A combined detection serum marker, kit and detection method for screening and diagnosis of pancreatic cancer
By combining the detection of proteins encoded by SHBG, CEACAM1, and GDF15 genes with biotinylated antibodies and ELISA technology, the problems of low sensitivity and poor specificity of existing pancreatic cancer biomarkers have been solved, achieving high sensitivity and high specificity for early screening and diagnosis of pancreatic cancer.
CN122193579APending Publication Date: 2026-06-12HANGZHOU FIRST PEOPLES HOSPITAL
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- HANGZHOU FIRST PEOPLES HOSPITAL
- Filing Date
- 2026-05-15
- Publication Date
- 2026-06-12
AI Technical Summary
⚠Technical Problem
Existing biomarkers for early screening and diagnosis of pancreatic cancer have low sensitivity and poor specificity, making them unable to effectively identify early or small tumors, and they also have the problem of non-specific elevation.
⚗Method used
A combined detection method for proteins encoded by the SHBG, CEACAM1, and GDF15 genes, along with biotinylated antibodies and ELISA technology, was used for pancreatic cancer screening and diagnosis via enzyme-linked immunosorbent assay (ELISA).
🎯Benefits of technology
This method improves the sensitivity and specificity of early pancreatic cancer screening, providing a highly sensitive, specific, and low-cost detection method suitable for the early diagnosis of pancreatic cancer.
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Figure CN122193579A_ABST
Abstract
The application relates to the technical field of biomedical diagnosis, and particularly discloses a combined serum marker for screening and diagnosing pancreatic cancer, a kit and a detection method, wherein the serum marker comprises one or more of a protein encoded by an SHBG gene, a protein encoded by a CEACAM1 gene and a protein encoded by a GDF15 gene; the amino acid sequence of the protein encoded by the SHBG gene is shown as SEQ ID NO. 1, the amino acid sequence of the protein encoded by the CEACAM1 gene is shown as SEQ ID NO. 2, and the amino acid sequence of the protein encoded by the GDF15 gene is shown as SEQ ID NO. 3. The application overcomes the defects of low sensitivity and poor specificity of the markers for early screening and diagnosis of pancreatic cancer in the prior art.
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