A composition containing ethyl spinosyn and fluroxure and its use

Abstract

The application relates to the technical field of pesticides, and discloses a composition containing ethyl spinosad and flurochloridone and application thereof. The composition mainly consists of ethyl spinosad and flurochloridone. The composition is used for pesticide application on crops. Ethyl spinosad and flurochloridone belong to different insecticides with different action mechanisms. The former is a neurotoxic agent with strong quick-acting property; the latter is an insect growth regulator with good persistence. The two mechanisms are complementary. After compounding, the composition can quickly kill adult insects and larvae, and can also long-acting control eggs and young insect stages, is beneficial to delaying the development of resistance, has good synergistic and persistent effects, has a higher prevention and treatment effect than single agents, can effectively avoid the generation of disease resistance, prolongs the action time of the composition, and has a good control effect.

Description

Technical Field

[0001] This invention relates to the field of pesticide technology, specifically to a composition containing ethyl spinosad and fluoxetine and its application. Background Technology

[0002] Chemical control is an important means of integrated pest management in agriculture. However, with the long-term and large-scale use of pesticides, the problem of pesticide resistance in pests has become increasingly prominent, while public concern about the quality and safety of agricultural products and the ecological environment is constantly increasing. Therefore, developing highly effective, low-toxicity, low-residue insecticide compositions that can delay the development of pesticide resistance in pests has become an important direction in the field of pesticide research and development.

[0003] Ethyl spinosad has contact and stomach poison effects, a broad insecticidal spectrum, and good control efficacy against a variety of pests, including Lepidoptera, Thysanoptera, and Diptera. It also exhibits low toxicity to natural enemies and mammals and good environmental compatibility. However, long-term use of ethyl spinosad alone carries the risk of resistance development. In some areas, pests such as diamondback moth and thrips have developed varying degrees of resistance to ethyl spinosad, leading to decreased efficacy. Furthermore, ethyl spinosad has limited effectiveness against insect eggs and a relatively short residual effect, often requiring frequent application to control pest populations with overlapping generations.

[0004] Fluorourylurea, also known as diphenylfluorourea, is a novel fluorobenzoylurea-based insect growth regulator. This class of insecticides exhibits excellent killing effects on various pests, including Lepidoptera, Coleoptera, and Homoptera, and is particularly effective against eggs and young larvae, with a relatively long residual effect. However, fluorourylurea acts relatively slowly, has poor rapid-acting effect on older larvae, and its long-term use alone carries the risk of resistance.

[0005] However, there are few reports on existing insecticidal compositions combining ethyl spinosad and flufenoxuron, and a lack of systematic research and application development regarding their synergistic mechanism. The combination of these two insecticides holds promise for achieving a complementary balance between rapid and sustained effects, while simultaneously delaying the development of insecticide resistance in pests through synergistic action on different targets. Therefore, developing a combined insecticidal composition containing ethyl spinosad and flufenoxuron to fully leverage their synergistic effect is of significant practical importance for pest control in agricultural production. Summary of the Invention

[0006] (a) Technical problems to be solved

[0007] To address the shortcomings of existing technologies, this invention provides a composition containing ethyl spinosad and fluoxyurea and its application, which solves the problems of high dosage and easy development of resistance when ethyl spinosad and fluoxyurea are used alone.

[0008] (II) Technical Solution

[0009] A composition containing ethyl spinosad and fluoxyfenozide, said composition comprising 20-50% by weight of the active ingredient, with the remainder being excipients;

[0010] The active ingredients include ethyl spinosad and fluoxyurea.

[0011] The weight ratio of ethyl spinosad to fluorouracil is 1:50 to 50:1.

[0012] Preferably, the weight ratio of ethyl spinosad to fluorouracil is 1:30 to 30:1.

[0013] Preferably, the weight ratio of ethyl spinosad to fluorouracil is 1:20 to 20:1.

[0014] Preferably, the weight ratio of ethyl spinosad to fluorouracil is 1:10 to 10:1.

[0015] Preferably, the weight ratio of ethyl spinosad to fluorouracil is 1:2.

[0016] Although both spinosad and flufenoxuron are highly effective insecticides, their mechanisms of action are quite different: spinosad is a neurotoxin that mainly activates nicotinic acetylcholine receptors in insects and affects γ-aminobutyric acid receptors, leading to continuous disruption of nerve signals, causing pests to rapidly become excited, paralyzed, and eventually die. It has the characteristics of being fast-acting, stomach poison, and contact poison.

[0017] Fluorocyanate is a benzoylurea insect growth regulator that inhibits the activity of chitin synthase, thus preventing the deposition of chitin in the insect's epidermis and causing it to die during molting or egg hatching because it cannot form a normal body wall. It is characterized by its slow-acting, sustained effect and high efficacy against eggs and young larvae.

[0018] Ethyl spinosad and flufenoxuron are insecticides with different mechanisms of action—the former is a neurotoxin with rapid onset; the latter is an insect growth regulator with good residual effect. Their mechanisms are complementary, and when combined, they can quickly kill adults and larvae, and also effectively control eggs and young insect stages, thus delaying the development of resistance.

[0019] Preferably, the dosage form of the composition is a water-dispersible granule, and the excipients include dispersants, wetting agents, disintegrants, binders, and fillers;

[0020] The dispersant is one of polycarboxylate ultra-high efficiency dispersant SP-2888 and polycarboxylate ultra-high efficiency dispersant SP-2852; the wetting agent is one of sodium dodecyl sulfate and sodium dodecylbenzene sulfonate; the disintegrant is one of sodium carbonate and sodium bicarbonate; the binder is starch; and the filler is one of silica and high clay.

[0021] Preferably, the dosage form of the composition is a dispersible oil suspension, and the excipients include an emulsifier and methyl oleate; the emulsifier is one of dispersing emulsifier SP-OF3473 and dispersing emulsifier SP-OF3498D.

[0022] Preferably, the dosage form of the composition includes, but is not limited to, suspensions, wettable powders, water-dispersible granules, water emulsions, microemulsions, dispersible oil suspensions, microcapsule suspensions, granules, emulsifiable concentrates, soluble concentrates, and powders.

[0023] Preferably, the composition containing ethyl spinosad and fluoxetine is used for the prevention of crop diseases.

[0024] More preferably, the pests are diamondback moth, beet armyworm, cabbage looper, leaf miner, whitefly, thrips, and beetle.

[0025] (iii) Beneficial technical effects

[0026] Ethyl spinosad, as a neurotoxin, can rapidly kill adult insects and older larvae through contact or stomach poisoning, and is particularly effective against small pests such as thrips, compensating for the shortcomings of fluazinam, which has a slow effect and poor efficacy against thrips. Fluazinam, as an insect growth regulator, continuously kills eggs and young larvae by inhibiting chitin synthesis, significantly extending its residual effect, which precisely compensates for the lack of ovicidal activity and short residual effect of ethyl spinosad. The combination of these two insects can simultaneously control multiple target pests, including Lepidoptera (diamond moth, beet armyworm, etc.), Thysanoptera (thrips), Diptera (leaf miners), and Coleoptera (beetles), achieving full-stage pest coverage. Furthermore, because their targets are completely different, they can effectively delay the development of pesticide resistance, thereby reducing the number of applications and lowering the risk of pesticide residues, meeting the needs of green pest control and integrated pest management in agriculture. Detailed Implementation

[0027] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0028] Example

[0029] Examples 1-9 are water-dispersible granules. The specific preparation method of the composition containing ethyl spinosad and fluoxetine is as follows:

[0030] Ethyl spinosad, fluoylurea, dispersant, wetting agent, disintegrant, binder and filler are mixed evenly and then pulverized by air jet mill to obtain the required particle size to obtain granulation material. The granulation material is then quantitatively fed into a fluidized bed, granulated and dried by a granulation and drying machine to obtain a composition containing ethyl spinosad and fluoylurea.

[0031] The specific formulations for Examples 1-9 are shown in the table below:

[0032] Table 1:

[0033]

[0034] Table 2:

[0035]

[0036] Examples 10-18 are in the form of dispersible oil suspensions. A specific preparation method for a composition containing ethyl spinosad and fluoxetine is as follows:

[0037] Ethyl spinosad, fluazinam and emulsifier were mixed evenly, and methyl oleate was added to make up the balance to 100%. The mixture was ball-milled for 5 hours to control the particle size at 2 μm to obtain a dispersible oil suspension.

[0038] The specific formulations for Examples 10-18 are shown in the table below:

[0039] Table 3:

[0040]

[0041] The above-prepared formulation was used to apply pesticide to cabbage. The pesticide was applied only once during the experimental period. Water was used as a blank control. At the time of application, the cabbage was in the early rosette stage, and the diamondback moth in the field was in the peak occurrence period in spring, mainly in the early larval stage (2nd-3rd instar). The experiment was conducted in a glass greenhouse.

[0042] According to the investigation methods stipulated in the "Guidelines for Field Efficacy Trials of Pesticides (I)," a baseline survey was conducted before pesticide application, and surveys were conducted 1 and 7 days after application, for a total of 5 surveys. A fixed-plant survey method was used, randomly selecting 15 plants for fixed-plant marking, with at least 3 young larvae per plant. The number of live larvae of different instars visible on the entire plant's leaf surface was counted. Pupating diamondback moths after pesticide application were not counted, but newly appearing larvae were counted. The Duncan's multiple range test (DMRT) was used to analyze the significance of differences in the experimental data. The efficacy calculation formula is as follows:

[0043] Control efficacy (%) = [1 - (number of insects before treatment in the blank control area × number of insects after treatment in the drug-treated area) / (number of insects after treatment in the blank control area × number of insects before treatment in the drug-treated area)] × 100%.

[0044] Table 4:

[0045]

[0046] As shown in the table, the composition of the present invention has excellent pest control effect on diamondback moth, and the combination of the two has the best control effect, especially the ethyl spinosad and fluoxetine composition in a ratio of 1:2, which has the best control effect, and the control effect can reach more than 95.0% after one week.

[0047] Furthermore, experiments have shown that the composition containing ethyl spinosad and flufenoxuron in this application has excellent control effects on pests such as diamondback moth, beet armyworm, cabbage looper, leaf miner, whitefly, thrips, and beetles, with control efficacy exceeding 95%, which is superior to the control efficacy of single agents and has a significant synergistic effect.

Claims

1. A composition containing ethyl spinosad and fluoxyfenozide, characterized in that, The composition comprises 20-50% by weight of active ingredient, with the remainder being excipients; The active ingredients include ethyl spinosad and fluoxyurea. The weight ratio of ethyl spinosad to fluorouracil is 1:50 to 50:

1.

2. The composition containing ethyl spinosad and fluoxyfenozide according to claim 1, characterized in that, The weight ratio of ethyl spinosad to fluorouracil is 1:30 to 30:

1.

3. The composition containing ethyl spinosad and fluoxyfenozide according to claim 1, characterized in that, The weight ratio of ethyl spinosad to fluorouracil is 1:20 to 20:

1.

4. The composition containing ethyl spinosad and fluoxyfenozide according to claim 1, characterized in that, The weight ratio of ethyl spinosad to fluorouracil is 1:10 to 10:

1.

5. The composition containing ethyl spinosad and fluoxyfenozide according to claim 1, characterized in that, The weight ratio of ethyl spinosad to fluorouracil is 1:

2.

6. The composition containing ethyl spinosad and fluoxyfenozide according to claim 1, characterized in that, The composition is in the form of water-dispersible granules, and the excipients include dispersants, wetting agents, disintegrants, binders, and fillers. The dispersant is one of polycarboxylate ultra-high efficiency dispersant SP-2888 and polycarboxylate ultra-high efficiency dispersant SP-2852; the wetting agent is one of sodium dodecyl sulfate and sodium dodecylbenzene sulfonate; the disintegrant is one of sodium carbonate and sodium bicarbonate; the binder is starch; and the filler is one of silica and high clay.

7. The composition containing ethyl spinosad and fluoxyfenozide according to claim 1, characterized in that, The composition is in the form of a dispersible oil suspension, and the excipients include an emulsifier and methyl oleate; the emulsifier is one of dispersing emulsifier SP-OF3473 and dispersing emulsifier SP-OF3498D.

8. The composition containing ethyl spinosad and fluoxyfenozide according to claim 1, characterized in that, The dosage forms of the composition include, but are not limited to, suspensions, wettable powders, water-dispersible granules, water emulsions, microemulsions, dispersible oil suspensions, microcapsule suspensions, granules, emulsifiable concentrates, soluble concentrates, and powders.

9. The application of the composition containing ethyl spinosad and fluazinam according to claim 1 for the prevention of pests.

10. The application according to claim 9, characterized in that, The pests mentioned are diamondback moth, beet armyworm, cabbage looper, leaf miner, whitefly, thrips, and beetles.

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