Reagent preparation and application control linkage system

Abstract

The present application relates to the technical field of medical devices, in particular to a reagent preparation and application control linkage system, conductivity detection module, first reagent storage tank, second reagent storage tank, buffer tank, purified water source, reflux tank, mixing device, gas-liquid mixing device, large liquid storage chamber, negative pressure gas storage device, positive pressure gas storage device, double-head air pump, liquid suction pump, first pressure control device, second pressure control device, first to twenty-third solenoid valves, the reagent diluted by the reflux tank is defoamed and refluxed into the gas-liquid mixing device, the large liquid storage chamber is used for storing the reagent after dilution, the double-head air pump provides air source for the negative pressure gas storage device and the positive pressure gas storage device, the liquid suction pump sucks and quantifies different reagents and purified water, the first to twenty-third solenoid valves are used for on-off and logic control before each pipeline, and the first pressure control device and the second pressure control device can reach the required pressure value according to the set value.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and in particular to a reagent preparation and application control linkage system. Background Technology

[0002] Blood cell analysis is one of the three major routine clinical laboratory tests and a core supporting means for the diagnosis of blood-related diseases. However, the core technologies of blood analyzers, which combine high precision, strong specificity (capable of accurately identifying abnormal cells), and simultaneous multi-parameter detection, have long been monopolized by foreign companies. While such devices can output key diagnostic data with their efficient detection performance, significantly improving diagnostic accuracy and efficiency, they also suffer from practical problems such as high cost per test, complex instrument maintenance, and high overall operating costs.

[0003] High-speed, high-specificity, and high-throughput blood analyzer pipeline counting systems are typically used in high-level hospitals where the daily sample volume is very large, the required time-to-analyze (TAT) time is very short, reagent consumption is high, reagents need to be replaced frequently, which takes more time and incurs significant manufacturing, transportation, and warehousing costs for storing reagents, resulting in increased testing costs and human resource consumption. Summary of the Invention

[0004] The purpose of this invention is to provide a reagent preparation and application control linkage system, which aims to solve the problem of traditional blood analyzer automated counting systems incurring high manufacturing, transportation, and storage costs for reagent storage.

[0005] To achieve the above objectives, the present invention provides a reagent preparation and application control linkage system, comprising a conductivity detection module, a first reagent storage tank, a second reagent storage tank, a buffer tank, a purified water source, a reflux tank, a mixing device, a gas-liquid mixing device, a large liquid storage chamber, a negative pressure gas storage device, a positive pressure gas storage device, a dual-head air pump, a suction pump, a first pressure control device, a second pressure control device, a first solenoid valve, a second solenoid valve, a third solenoid valve, a fourth solenoid valve, a fifth solenoid valve, a sixth solenoid valve, a seventh solenoid valve, an eighth solenoid valve, a twelfth solenoid valve, a fourteenth solenoid valve, a fifteenth solenoid valve, a twentieth solenoid valve, a twenty-second solenoid valve, and a twenty-third solenoid valve;

[0006] The first reagent storage tank, the first solenoid valve, and the buffer tank are connected in sequence; the second reagent storage tank, the second solenoid valve, and the buffer tank are connected in sequence; the fourth solenoid valve, the third solenoid valve, and the buffer tank are connected in sequence; the negative pressure gas storage device, the first pressure control device, the fifth solenoid valve, the dual-head air pump, the sixth solenoid valve, the positive pressure gas storage device, and the second pressure control device are connected in sequence; the gas-liquid mixing device, the fourteenth solenoid valve, the mixing device, the liquid suction pump, the twenty-third solenoid valve, and the purified water source are connected in sequence; the fifteenth solenoid valve is connected to the liquid suction pump; the thirteenth solenoid valve and the seventh solenoid valve are respectively connected to the gas-liquid mixing device; the eighth solenoid valve is connected to the seventh solenoid valve; the gas-liquid mixing device, the conductivity detection module, and the twenty-second solenoid valve are connected in sequence; the large liquid storage chamber, the twentyth solenoid valve, and the conductivity detection module are connected in sequence; and the large liquid storage chamber, the reflux tank, the twelfth solenoid valve, and the gas-liquid mixing device are connected in sequence.

[0007] The rated pressure of the positive pressure gas storage device is 70 kPa.

[0008] The rated pressure of the negative pressure gas storage device is 40 kPa.

[0009] The first reagent storage container, the second reagent storage container, and the buffer container all have a volume of 500ml.

[0010] The mixing device and the gas-liquid mixing device each have a volume of 500ml.

[0011] The present invention provides a reagent preparation and application control linkage system, wherein the conductivity detection module (DS) CONC is used to test whether the diluted reagent meets the reagent specifications. The first reagent storage tank (CONC-DIL1) and the second reagent storage tank (CONC-DIL2) are used to store the diluted reagent. The buffer tank (CONC-DIL) is used to provide concentrated reagent (CONC-DS) at normal pressure. The purified water source (RO) is externally supplied purified water with a power source. The reflux tank (DS-OUT) is used to defoam the diluted reagent and return it to the gas-liquid mixing device (MIX2). The mixing device (MIX1) is the first mixing and dilution unit, and the gas-liquid mixing device (MIX2) is the second mixing and dilution unit, and performs suction and discharge functions. The large liquid storage chamber (dilution DSL tank) is used to store the diluted reagent. The dual-head air pump (P1) provides air to the negative pressure gas storage device (PT1) and the positive pressure gas storage device (PT2). The suction pump (D-PUMP) attracts and quantifies different reagents and purified water for proportional mixing. The first solenoid valve (V1), The second solenoid valve (V2), the third solenoid valve (V3), the fourth solenoid valve (V4), the fifth solenoid valve (V5), the sixth solenoid valve (V6), the seventh solenoid valve (V7), the eighth solenoid valve (V8), the ninth solenoid valve (V9), the tenth solenoid valve (V10), the eleventh solenoid valve (V11), the twelfth solenoid valve (V12), the thirteenth solenoid valve (V13), the fourteenth solenoid valve (V14), the fifteenth solenoid valve (V15), the sixteenth solenoid valve (V16), the seventeenth solenoid valve (V17), the eighteenth solenoid valve (V18), the nineteenth solenoid valve (V19), the twentieth solenoid valve (V20), the twenty-first solenoid valve (V21), the twenty-second solenoid valve (V22), and the twenty-third solenoid valve (V23) are used for on / off control and logic control between various pipelines. The first pressure control device (VS1) and the second pressure control device (PS1) can achieve the required pressure value according to the set value.

[0012] Specifically, the dual-head air pump (P1) is activated, the solenoid valve assembly is activated, and the negative pressure gas storage device (PT1) and the positive pressure gas storage device (PT2) are filled with positive and negative pressures of different levels. Simultaneously, the first reagent storage tank (CONC-DIL1), in conjunction with the solenoid valve assembly, draws the reagents from the first reagent storage tank (CONC-DIL1) and the second reagent storage tank (CONC-DIL2) into the buffer tank (CONC-DIL) according to a specific ratio. The buffer tank (CONC-DIL), in conjunction with the solenoid valve assembly and logic control switching time, draws the purified water source (RO) and concentrated reagent (CONC-DS) into the mixing device (MIX1) for mixing and dilution. The gas-liquid mixing device (MIX2), through the operation of the solenoid valve assembly and in conjunction with the negative pressure gas storage device (PT1) and the positive pressure gas storage device (PT2), achieves a second mixing and dilution. The conductivity detection module (DS)... CONC is responsible for detecting the reagent diluted from the gas-liquid mixing device (MIX2) and cooperating with the solenoid valve to control the filling of the large storage chamber (dilution DSL tank) with liquid.

[0013] The beneficial effects of this system:

[0014] To achieve proportional dilution of concentrated reagents;

[0015] Achieve 32-fold dilution and reduce warehousing costs;

[0016] Reduce the frequency of reagent replacement and shorten the ATA time to meet the requirements of efficient instrument operation;

[0017] Reduce the testing cost per sample. Attached Figure Description

[0018] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the accompanying drawings used in the description of the embodiments or the prior art will be briefly introduced below.

[0019] Figure 1 This is a connection diagram of a reagent preparation and application control linkage system provided by the present invention.

[0020] Figure 2 This is a schematic diagram of the circuit signal input of a reagent preparation and application control linkage system provided by the present invention.

[0021] Figure 3 This is a schematic diagram of the circuit signal acquisition for a reagent preparation and application control linkage system provided by the present invention.

[0022] In the diagram: 1-Conductivity detection module, 2-First reagent storage tank, 3-Second reagent storage tank, 4-Buffer tank, 5-Purified water source, 6-Reflux tank, 7-Mixing device, 8-Gas-liquid mixing device, 9-Large liquid storage chamber, 10-Negative pressure gas storage device, 11-Positive pressure gas storage device, 12-Dual-head air pump, 13-Liquid suction pump, 14-First pressure control device, 15-Second pressure control device, 16-First solenoid valve, 17-Second solenoid valve, 18-Third solenoid valve, 19-Fourth solenoid valve, 20-Fifth solenoid valve, 21-Sixth solenoid valve, 22-Seventh solenoid valve, 23-Eighth solenoid valve, 24-Twelfth solenoid valve, 25-Fourteenth solenoid valve, 26-Fifteenth solenoid valve, 27-Twentieth solenoid valve, 28-Twenty-second solenoid valve, 29-Twenty-third solenoid valve. Detailed Implementation

[0023] The embodiments of the present invention are described in detail below. Examples of the embodiments are shown in the accompanying drawings. The embodiments described below with reference to the accompanying drawings are exemplary and intended to explain the present invention, but should not be construed as limiting the present invention.

[0024] Please see Figures 1 to 3This invention provides a reagent preparation and application control linkage system, comprising: a conductivity detection module 1, a first reagent storage tank 2, a second reagent storage tank 3, a buffer tank 4, a purified water source 5, a reflux tank 6, a mixing device 7, a gas-liquid mixing device 8, a large liquid storage chamber 9, a negative pressure gas storage device 10, a positive pressure gas storage device 11, a dual-head air pump 12, a liquid suction pump 13, a first pressure control device 14, a second pressure control device 15, a first solenoid valve 16, a second solenoid valve 17, a third solenoid valve 18, and a fourth solenoid valve 19. 9. Fifth solenoid valve 20, sixth solenoid valve 21, seventh solenoid valve 22, eighth solenoid valve 23, twelfth solenoid valve 24, fourteenth solenoid valve 25, fifteenth solenoid valve 26, twentieth solenoid valve 27, twenty-second solenoid valve 28, and twenty-third solenoid valve 29; the first reagent storage tank 2, the first solenoid valve 16, and the buffer tank 4 are connected in sequence; the second reagent storage tank 3, the second solenoid valve 17, and the buffer tank 4 are connected in sequence; the fourth solenoid valve 19 and the third solenoid valve 1... The buffer tank 4 and the negative pressure gas storage device 10, the first pressure control device 14, the fifth solenoid valve 20, the dual-head air pump 12, the sixth solenoid valve 21, the positive pressure gas storage device 11 and the second pressure control device 15 are connected in sequence. The gas-liquid mixing device 8, the fourteenth solenoid valve 25, the mixing device 7, the liquid suction pump 13, the twenty-third solenoid valve 29 and the purified water source 5 are connected in sequence. The fifteenth solenoid valve 26 is connected to the liquid suction pump 13. The thirteenth solenoid valve 28 and the seventh solenoid valve 22 are respectively connected to the gas-liquid mixing device 8. The eighth solenoid valve 23 is connected to the seventh solenoid valve 22. The gas-liquid mixing device 8, the conductivity detection module 1 and the twenty-second solenoid valve 28 are connected in sequence. The large liquid storage chamber 9, the twentyth solenoid valve 27 and the conductivity detection module 1 are connected in sequence. The large liquid storage chamber 9, the reflux tank 6, the twelfth solenoid valve 24 and the gas-liquid mixing device 8 are connected in sequence.

[0025] In this embodiment, the conductivity detection module 1 (DSCONC) is used to test whether the diluted reagent meets the reagent specifications. The first reagent storage tank 2 (CONC-DIL1) and the second reagent storage tank 3 (CONC-DIL2) are used to store the diluted reagent. The buffer tank 4 (CONC-DIL) is used to provide concentrated reagent (CONC-DS) at atmospheric pressure. The purified water source 5 (RO) is externally supplied purified water with a power source. The reflux tank 6 (DS-OUT) is used to defoam the diluted reagent and return it to the gas-liquid mixing device 8. In MIX2, the mixing device 7 (MIX1) is the first mixing and dilution unit, the gas-liquid mixing device 8 (MIX2) is the second mixing and dilution unit, and performs suction and discharge functions. The large liquid storage chamber 9 (dilution DSL tank) is used to store the diluted reagents. The dual-head air pump 12 (P1) provides air to the negative pressure gas storage device 10 (PT1) and the positive pressure gas storage device 11 (PT2). The suction pump 13 (D-PUMP) attracts and quantifies different reagents and purified water for proportional mixing. The first solenoid valve 16 (V1) and the second solenoid valve 13 (P1) are used for mixing. Solenoid valve 17 (V2), the third solenoid valve 18 (V3), the fourth solenoid valve 19 (V4), the fifth solenoid valve 20 (V5), the sixth solenoid valve 21 (V6), the seventh solenoid valve 22 (V7), the eighth solenoid valve 23 (V8), the ninth solenoid valve 24 (V9), the tenth solenoid valve 25 (V10), the eleventh solenoid valve 26 (V11), the twelfth solenoid valve 24 (V12), the thirteenth solenoid valve 28 (V13), the fourteenth solenoid valve 25 (V14), and the fifteenth solenoid valve 26 (V15). The sixteenth solenoid valve 31 (V16), the seventeenth solenoid valve 27 (V17), the eighteenth solenoid valve 33 (V18), the nineteenth solenoid valve 34 (V19), the twentieth solenoid valve 27 (V20), the twenty-first solenoid valve 36 (V21), the twenty-second solenoid valve 28 (V22), and the twenty-third solenoid valve 29 (V23) are used for the on / off and logic control between various pipelines. The first pressure control device 14 (VS1) and the second pressure control device 15 (PS1) can achieve the required pressure value according to the set value.

[0026] Specifically, the dual-head air pump 12 (P1) is activated, the solenoid valve assembly is activated, and the negative pressure gas storage device 10 (PT1) and the positive pressure gas storage device 11 (PT2) are filled with positive and negative pressures of different pressures; simultaneously, the first reagent storage tank 2 (CONC-DIL1), in conjunction with the solenoid valve assembly, draws the reagents from the first reagent storage tank 2 (CONC-DIL1) and the second reagent storage tank 3 (CONC-DIL2) into the buffer tank 4 (CONC-DIL) in a proportional manner; the liquid suction pump 13 (D-PUMP) is activated in conjunction with the solenoid valve assembly and The logic control switching time draws the purified water source 5 (RO) and concentrated reagent (CONC-DS) into the mixing device 7 (MIX1) for mixing and dilution; the gas-liquid mixing device 8 (MIX2) achieves a second mixing and dilution by operating a solenoid valve group and cooperating with the negative pressure gas storage device 10 (PT1) and the positive pressure gas storage device 11 (PT2); the conductivity detection module 1 (DSCONC) is responsible for detecting the reagent diluted from the gas-liquid mixing device 8 (MIX2) and, in conjunction with the solenoid valve control, fills the large liquid storage chamber 9 (dilution DSL tank) with liquid.

[0027] Furthermore, the rated pressure of the positive pressure gas storage device 11 is 70 kPa, the rated pressure of the negative pressure gas storage device 10 is -40 kPa, the volume of the first reagent storage tank 2, the second reagent storage tank 3, and the buffer tank 4 is 500 ml, and the volume of the mixing device 7 and the gas-liquid mixing device 8 is 500 ml.

[0028] To better understand this technical solution, the following embodiments are provided for further explanation:

[0029] Example 1

[0030] In one application scenario, the reagent preparation control linkage logic is as follows:

[0031] The dual-head air pump 12 (P1) is started, the solenoid valve is activated, the fifth solenoid valve 20 (V5) and the sixth solenoid valve 21 (V6) are opened, and the first pressure control device 14 (VS1) and the second pressure control device 15 (PS1) monitor the pressure value at the same time.

[0032] After the pressure values ​​of the first pressure control device 14 (VS1) and the second pressure control device 15 (PS1) reach the required level, the solenoid valve is activated, the fifth solenoid valve 20 (V5) and the sixth solenoid valve 21 (V6) are closed, and the dual-head air pump 12 (P1) is stopped.

[0033] When the solenoid valve is activated, the third solenoid valve 18 (V3) opens, and at the same time the buffer tank 4 (CONC-DIL) is filled with pressure, and the pressure value of the first pressure control device 14 (VS1) is monitored.

[0034] After the pressure value monitoring of the first pressure control device 14 (VS1) reaches the required level, the solenoid valve is activated and the third solenoid valve 18 (V3) is closed.

[0035] When the solenoid valve is activated, the first solenoid valve 16 (V1) is opened for a period of time;

[0036] When the time is reached, the solenoid valve activates, and the first solenoid valve 16 (V1) closes.

[0037] When the solenoid valve is activated, the fourth solenoid valve 19 (V4) opens, and at the same time the buffer tank 4 (CONC-DIL) is filled with pressure, and the pressure value of the second pressure control device 15 (PS1) is monitored.

[0038] After the pressure value monitoring of the second pressure control device 15 (PS1) reaches the required level, the solenoid valve is activated and the fourth solenoid valve 19 (V4) is closed.

[0039] When the solenoid valve is activated, the second solenoid valve 17 (V2) opens, and after a period of time, the second reagent storage tank 3 (CONC-DIL2) is filled with reagent in the reverse direction;

[0040] The suction pump 13 (D-PUMP) is activated, and at the same time the solenoid valve 26 (V15) is activated, and the concentrated reagent is drawn into the mixing device 7 (MIX1).

[0041] When the solenoid valve is activated, the twenty-third solenoid valve 29 (V23) opens, and the purified water source 5 (RO) is drawn to the mixing device 7 (MIX1) and mixed with the concentrated reagent in the first mixing and dilution unit;

[0042] When the solenoid valves are activated, the fifteenth solenoid valve 26 (V15) and the twenty-third solenoid valve 29 (V23) close, and the suction pump 13 (D-PUMP) stops.

[0043] When the solenoid valve is activated, the seventh solenoid valve 22 (V7) opens, and at the same time, the gas-liquid mixing device 8 (MIX2) is filled with pressure, and the pressure value of the first pressure control device 14 (VS1) is monitored.

[0044] After the pressure value monitoring of the first pressure control device 14 (VS1) reaches the required level, the solenoid valve is activated and the seventh solenoid valve 22 (V7) is closed.

[0045] When the solenoid valve is activated, the fourteenth solenoid valve 25 (V14) opens, and the mixed liquid in the mixing device 7 (MIX1) is drawn into the gas-liquid mixing device 8 (MIX2) to achieve gas-liquid mixing;

[0046] When the solenoid valve is activated, the fourteenth solenoid valve 25 (V14) closes and the seventh solenoid valve 22 (V7) opens. At the same time, the gas-liquid mixing device 8 (MIX2) is filled with pressure, and the pressure value of the second pressure control device 15 (PS1) is monitored.

[0047] After the pressure value monitoring of the second pressure control device 15 (PS1) reaches the required level, the solenoid valve is activated and the seventh solenoid valve 22 (V7) is closed.

[0048] When the solenoid valve is activated, the twenty-second solenoid valve 28 (V22) opens, and the liquid in the gas-liquid mixing device 8 (MIX2) flows into the conductivity detection module 1 (DSCONC);

[0049] The conductivity detection module 1 (DSCONC) monitors the indicators; after the monitoring meets the standards, the solenoid valve is activated, the 22nd solenoid valve 28 (V22) is closed, and the 20th solenoid valve 27 (V20) is opened;

[0050] The liquid in the gas-liquid mixing device 8 (MIX2) flows into the large liquid storage chamber 9 (DSL tank);

[0051] When the solenoid valve is activated, the twentieth solenoid valve 27 (V20) closes.

[0052] When the solenoid valve is activated, the seventh solenoid valve 22 (V7) opens, and at the same time, the gas-liquid mixing device 8 (MIX2) is filled with pressure, and the pressure value of the first pressure control device 14 (VS1) is monitored.

[0053] After the pressure value monitoring of the first pressure control device 14 (VS1) reaches the required level, the solenoid valve is activated and the seventh solenoid valve 22 (V7) is closed.

[0054] The solenoid valve is activated, and the twelfth solenoid valve 24 (V12) opens;

[0055] The liquid in the large storage chamber 9 (DSL) flows into the return tank 6 (DS_OUT) and then back into the gas-liquid mixing device 8 (MIX2);

[0056] When the solenoid valves are activated, the twelfth solenoid valve 24 (V12) closes and the thirteenth solenoid valve 28 (V13) opens.

[0057] The solenoid valve is activated, and the twelfth solenoid valve 24 (V12) is closed;

[0058] Repeated actions achieve the dilution function.

[0059] Example 2

[0060] System circuit signal acquisition:

[0061] The conductivity detection module 1 (DSCONC) is connected to the HX interface;

[0062] ADJ_RIN_EN and ADJ_ROUT_EN are connected to a high level (1);

[0063] The circuit acquires the signal from R22;

[0064] ADJ_RIN_EN and ADJ_ROUT_EN are connected to a low level of 0;

[0065] The circuit acquires signals from the HX interface;

[0066] AD5933_CLK_EN input signal;

[0067] The AD5933_IIC_SCL and AD5933_IIC_SDA combination outputs the conductivity detection module 1 (DSCONC) value.

[0068] The above-disclosed embodiments are merely preferred embodiments of a reagent preparation and application control linkage system of this application and should not be construed as limiting the scope of this application. Those skilled in the art can understand that implementing all or part of the above embodiments and making equivalent changes in accordance with the claims of this application still fall within the scope of this application.

Claims

1. A reagent preparation and application control linkage system, characterized in that, It includes a conductivity detection module, a first reagent storage tank, a second reagent storage tank, a buffer tank, a purified water source, a reflux tank, a mixing device, a gas-liquid mixing device, a large liquid storage chamber, a negative pressure gas storage device, a positive pressure gas storage device, a dual-head air pump, a suction pump, a first pressure control device, a second pressure control device, a first solenoid valve, a second solenoid valve, a third solenoid valve, a fourth solenoid valve, a fifth solenoid valve, a sixth solenoid valve, a seventh solenoid valve, an eighth solenoid valve, a twelfth solenoid valve, a fourteenth solenoid valve, a fifteenth solenoid valve, a twentieth solenoid valve, a twenty-second solenoid valve, and a twenty-third solenoid valve. The first reagent storage tank, the first solenoid valve, and the buffer tank are connected in sequence; the second reagent storage tank, the second solenoid valve, and the buffer tank are connected in sequence; the fourth solenoid valve, the third solenoid valve, and the buffer tank are connected in sequence; the negative pressure gas storage device, the first pressure control device, the fifth solenoid valve, the dual-head air pump, the sixth solenoid valve, the positive pressure gas storage device, and the second pressure control device are connected in sequence; the gas-liquid mixing device, the fourteenth solenoid valve, the mixing device, the liquid suction pump, the twenty-third solenoid valve, and the purified water source are connected in sequence; the fifteenth solenoid valve is connected to the liquid suction pump; the thirteenth solenoid valve and the seventh solenoid valve are respectively connected to the gas-liquid mixing device; the eighth solenoid valve is connected to the seventh solenoid valve; the gas-liquid mixing device, the conductivity detection module, and the twenty-second solenoid valve are connected in sequence; the large liquid storage chamber, the twentyth solenoid valve, and the conductivity detection module are connected in sequence; and the large liquid storage chamber, the reflux tank, the twelfth solenoid valve, and the gas-liquid mixing device are connected in sequence.

2. The reagent preparation and application control linkage system as described in claim 1, characterized in that, The rated pressure of the positive pressure gas storage device is 70 kPa.

3. The reagent preparation and application control linkage system as described in claim 1, characterized in that, The rated pressure of the negative pressure gas storage device is 40 kPa.

4. The reagent preparation and application control linkage system as described in claim 1, characterized in that, The first reagent storage container, the second reagent storage container, and the buffer container all have a volume of 500ml.

5. The reagent preparation and application control linkage system as described in claim 1, characterized in that, Both the mixing device and the gas-liquid mixing device have a volume of 500 ml.

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