An antibacterial peptide composite preparation for preventing and treating plant fungal diseases and application thereof

By preparing an antimicrobial peptide compound formulation, nanomicelles are formed using components such as polyamide-quaternary ammonium salt coupling compounds and gallic acid carbonate-benzimidazole derivatives to encapsulate the antimicrobial peptides, thus constructing a multi-target synergistic attack system. This solves the problems of easy degradation and drug resistance of antimicrobial peptides in the field environment, and achieves efficient and stable control of plant fungal diseases.

CN122181524APending Publication Date: 2026-06-12呼伦贝尔市林业和草原事业发展中心(呼伦贝尔市林草种苗质量检验检测中心)
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
呼伦贝尔市林业和草原事业发展中心(呼伦贝尔市林草种苗质量检验检测中心)
Filing Date
2026-03-18
Publication Date
2026-06-12

AI Technical Summary

Technical Problem

Existing antimicrobial peptide formulations are easily degraded and inactivated in complex field environments, have unstable control effects and short duration of action, and their single mechanism of action easily leads to drug resistance in pathogenic fungi.

Method used

By preparing an antimicrobial peptide complex formulation, nanoscale micelles or complex micelles are formed using components such as polyamide-quaternary ammonium salt coupling compounds, gallic acid carbonate-benzimidazole derivatives, and surfactants to encapsulate the antimicrobial peptides, thereby constructing a multi-target synergistic attack system and enhancing stability and prevention and control effects.

Benefits of technology

It significantly improves the control effect on plant fungal diseases, extends the effective period, and reduces the risk of pathogens developing resistance, which is in line with the development direction of green and sustainable agriculture.

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Abstract

The application discloses an agricultural biotechnology field and discloses an antibacterial peptide composite preparation for preventing and treating plant fungal diseases and application thereof. The preparation comprises core antibacterial peptide epsilon-polylysine, polyamide-quaternary ammonium salt conjugate and gallic acid carbonate-benzimidazole derivative, and is supplemented with Tween, glycerol, sodium citrate and other auxiliary agents and water. A preparation method is as follows: first, two kinds of functional compounds are mixed with surfactants and antifreezes in water to form an auxiliary agent phase; then, the antibacterial peptide is dissolved in water and mixed with the auxiliary agent phase after adjusting the pH value; finally, a uniform preparation is obtained through high-pressure homogenization treatment. The composite preparation significantly enhances the prevention and treatment effect on plant pathogenic fungi through the synergistic effect of multiple active ingredients, has the advantages of high efficiency, stability and difficulty in inducing drug resistance, and is suitable for green prevention and control of various crop fungal diseases.
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