A hand sanitizer based on high-purity artemisia extract and a preparation method thereof

Abstract

The application belongs to the technical field of hand sanitizer, and specifically provides a hand sanitizer based on high-purity mugwort extract and a preparation method thereof.The hand sanitizer based on high-purity mugwort extract comprises the following components: an anionic surfactant, a non-ionic surfactant, a functional additive, a hand-care agent, sodium chloride, potassium sorbate, citric acid monohydrate and deionized water.The hand sanitizer based on high-purity mugwort extract prepared by the application has the effects of bacteriostasis, moisturization and cleaning.

Description

Technical Field

[0001] This application belongs to the field of hand sanitizer technology, and in particular relates to a hand sanitizer based on a high-purity extract of Artemisia argyi and its preparation method. Background Technology

[0002] Hand sanitizer, a daily cleaning and care product for the general public, has become a lifestyle choice. Compared to traditional soaps, hand sanitizers produce richer foam, are easier to use, and offer skincare benefits while cleaning. There are many types of hand sanitizers, primarily formulated with non-soap surfactants, such as α-alkenyl sulfonates, alkyl sulfates, and alkyl ether sulfates. These surfactants possess excellent detergency, emulsification, and foaming properties, effectively removing dirt, oil, and microorganisms from the skin's surface. However, most hand sanitizers contain chemical antibacterial ingredients, which can be highly irritating to the skin, causing side effects such as irritation and allergies. Furthermore, issues related to drug resistance and safety are gradually emerging. Long-term use of hand sanitizers containing these ingredients may damage the skin's lipid barrier, leading to dryness and itching, and may also cause discomfort due to residual ingredients. Additionally, some chemical antibacterial ingredients have long residual times in the environment, poor biodegradability, and can cause environmental pollution.

[0003] To address these issues, many manufacturers currently add value-added ingredients to their formulas, such as antibacterial agents, plant-based ingredients, vitamins, and moisturizing components—natural and green ingredients—to enhance the product's gentleness and safety while maintaining its cleaning effectiveness. For example, patent application CN104274341A discloses an antibacterial hand sanitizer. This application combines traditional Chinese medicine extracts—such as prickly pear stem extract, Bletilla striata root extract, and Scutellaria baicalensis extract—with a naturally derived cashew phenol quaternary ammonium salt surfactant, achieving excellent antibacterial and cleaning effects. It is non-toxic, harmless, gentle, and non-irritating to the human body.

[0004] However, plant extracts are typically complex mixtures, rich in various active ingredients such as flavonoids, polyphenols, and volatile oils. These ingredients are highly susceptible to oxidative degradation during storage, leading to problems such as discoloration, off-flavors, and decreased efficacy. The aforementioned document only adds plant extracts to the formulation through simple physical mixing without any protection measures for their stability. This makes it difficult to maintain the stability of the active ingredients and ensure their continued efficacy over a long shelf life. Summary of the Invention

[0005] To address the aforementioned issues and further improve the stability of hand sanitizers, this application provides a hand sanitizer based on a high-purity extract of Artemisia argyi and its preparation method.

[0006] This application first provides a hand sanitizer based on a high-purity extract of Artemisia argyi, comprising the following components by weight in a total of 100 parts: 10-15 parts of anionic surfactant, 2-3 parts of nonionic surfactant, 3-10 parts of functional additives, 1-4 parts of hand conditioner, 1-2 parts of sodium chloride, 0.1-0.3 parts of potassium sorbate, 0.2-1 parts of citric acid monohydrate, and deionized water to bring the total to 100 parts.

[0007] Furthermore, the anionic surfactant is sodium lauryl ether sulfate or sodium lauryl polyoxyethylene ether sulfate.

[0008] Furthermore, the nonionic surfactant is one of fatty alcohol polyoxyethylene ether AEO-9, alkyl glycoside APG0810, and coconut oil fatty acid diethanolamide.

[0009] Furthermore, the preparation method of the functional additive includes the following steps: freeze-dried powder of high-purity Artemisia argyi extract and D-α-tocopherol polyethylene glycol succinate are dissolved in ethanol respectively, mixed, and then redissolved in water by rotary evaporation to obtain the functional additive.

[0010] Furthermore, the mass ratio of the freeze-dried powder of the high-purity Artemisia argyi extract to D-α-tocopherol polyethylene glycol succinate is 1:5-10.

[0011] Furthermore, the hand care agent is composed of a polymeric film-forming agent and glycerin.

[0012] Furthermore, the polymeric film-forming agent is pullulan, and the humectant is glycerin or panthenol.

[0013] Furthermore, the mass ratio of the polymeric film-forming agent to the humectant is 1:2-5.

[0014] Furthermore, this application provides a method for preparing a hand sanitizer based on a high-purity extract of Artemisia argyi, comprising the following steps: S1, adding deionized water, anionic surfactant, and nonionic surfactant to a reaction vessel and stirring to obtain a surfactant mixture; S2, adding functional additives and hand conditioner to the surfactant mixture and stirring to obtain an efficacy mixture; S3, adding sodium chloride and potassium sorbate to the efficacy mixture and stirring to dissolve, adding citric acid monohydrate to adjust the pH, and then adding deionized water to make up the volume to obtain a mixture; S4, stirring the mixture evenly and aging it to obtain a hand sanitizer based on a high-purity extract of Artemisia argyi.

[0015] Furthermore, in step S3, the pH is adjusted to 6-7.

[0016] Compared with the prior art, this application has the following beneficial effects: 1. The hand sanitizer prepared in this application has good antibacterial and moisturizing effects by adding high-purity Artemisia argyi extract. Compared with traditional antibacterial hand sanitizers that add chemical reagents to inhibit bacteria, high-purity Artemisia argyi extract is a natural ingredient, green and healthy, reduces skin irritation, and has a fresh herbal fragrance.

[0017] 2. This application utilizes functional additives to encapsulate the freeze-dried powder particles of Artemisia argyi high-purity extract into micelles by self-assembling D-α-tocopherol polyethylene glycol succinate. This effectively reduces particle aggregation and sedimentation, resulting in uniform dispersion of the freeze-dried powder of Artemisia argyi high-purity extract without sedimentation or stratification, leading to a uniform product appearance and consistent efficacy. Simultaneously, the tocopherol portion of the D-α-tocopherol polyethylene glycol succinate molecule contains phenolic hydroxyl groups, which have the ability to scavenge free radicals, protecting the active ingredients in the high-purity Artemisia argyi extract from oxidative degradation. Furthermore, no additional synthetic antioxidants are required, thereby improving the dispersion stability of the freeze-dried powder of Artemisia argyi high-purity extract and the shelf life of the hand sanitizer, while also ensuring safety.

[0018] 3. The polyethylene glycol terminal hydroxyl groups of the D-α-tocopherol polyethylene glycol succinate micelle shell form a physical cross-linking network with the hydroxyl groups of pullulan and glycerol through intermolecular hydrogen bonds. After hand washing, as water evaporates, the hydrogen bond network contracts to form a transparent, breathable, and peelable moisturizing film, anchoring the high-purity Artemisia argyi extract in the film. This helps to lock in moisture and keep hands moisturized for a short time. At the same time, the active ingredients of Artemisia argyi are slowly released to the skin surface, providing short-term antibacterial, anti-inflammatory, and antioxidant protection after hand washing. The film naturally falls off during the next hand washing or gentle rubbing, leaving no stickiness or residue. Detailed Implementation

[0019] To make the inventive objectives, technical solutions, and beneficial effects of this application clearer, the following detailed description is provided in conjunction with embodiments. Obviously, the described embodiments are only a portion of the embodiments of this application, and not all of them. All other embodiments obtained by those skilled in the art based on the embodiments of this application without inventive effort are within the scope of protection of this application.

[0020] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0021] When using “including,” “having,” and “contains” as described herein, the intention is to cover non-exclusive inclusion, unless an explicit qualifying term such as “only” is used, in which case another component may be added.

[0022] In this application, "at least one" means one or more, such as one, two, or more. "Multiple" or "several" means at least two, such as two, three, etc., and "multi-layered" means at least two layers, such as two layers, three layers, etc., unless otherwise explicitly specified. In the description of this application, "several" means at least one, such as one, two, etc., unless otherwise explicitly specified.

[0023] When a numerical range is disclosed herein, the range is considered continuous and includes the minimum and maximum values ​​of the range, as well as every value between the minimum and maximum values. Furthermore, when the range refers to integers, it includes every integer between the minimum and maximum values ​​of the range. Additionally, when multiple ranges are provided to describe a feature or characteristic, the ranges may be combined. In other words, unless otherwise specified, all ranges disclosed herein should be understood to include any and all subranges to which they are incorporated.

[0024] Unless otherwise specified, all steps in this application may be performed sequentially or randomly. For example, the method comprising steps (a) and (b) indicates that the method may include steps (a) and (b) performed sequentially, or it may include steps (b) and (a) performed sequentially. For example, the mention that the method may also include step (c) indicates that step (c) may be added to the method in any order; for example, the method may include steps (a), (b), and (c), or it may include steps (a), (c), and (b), or it may include steps (c), (a), and (b), etc. Unless otherwise stated, singular terms may include plural forms and should not be construed as having a quantity of one.

[0025] The present application will be further illustrated by the following examples, but these examples do not limit the scope of the present application.

[0026] When numerical ranges are given in the embodiments, it should be understood that, unless otherwise stated in this application, both endpoints of each numerical range and any value between the two endpoints may be selected. Unless otherwise defined, all technical and scientific terms used in this application have the same meaning as commonly understood by one of ordinary skill in the art. Where specific conditions are not specified in the embodiments, conventional conditions or conditions recommended by the manufacturer shall apply. All reagents or instruments whose manufacturers are not specified are conventional products that can be purchased commercially. In addition to the specific methods, equipment, and materials used in the embodiments, based on the knowledge of the prior art possessed by one of ordinary skill in the art and the description in this application, any prior art methods, equipment, and materials similar to or equivalent to those described, used, or made by the methods, equipment, and materials in the embodiments of this application may be used to implement this application.

[0027] Example 1 The high-purity Artemisia argyi extract in this embodiment was prepared according to the application document with publication number CN118648689A.

[0028] The hand sanitizer based on high-purity Artemisia argyi extract in this embodiment comprises the following components in a total weight of 100g: 10g anionic surfactant, 2g nonionic surfactant, 5g functional additive, 2g hand conditioner, 1g sodium chloride, 0.1g potassium sorbate, 0.3g citric acid monohydrate, and deionized water to bring the total weight to 100g.

[0029] The preparation method of the hand sanitizer based on high-purity Artemisia argyi extract in this embodiment is as follows: S1. Add 60 mL of deionized water and sodium lauryl ether sulfate to the reaction vessel, stir at 80 °C and 150 r / min in a magnetic stirrer until completely dissolved, add fatty alcohol polyoxyethylene ether, stir at 200 r / min for 20 min until completely dissolved to obtain a surfactant mixture. S2, add functional additives, 0.66g pullulan polysaccharide and 1.34g panthenol to the cooled surfactant mixture, stir and mix to obtain the efficacy mixture; S3, add sodium chloride and potassium sorbate to the functional mixture, stir at 200 r / min for 15 min, add citric acid monohydrate to adjust the pH to 6.5, and then add deionized water to make up to 100 mL to obtain the mixture. S4. The mixture is placed in a water bath at 30°C and stirred at 200 r / min for 1.5 h. After being mixed evenly, it is aged for 24 h to obtain a hand sanitizer based on high-purity Artemisia argyi extract.

[0030] The preparation method of the functional additive in this embodiment is as follows: 0.83g of lyophilized Artemisia argyi extract and 4.17g of D-α-tocopherol polyethylene glycol succinate were added to an ethanol-water mixed solvent (ethanol:water = 1:1, v / v) and sonicated for 10 min. The two were then mixed and the ethanol was removed by rotary evaporation at 50℃. The mixture was then redissolved in 50mL of deionized water to obtain the functional additive.

[0031] Example 2 The high-purity Artemisia argyi extract in this embodiment was prepared according to the application document with publication number CN118648689A.

[0032] The hand sanitizer based on high-purity Artemisia argyi extract in this embodiment comprises the following components in a total weight of 100g: 13g anionic surfactant, 2.5g nonionic surfactant, 8g functional additive, 2.5g hand conditioner, 1.5g sodium chloride, 0.1g potassium sorbate, 0.5g citric acid monohydrate, and deionized water to bring the total weight to 100g.

[0033] The preparation method of the hand sanitizer based on high-purity Artemisia argyi extract in this embodiment is as follows: S1, add 60 mL of deionized water and sodium lauryl polyoxyethylene ether sulfate to the reaction vessel, stir at 80 °C and 150 r / min in a magnetic stirrer until completely dissolved, add coconut oil fatty acid diethanolamide, stir at 200 r / min for 20 min until completely dissolved to obtain a surfactant mixture. S2, add functional additives, 0.63g pullulan polysaccharide and 1.88g glycerin to the cooled surfactant mixture, stir and mix to obtain the functional mixture; S3, add sodium chloride and potassium sorbate to the functional mixture and stir to disperse. Add citric acid monohydrate to adjust the pH to 6.5 and then add deionized water to make up to 100 mL to obtain the mixture. S4. The mixture is placed in a water bath at 30°C and stirred at 200 r / min for 1.5 h. After being mixed evenly, it is aged for 24 h to obtain a hand sanitizer based on high-purity Artemisia argyi extract.

[0034] The preparation method of the functional additive in this embodiment is as follows: 0.89g of lyophilized Artemisia argyi extract and 7.11g of D-α-tocopherol polyethylene glycol succinate were added to an ethanol-water mixed solvent (ethanol:water = 1:1, v / v) and sonicated for 10 min. The two were then mixed and the ethanol was removed by rotary evaporation at 50℃. The mixture was then redissolved in 50mL of deionized water to obtain the functional additive.

[0035] Example 3 The high-purity Artemisia argyi extract in this embodiment was prepared according to the application document with publication number CN118648689A.

[0036] The hand sanitizer based on high-purity Artemisia argyi extract in this embodiment comprises the following components in a total weight of 100g: 15g anionic surfactant, 3g nonionic surfactant, 10g functional additive, 3g hand conditioner, 1.5g sodium chloride, 0.2g potassium sorbate, 0.8g citric acid monohydrate, and deionized water to bring the total weight to 100g.

[0037] The preparation method of the hand sanitizer based on high-purity Artemisia argyi extract in this embodiment is as follows: S1. Add 60 mL of deionized water and sodium lauryl polyoxyethylene ether sulfate to the reaction vessel, stir at 80 °C and 150 r / min in a magnetic stirrer until completely dissolved, add alkyl glycoside APG0810, stir at 200 r / min for 20 min until completely dissolved to obtain a surfactant mixture. S2, add functional additives, 0.5g pullulan polysaccharide and 2.5g glycerin to the cooled surfactant mixture, stir and mix to obtain the functional mixture; S3, add sodium chloride and potassium sorbate to the functional mixture and stir to disperse. Add citric acid monohydrate to adjust the pH to 7 and then add deionized water to make up to 100 mL to obtain the mixture. S4. The mixture is placed in a water bath at 30°C and stirred at 200 r / min for 1.5 h. After being mixed evenly, it is aged for 24 h to obtain a hand sanitizer based on high-purity Artemisia argyi extract.

[0038] The preparation method of the functional additive in this embodiment is as follows: 0.9g of lyophilized Artemisia argyi extract and 9.1g of D-α-tocopherol polyethylene glycol succinate were added to an ethanol-water mixed solvent (ethanol:water = 1:1, v / v) and sonicated for 10 min. The two were then mixed and the ethanol was removed by rotary evaporation at 50℃. The mixture was then redissolved in 50mL of deionized water to obtain the functional additive.

[0039] Comparative Example 1 The hand sanitizer based on high-purity Artemisia argyi extract in this comparative example comprises the following components per 100g total weight: 13g anionic surfactant, 2.5g nonionic surfactant, 0.89g freeze-dried powder of high-purity Artemisia argyi extract, 2.5g hand conditioner, 1.5g sodium chloride, 0.1g potassium sorbate, 0.5g citric acid monohydrate, and deionized water to bring the total to 100g.

[0040] The preparation method of the hand sanitizer based on high-purity Artemisia argyi extract in this comparative example is as follows: S1, add 60 mL of deionized water and sodium lauryl polyoxyethylene ether sulfate to the reaction vessel, stir at 80 °C and 150 r / min in a magnetic stirrer until completely dissolved, add coconut oil fatty acid diethanolamide, stir at 200 r / min for 20 min until completely dissolved to obtain a surfactant mixture. S2, add the freeze-dried powder of high-purity Artemisia argyi extract, 0.63g pullulan polysaccharide and 1.88g glycerin to the cooled surfactant mixture, stir and mix to obtain the efficacy mixture; S3, add sodium chloride and potassium sorbate to the functional mixture and stir to disperse. Add citric acid monohydrate to adjust the pH to 6.5 and then add deionized water to make up to 100 mL to obtain the mixture. S4. The mixture is placed in a water bath at 30°C and stirred at 200 r / min for 1.5 h. After being mixed evenly, it is aged for 24 h to obtain a hand sanitizer based on high-purity Artemisia argyi extract.

[0041] Comparative Example 2 The hand sanitizer based on high-purity Artemisia argyi extract in this comparative example comprises the following components per 100g total weight: 13g anionic surfactant, 2.5g nonionic surfactant, 8g functional additives, 1.5g sodium chloride, 0.1g potassium sorbate, 0.5g citric acid monohydrate, and deionized water to bring the total weight to 100g.

[0042] The preparation method of the hand sanitizer based on high-purity Artemisia argyi extract in this comparative example is as follows: S1, add 60 mL of deionized water and sodium lauryl polyoxyethylene ether sulfate to the reaction vessel, stir at 80 °C and 150 r / min in a magnetic stirrer until completely dissolved, add coconut oil fatty acid diethanolamide, stir at 200 r / min for 20 min until completely dissolved to obtain a surfactant mixture. S2, add functional additives to the cooled surfactant mixture and stir to obtain the functional mixture; S3, add sodium chloride and potassium sorbate to the functional mixture and stir to disperse. Add citric acid monohydrate to adjust the pH to 6.5 and then add deionized water to make up to 100 mL to obtain the mixture. S4. The mixture is placed in a water bath at 30°C and stirred at 200 r / min for 1.5 h. After being mixed evenly, it is aged for 24 h to obtain a hand sanitizer based on high-purity Artemisia argyi extract.

[0043] The preparation method of the functional additives in this comparative example is as follows: 0.89g of lyophilized Artemisia argyi extract and 7.11g of D-α-tocopherol polyethylene glycol succinate were added to an ethanol-water mixed solvent (ethanol:water = 1:1, v / v) and sonicated for 10 min. The two were then mixed and the ethanol was removed by rotary evaporation at 50℃. The mixture was then redissolved in 50mL of deionized water to obtain the functional additive.

[0044] Comparative Example 3 The hand sanitizer based on high-purity Artemisia argyi extract in this comparative example comprises the following components per 100g total weight: 13g anionic surfactant, 2.5g nonionic surfactant, 8g functional additives, 2.5g hand conditioner, 1.5g sodium chloride, 0.1g potassium sorbate, 0.5g citric acid monohydrate, and deionized water to bring the total to 100g.

[0045] The preparation method of the hand sanitizer based on high-purity Artemisia argyi extract in this comparative example is as follows: S1, add 60 mL of deionized water and sodium lauryl polyoxyethylene ether sulfate to the reaction vessel, stir at 80 °C and 150 r / min in a magnetic stirrer until completely dissolved, add coconut oil fatty acid diethanolamide, stir at 200 r / min for 20 min until completely dissolved to obtain a surfactant mixture. S2, add functional additives, 0.63g pullulan polysaccharide and 1.88g glycerin to the cooled surfactant mixture, stir and mix to obtain the functional mixture; S3, add sodium chloride and potassium sorbate to the functional mixture and stir to disperse. Add citric acid monohydrate to adjust the pH to 6.5 and then add deionized water to make up to 100 mL to obtain the mixture. S4. The mixture is placed in a water bath at 30°C and stirred at 200 r / min for 1.5 h. After being mixed evenly, it is aged for 24 h to obtain a hand sanitizer based on high-purity Artemisia argyi extract.

[0046] The preparation method of the functional additives in this comparative example is as follows: A functional additive was prepared by ultrasonically dispersing 0.89g of lyophilized Artemisia argyi extract and 7.11g of vitamin E in 40mL of deionized water.

[0047] Performance testing Antibacterial activity: Accurately weigh 8.2g of MHA solid culture medium and 200mL of sterile water, boil in a pot for high-temperature sterilization, pour 10mL of solid culture medium into each petri dish, dilute the remaining MHA and MHB at a 1:1 ratio, and cool to 37℃. Add Escherichia coli with OD600=0.5 to the diluted culture medium (100μL of bacterial suspension to 50mL of MHA); pour the medium into plates a second time, adding 20mL of diluted culture medium to each petri dish, cool and set aside. Remove the upper layer of culture medium using a 6mm diameter Oxford cup, divide the entire plate in half, add 50μL of hand sanitizer to each well, and record the diameter of the inhibition zone.

[0048] Foaming performance test: Add 0.5 mL of hand sanitizer to 50 mL of water, and then to a 250 mL graduated cylinder (40 mm × 300 mm). Cover the top of the graduated cylinder and tilt it up and down 10 times. Record the foam height after 10 minutes and record the height difference to determine the foaming performance of the hand sanitizer.

[0049] According to GB / T 34855-2017, the stability of hand sanitizer was tested. Two samples of no less than 100 ml were taken and placed in 250 ml colorless wide-mouth glass bottles with stoppers. One sample was placed in an incubator at (40±2)℃ for 24 hours. After being taken out and allowed to return to room temperature, it was compared with the sample before the test. The other sample was placed in a refrigerator at (-5±2)℃ for 24 hours. After being taken out and allowed to return to room temperature, it was compared with the sample before the test.

[0050] Sensory evaluation: A sensory evaluation team of 30 people (male to female ratio of 1:1) was formed after training. The evaluators independently filled out the scoring sheet according to the evaluation criteria in Table 1, and the feedback data was collected and analyzed.

[0051] Skin hydration improvement rate: Apply an appropriate amount of hand sanitizer to the back of the volunteer's hand, rub for 1 minute, rinse with water, dry with a soft towel, and test the skin hydration before and after treatment using a skin tester.

[0052] Table 1 Sensory Evaluation Criteria for Hand Sanitizer Table 2. Performance test results of hand sanitizers in Examples 1-3 and Comparative Examples 1-3 Table 3. Stability test results of hand sanitizers in Examples 1-3 and Comparative Examples 1-3 Analysis of Examples 1-3 and Comparative Examples 1-3, combined with Tables 2 and 3, shows that this application, by adding functional additives and hand care agents, utilizes D-α-tocopherol polyethylene glycol succinate to self-assemble into micelles to encapsulate the freeze-dried powder of Artemisia argyi high-purity extract, while adding pullulan polysaccharide and humectants, to make the hand sanitizer have good stability, good cleaning and antibacterial effects, and can also protect the skin from irritation and increase the skin's moisture content.

[0053] Analyzing Tables 2 and 3, the hand sanitizer prepared in Comparative Example 1 based on high-purity Artemisia argyi extract, compared to Examples 1-3, lacks the addition of D-α-tocopherol polyethylene glycol succinate. This prevents the dispersion and protection of the high-purity Artemisia argyi extract, resulting in a smaller antibacterial zone diameter and decreased antibacterial effect. Furthermore, it exhibits stratification and precipitation at (-5±2)℃ and (40±2)℃, indicating decreased stability. Similarly, the hand sanitizer prepared in Comparative Example 2 based on high-purity Artemisia argyi extract, compared to Examples 1-3, lacks a hand moisturizer, failing to form a moisturizing film after handwashing. This further reduces the antibacterial effect of the hand sanitizer prepared in Comparative Example 2 based on high-purity Artemisia argyi extract. The skin moisture content of the hand sanitizer containing the extract decreased, and the sensory evaluation score decreased. The hand sanitizer based on the high-purity Artemisia argyi extract prepared in Comparative Example 3, compared with Examples 1-3, did not use D-α-tocopherol polyethylene glycol succinate, but directly used vitamin E as an antioxidant, which could not disperse the high-purity Artemisia argyi extract. As a result, the hand sanitizer based on the high-purity Artemisia argyi extract in Comparative Example 2 showed stratification and precipitation under (-5±2)℃ and (40±2)℃ conditions, and the stability decreased. Compared with Comparative Example 1, the addition of the antioxidant vitamin E protected the active ingredients of the high-purity Artemisia argyi extract, improved the antibacterial effect, and increased the diameter of the antibacterial zone.

[0054] Although this application has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this application should be included within the protection scope of this application.

Claims

1. A hand sanitizer based on a high-purity extract of Artemisia argyi, characterized in that, Based on a total weight of 100 parts, the product includes the following components by weight: 10-15 parts of anionic surfactant, 2-3 parts of nonionic surfactant, 3-10 parts of functional additives, 1-4 parts of hand conditioner, 1-2 parts of sodium chloride, 0.1-0.3 parts of potassium sorbate, 0.2-1 parts of citric acid monohydrate, and deionized water to make up to 100 parts.

2. The hand sanitizer based on high-purity Artemisia argyi extract according to claim 1, characterized in that, The anionic surfactant is sodium lauryl ether sulfate or sodium lauryl polyoxyethylene ether sulfate.

3. The hand sanitizer based on high-purity Artemisia argyi extract according to claim 1, characterized in that, The nonionic surfactant is one of fatty alcohol polyoxyethylene ether AEO-9, alkyl glycoside APG0810, and coconut oil fatty acid diethanolamide.

4. The hand sanitizer based on high-purity Artemisia argyi extract according to claim 1, characterized in that, The preparation method of the functional additive includes the following steps: freeze-dried powder of high purity Artemisia argyi extract and D-α-tocopherol polyethylene glycol succinate are dissolved in ethanol respectively, mixed, and then redissolved in water by rotary evaporation to obtain the functional additive.

5. The hand sanitizer based on a high-purity extract of Artemisia argyi according to claim 4, characterized in that, The mass ratio of the freeze-dried powder of Artemisia argyi high-purity extract to D-α-tocopherol polyethylene glycol succinate is 1:5-10.

6. The hand sanitizer based on high-purity Artemisia argyi extract according to claim 1, characterized in that, The hand cream is composed of a polymeric film-forming agent and glycerin.

7. A hand sanitizer based on a high-purity extract of Artemisia argyi according to claim 6, characterized in that, The polymeric film-forming agent is pullulan polysaccharide, and the humectant is glycerin or panthenol.

8. A hand sanitizer based on a high-purity extract of Artemisia argyi according to claim 6, characterized in that, The mass ratio of the polymeric film-forming agent to the moisturizer is 1:2-5.

9. A method for preparing a hand sanitizer based on a high-purity extract of Artemisia argyi as described in any one of claims 1-8, characterized in that, The process includes the following steps: S1, adding deionized water, anionic surfactant, and nonionic surfactant to a reaction vessel and stirring to obtain a surfactant mixture; S2, adding functional additives and hand cream to the surfactant mixture and stirring to obtain an efficacy mixture; S3, adding sodium chloride and potassium sorbate to the efficacy mixture and stirring to dissolve, adding citric acid monohydrate to adjust the pH, and then adding deionized water to make up the volume to obtain a mixture; S4, stirring the mixture evenly and aging it to obtain a hand sanitizer based on a high-purity extract of Artemisia argyi.

10. The method for preparing a hand sanitizer based on a high-purity extract of Artemisia argyi according to claim 9, characterized in that, In step S3, the pH is adjusted to 6-7.

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