A preparation of Coptis chinensis for treating damp-heat and qi stagnation in the gastrointestinal tract and its preparation method

By constructing a nano-targeted delivery system and a thermosensitive gel matrix formulation, the problems of low extraction efficiency of active ingredients and non-targeted drug release in traditional Xianglian formulations have been solved, achieving precise targeted drug release and efficient therapeutic effects, and improving the stability and safety of the formulation.

CN122124179APending Publication Date: 2026-06-02HUBEI XIANGLIAN PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HUBEI XIANGLIAN PHARMA
Filing Date
2026-04-22
Publication Date
2026-06-02

AI Technical Summary

Technical Problem

Traditional Xianglian preparations have many problems in terms of active ingredient extraction, drug delivery and formulation production, including loss due to oxidation and decomposition of heat-sensitive components, low extraction efficiency of active ingredients, lack of targeted delivery system, non-selective release of drugs in the gastrointestinal tract, and unstable formulation quality, making it difficult to meet the needs of personalized medication.

Method used

A thermosensitive gel matrix formulation was constructed by combining a nano-targeted delivery system with targeted peptide modification of colonic epithelial cells. The precise extraction and targeted release of the drug were achieved by supercritical CO2 extraction and dynamic cyclic extraction combined with near-infrared online monitoring technology. The thermosensitive gel matrix formulation was prepared using 3D printing technology.

Benefits of technology

It achieves efficient retention and precise targeted release of active pharmaceutical ingredients, increases local drug concentration, reduces systemic side effects, ensures formulation quality stability, and meets personalized medication needs.

✦ Generated by Eureka AI based on patent content.

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Abstract

This invention relates to the field of granule preparation technology, and discloses a Coptis chinensis preparation for treating gastrointestinal damp-heat stagnation and its preparation method. First, the preparation components, including total alkaloids of Coptis chinensis, volatile oil of Aucklandia lappa, dry extract powder of excipient medicinal materials, chitosan, and pectin, are determined according to specific weight ratios. For different components, supercritical CO2 extraction, dynamic cyclic extraction combined with near-infrared online monitoring technology, and standardized water decoction process are used to accurately extract and prepare the preparation. Then, a chitosan-pectin nano-targeted delivery system is constructed, and colon-targeted nanoparticles are obtained by modifying colonic epithelial cell-targeting peptides. These nanoparticles are then obtained by vacuum freeze-drying and fluidized bed microsphere granulation. Simultaneously, the volatile oil of Aucklandia lappa is treated with β-cyclodextrin inclusion complex. Finally, the nanoparticles are mixed with the volatile oil inclusion complex, dry extract powder of excipient medicinal materials, enteric-coated excipients, and fillers to prepare a thermosensitive bio-ink. A thermosensitive gel framework preparation is then obtained using semi-solid extrusion 3D printing technology.
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