A method for preparing high purity tertiary alcohols

The purification problem of E-nerolidol was solved by recrystallization and hydrolysis distillation following the reaction of p-nitrobenzoyl chloride with E-nerolidol, achieving high purity and high yield, which is suitable for pharmaceutical raw materials.

CN122127205APending Publication Date: 2026-06-02SHANGHAI AOBO PHARMTECH INC LTD +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI AOBO PHARMTECH INC LTD
Filing Date
2025-12-01
Publication Date
2026-06-02

AI Technical Summary

Technical Problem

Existing technologies cannot effectively purify E-nerolidol to meet the quality standards for pharmaceutical raw materials, and its structural stability results in low molecular reactivity, making derivatization purification difficult.

Method used

High-purity tertiary alcohols are prepared by reacting p-nitrobenzoyl chloride with tertiary alcohol compounds, recrystallizing, followed by alkaline hydrolysis and distillation. The specific steps include acyl chloride reaction, recrystallization, and hydrolysis distillation under an alkaline catalyst.

Benefits of technology

The purity of E-nerolidol reached over 99.5%, with impurity content below 0.1%, making it suitable for use as a pharmaceutical raw material. It also boasts high yield and low cost, making it suitable for industrial production.

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Abstract

This invention belongs to the field of organic synthesis technology and relates to a method for preparing high-purity tertiary alcohols, comprising: (1) reacting the crude product of the compound shown in Formula I with p-nitrobenzoyl chloride; (2) recrystallizing the obtained product to obtain the compound shown in Formula II; and (3) hydrolyzing and distilling the compound shown in Formula II to obtain the pure product of the compound shown in Formula I, as shown below. The high-purity tertiary alcohol prepared by this method has a single impurity content of less than 0.1% and has been successfully applied to E-nerolidol, with a purity sufficient to meet the requirements for use as a pharmaceutical raw material. This method has high yield, low cost, and is suitable for industrial production.
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