2-3mm thick, with a yellowish-white surface, firm; Adenophora stricta: sliced ​​thickly, 2-4mm thick, with a yellowish-white cut surface, flat, loose, and whole pieces; Adenophora stricta var. chinensis: small pieces, 3-5mm long, 5-8mm in diameter; Scutellaria baicalensis: sliced ​​thinly, 0.8-1.5mm thick, with a yellowish-brown or yellowish-green cut surface; Belamcanda chinensis: sliced ​​thinly, 1-2mm thick, with a bright yellow color; Lonicera japonica: 2-3cm long, yellowish-white or greenish-white; Oroxylum indicum: whole pieces, with a light yellowish-white surface, translucent wings, and a silky luster.

[0043] Then, the tea bags are packaged in sealed bags and stored under specific conditions (temperature 20 ℃; humidity 20%; protection from light).

[0044] Example 2 By weight, take 3 parts of Scrophularia, 3 parts of Ophiopogon japonicus, 3 parts of Adenophora stricta, 3 parts of Adenophora nigra, 3 parts of Scutellaria baicalensis, 1 part of Platycodon grandiflorus, 1 part of Belamcanda chinensis, 1 part of Lonicera japonica, 1 part of Oroxylum indicum, and 2 parts of Glycyrrhiza uralensis Use a shredder-type herb cutter and sorting machine to prepare and clean the following Chinese medicinal herbs, and mix them according to the above proportions.

[0045] Among them, Scrophularia: sliced ​​thinly, 0.8mm thick, with a flat, black cut surface; Ophiopogon japonicus: medium-sized pieces, 18mm long, 5-6mm in diameter, flattened, whole pieces; Platycodon grandiflorus: sliced ​​thinly to very thinly, 0.8mm thick, with a flat, whole, yellowish-white cut surface; Glycyrrhiza uralensis: sliced ​​thickly, 2-3mm thick, with a yellowish-white surface and firm texture; Adenophora stricta: sliced ​​thickly, 3mm thick, with a yellowish-white cut surface, flat, loose, and whole pieces; Adenophora stricta var. chinensis: small pieces, 4mm long, 6mm in diameter; Scutellaria baicalensis: sliced ​​thinly, 1.0mm thick, with a yellowish-brown or yellowish-green cut surface; Belamcanda chinensis: sliced ​​thinly, 1-2mm thick, with a bright yellow color; Lonicera japonica: 2-3cm long, yellowish-white or greenish-white; Oroxylum indicum: whole pieces, with a light yellowish-white surface, translucent wings, and a silky luster.

[0046] The above raw materials were soaked in 15% alcohol for 1 hour, then dried at 20°C to remove the alcohol and some water; then water was added and soaked for 2 hours, followed by freeze drying.

[0047] Then, the tea bags are packaged in sealed bags and stored under specific conditions (temperature 20 ℃; humidity 20%; protection from light).

[0048] Example 3 By weight, take 3 parts of Scrophularia, 3 parts of Ophiopogon japonicus, 3 parts of Adenophora stricta, 3 parts of Adenophora nigra, 3 parts of Scutellaria baicalensis, 1 part of Platycodon grandiflorus, 1 part of Belamcanda chinensis, 1 part of Lonicera japonica, 1 part of Oroxylum indicum, and 2 parts of Glycyrrhiza uralensis Use a shredder-type herb cutter and sorting machine to prepare and clean the following Chinese medicinal herbs, and mix them according to the above proportions.

[0049] Among them, Scrophularia: sliced ​​thinly, 0.8mm thick, with a flat, black cut surface; Ophiopogon japonicus: medium-sized pieces, 18mm long, 5-6mm in diameter, flattened, whole pieces; Platycodon grandiflorus: sliced ​​thinly to very thinly, 0.8mm thick, with a flat, whole, yellowish-white cut surface; Glycyrrhiza uralensis: sliced ​​thickly, 2-3mm thick, with a yellowish-white surface and firm texture; Adenophora stricta: sliced ​​thickly, 3mm thick, with a yellowish-white cut surface, flat, loose, and whole pieces; Adenophora stricta var. chinensis: small pieces, 4mm long, 6mm in diameter; Scutellaria baicalensis: sliced ​​thinly, 1.0mm thick, with a yellowish-brown or yellowish-green cut surface; Belamcanda chinensis: sliced ​​thinly, 1-2mm thick, with a bright yellow color; Lonicera japonica: 2-3cm long, yellowish-white or greenish-white; Oroxylum indicum: whole pieces, with a light yellowish-white surface, translucent wings, and a silky luster.

[0050] The above raw materials were soaked in 15% alcohol for 1 hour, then dried at 20°C to remove the alcohol and some water. Then, water was added and soaked for 2 hours. Then, alcohol was added according to the weight of the water to make the alcohol volume fraction 15%, and soaked for 1 hour. Then, the raw materials were dried at 20°C to remove the alcohol and some water. Then, water was added and soaked for 2 hours, and then freeze-dried.

[0051] Then, the tea bags are packaged in sealed bags and stored under specific conditions (temperature 20 ℃; humidity 20%; protection from light).

[0052] Comparative Example 1 By weight, take 3 parts of Scrophularia, 3 parts of Ophiopogon japonicus, 3 parts of Adenophora stricta, 3 parts of Adenophora nigra, 3 parts of Scutellaria baicalensis, 1 part of Platycodon grandiflorus, 1 part of Belamcanda chinensis, 1 part of Lonicera japonica, 1 part of Oroxylum indicum, and 2 parts of Glycyrrhiza uralensis Using a shredder-type herb slicer and a sorting machine, each raw material is sliced ​​into thin slices (1-2 mm thick) to prepare Chinese herbal medicine slices.

[0053] Then, the tea bags are packaged in sealed bags and stored under specific conditions (temperature 20 ℃; humidity 20%; protection from light).

[0054] Comparative Example 2 Most of the parameters are the same as in Example 3, except that the volume fraction of alcohol is changed to 75% and the alcohol soaking time is 5 hours; other parameters remain unchanged.

[0055] Effect (1) The water-soluble extract and baicalin components of Example 1 and Comparative Example 1 were determined respectively.

[0056] Experimental procedure for water-soluble extracts: Add the above formula to a sealed glass cup, add 300 mL of boiling water, and let it soak naturally for 4 hours; accurately transfer 25 mL of tea infusion, evaporate to dryness, and dry in a forced-air dryer at 105℃ for 3 hours, and calculate the content of extracts.

[0057] Baicalin content determination: Accurately measure 50 mL of the above extract solution, evaporate to dryness, accurately add 50 mL of methanol to dissolve, filter, and determine the baicalin content according to the percentage of baicalin extracted to the total amount of the herb. Specifically, follow the [Content Determination] method for Scutellaria baicalensis in the 2020 edition of the Chinese Pharmacopoeia, Part I.

[0058] result In Example 1, Each 100mL of tea infusion contains 2.688g of extract; in Comparative Example 1, each 100mL of tea infusion contains 2.491g of extract. This is because the selection and precise cutting of the Chinese medicinal materials in this application facilitates the extraction of active ingredients, thus laying a solid foundation for the subsequent treatment of diseases.

[0059] By separately determining the content of baicalin, the percentage of baicalin obtained from the soaking in Example 1 was 0.3% of the total amount of medicine; while the percentage of baicalin obtained from the soaking in Comparative Example 1 was 0.18% of the total amount of medicine. It can be seen that, whether considering the overall effective components or a single component (baicalin), Example 1 is superior to Comparative Example 1.

[0060] As can be seen from the above, by carefully selecting and properly slicing baicalin, the effective components of the medicinal material can be released more quickly and in greater quantities, thereby achieving better therapeutic effects.

[0061] (2) The water-soluble extracts and baicalin components of Examples 2, 3, and Comparative Example 2 were determined respectively. The methods were the same as in (1). The results are as follows: As can be seen from the above, the amount of extract in the tea treated as in Examples 2 and 3 increased significantly; however, in Comparative Example 2, the increased alcohol content and steeping time led to the loss of effective components from the medicinal herbs, resulting in a decrease in the content of extract. Therefore, in this application, an alcohol concentration of 15% to 30% and an alcohol steeping time of 0.5 to 2 hours yielded better results.

[0062] (3) Verification of the efficacy of the herbal tea in Example 1: I. Criteria for Case Selection Symptoms such as dry and itchy throat, sore throat, hoarseness, and dry cough caused by acute or chronic pharyngitis; The initial symptoms of an upper respiratory tract infection may appear, such as sore throat, red eyes, and hoarseness.

[0063] Age: 12-80 years old II. Diagnostic Criteria Western medicine diagnostic criteria: Meets the diagnostic criteria for pharyngitis in the "Guiding Principles for Clinical Research of New Traditional Chinese Medicines". Main symptoms: Sore throat or pain when swallowing, dryness and burning sensation in the throat. Secondary symptoms: General malaise, fever, chills, aches and pains in the limbs, loss of appetite.

[0064] Traditional Chinese Medicine (TCM) syndrome differentiation criteria: Meets the TCM syndrome differentiation criteria for pharyngitis in the "Guiding Principles for Clinical Research of New Chinese Herbal Drugs". Main symptoms of wind-cold syndrome: sore throat, difficulty swallowing. Secondary symptoms: chills, no fever or slight fever, general malaise, no thirst, headache, no sweating, runny nose with clear discharge. Examination: pharyngeal mucosa is pale red or not red, no edema in the pharyngeal mucosa. Tongue appearance: tongue body is not red, coating is thin and white. Pulse appearance: floating and tight.

[0065] Main symptoms of wind-heat syndrome: sore throat, dryness and burning sensation in the throat, difficulty swallowing. Secondary symptoms: fever, chills, thirst. Examination: red or bright red pharyngeal mucosa, swollen and red uvula, and hyperplasia of lymphoid follicles on the posterior pharyngeal wall. Tongue appearance: red at the tip and edges of the tongue with a thin white or thin yellow coating. Pulse: floating and rapid.

[0066] Main symptoms of Lung and Stomach Heat Syndrome: Severe sore throat, radiating to the ear, difficulty swallowing, dry throat, and excessive thirst. Secondary symptoms: Fever, cough, thick sputum, headache, dry stool, and dark yellow urine. Examination: Bright red throat, with a lump under the jaw. Tongue appearance: Pale red tongue with a thin yellow coating. Pulse appearance: Rapid and forceful pulse.

[0067] III. Treatment Plan All confirmed cases were treated with the herbal tea formula of Example 1 of this invention, one dose per day, which was steeped in hot water for ten minutes and then drunk as tea.

[0068] IV. Efficacy Evaluation Criteria The efficacy criteria for pharyngitis were formulated with reference to the "Guiding Principles for Clinical Research of New Traditional Chinese Medicines".

[0069] (1) Clinical cure: clinical symptoms and signs disappear after medication.

[0070] (2) Significant effect: Symptoms and signs are significantly improved after medication.

[0071] (3) Effective: Clinical symptoms and signs improved after medication, and continued medication is required.

[0072] (4) Ineffective: Symptoms and signs did not improve significantly after medication.

[0073] V. Sample Statistical Results Using population sampling, a group of patients with sore throat, dry cough, and early stage of upper respiratory tract infection was collected and counted. An experimental observation group (treated with the herbal tea of ​​Example 1) and a blank control group (not treated with the herbal tea of ​​Example 1 or any other treatment) were set up and observed for 4 weeks. The efficacy of the herbal tea was statistically analyzed.

[0074] For symptoms of sore throat, dry cough, and initial symptoms of upper respiratory tract infection: the symptom improvement rate in the experimental observation group was significantly better than that in the blank control group, and the incidence of severe respiratory infections such as fever and pneumonia was significantly lower in the experimental observation group than in the blank control group.

[0075] VI. Clinical Efficacy Observation Record Twenty cases of indication were followed up and treated with the herbal tea of ​​this invention. All cases showed improvement, with 4 cases achieving clinical cure and 16 cases showing improvement. All cases demonstrated good clinical efficacy without complications. Examples 2 and 3 contain more infused ingredients in the tea, resulting in even better therapeutic effects.

[0076] Those skilled in the art will understand that, for the sake of convenience and brevity, the specific working process and related descriptions of the system described above can be found in the corresponding processes in the foregoing method embodiments, and will not be repeated here.

[0077] Those skilled in the art will understand that, for the sake of convenience and brevity, the specific working process and related descriptions of the storage device and processing device described above can be referred to the corresponding processes in the foregoing method embodiments, and will not be repeated here.

[0078] The term "comprising" or any other similar term is intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus / device that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent in such process, method, article, or apparatus / device.

[0079] The preferred embodiments shown above describe the technical solution of the present invention. However, it will be readily understood by those skilled in the art that the scope of protection of the present invention is obviously not limited to these specific embodiments. Without departing from the principles of the present invention, those skilled in the art can make equivalent changes or substitutions to the relevant technical features, and the technical solutions after these changes or substitutions will all fall within the scope of protection of the present invention.

Claims

1. A traditional Chinese medicine tea for the prevention or treatment of upper respiratory tract infections, characterized in that, It is made from the following ingredients in parts by weight: 2-4 parts of Scrophularia ningpoensis, 2-4 parts of Ophiopogon japonicus, 1-3 parts of Adenophora stricta, 2-4 parts of Adenophora stricta, 2-4 parts of Scutellaria baicalensis, 0.5-1.5 parts of Platycodon grandiflorus, 0.5-1.5 parts of Belamcanda chinensis, 0.5-1.5 parts of Lonicera japonica, 0.5-1.5 parts of Oroxylum indicum, and 1-3 parts of Glycyrrhiza uralensis.

2. The herbal tea beverage according to claim 1, characterized in that, It is made from the following ingredients in parts by weight: 3 parts Scrophularia, 3 parts Ophiopogon japonicus, 3 parts Adenophora stricta, 3 parts Adenophora buergeriana, 3 parts Scutellaria baicalensis, 1 part Platycodon grandiflorus, 1 part Belamcanda chinensis, 1 part Lonicera japonica, 1 part Oroxylum indicum, and 2 parts Glycyrrhiza uralensis.

3. A method for preparing the traditional Chinese medicine tea beverage as described in claim 1 or 2, characterized in that, include: (1) Carefully select each raw material; (2) Slice some of the raw materials; (3) Under specific conditions, prepare each raw material into a bag according to the above proportions.

4. The preparation method according to claim 3, characterized in that, In step (2), the Scrophularia, Adenophora, Scutellaria, Platycodon, Belamcanda, and Glycyrrhiza are sliced; the slices include very thin slices, thin slices, or thick slices; among them, the thickness of the very thin slices is less than 0.5 mm; the thickness of the thin slices is 1~2 mm; and the thickness of the thick slices is 2~4 mm.

5. The preparation method according to claim 3, characterized in that, Slice the following ingredients thinly or very thinly: Slice the following ingredients: Slice the following ingredients: Slice the following ingredients: Scrophularia ningpoensis thinly or very thinly; Slice the following ingredients: Platycodon grandiflorus thinly or very thinly; Slice the following ingredients: Glycyrrhiza uralensis thickly; Scutellaria baicalensis thickly; Scutellaria baicalensis thin ....

6. The preparation method according to claim 4, characterized in that, The specifications of each raw material in step (3) are as follows: Scrophularia: 0.5-1mm thick, flat and black in color; Ophiopogon japonicus: 15-20mm long and 5-6mm in diameter, flattened and whole; Platycodon grandiflorus: 0.5-1mm thick, flat and whole in color, yellowish-white in color; Glycyrrhiza uralensis: 2-3mm thick, yellowish-white in color, and solid in texture; Adenophora stricta: 2-4mm thick, yellowish-white in color, flat and whole in slices; Adenophora stricta: 3-5mm long and 5-8mm in diameter; Scutellaria baicalensis: 0.8-1.5mm thick, yellowish-brown or yellowish-green in color; Belamcanda chinensis: 1-2mm thick and bright yellow in color; Lonicera japonica: 2-3cm long and yellowish-white or greenish-white in color; Oroxylum indicum: whole slices, light yellowish-white in color, with translucent wings and a silky luster.

7. The preparation method according to claim 4, characterized in that, Specific conditions are: temperature 15℃~20℃; humidity 15%~50%; avoid light.

8. The preparation method according to claim 3, characterized in that, Also includes: Each raw material is soaked in alcohol, then in water, and then freeze-dried to obtain freeze-dried raw materials.

9. The preparation method according to claim 8, characterized in that, The concentration of the alcohol is 15% to 30%; the alcohol soaking time is 0.5 h to 2 h; after soaking in alcohol, it is dried.

10. The use of a traditional Chinese medicine tea as described in claim 1 or 2 in the preparation of a drug for the prevention or treatment of upper respiratory tract infections.

Images