A pesticide composition and use thereof

Abstract

The present application relates to the technical field of pesticide compounding, in particular to a kind of pesticide composition, and the active ingredient of the pesticide composition includes active ingredient A, active ingredient B and active ingredient C, the active ingredient A is double amide insecticide, the active ingredient B is prothioconazole, and the active ingredient C is fludioxonil.The pesticide composition of the present application is compounded with three compounds with different action mechanisms, which plays a role in preventing insects and killing bacteria, can effectively slow down the generation of pest and pathogen resistance, reduce pesticide dosage, reduce pesticide residues and reduce production costs.

Description

[0001] This invention application is a divisional application of application number 202410657249.3, filed on May 25, 2024, entitled "A pesticide composition and its application". Technical Field

[0002] This invention belongs to the field of pesticide compound technology, specifically relating to a pesticide composition and its application. Background Technology

[0003] Prothioconazole is a trithione fungicide discovered, developed, and produced by Bayer Crop Science. Its mechanism of action is to inhibit the demethylation of lanosterol, a precursor of sterols in fungi, at the 14-position of 2,4-methylenedihydrolanosterol. Prothioconazole not only has systemic activity but also excellent protective, curative, and eradicative activities, and it significantly increases yield. Prothioconazole has low toxicity, no teratogenicity or mutagenicity, and is non-toxic to embryos. It is safe for humans and the environment and is mainly used to control numerous diseases in cereals, wheat, and legumes. It has good control efficacy against almost all wheat diseases, such as powdery mildew, sheath blight, wilt, leaf spot, rust, sclerotinia rot, net blight, and clouding. Its structural formula is as follows:

[0004] Fludioxonil is a novel pyrrole-based, non-systemic, broad-spectrum fungicide. As a seed treatment fungicide, suspension seed coatings can control many diseases. Fludioxonil drenching or soil treatment is highly effective against root diseases such as damping-off, root rot, wilt, and stem blight in various crops. Additionally, fludioxonil can be used as a spray to control gray mold and sclerotinia rot in various crops. Fludioxonil has excellent seed safety, does not affect seed germination, and promotes earlier, more uniform, and vigorous seedling emergence. Its structural formula is as follows:

[0005] Diamide insecticides exhibit high selectivity for ryanodine in target insects and mammals, and show no cross-resistance with existing insecticides of other mechanisms of action. The active ingredient A of this invention comprises fluchlordiniliprole (Formula I) and cyantraniliprole (Formula II). Their chemical structural formulas are as follows:

[0006] The chemical name of the compound of formula (I) is 3-bromo-1-(3-chloropyridin-2-yl)- N -[4,6-Dichloro-3-fluoro-2-(methylcarbamoyl)phenyl]-1 H -Pyrazole-5-carboxamide, empirical formula: C 17 H 10BrCl3FN5O2. Belongs to the benzamide class of insecticides. It effectively activates ryanodine (muscle) receptors in insects, leading to the excessive release of calcium ions from intracellular calcium stores, resulting in insect paralysis and death. It exhibits high activity against the larvae of lepidopteran pests, has a broad insecticidal spectrum, and good persistence.

[0007] Compound (II) is a second-generation ryanodine receptor inhibitor insecticide developed by DuPont after chlorantraniliprole. After action, it causes the release of endogenous calcium ions from insect striated and smooth muscle cells, disrupting the calcium ion balance inside and outside insect organelles, affecting muscle contraction, and ultimately leading to paralysis and death in insects. This agent has good systemic properties and can be translocated within the xylem. Compared to chlorantraniliprole, it has a broader insecticidal spectrum, controlling not only chewing lepidopteran and coleopteran pests but also piercing-sucking pests such as hemiptera. Bromnipotentiol exhibits no cross-resistance with organophosphates, carbamates, or pyrethroid insecticides, and has high safety for non-target arthropods and good environmental compatibility.

[0008] Currently, there are many types of seed coating agents on the market, with varying effects. Many agents are only effective against diseases or pests, but in production, diseases and pests often occur simultaneously. With the continuous development of science and technology, people have put forward new requirements for crop cultivation. Since some diseases and pests can be prevented through seed treatment, it is necessary to select appropriate seed coating agents to package crop seeds, thereby achieving the effect of preventing and controlling diseases and pests. Summary of the Invention

[0009] Based on the above, the present invention aims to provide a pesticide composition that is mainly used to control plant diseases and pests, and has a significant control effect, especially suitable for controlling corn diseases and pests.

[0010] To achieve the above objectives, the present invention adopts the following technical solution: a pesticide composition, wherein the active ingredients of the pesticide composition include active ingredient A, active ingredient B and active ingredient C, wherein active ingredient A is a diamide insecticide, active ingredient B is prothioconazole and active ingredient C is fludioxonil.

[0011] Furthermore, the mass ratio of active ingredient B to active ingredient C is 1:20 to 20:1, or any value within the above range. Furthermore, the mass ratio of active ingredient B to active ingredient C is 1:20, 1:10, 1:5, 1:3, 1:1, 3:1, 5:1, 10:1, 15:1, 20:1, or any value within the above range. Furthermore, the mass ratio of active ingredient B to active ingredient C is 1:20 to 15:1, or any value within the above range. Furthermore, the ratios 1:20, 1:10, 1:5, 1:3, 1:1, 3:1, 5:1, 10:1, 15:1, or any value within the above ranges; Furthermore, the diamide insecticide is selected from either fluchlorfenapyr or brofenoxam; Furthermore, the mass ratio of active ingredient A to active ingredient B to active ingredient C is 5~45:1~20:1~20, or any value within the above range; Furthermore, the mass ratio of active ingredient A to active ingredient B to active ingredient C is 5~35:1~15:1~10, or any value within the above range; Furthermore, the mass ratio of active ingredient A to active ingredient B to active ingredient C is 5~45:1~20:1~20, or any value within the above range; Furthermore, the mass ratio of active ingredient A to active ingredient B to active ingredient C is 5~35:1~15:1~10, or any value within the above range; Furthermore, the mass ratio of active ingredient A to active ingredient B to active ingredient C is 15~35:1~3:1, or any value within the above range; Furthermore, based on the total weight of the pesticide composition being 100 wt%, the total content of active ingredient A, active ingredient B, and active ingredient C in the pesticide composition is 1% to 80%; Furthermore, based on the total weight of the pesticide composition being 100 wt%, the total content of active ingredient A, active ingredient B, and active ingredient C in the pesticide composition is 1% to 50%; Furthermore, the pesticide composition further includes an adjuvant selected from one or more of the following: wetting agents, dispersants, emulsifiers, thickeners, disintegrants, antifreeze agents, defoamers, solvents, preservatives, stabilizers, warning colors, film-forming agents, synergists, and carriers. The wetting agent is selected from one or more of the following: alkylbenzene sulfonates, alkylnaphthalene sulfonates, lignin sulfonates, sodium dodecyl sulfate, sodium dioctyl succinate sulfonate, α-olefin sulfonates, alkylphenol polyoxyethylene ethers, castor oil polyoxyethylene ethers, alkylphenol ethoxylates, fatty alcohol ethoxylates, sodium fatty alcohol polyoxyethylene ether sulfate, silkworm excrement, soapberry powder, soapberry powder, SOPA, detergents, emulsifiers 2000 series, and wetting and penetrating agents F; and / or The dispersant is selected from one or more of the following: lignin sulfonates, alkyl naphthalene sulfonates formaldehyde condensates, naphthalene sulfonates, tristyrylphenol ethoxylate phosphates, fatty alcohol ethoxylates, alkylphenol polyoxyethylene ethers, alkylphenol polyoxyethylene ether methyl ether condensates sulfates, fatty amine polyoxyethylene ethers, glycerol fatty acid ester polyoxyethylene ethers, polycarboxylates, polyacrylic acids, phosphates, EO-PO block copolymers, and EO-PO graft copolymers; and / or The emulsifier is selected from one or more of the following: calcium dodecylbenzenesulfonate, alkylphenol formaldehyde resin polyoxyethylene ether, phenethylphenol polyoxyethylene polyoxypropylene ether, fatty alcohol ethylene oxide-propylene oxide copolymer, styrene-phenol polyoxyethylene ether, castor oil polyoxyethylene ether, and alkylphenol ether phosphate; and / or The thickener is selected from one or more of xanthan gum, organobentonite, gum arabic, sodium alginate, magnesium aluminum silicate, carboxymethyl cellulose, and silica; and / or The disintegrant is selected from one or more of sodium sulfate, ammonium sulfate, aluminum chloride, sodium chloride, ammonium chloride, bentonite, glucose, sucrose, starch, cellulose, urea, sodium carbonate, sodium bicarbonate, citric acid, and tartaric acid; and / or Antifreeze is selected from one or more of alcohols, alcohol ethers, chlorinated hydrocarbons, and inorganic salts; and / or Defoamer selected from C 10 -C 20 Saturated fatty acid compounds, silicone oil, silicone compounds, C8-C 10 One or more of the fatty alcohols; and / or The solvent is selected from one or more of benzene, toluene, xylene, mesitylene, methanol, ethanol, isopropanol, n-butanol, dimethyl sulfoxide, dimethylformamide, cyclohexanone, hydrocarbon carbonates, diesel oil, solvent oil, vegetable oil, vegetable oil derivatives, and water; and / or The preservative is selected from one or more of propionic acid, sodium propionate, sorbic acid, sodium sorbate, potassium sorbate, benzoic acid, sodium benzoate, sodium p-hydroxybenzoate, methyl p-hydroxybenzoate, Kathon, and 1,2-benzisothiazolin-3-one; and / or The stabilizer is selected from one or more of the following: disodium hydrogen phosphate, oxalic acid, succinic acid, adipic acid, borax, 2,6-di-tert-butyl-p-cresol, triethanolamine oleate, epoxidized vegetable oil, kaolin, bentonite, attapulgite, silica, talc, montmorillonite, and starch; and / or Warning colors are selected from one or more of the following: blue, green, red, and purple; and / or Film-forming agents are selected from one or more of sodium carboxymethyl starch, cellulose derivatives (sodium carboxymethyl cellulose, sodium alginate, polyvinyl alcohol), and polyacrylic acid; and / or Synergists are selected from synergistic phosphorus, synergistic ether; and / or The carrier is selected from one or more of the following: ammonium salts, ground natural minerals, ground artificial minerals, silicates, resins, waxes, solid fertilizers, water, organic solvents, mineral oils, vegetable oils, and vegetable oil derivatives. Furthermore, the pesticide composition is in the form of either a solid seed treatment formulation or a liquid seed treatment formulation. Furthermore, the pesticide composition is formulated as any one of seed treatment dry powder, seed treatment dispersible powder, seed treatment liquid, seed treatment emulsion, or seed treatment suspension. Furthermore, the pesticide composition is in the form of a seed treatment suspension. The application of the pesticide composition described above in the control of plant diseases and / or pests.

[0012] Furthermore, the plants mentioned include corn, wheat, soybeans, rice, peanuts and / or cotton; Furthermore, the plant is corn, and the corn disease is any one of corn stem base rot, corn sheath blight, corn silk smut, corn ear and kernel rot, corn seedling blight, corn rough dwarf disease, or corn topping disease. Furthermore, the aforementioned corn disease is corn stalk base rot; Corn stalk rot, also known as corn stalk base rot or bacterial wilt, is caused by single or combined infections of various pathogens, primarily affecting the root system and stalk base of corn plants. The incidence rate is typically 15%–20%, but can reach over 70% in severe cases. Yield losses due to this disease are generally around 20%, with severe cases resulting in yield reductions of approximately 50%. Corn stalk rot occurs in all major corn-producing areas of China. In recent years, however, with the continuous increase in the area of ​​continuous corn cropping, the widespread application of straw return to the field, and the use of no-till planting and high-density planting techniques, corn stalk rot has gradually become more severe, becoming a pressing problem in corn production and a significant limiting factor affecting yield.

[0013] Furthermore, the corn pests mentioned are any one of the following: two-spotted cutworm, small cutworm, wireworm, corn aphid, armyworm, beet armyworm, cotton bollworm, or corn borer; Furthermore, the corn pest mentioned is the two-spotted cutworm; The two-spotted cutworm belongs to the order Lepidoptera, family Noctuidae. Its larvae primarily feed on the base of host crops, biting and damaging tender root tissues, leading to seedling death. This is especially true for corn seedlings at the 3-5 leaf stage, as early detection is difficult, often resulting in replanting or complete crop failure, severely impacting corn production. Traditional pesticide spraying is ineffective against larvae hiding in the root system or under straw. Therefore, seed coating with seed dressing agents is an effective method for controlling the two-spotted cutworm in corn. Compared with the prior art, the beneficial effects of the technical solution of the present invention are as follows: 1) The pesticide composition of the present invention can control both insect pests and diseases in corn, broaden the control spectrum, save labor, and reduce production costs; 2) The three active ingredients in the pesticide composition of the present invention, when combined, exhibit a certain synergistic effect on the control of pests and diseases within a certain range, thereby improving the control effect; 3) The pesticide composition of the present invention can prolong the duration of action of the agent, reduce the number of times the agent is used, delay the development of pesticide resistance in pests and fungi, and prolong the service life of a single agent. Detailed Implementation

[0014] To make the technical solution, objectives and advantages of the present invention clearer, the present invention is described with reference to the following specific embodiments. However, the present invention can be implemented in various forms and should not be limited to the embodiments described herein.

[0015] Formulation preparation example: Seed treatment suspension preparation process: The active ingredients, additives, and water are mixed and stirred evenly under high shear according to the formula, and then sand milled for 2.5 hours to make the average particle size reach 1-5 micrometers. Finally, thickener, preservative, and film-forming agent are added and shearing and stirring are continued to be uniform to obtain the seed treatment suspension.

[0016] Preparation Example 1: 29% Fluchlorfenapyr·Prothioconazole·Fluoxadiazon Seed Treatment Suspension (25%+3%+1%) Components content Fluchlorfenapyr 25% Prothioconazole 3% Fludioxonil 1% Fatty alcohol ethylene oxide-propylene oxide copolymer 3% Alkylphenol polyoxyethylene ether phosphate salt 2% Sodium dodecylbenzenesulfonate 2% Sodium carboxymethyl cellulose 1% Xanthan Gum 0.2% Rose red pigment 5% Ethylene glycol 5% Magnesium aluminum silicate 1% silicone defoamer 0.5% Methylparaben 1.5% Deionized water Make up the surplus Preparation Example 2: 27% Fluchlorfenapyr·Prothioconazole·Fluoxadiazon Seed Treatment Suspension (25%+1%+1%) Components content Fluchlorfenapyr 25% Prothioconazole 1% Fludioxonil 1% Fatty amine polyoxyethylene ether 2% Alkylphenol polyoxyethylene ether phosphate salt 3% Sodium lignosulfonate 2% Polyacrylic acid 1.5% Xanthan Gum 0.2% Rose red pigment 5% Propylene glycol 5% Magnesium aluminum silicate 1% silicone defoamer 0.5% Sodium propionate 1% Deionized water Make up the surplus Preparation Example 3: 39% Bromoxynil·Prothioconazole·Fluoxadiazon Seed Treatment Suspension (35%+3%+1%) Components content bromocyanamide 35% Prothioconazole 3% Fludioxonil 1% Isomeric tridecyl alcohol polyoxyethylene ether 2% Glyceryl fatty acid esters polyoxyethylene ether phosphates 4% Sodium polycarboxylate 2% Sodium carboxymethyl starch 1% Xanthan Gum 0.2% Rose red pigment 7% Propylene glycol 5% Magnesium aluminum silicate 1% silicone defoamer 0.5% Sodium sorbate 1% Deionized water Make up the surplus Preparation Example 4: 17% Bromnifloxacin·Prothioconazole·Fluoxadiazon Seed Treatment Suspension (15%+1%+1%) Components content bromocyanamide 15% Prothioconazole 1% Fludioxonil 1% Isomeric tridecyl alcohol polyoxyethylene ether 2% Styrene-phenol polyoxyethylene ether phosphate salt 2% Alkyl aryl polyoxyethylene polyoxypropylene ether 3% Sodium carboxymethyl starch 1% Xanthan Gum 0.2% Rose red pigment 4% Glycerol 5% Magnesium aluminum silicate 1% silicone defoamer 0.5% Sodium carboxymethyl starch 2% Deionized water Make up the surplus Control Example 1: 28% Fluchlorfenapyr·Prothioconazole Seed Treatment Suspension (25%+3%) Components content Fluchlorfenapyr 25% Prothioconazole 3% Alkylphenol polyoxyethylene ether 3% Alkylphenol polyoxyethylene ether phosphate 3% naphthalenesulfonate formaldehyde condensate 2% Sodium carboxymethyl starch 1% Xanthan Gum 0.2% Rose red pigment 6% Ethylene glycol 5% Magnesium aluminum silicate 1% silicone defoamer 0.5% Sodium benzoate 1% Deionized water Make up the surplus Control Example 2: 26% Fluchlorfenapyr·Fluordioxonil Seed Treatment Suspension (25%+1%) Components content Fluchlorfenapyr 25% Fludioxonil 1% Fatty alcohol polyoxyethylene ether 1% Castor oil polyoxyethylene ether phosphate 3% polycarboxylate 2% Sodium lignosulfonate 3% Polyacrylic acid 1% Xanthan Gum 0.2% Rose red pigment 6% Ethylene glycol 4% Magnesium aluminum silicate 1% silicone defoamer 0.5% Sodium benzoate 2% Deionized water Make up the surplus Control Example 3: 26% Fluchlorfenapyr·Prothioconazole Seed Treatment Suspension (25%+1%) Components content Fluchlorfenapyr 25% Prothioconazole 1% Fatty alcohol polyoxyethylene ether 1% EO / PO block copolymer 2% Alkyl aryl polyoxyethylene polyoxypropylene ether 4% Sodium carboxymethyl cellulose 1% Xanthan Gum 0.2% Rose red pigment 6% Propylene glycol 5% Magnesium aluminum silicate 1% silicone defoamer 0.5% Sodium sorbate 2% Deionized water Make up the surplus Control Example 4: 38% bromocyanamide·prothioconazole seed treatment suspension (35%+3%) Components content bromocyanamide 35% Prothioconazole 3% Phenethylphenol polyoxyethylene polyoxypropylene ether 2% Alkylphenol polyoxyethylene ether phosphate 3% naphthalenesulfonate formaldehyde condensate 2% Polyvinyl alcohol 1% Xanthan Gum 0.2% Rose red pigment 7% Ethylene glycol 5% Magnesium aluminum silicate 1% silicone defoamer 0.5% Kathon 1% Deionized water Make up the surplus Control Example 5: 36% bromocyanamide·fludioxonil seed treatment suspension (35%+1%) Components content bromocyanamide 35% Fludioxonil 1% Isomeric tridecyl alcohol polyoxyethylene ether 2% Alkylphenol polyoxyethylene ether phosphate 3% EO / PO block copolymer 2% Calcium lignosulfonate 2% Polyacrylic acid 1% Xanthan Gum 0.2% Rose red pigment 7% Ethylene glycol 5% Magnesium aluminum silicate 1% silicone defoamer 0.5% Potassium benzoate 1% Deionized water Make up the surplus Control Example 6: 16% bromocyanamide·prothioconazole seed treatment suspension (15%+1%) Components content bromocyanamide 15% Prothioconazole 1% Castor oil polyoxyethylene ether phosphate 3% Sodium lignosulfonate 2% Alkylphenol formaldehyde resin polyoxyethylene ether 4% Polyvinyl alcohol 1% Xanthan Gum 0.2% Rose red pigment 6% Propylene glycol 5% Magnesium aluminum silicate 1% silicone defoamer 0.5% Sodium benzoate 1% Deionized water Make up the surplus Control Example 7: 16% bromocyanamide·fludioxonil seed treatment suspension (15%+1%) Components content bromocyanamide 15% Fludioxonil 1% Glyceryl fatty acid ester polyoxyethylene ether 3% Styrene-phenol polyoxyethylene ether phosphate salt 3% Alkylphenol polyoxyethylene ether phosphate salt 3% Sodium alginate 1% Xanthan Gum 0.2% Rose red pigment 6% Glycerol 5% Magnesium aluminum silicate 1% silicone defoamer 0.5% Potassium benzoate 1% Deionized water Make up the surplus Indoor activity test: Example 1: Indoor activity test of Fusarium graminearum Test basis: The test refers to NY / T 1156.2-2006 "Guidelines for Indoor Bioassay Tests of Pesticides - Fungicides Part II: Test on Inhibition of Mycelial Growth of Pathogenic Fungi - Plate Method".

[0017] Test strain: Fusarium graminearum ( Fusarium graminearum After activation, the strain is stored at 4°C for later use.

[0018] Test reagents: 97% prothioconazole technical, 98% fludioxonil technical, 95% fluchlorfenapyr technical, 94% bromocyanamide technical.

[0019] Test medium: Potato dextrose agar (PDA) was used as the test medium.

[0020] Other reagents: acetone (analytical grade), Tween 80 (chemically pure), all of which are commercially available.

[0021] Preparation of the formulation: The technical grade prothioconazole, fludioxonil, fluchlorfenapyr, and cyantraniliprole were dissolved in acetone to prepare high-concentration stock solutions. Prothioconazole and fludioxonil were then mixed in ratios of 1:20, 1:10, 1:5, 1:3, 1:1, 3:1, 5:1, 10:1, 15:1, and 20:1 to prepare 10 sets of mixed solutions. The single agents and mixed solutions were then diluted with 0.1% Tween 80 aqueous solution to obtain 5 series of mass concentrations.

[0022] Based on this, a better ratio of prothioconazole to fludioxonil was selected, and the better ratio mixture was used as a fungicide combination, which was then compounded with fluchlorfenapyr and cyananthramide in different mass ratios.

[0023] Experimental replication: Four petri dishes were used for each concentration of the test reagent, with one petri dish for each replicate, for a total of four replicates. A 0.1% Tween 80 aqueous solution without the reagent was used as a blank control.

[0024] Preparation of drug-containing culture medium: In a clean bench, pre-sterilized and thawed culture medium was added to sterile Erlenmeyer flasks, 72 mL to each flask, and cooled to approximately 45°C. Then, using a pipette, 8 mL of the prepared drug solution was sequentially pipetted in ascending order of concentration and added to the sterile Erlenmeyer flasks. The mixture was thoroughly mixed, and then poured evenly into four 9 cm diameter petri dishes to prepare PDA plates containing the corresponding concentrations of drug. Each treatment was repeated four times. The blank control consisted of a 0.1% Tween 80 aqueous solution without the drug.

[0025] Inoculation: Under aseptic conditions, use a sterile punch to cut off a mycelial cake from the edge of the pre-cultured Fusarium graminearum. Inoculate the mycelial cake into the center of the drug-containing plate using an inoculator, cover with the cap, and place in a constant temperature incubator at 25°C for incubation.

[0026] Experimental investigation: The growth of pathogenic fungal hyphae was investigated based on the colony growth in the blank control culture dishes. The diameter of the colonies (cm) was measured with a ruler, and the diameter of each colony was measured once using the cross-sectional method, and the average value was taken.

[0027] Data statistics and analysis: Based on the survey results, the inhibition rate of mycelial growth of the tested target bacteria by each treatment concentration was calculated, in percentage (%). The calculation results were rounded to two decimal places.

[0028]

[0029] In the formula: D – Colony growth diameter; D1—colony diameter; D2 – Diameter of the mushroom cake.

[0030]

[0031] In the formula: I – Mycelial growth inhibition rate; D0—Correlation diameter of the blank control group; D T — Diameter of colonies grown after chemical treatment.

[0032] The data were processed using probability value analysis. IBM SPSS Statistics 20 statistical analysis system was used to analyze the data and derive the toxicity regression line and EC5. 50 The values ​​and correlation coefficients are used to evaluate the activity of the test reagent on the biological sample.

[0033] Sun Yunpei's method: Evaluating the synergistic effect of drug mixtures based on the co-toxicity coefficient (CTC), the co-toxicity coefficient of the compound... CTC ≥120 exhibits a synergistic effect; CTC≤80 It exhibits antagonistic effects; 80 < CTC <120 exhibits an additive effect.

[0034] Calculation of the co-toxicity coefficient (CTC value) of the mixture:

[0035] In the formula: ATI —Measured toxicity index of the mixture; S —EC of standard reagents 50 The unit is milligrams per liter (mg / L); M EC of the mixture 50 The unit is milligrams per liter (mg / L).

[0036]

[0037] In the formula: TTI —Theoretical toxicity index of the mixture; TI A —A. Toxicity index of drug A; P A —The percentage content of drug A in the mixture, expressed as a percentage (%). TI B —Toxicity index of drug B; P B —Percentage content of agent B in the mixture, expressed as percentage (%).

[0038]

[0039] In the formula: CTC —Cotoxicity coefficient; ATI —Measured toxicity index of the mixture; TTI —Theoretical toxicity index of mixed preparations.

[0040] The test results are shown in the table below: Table 1. Results of indoor toxicity assays of prothioconazole, fludioxonil, and their mixtures against Fusarium graminearum. Test reagents virulence regression equation Correlation coefficient R <![CDATA[EC 50 (mg.L -1 )]]> Cotoxicity coefficient Prothioconazole (A) y = 2.598x - 1.336 0.991 3.268 - Fludioxonil (B) y = 2.490x - 1.004 0.992 2.531 - A:B=1:20 y = 2.310x - 0.693 0.995 1.996 128.180 A:B=1:10 y = 2.327x - 0.639 0.994 1.881 137.372 A:B=1:5 y = 2.312x - 0.588 0.993 1.796 146.428 A:B=1:3 y = 2.237x - 0.567 0.995 1.793 149.594 A:B=1:1 y = 2.310x - 0.583 0.992 1.788 159.545 A:B=3:1 y = 2.457x - 0.729 0.988 1.980 153.851 A:B=5:1 y = 2.134x - 0.774 0.999 2.305 135.216 A:B=10:1 y = 2.513x - 0.998 0.984 2.495 127.604 A:B=15:1 y = 2.520x - 1.062 0.983 2.638 121.667 A:B=20:1 y = 2.516x - 1.140 0.990 2.838 113.577 Indoor test results showed that prothioconazole and fludioxonil have different mechanisms of action, and their combined use is beneficial to improve control efficacy. Both prothioconazole and fludioxonil have good control effects against Fusarium graminearum. Prothioconazole and fludioxonil exhibit a synergistic effect within a ratio of 1:20 to 15:1, with a more significant synergistic effect within a mass ratio of 1:5 to 5:1. The 1:1 mass ratio of prothioconazole to fludioxonil showed better activity, with its EC50 value being [missing information]. 50 The concentration was 1.788 mg / L, and the co-toxicity coefficient was 159.545.

[0041] Table 2. Results of indoor toxicity tests on Fusarium graminearum using a mixture of prothioconazole and fludioxonil (1:1) and its mixture with diamide insecticides. Test reagents virulence regression equation Correlation coefficient R <![CDATA[EC 50 (mg.L -1 )]]> Cotoxicity coefficient Prothioconazole: Fludioxonil (1:1) y = 2.27x - 0.536 0.993 1.723 / Fluchlorfenapyr / / ＞200 / bromocyanamide / / ＞200 / Fluchlorfenapyr: Prothioconazole: Fludioxonil (5:1:1) y = 2.191x - 0.329 0.997 1.413 121.939 Fluchlorfenapyr: Prothioconazole: Fludioxonil (15:1:1) y = 2.221x - 0.211 0.995 1.245 138.394 Fluchlorfenapyr: Prothioconazole: Fludioxonil (25:1:1) y = 2.336x - 0.177 0.987 1.190 144.790 Fluchlorfenapyr: Prothioconazole: Fludioxonil (35:1:1) y = 2.245x - 0.223 0.996 1.257 137.072 Fluchlorfenapyr: Prothioconazole: Fludioxonil (45:1:1) y = 2.161x - 0.304 0.994 1.382 124.674 Bromnifloxacin: Prothioconazole: Fludioxonil (5:1:1) y = 2.179x - 0.277 0.996 1.340 128.582 Bromnifloxacin: Prothioconazole: Fludioxonil (15:1:1) y = 2.233x - 0.136 0.997 1.150 149.826 Bromnifloxacin: Prothioconazole: Fludioxonil (25:1:1) y = 2.170x - 0.253 0.995 1.308 131.728 Bromnifloxacin: Prothioconazole: Fludioxonil (35:1:1) y = 2.027x - 0.286 0.992 1.384 124.494 Bromnifloxacin: Prothioconazole: Fludioxonil (45:1:1) y = 2.098x - 0.377 0.987 1.513 113.880 Note 1. The concentration in the mixture of fluchlorfenapyr: prothioconazole: fludioxonil and bromocyanamide: prothioconazole: fludioxonil refers to the concentration of the "prothioconazole: fludioxonil" mixture; 2. Flufenoxuron and bromuconazole showed no significant inhibitory activity against Fusarium graminearum at the designed maximum concentration of 200 mg / L, making it impossible to calculate the EC50. 50 And the toxicity regression equation.

[0042] Table 3. Results of indoor toxicity tests on Fusarium graminearum using a mixture of prothioconazole and fludioxonil (3:1) and its mixture with diamide insecticides. Test reagents virulence regression equation Correlation coefficient R <![CDATA[EC 50 (mg.L -1 )]]> Cotoxicity coefficient Prothioconazole: Fludioxonil (3:1) y = 2.426x - 0.679 0.987 1.905 / Fluchlorfenapyr / / ＞200 / bromocyanamide / / ＞200 / Fluchlorfenapyr: Prothioconazole: Fludioxonil (5:3:1) y = 2.140x - 0.392 0.980 1.524 125.000 Fluchlorfenapyr: Prothioconazole: Fludioxonil (15:3:1) y = 2.163x - 0.316 0.985 1.400 136.071 Fluchlorfenapyr: Prothioconazole: Fludioxonil (25:3:1) y = 2.209x - 0.209 0.993 1.242 153.382 Fluroxyfenozide: Prothioconazole: Fludioxonil (35:3:1) y = 2.204x - 0.288 0.993 1.351 141.007 Fluroxyfenozide: Prothioconazole: Fludioxonil (45:3:1) y = 2.148x - 0.331 0.998 1.425 133.684 Bromnifloxacin: Prothioconazole: Fludioxonil (5:3:1) y = 2.094x - 0.370 0.987 1.502 126.831 Bromnifloxacin: Prothioconazole: Fludioxonil (15:3:1) y = 2.169x - 0.344 0.989 1.441 132.200 Bromnifloxacin: Prothioconazole: Fludioxonil (25:3:1) y = 2.179x - 0.266 0.992 1.325 143.774 Bromnifloxacin: Prothioconazole: Fludioxonil (35:3:1) y = 2.222x - 0.224 0.991 1.262 150.951 Bromnifloxacin: Prothioconazole: Fludioxonil (45:3:1) y = 2.041x - 0.310 0.987 1.418 134.344 Note 1. The concentration in the mixture of fluchlorfenapyr: prothioconazole: fludioxonil and bromocyanamide: prothioconazole: fludioxonil refers to the concentration of the "prothioconazole: fludioxonil" mixture; 2. Flufenoxuron and bromuconazole showed no significant inhibitory activity against Fusarium graminearum at the designed maximum concentration of 200 mg / L, making it impossible to calculate the EC50. 50 And the toxicity regression equation.

[0043] Diamide insecticides have no significant activity against Fusarium graminearum. However, mixtures of diamide insecticides with a mass ratio of 1:1 and 3:1 of prothioconazole and fludioxonil showed a synergistic effect against Fusarium graminearum.

[0044] Example 2: Indoor toxicity test of the two-spotted cutworm.

[0045] Test basis: The test refers to NY / T 1154.7-2006 "Guidelines for Indoor Bioassay of Pesticides - Insecticides Part 7: Determination of Combined Effects of Mixtures" and NY / T 1154.6-2008 "Guidelines for Indoor Bioassay of Pesticides - Insecticides Part 6: Insect Immersion Method".

[0046] Experimental target: Two-spotted cutworm ( Athetis lepigone (Moschler) Fourth instar larvae.

[0047] Test agents: 97% prothioconazole technical, 98% fludioxonil technical, 95% fluchlorfenapyr technical, 94% bromocyanamide technical.

[0048] Other reagents: acetone (analytical grade), Tween 80 (chemically pure). All of the above reagents are commercially available.

[0049] Determination method: Prepare stock solutions for each single agent separately, and design appropriate ratios based on the purpose of mixing and the activity of the agents. Prepare five series of mass concentrations for each single agent and each group of mixed agents according to the same ratio. Treat 20 test insects per treatment, and repeat 4 times. Immerse the test insects in each concentration of drug solution for 10 seconds, absorb excess drug solution with filter paper, and place the treated test insects in a constant temperature insect rearing room at 25±1℃, relative humidity 65%±5%, and light intensity L:D=14h:10h.

[0050] Data statistics and analysis: The mortality of the test insects was checked 24 hours after treatment, and the total number of insects and the number of dead insects were recorded. The corrected mortality rate for each treatment was calculated based on the survey data. The calculations were performed according to formulas (1) and (2), and the results were rounded to two decimal places:

[0051] In the formula: P — Mortality rate, expressed as a percentage (%); K —This indicates the number of dead insects, expressed in heads; N — This indicates the total number of insects treated, in units of heads.

[0052] ············(2) In the formula: P 1 —Adjusted mortality rate, in percentages (%); P t —The mortality rate is expressed as a percentage (%). P 0 — Mortality rate in blank control group, expressed as a percentage (%).

[0053] If the control mortality rate is <5%, no correction is needed; if the control mortality rate is between 5% and 20%, correction should be made according to formula (2); if the control mortality rate is >20%, the experiment needs to be repeated.

[0054] The data was processed using probability value analysis. The IBM SPSS Statistics 20 statistical analysis system can be used to analyze the data and determine the toxicity regression line and LC-value. 50 Values ​​and correlation coefficients are used to evaluate the activity of the test reagent on the biological sample.

[0055] The co-toxicity coefficient (CTC value) of the mixture is calculated according to formulas (3), (4), and (5): ··········(3) In the formula: ATI —Measured toxicity index of the mixture; S LC of standard insecticides 50 The unit is milligrams per liter (mg / L); M LC of the mixture 50 The unit is milligrams per liter (mg / L).

[0056] ······(4) In the formula: TTI —Theoretical toxicity index of the mixture; TI A —A. Toxicity index of drug A; P A —The percentage content of drug A in the mixture, expressed as a percentage (%). TI B —Toxicity index of drug B; P B —Percentage content of agent B in the mixture, expressed as percentage (%).

[0057] ··········(5) In the formula: CTC —Cotoxicity coefficient; ATI —Measured toxicity index of the mixture; TTI —Theoretical toxicity index of mixed preparations.

[0058] Co-toxicity coefficient of compound CTC ≥120 exhibits a synergistic effect; CTC≤ 80 exhibits antagonistic effects; 80 < CTC <120 exhibits an additive effect.

[0059] The test results are shown in the table below: Table 4. Results of indoor toxicity tests on *Cephalosporin* and its mixture with diamide insecticides. Test reagents virulence regression equation Correlation coefficient R <![CDATA[LC 50 (mg.L -1 )]]> Cotoxicity coefficient Fluchlorfenapyr y = 1.814x - 0.328 0.995 1.516 / bromocyanamide y = 2.191x - 0.490 0.992 0.598 / Prothioconazole: Fludioxonil (3:1) / / ＞200 / Prothioconazole: Fludioxonil (1:1) / / ＞200 / Fluchlorfenapyr: Prothioconazole: Fludioxonil (15:3:1) y = 1.630x - 0.164 0.999 1.261 120.222 Fluchlorfenapyr: Prothioconazole: Fludioxonil (25:3:1) y = 1.630x - 0.026 0.998 1.038 146.050 Fluroxyfenozide: Prothioconazole: Fludioxonil (35:3:1) y = 1.421x - 0.054 0.998 1.091 138.955 Fluchlorfenapyr: Prothioconazole: Fludioxonil (15:1:1) y = 1.878x - 0.013 0.987 1.106 137.071 Fluchlorfenapyr: Prothioconazole: Fludioxonil (25:1:1) y = 1.827x - 0.014 0.982 1.017 149.066 Fluchlorfenapyr: Prothioconazole: Fludioxonil (35:1:1) y = 1.754x + 0.039 0.993 0.950 159.579 Bromnifloxacin: Prothioconazole: Fludioxonil (15:3:1) y = 2.261x + 0.700 0.981 0.490 122.041 Bromnifloxacin: Prothioconazole: Fludioxonil (25:3:1) y = 2.125x + 0.883 0.988 0.384 155.729 Bromnifloxacin: Prothioconazole: Fludioxonil (35:3:1) y = 2.169x + 0.743 0.996 0.455 131.429 Bromnifloxacin: Prothioconazole: Fludioxonil (15:1:1) y = 2.088x + 0.799 0.992 0.414 144.444 Bromnifloxacin: Prothioconazole: Fludioxonil (25:1:1) y = 2.104x + 0.787 0.990 0.422 141.706 Bromnifloxacin: Prothioconazole: Fludioxonil (35:1:1) y = 2.116x + 0.698 0.993 0.468 127.778 Note: 1. The concentrations of fluchlorfenapyr: prothioconazole: fludioxonil and broflanilide: prothioconazole: fludioxonil in the mixed solution are the concentrations of fluchlorfenapyr and broflanilide, respectively; 2. Prothioconazole: Fludioxonil at ratios of 1:1 and 3:1 showed no significant activity against *Brussels sprouts* at the designed maximum concentration of 200 mg / L, making LC50 calculation impossible. 50 And the toxicity regression equation.

[0060] Indoor activity assays showed that the mixture of prothioconazole and fludioxonil had no significant activity against the two-spotted cutworm. The diamide insecticides flufenoxuron and bromocyanamide exhibited good toxicity against the two-spotted cutworm, with LC50 data... 50 1.516 mg / L -1 0.598 mg / L -1 The experimental results showed that combining prothioconazole and fludioxonil with diamide insecticides to form a ternary compound formulation significantly increased the toxicity of diamide insecticides, enhanced the control effect on pests, and significantly reduced the dosage. In addition, combining the three agents in appropriate ratios (3:1, 1:1) broadened the spectrum of disease and insect control, allowing for the concurrent control of corn diseases, saving labor and costs, and improving safety.

[0061] Example 3: Indoor artificial inoculation test for the control efficacy of two-spot cutworm: Test location: Sunshine greenhouse in Jimo City, Qingdao City, Shandong Province.

[0062] The crop tested was maize.

[0063] Experimental target: Two-spotted cutworm, the insect source was a population continuously cultured indoors for multiple generations.

[0064] Rearing conditions: Temperature 26±1℃, photoperiod: L:D=14h:10h, relative humidity 60%~80%.

[0065] Drug design: Table 5 Test reagents and dosages serial number Drug Name Dosage of active ingredient (g / 100kg seeds) 1 29% Fluchlorfenapyr•Prothioconazole•Fluoxadiazon Seed Treatment Suspension Concentrate (25%+3%+1%) 100 2 27% Fluchlorfenapyr•Prothioconazole•Fluoxadiazon Seed Treatment Suspension Concentrate (25%+1%+1%) 100 3 39% Bromoxynil•Prothioconazole•Fluoxadiazon Seed Treatment Suspension Concentrate (35%+3%+1%) 100 4 17% Bromoxynil•Prothioconazole•Fluoxadiazon Seed Treatment Suspension Concentrate (15%+1%+1%) 100 5 28% Fluchlorfenapyr•Prothioconazole Seed Treatment Suspension (25%+3%) 135.5 6 26% Fluchlorfenapyr·Fluordiamide Seed Treatment Suspension (25%+1%) 135.5 7 26% Fluchlorfenapyr•Prothioconazole Seed Treatment Suspension (25%+1%) 135.5 8 38% Bromoxynil•Prothioconazole Seed Treatment Suspension (35%+3%) 135.5 9 36% Bromoxynil•Fluordioxonil Seed Treatment Suspension (35%+1%) 135.5 10 16% Bromnifloxacin•Prothioconazole Seed Treatment Suspension (15%+1%) 135.5 11 16% Bromoxynil•Fluordioxonil Seed Treatment Suspension (15%+1%) 135.5 12 33% Chlorantraniliprole•Prothioconazole•Fluoxadiazon (20%+10%+1%) 135.5 13 30% Brombutamide Seed Treatment Suspension 288 14 25% Fluchlorfenapyr Seed Treatment Suspension 200 15 Blank control - Experimental design: Healthy, uniformly developed 3rd instar larvae were selected for the experiment. Different pesticide treatments were applied to the corn seeds before sowing, and the coated seeds were then allowed to air dry naturally. The coated seeds were sown in flowerpots (20cm in diameter and 17cm in height), with 3 seeds per pot.

[0066] Thin the corn seedlings during the one-leaf-one-heart stage, leaving one healthy seedling per pot. Inoculate each pot with one starved two-spotted cutworm, and surround the pot with a plastic sheet (about 20cm high) to prevent the larvae from escaping. Sprinkle a 1cm layer of kraft paper scraps around the corn seedlings as a mulch. Each treatment consists of 30 pots, and each treatment is replicated 4 times. Five days after inoculation, investigate the damage to the plants in each treatment, and calculate the plant damage index and control effect.

[0067] Standards for classifying the degree of plant damage: Level 0: No feeding; Grade 1: Feeds on the outermost epidermis, with one hole or a small notch, the depth of which is ≤10% of the seedling stem diameter; Level 2: Feeding on one or more notches or holes, with the cumulative feeding depth between 10% and 30% of the seedling stem diameter; Level 3: Feeding on one or more notches or holes; the cumulative feeding depth is less than 30% of the seedling stem diameter and less than 50% of the seedling stem diameter. Level 4: Broken seedlings, or cumulative feeding depth > 50% of the seedling stem diameter.

[0068] Methods for calculating drug efficacy:

[0069] The test results are shown in the table below: Table 6. Control efficacy of the tested pesticides against the two-spotted cutworm. serial number Drug Name Victimization index Seedling protection effect (%) 1 29% Fluchlorfenapyr•Prothioconazole•Fluoxadiazon Seed Treatment Suspension Concentrate (25%+3%+1%) 8.96 88.92 2 27% Fluchlorfenapyr•Prothioconazole•Fluoxadiazon Seed Treatment Suspension Concentrate (25%+1%+1%) 11.46 85.82 3 39% Bromoxynil•Prothioconazole•Fluoxadiazon Seed Treatment Suspension Concentrate (35%+3%+1%) 13.54 83.25 4 17% Bromoxynil•Prothioconazole•Fluoxadiazon Seed Treatment Suspension Concentrate (17%+1%+1%) 11.25 86.08 5 28% Fluchlorfenapyr•Prothioconazole Seed Treatment Suspension (25%+3%) 23.96 70.36 6 26% Fluchlorfenapyr·Fluordiamide Seed Treatment Suspension (25%+1%) 26.04 67.78 7 26% Fluchlorfenapyr•Prothioconazole Seed Treatment Suspension (25%+1%) 26.46 67.27 8 38% Bromoxynil•Prothioconazole Seed Treatment Suspension (35%+3%) 25.63 68.30 9 36% Bromoxynil•Fluordioxonil Seed Treatment Suspension (35%+1%) 24.38 69.85 10 16% Bromnifloxacin•Prothioconazole Seed Treatment Suspension (15%+1%) 26.25 67.53 11 16% Bromoxynil•Fluordioxonil Seed Treatment Suspension (15%+1%) 22.71 65.06 12 33% Chlorantraniliprole•Prothioconazole•Fluoxadiazon (20%+10%+1%) 21.88 66.35 13 30% Brombutamide Seed Treatment Suspension 25.21 68.81 14 25% Fluchlorfenapyr Seed Treatment Suspension 24.79 69.33 15 Blank control 80.83 - As shown in Table 6, the ternary compound pesticides all showed significant control effects against the two-spotted cutworm. Compared with the blank control pesticide treatment, the disease index was reduced, and the seedling protection effect was better.

[0070] Field efficacy trials: Example 4: Field efficacy trial of pesticides for maize stalk base rot Experimental target: Maize stalk rot; Experimental crop: Maize (Denghai 605), purchased commercially; Experimental site: Experimental field in Wenyang Town, Feicheng City, Shandong Province. The soil fertility of the experimental site is moderate to high, the soil is evenly distributed, and irrigation and drainage are convenient.

[0071] Experimental Design: Maize was sown on June 20, 2020, with a row spacing of 0.6 m and a plant spacing of 0.2 m. This experiment followed a randomized block design, with a plot area of ​​20 m². 2 Each treatment was repeated 4 times.

[0072] Experimental reagent design: Table 7 Test reagents and dosages serial number Drug Name Dosage of active ingredient (g / 100kg seeds) 1 29% Fluchlorfenapyr•Prothioconazole•Fluoxadiazon Seed Treatment Suspension Concentrate (25%+3%+1%) 100 2 27% Fluchlorfenapyr•Prothioconazole•Fluoxadiazon Seed Treatment Suspension Concentrate (25%+1%+1%) 100 3 39% Bromoxynil•Prothioconazole•Fluoxadiazon Seed Treatment Suspension Concentrate (35%+3%+1%) 100 4 17% Bromoxynil•Prothioconazole•Fluoxadiazon Seed Treatment Suspension Concentrate (17%+1%+1%) 100 5 28% Fluchlorfenapyr•Prothioconazole Seed Treatment Suspension (25%+3%) 135.5 6 26% Fluchlorfenapyr·Fluordiamide Seed Treatment Suspension (25%+1%) 135.5 7 26% Fluchlorfenapyr•Prothioconazole Seed Treatment Suspension (25%+1%) 135.5 8 38% Bromoxynil•Prothioconazole Seed Treatment Suspension (35%+3%) 135.5 9 36% Bromoxynil•Fluordioxonil Seed Treatment Suspension (35%+1%) 135.5 10 16% Bromnifloxacin•Prothioconazole Seed Treatment Suspension (15%+1%) 135.5 11 16% Bromoxynil•Fluordioxonil Seed Treatment Suspension (15%+1%) 135.5 12 33% Chlorantraniliprole•Prothioconazole•Fluoxadiazon (20%+10%+1%) 135.5 13 100g / L prothioconazole suspension seed coating agent 25 14 25g / L fludioxonil suspension seed coating agent 12.5 15 Blank control - Experimental treatments: Seeds were treated with the experimental agents according to the experimental design, with water-treated seeds serving as a control. Before sowing, measured amounts of agent and seeds were weighed according to the required dosage for each treatment, poured into a seed-coating bottle, and evenly mixed with the seeds. The seeds were then dried before use. No other fungicides for controlling maize stalk rot were applied after sowing. Field management was carried out according to local cultivation techniques, and maize stalk rot occurred naturally in the experimental field.

[0073] Disease survey: An experimental survey was conducted during the corn seedling stage. Five points were randomly selected in each plot, and 20 corn plants were marked at each point, for a total of 100 plants per plot. The occurrence of stem rot was investigated, the number of diseased plants was counted, and the control effect was calculated.

[0074] Methods for calculating drug efficacy:

[0075] The test results are shown in the table below: Table 8. Control efficacy of the tested agents against maize stalk rot. serial number Drug Name Incidence rate (%) Prevention and control effect (%) 1 29% Fluchlorfenapyr•Prothioconazole•Fluoxadiazon Seed Treatment Suspension Concentrate (25%+3%+1%) 7.00 88.57 2 27% Fluchlorfenapyr•Prothioconazole•Fluoxadiazon Seed Treatment Suspension Concentrate (25%+1%+1%) 8.25 86.53 3 39% Bromoxynil•Prothioconazole•Fluoxadiazon Seed Treatment Suspension Concentrate (35%+3%+1%) 9.50 84.49 4 17% Bromoxynil•Prothioconazole•Fluoxadiazon Seed Treatment Suspension Concentrate (17%+1%+1%) 6.25 89.80 5 28% Fluchlorfenapyr•Prothioconazole Seed Treatment Suspension (25%+3%) 16.75 72.65 6 26% Fluchlorfenapyr·Fluordiamide Seed Treatment Suspension (25%+1%) 16.25 73.47 7 26% Fluchlorfenapyr•Prothioconazole Seed Treatment Suspension (25%+1%) 17.25 71.84 8 38% Bromoxynil•Prothioconazole Seed Treatment Suspension (35%+3%) 17.00 72.24 9 36% Bromoxynil•Fluordioxonil Seed Treatment Suspension (35%+1%) 15.50 74.69 10 16% Bromnifloxacin•Prothioconazole Seed Treatment Suspension (15%+1%) 17.75 71.02 11 16% Bromoxynil•Fluordioxonil Seed Treatment Suspension (15%+1%) 15.75 74.29 12 33% Chlorantraniliprole•Prothioconazole•Fluoxadiazon (20%+10%+1%) 13.25 78.37 13 100g / L prothioconazole suspension seed coating agent 21.25 65.31 14 25g / L fludioxonil suspension seed coating agent 19.50 68.16 15 Blank control 61.25 - As shown in Table 8, the results of the field efficacy test indicate that when the three-component mixed pesticide was applied to corn seeds, with an effective ingredient dosage of 100 g / 100 kg of seeds, the average disease incidence rate of each treatment was 6.25%~9.50%, and the control effect on corn stem rot was 84.49%~89.80%, demonstrating good control effect.

[0076] Through indoor toxicity testing and field efficacy trials, the combination of prothioconazole, fludioxonil, and a diamide insecticide (either fluchlorotrona or bromocyanamide) described in this invention exhibits good control effects against corn pests and diseases. The pesticide composition or formulation obtained by this invention shows significant efficacy, superior to single agents in delaying the development of resistance and prolonging pesticide retention. Furthermore, no phytotoxicity was observed in the experiments, indicating that the improved synergistic effect of the resulting pesticide composition or formulation reduces production and usage costs while ensuring crop safety.

[0077] Although the present invention has been described in detail above with general description and specific embodiments, some modifications or improvements can be made to it based on the present invention, which will be obvious to those skilled in the art. Therefore, all such modifications or improvements made without departing from the spirit of the present invention are within the scope of protection claimed by the present invention.

Claims

1. A pesticide composition, characterized in that, The pesticide composition comprises active ingredients A, B, and C, wherein active ingredient A is a diamide insecticide, active ingredient B is prothioconazole, and active ingredient C is fludioxonil.

2. The pesticide composition according to claim 1, characterized in that, The mass ratio of active ingredient B to active ingredient C is 1:20 to 20:1; Preferably, the mass ratio of active ingredient B to active ingredient C is 1:20 to 15:

1.

3. The pesticide composition according to claim 1, characterized in that, The diamide insecticide mentioned is bromocyanamide.

4. The pesticide composition according to claim 1, characterized in that, The mass ratio of active ingredient A to active ingredient B to active ingredient C is 5~45:1~20:1~20; Preferably, the mass ratio of active ingredient A to active ingredient B to active ingredient C is 5~35:1~15:1~10.

5. The pesticide composition according to claim 1, characterized in that, Based on the total weight of the pesticide composition being 100 wt%, the total content of active ingredient A, active ingredient B, and active ingredient C in the pesticide composition is 1% to 80%.

6. The pesticide composition according to claim 1, characterized in that, The pesticide composition further includes adjuvants selected from one or more of the following: wetting agents, dispersants, emulsifiers, thickeners, disintegrants, antifreeze agents, defoamers, solvents, preservatives, stabilizers, warning colors, film-forming agents, synergists, and carriers.

7. The pesticide composition according to claim 1, characterized in that, The pesticide composition can be prepared into any agriculturally acceptable formulation.

8. The pesticide composition according to claim 7, characterized in that, The formulation is any one of seed treatment dry powder, seed treatment dispersible powder, seed treatment liquid, seed treatment emulsion, or seed treatment suspension. Preferably, the formulation is a seed treatment suspension.

9. The use of the pesticide composition according to any one of claims 1-8 in the prevention and control of plant diseases and / or pests.

10. The application according to claim 9, wherein the plant includes corn, wheat, soybean, rice, peanut and / or cotton; Preferably, the plant is corn; More preferably, the corn disease is any one of corn stem base rot, corn sheath blight, corn silk smut, corn ear and kernel rot, corn seedling blight, corn rough dwarf disease, or corn topping disease; the corn pest is any one of two-spotted cutworm, cutworm, wireworm, corn aphid, armyworm, beet armyworm, cotton bollworm, or corn borer.

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