Oral care composition

Abstract

Disclosed herein are oral care compositions, in particular, oral care compositions that provide enhanced stain resistance. According to one aspect of the invention, there is provided an oral care composition comprising: a thickening system comprising a crosslinked polyacrylic acid and / or a salt thereof and one or more thickening agents selected from the group consisting of a polysaccharide, a thickening silica, and combinations of two or more thereof; a polyol; and from about 5 to about 64 wt.% water, wherein all weight percents are based on the total weight of the oral care composition.

Description

[0001] Cross-references to related applications

[0002] This application claims priority to U.S. Patent Application No. 63 / 600,195 entitled Oral Care Compositions, filed November 17, 2023, and U.S. Patent Application No. 63 / 600,232 entitled Oral Care Compositions, the contents of which are incorporated herein by reference in their entirety for all purposes. Background Technology

[0003] Everyday residues from substances such as tobacco, tea, coffee, and colored foods can easily accumulate on the tooth surface through the salivary protein membrane. If teeth are not cleaned promptly and effectively, over time, these residues will gradually turn yellow or even black, forming extrinsic stains and plaques, thus affecting oral hygiene and the appearance of teeth. Whitening toothpaste is generally designed to reduce extrinsic stains and can also reduce existing stains on the tooth surface to some extent.

[0004] Currently, there is a strong consumer demand for teeth whitening, and some people are even resorting to methods like professional teeth cleaning to whiten their teeth, but this is costly and carries certain risks. Most people hope to whiten their teeth using various whitening toothpastes. Existing whitening toothpastes mostly achieve their whitening effect by adding special abrasive particles or peroxides. However, these abrasive particles can damage tooth enamel and the tooth surface, making it easier for stains to accumulate. Summary of the Invention

[0005] This invention is intended only to provide a simplified overview of some aspects of one or more embodiments of the present disclosure. Further areas of application of the present disclosure will become apparent from the detailed embodiments provided below. This invention is not a broad review, nor is it intended to identify key or essential elements of the teachings, nor to depict the scope of the disclosure. Rather, its purpose is merely to present one or more concepts in a simplified form as a prelude to the detailed embodiments described below.

[0006] Several aspects of the present invention relate to oral care compositions, for example, providing oral care compositions with enhanced resistance to tooth stains. According to one aspect of the invention, an oral care composition is provided comprising: a thickening system comprising crosslinked polyacrylic acid and / or its salts and one or more thickeners selected from polysaccharides, thickening silica, and combinations thereof; a polyol; and about 14 to about 64 wt.% water, wherein all weight percentages are based on the total weight of the oral care composition.

[0007] According to another aspect of the invention, an oral care composition comprising: a thickening system comprising: about 0.2 to about 5 wt.% of crosslinked polyacrylic acid and / or its salts, and one or more thickeners selected from polysaccharides, thickening silica, and combinations thereof; a polyol system comprising glycerol and sorbitol, wherein glycerol and sorbitol are present in a weight ratio of about 1:1 to about 3:1; and about 5 to about 64 wt.% of water, wherein the oral care composition is free of whitening agents, and all weight percentages are based on the total weight of the oral care composition.

[0008] The following is a list of non-limiting exemplary implementations:

[0009] According to embodiment 1, an oral care composition comprising: a thickening system comprising crosslinked polyacrylic acid and / or its salts and one or more thickeners selected from polysaccharides, thickening silica and combinations of two or more thereof; and about 14 to about 64 wt.% water, wherein all weight percentages are based on the total weight of the oral care composition.

[0010] According to embodiment 2, an oral care composition according to embodiment 1 is provided, wherein the crosslinked polyacrylic acid and / or its salt is branched polyacrylic acid and / or its salt.

[0011] According to embodiment 3, an oral care composition according to embodiment 1 or 2 is provided, wherein the crosslinked polyacrylic acid and / or its salts contain carbomer.

[0012] According to embodiment 4, an oral care composition according to any one of the preceding embodiments is provided, wherein the crosslinked polyacrylic acid and / or its salts are composed of one or more carbomers.

[0013] According to embodiment 5, an oral care composition according to any one of the preceding embodiments is provided, wherein the crosslinked polyacrylic acid and / or its salts are present in an amount of about 0.2 to about 5 wt.%, optionally about 0.2 to about 1 wt.%.

[0014] According to embodiment 6, an oral care composition according to any one of the preceding embodiments is provided, which further comprises one or more polyols optionally present in a total amount of about 20 to about 40 wt.%.

[0015] According to embodiment 7, an oral care composition according to embodiment 6 is provided, wherein the one or more polyols are a polyol system.

[0016] According to embodiment 8, an oral care composition according to embodiment 7 is provided, wherein the polyol system comprises at least two polyols selected from: glycerol, inositol, maltitol, mannitol, sorbitol, xylitol, propylene glycol, polypropylene glycol (PPG), polyethylene glycol (PEG), block copolymers of PPG and PEG, sugars, and combinations of two or more thereof.

[0017] According to embodiment 9, an oral care composition according to embodiment 7 or 8 is provided, wherein the polyol system comprises at least two polyols selected from the group consisting of glycerol, inositol, maltitol, mannitol, sorbitol, xylitol, propylene glycol, polypropylene glycol (PPG), polyethylene glycol (PEG), and combinations of two or more thereof.

[0018] According to embodiment 10, an oral care composition according to any one of embodiments 6 to 9 is provided, wherein the polyol system comprises glycerin and sorbitol.

[0019] According to embodiment 11, an oral care composition according to embodiment 10 is provided, wherein glycerin and sorbitol are present in a weight ratio of glycerin to sorbitol of about 1:1 to about 3:1.

[0020] According to embodiment 12, an oral care composition according to any one of embodiments 6 to 11 is provided, wherein the total amount of polyols in the oral care composition is about 20 to about 33 wt.

[0021] According to embodiment 13, an oral care composition according to any one of the preceding embodiments is provided, which further comprises optionally about 1 to about 35 wt.% of an abrasive.

[0022] According to embodiment 14, an oral care composition according to embodiment 13 is provided, wherein the abrasive is selected from the following: silica, silicates, silicon, bentonite, zeolite, kaolin, mica, pumice, calcium carbonate, cuttlebone, insoluble phosphates, polycarbonate, microcrystalline wax, microcrystalline cellulose, and combinations of two or more thereof.

[0023] According to embodiment 15, an oral care composition according to embodiment 13 is provided, wherein the abrasive comprises: silica, silicate, silicon, bentonite, zeolite, kaolin, mica, pumice, calcium carbonate, cuttlebone, insoluble phosphate, polycarbonate, microcrystalline wax, microcrystalline cellulose, and combinations of two or more thereof.

[0024] According to embodiment 16, an oral care composition according to any one of embodiments 13 to 15 is provided, wherein the abrasive comprises silica.

[0025] According to embodiment 17, an oral care composition according to any one of the preceding embodiments is provided, wherein water is present in an amount of about 30 to about 50 wt.%.

[0026] According to embodiment 18, an oral care composition according to any one of the preceding embodiments is provided, wherein water is present in an amount of about 32 to about 45 wt.%.

[0027] According to embodiment 19, an oral care composition according to any one of the preceding embodiments is provided, which further comprises, optionally, an amount of about 0.1 to about 7 wt.% of a fluoride source.

[0028] According to embodiment 20, an oral care composition according to embodiment 19 is provided, wherein the fluoride source is selected from: stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium fluorosilicate, amine fluoride, ammonium fluoride, and combinations of two or more thereof.

[0029] According to embodiment 21, an oral care composition according to any one of the preceding embodiments is provided, which further comprises an anti-calculus agent in an amount of about 0.5 to about 10 wt.%.

[0030] According to embodiment 22, an oral care composition according to embodiment 21 is provided, wherein the anti-stone agent is selected from: tetrasodium pyrophosphate, ammonium tripolyphosphate, hexametaphosphate, polycarboxylate polymer, polyvinyl methyl ether / maleic anhydride copolymer, and combinations of two or more thereof.

[0031] According to embodiment 23, an oral care composition according to any one of the preceding embodiments is provided, wherein the thickening system is present in an amount of about 2 to about 15 wt.%.

[0032] According to embodiment 24, an oral care composition according to any one of the preceding embodiments is provided, wherein the thickening system comprises thickening silica.

[0033] According to embodiment 25, an oral care composition according to any one of the preceding embodiments is provided, wherein the thickening system comprises a polysaccharide.

[0034] According to embodiment 26, an oral care composition according to embodiment 25 is provided, wherein the polysaccharide is a natural gum.

[0035] According to embodiment 27, an oral care composition according to embodiment 26 is provided, wherein the natural gum is selected from alginate, pectin, carrageenan, gum arabic, tragacanth gum, black privet gum, agarose, guar gum, pectin, gellan gum, tara gum, locust bean gum, tamarind gum, locust bean gum, Seneca gum, sclerotium gum, gellan gum, xanthan gum, and combinations of two or more thereof.

[0036] According to embodiment 28, an oral care composition according to any one of the preceding embodiments is provided, wherein the thickening system comprises xanthan gum.

[0037] According to embodiment 29, an oral care composition according to any one of the preceding embodiments is provided, wherein the oral care composition is substantially free of or free of polyvinyl thickener.

[0038] According to embodiment 30, an oral care composition according to any one of the preceding embodiments is provided, wherein the oral care composition is substantially free of or free of peroxides.

[0039] According to embodiment 31, an oral care composition according to any one of the foregoing embodiments is provided, wherein the oral care composition is substantially free of or free of whitening agents.

[0040] According to embodiment 32, an oral care composition comprising: a thickening system comprising: about 0.2 to about 5 wt.% of crosslinked polyacrylic acid and / or its salts, and one or more thickeners selected from polysaccharides, thickening silica, and combinations thereof; a polyol system comprising glycerol and sorbitol, wherein glycerol and sorbitol are present in a weight ratio of about 1:1 to about 3:1; and about 5 to about 64 wt.% of water, wherein the oral care composition is free of whitening agents, and all weight percentages are based on the total weight of the oral care composition.

[0041] According to embodiment 33, an oral care composition according to embodiment 32 is provided, wherein the crosslinked polyacrylic acid and / or its salts are present in an amount of about 0.5 to about 4 wt.%.

[0042] According to embodiment 34, an oral care composition according to embodiment 32 or 33 is provided, wherein the total amount of polyols in the oral care composition is about 20 to about 40 wt.

[0043] According to embodiment 35, an oral care composition according to embodiment 34 is provided, wherein the total amount of polyols in the oral care composition is about 20 to about 33 wt.

[0044] According to embodiment 36, an oral care composition according to any one of embodiments 32 to 35 is provided, wherein the thickening system comprises thickening silica.

[0045] According to embodiment 37, an oral care composition according to any one of embodiments 32 to 36 is provided, wherein the thickening system comprises a polysaccharide selected from natural gums including: alginate, pectin, carrageenan, gum arabic, tragacanth gum, black privet gum, agarose, guar gum, pectin, gellan gum, tara gum, locust bean gum, tamarind gum, locust bean gum, Seneca gum, sclerotium gum, gellan gum, xanthan gum, and combinations of two or more thereof.

[0046] According to embodiment 38, an oral care composition according to any one of the preceding embodiments is provided, wherein the oral care composition is substantially free of or contains no calcium carbonate.

[0047] According to embodiment 39, an oral care composition according to any one of the preceding embodiments is provided, wherein the relative tooth abrasion of the oral care composition is about 10 to about 250, as determined according to standard DIN EN ISO 11609. Detailed Implementation

[0048] For illustrative purposes, the principles of the invention are described by reference to various exemplary embodiments thereof. Although certain embodiments of the invention have been specifically described herein, those skilled in the art will readily recognize that the same principles apply equally to and can be used in other compositions and methods. Before explaining the embodiments disclosed herein in detail, it should be understood that the invention is not limited in its application to the details of any particular embodiment disclosed herein. The terminology used herein is for descriptive purposes and not for limiting purposes.

[0049] As used herein and in the appended claims, the singular forms “a,” “an,” and “the” include plural references unless the context otherwise requires. The singular form of any class of ingredients refers not only to one chemical substance in that class but also to mixtures of such chemical substances. The terms “a” (or “an”), “one or more,” and “at least one” are used interchangeably herein. The terms “comprising,” “including,” and “having” are used interchangeably. The term “include” should be construed as “including, but not limited to.”

[0050] As used throughout, a range is used as a shorthand to describe the individual values ​​within that range. Any value within the range can be chosen as the endpoint of the range. Therefore, the range 1-5 specifically includes 1, 2, 3, 4, and 5, as well as subranges such as 2-5, 3-5, 2-3, 2-4, 1-4, etc.

[0051] When referring to numbers, the term "about" means any number within the range of 10% of that number. For example, the phrase "about 2 wt.%" refers to a number between 1.8 wt.% and 2.2 wt.%, inclusive.

[0052] All references cited in this document are incorporated herein by reference in their entirety. In the event of any discrepancy between the definitions in this disclosure and those in the cited references, this disclosure shall prevail.

[0053] The abbreviations and symbols used herein have their ordinary meanings unless otherwise stated. The abbreviation "wt.%" refers to a percentage by weight relative to the oral care composition. The symbol "°" refers to degrees, such as temperature or angle. The symbols "h", "min", "mL", "nm", and "μm" refer to hours, minutes, milliliters, nanometers, and micrometers, respectively. The abbreviation "UV-VIS" refers to a spectrometer or spectroscopy, meaning ultraviolet-visible light. The abbreviation "rpm" indicates revolutions per minute.

[0054] When referring to chemical structures and names, the symbols "C", "H", and "O" represent carbon, hydrogen, and oxygen, respectively. The symbols "-", "=", and "≡" represent single, double, and triple bonds, respectively.

[0055] As used in this article, "volatile" means having a flash point of less than about 100°C. As used in this article, "non-volatile" means having a flash point of greater than about 100°C.

[0056] Any member of a species list used to exemplify or define a genus may be distinct from, overlap with, be a subset of, be equivalent to, or be nearly identical to, or be the same as any other member of that genus. Furthermore, for example, when listing the Markush group, the species list defining or defining the genus is open-ended and assumes the existence of other species that define or define the genus as well as, or better than, any other species listed, unless explicitly stated otherwise.

[0057] The phrases “mixtures thereof,” “combinations thereof,” or “combinations of two or more thereof” do not require that the mixture include all of A, B, C, D, E, and F (although it may include all of A, B, C, D, E, and F). Rather, it indicates a mixture that may include any two or more of A, B, C, D, E, and F. In other words, it is equivalent to the phrase “one or more elements selected from the group consisting of A, B, C, D, E, F, and mixtures of any two or more of A, B, C, D, E, and F.” Similarly, the term “a salt thereof” also refers to “salts thereof.” Therefore, when this disclosure refers to "an element selected from the group consisting of A, B, C, D, E, F, their salts and mixtures thereof", it means that it may include one or more of A, B, C, D and F, one or more of the salts of A, B, C, D, E and F, or a mixture of any two of the salts of A, B, C, D, E, F, the salts of A, B, C, D, E and F.

[0058] All components and elements positively described in this disclosure may be negatively excluded from the claims. In other words, the oral care compositions of this disclosure may be free of or substantially free of all components and elements positively described throughout this disclosure. In some cases, the oral care compositions of this disclosure may be substantially free of non-accidental amounts of the ingredients or compounds described herein. A non-accidental amount of an ingredient or compound is the amount of an ingredient or compound added alone to the oral care composition. For example, an oral care composition may be substantially free of non-accidental amounts of an ingredient or compound, although such an ingredient or compound may be present as part of a raw material contained as a blend of two or more compounds.

[0059] Some of the components in the defined categories may overlap. In cases where overlap is possible and the oral care composition contains two components (or more than two overlapping components), the overlapping compounds do not represent more than one component. For example, some compounds can be characterized as polyols and sweeteners. If a particular oral care composition involves both polyols and sweeteners, then xylitol will be used only as either a polyol or a sweetener, not both.

[0060] For readability purposes, chemical functional groups are presented in their adjective forms; for each adjective, the word "group" is assumed to be present. For example, the adjective "alkyl" without a noun should be read as "alkyl group".

[0061] Several aspects of this invention relate to oral care compositions, for example, providing oral care compositions that enhance resistance to tooth stains. While conventional whitening oral care compositions focus on using whitening agents to whiten teeth, the inventors have surprisingly discovered that certain oral care compositions disclosed herein can reduce and / or prevent future staining by increasing the resistance of teeth to stains.

[0062] According to one aspect of the invention, an oral care composition comprising: a thickening system comprising crosslinked polyacrylic acid and / or its salts and one or more thickeners selected from polysaccharides, thickening silica and combinations thereof; a polyol; and about 14 to about 64 wt.% water, wherein all weight percentages are based on the total weight of the oral care composition.

[0063] According to another aspect of the invention, an oral care composition comprising: a thickening system comprising about 0.2 to about 5 wt.% crosslinked polyacrylic acid and / or its salts, and one or more thickeners selected from polysaccharides, thickening silica, and combinations thereof; a polyol system comprising glycerol and sorbitol, wherein glycerol and sorbitol are present in a weight ratio of about 1:1 to about 3:1; and about 14 to about 64 wt.% water, wherein the oral care composition is free of whitening agents, and all weight percentages are based on the total weight of the oral care composition.

[0064] In some preferred embodiments, the oral care composition may have a reduced amount of polyvinyl thickener, and may be substantially free of or contain no polyvinyl thickener. For example, based on the weight of the oral care composition, the oral care composition may preferably have about 4 wt.% or less, about 3 wt.% or less, about 2 wt.% or less, about 1 wt.% or less, about 0.5 wt.% or less, or about 0.1 wt.% or less of polyvinyl thickener. In at least one embodiment, the oral care composition comprises about 0 wt.% or 0 wt.% of polyvinyl thickener.

[0065] Additionally and / or alternatively, the oral care composition may preferably have a reduced amount of peroxide, and be substantially free of or contain no peroxide. For example, based on the weight of the oral care composition, the oral care composition may preferably have about 4 wt.% or less, about 3 wt.% or less, about 2 wt.% or less, about 1 wt.% or less, about 0.5 wt.% or less, or about 0.1 wt.% or less of peroxide. In at least one embodiment, the oral care composition contains about 0 wt.% or 0 wt.% of peroxide.

[0066] In some preferred embodiments, the oral care composition has a reduced amount of whitening agent, and is substantially free of or contains no whitening agent. For example, based on the weight of the oral care composition, the oral care composition may preferably have about 4 wt.% or less, about 3 wt.% or less, about 2 wt.% or less, about 1 wt.% or less, about 0.5 wt.% or less, or about 0.1 wt.% or less of whitening agent. In at least one embodiment, the oral care composition contains about 0 wt.% or 0 wt.% of whitening agent.

[0067] Additionally and / or alternatively, the oral care composition may preferably have a reduced amount of carbonate (e.g., calcium carbonate), and be substantially carbonate-free or carbonate-free. For example, based on the weight of the oral care composition, the oral care composition may preferably have about 4 wt.% or less, about 3 wt.% or less, about 2 wt.% or less, about 1 wt.% or less, about 0.5 wt.% or less, or about 0.1 wt.% or less of carbonate (e.g., calcium carbonate). In at least one embodiment, the oral care composition contains about 0 wt.% or 0 wt.% of carbonate (e.g., calcium carbonate).

[0068] Preferably, the oral care composition provides stain resistance while having a desirable relative tooth abrasion. In some preferred embodiments, the relative tooth abrasion of the oral care composition is about 250 or less, about 200 or less, about 150 or less, about 125 or less, about 100 or less, or about 75 or less, as determined according to standard DIN EN ISO 11609. Alternatively or additionally, the oral care composition may preferably have about 10 or more, about 50 or more, or about 75 or more, as determined according to standard DIN EN ISO 11609. For example, the relative tooth abrasion of the oral care composition may preferably be about 10 to about 250, about 50 to about 200, or any other range formed by the disclosure herein, as determined according to standard DIN EN ISO 11609.

[0069] Oral care compositions may be in the form of dental floss, toothpaste, mouthwash, gel, varnish, leave-on products (e.g., gel, varnish, etc.) and / or similar forms. The formulation of an oral care composition may or may not contain suitable components, as listed below, depending on the specific combination of other ingredients and the form of the oral care composition. Additionally or alternatively, in some embodiments, the oral care composition may have a single phase comprising components and / or ingredients of the oral care composition. In other embodiments, the oral care composition may comprise two or more phases, such as biphasic, triphasic, tetraphasic, or pentapeptides.

[0070] Oral care compositions typically comprise a thickening system containing one or more cross-linked polyacrylic acids and / or their salts, and one or more thickeners selected from polysaccharides, thickening silica, and combinations thereof. In some embodiments, the thickening system consists of one or more cross-linked polyacrylic acids and / or their salts, and one or more thickeners selected from polysaccharides, thickening silica, and combinations thereof, such as those described herein.

[0071] Based on the total weight of the oral care composition, the thickening system may be present in the oral care composition in an amount ranging from about 2 to about 15 wt.%. For example, based on the total weight of the oral care composition, the total amount of the thickening system can preferably be about 2 to about 10 wt.%, about 2 to about 8 wt.%, about 2 to about 7 wt.%, about 2 to about 6 wt.%, about 2 to about 5 wt.%, about 2 to about 4 wt.%; about 3 to about 10 wt.%, about 3 to about 8 wt.%, about 3 to about 7 wt.%, about 3 to about 6 wt.%, about 3 to about 5 wt.%; about 4 to about 15 wt.%, about 4 to about 12 wt.%, about 4 to about 10 wt.%, about 4 to about 8 wt.%, about 4 to about 7 wt.%, about 4 to about 6 wt.%, about 4 to about 5 wt.%; about 5 to about 15 wt.%, about 5 to about 12 wt.%, about 5 to about 10 wt.%, about 5 to about 8 wt.%, about 5 to about 7 wt.%, about 5 to about 6 wt.%; about 6 to about 10 wt.%, about 6 to about 8 wt.%; from about 7 to about 15 wt.%, about 7 to about 12 wt.%; wt.%, about 7 to about 10 wt.%, about 7 to about 9 wt.%; about 9 to about 15 wt.%, about 9 to about 12 wt.%, about 9 to about 11 wt.%; about 11 to about 15 wt.%, about 11 to about 14 wt.%, about 13 to about 15 wt.%, or any range or subrange thereof.

[0072] Based on the total weight of the oral care composition, the thickening system typically contains one or more crosslinked acrylic acids and / or their salts, for example, in an amount of about 0.2 to about 4 wt.%. In some cases, based on the total weight of the oral care composition, one or more crosslinked acrylic acids and / or salts may preferably be present in amounts of about 0.2 to about 3 wt.%, about 0.2 to about 2.5 wt.%, about 0.2 to about 2 wt.%, about 0.2 to about 1.5 wt.%, about 0.2 to about 1.25 wt.%, about 0.2 to about 1 wt.%, about 0.2 to about 0.75 wt.%, about 0.2 to about 0.5 wt.%; about 0.35 to about 4 wt.%, about 0.35 to about 3 wt.%, about 0.35 to about 2.5 wt.%, about 0.35 to about 2 wt.%, about 0.35 to about 1.5 wt.%, about 0.35 to about 1.25 wt.%, about 0.35 to about 1 wt.%, about 0.35 to about 0.75 wt.%, about 0.35 to about 0.5 wt.%; about 0.5 to about 4 wt.%, about 0.5 to about 3 wt.%; wt.%, about 0.5 to about 2.5 wt.%, about 0.5 to about 2 wt.%, about 0.5 to about 1.5 wt.%, about 0.5 to about 1.25 wt.%, about 0.5 to about 1 wt.%, about 0.5 to about 0.75 wt.%; about 0.75 to about 4 wt.%, about 0.75 to about 3 wt.%, about 0.75 to about 2.5 wt.%, about 0.75 to about 2 wt.%, about 0.75 to about 1.5 wt.%, about 0.75 to about 1.25 wt.%, about 0.75 to about 1 wt.%; about 1 to about 4 wt.%, about 1 to about 3 wt.%, about 1 to about 2.5 wt.%, about 1 to about 2 wt.%, about 1 to about 1.5 wt.%, about 1 to about 1.25 wt.%; about 1.5 to about 4 wt.%, about 1.5 to about 3 wt.%, about 1.5 to about 2.5 wt. The amount is present in wt.%, about 1.5 to about 2 wt.%; about 2 to about 4 wt.%; about 2 to about 3 wt.%; about 2 to about 2.5 wt.%; about 2.5 to about 4 wt.%; about 2.5 to about 3 wt.%; about 3 to about 4 wt.%; or any range or subrange thereof.

[0073] Crosslinked polyacrylic acid and / or its salts may be selected from branched polyacrylic acid and / or its salts. In some cases, the polyacrylic acid and / or its salts consist of branched polyacrylic acid and / or its salts. However, in further cases, the oral care composition comprises at least one linear polyacrylic acid and / or its salt.

[0074] Crosslinked polyacrylic acid and / or its salts may be carbomers. Carbomers may include Carbopol or the group consisting of Carbopols. For example, personal care compositions may include, or in some cases exclude, polyacrylic acid and / or its salts selected from: Carbopol 2984, Carbopol 934, Carbopol Ultrez 10, Carbopol 940, Carbopol 941, Carbopol 956, Carbopol 981, Carbopol 2020, and combinations of two or more thereof. In some cases, the polyacrylic acid and / or its salts comprise one or more of the following or selected from the group consisting of: Carbopol 2984, Carbopol 910, Carbopol 934P, Carbopol Ultrez 10, Carbopol 940, Carbopol 941, Carbopol 956, Carbopol 971P, Carbopol 974P, Carbopol 981, Carbopol 2020, and / or combinations of two or more of them. In at least one embodiment, the carbomer comprises or consists of carbopol ETD NF 2020. Additionally or alternatively, the crosslinked polyacrylic acid and / or its salts may be selected from carbomers.

[0075] Based on the total weight of the oral care composition, one or more thickeners selected from polysaccharides, thickening silica, and combinations thereof may preferably be present in amounts of about 1 to about 10 wt.%, about 1 to about 8 wt.%, about 1 to about 6 wt.%, about 1 to about 5 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%, about 1 to about 2 wt.%; about 2 to about 10 wt.%, about 2 to about 8 wt.%, about 2 to about 6 wt.%, about 2 to about 5 wt.%, about 2 to about 4 wt.%, about 2 to about 3 wt.%; about 3 to about 10 wt.%, about 3 to about 8 wt.%, about 3 to about 6 wt.%, about 3 to about 5 wt.%, about 3 to about 4 wt.%; about 5 to about 10 wt.%, about 5 to about 8 wt.%, about 5 to about 6 wt.%; about 7 to about 10 wt.%, about 7 to about 8 wt.%, about 8 to about 10 wt.%, or any range or subrange thereof.

[0076] The polysaccharide may be selected from cellulose, cellulose derivatives, natural gums, and combinations thereof. In some embodiments, the polysaccharide is a natural gum. Examples of natural gums that may be included in the oral care composition or, in some embodiments, not included in the oral care composition include alginate, pectin, carrageenan, gum arabic, tragacanth gum, black privet gum, agarose, guar gum, pectin, gellan gum, tara gum, locust bean gum, tamarind gum, locust bean gum, Seneca gum, sclerotium gum, gellan gum, xanthan gum, or combinations thereof. For example, the thickening system may contain natural gums including gum arabic, tragacanth gum, black privet gum, agarose, guar gum, pectin, gellan gum, tara gum, locust bean gum, tamarind gum, locust bean gum, Seneca gum, sclerotium gum, gellan gum, xanthan gum, or combinations thereof. In some cases, oral care compositions comprise natural gums selected from xanthan gum, carrageenan, pectin, alginate, pectin, and combinations of two or more thereof. In at least one embodiment, the natural gum comprises xanthan gum.

[0077] The polysaccharide can be cellulose. Examples of cellulose include any cellulose ether selected from the following: carboxymethyl cellulose (CMC), ethyl cellulose (EC), hydroxypropyl cellulose (HPC), hydroxypropyl methyl cellulose (HPMC), methyl hydroxyethyl cellulose (MHEC), and mixtures thereof. In some embodiments, the cellulose is a modified cellulose selected from the following: microcrystalline cellulose (MCC) (e.g., in its anhydrous or hydrated form) and cellulose ethers (e.g., hydroxypropyl cellulose (HPC) and hydroxypropyl methyl cellulose (HPMC)).

[0078] Thickening systems may include thickened silica. Thickened silica (sometimes referred to as silica thickeners, which form polymer structures or gels in aqueous media) may be present. Thickened silica typically differs physically and functionally from granular silica abrasives because silica thickeners are finely dispersed and provide little or no abrasive action.

[0079] The thickening system may include thickened silica with a particle size distribution (D95) of less than or equal to 7 μm and a BET surface area of ​​greater than or equal to 150 m². 2 / g. In some cases, the BET surface area of ​​thickened silica is greater than or equal to 175m². 2 / g, greater than or equal to 200 m 2 / g, or greater than or equal to 250 m 2 / g. For example, the BET surface area of ​​thickened silica can be from about 150 to about 350 m². 2 / g, approximately 170 to approximately 350 m 2 / g, approximately 190 to approximately 350 m 2 / g, approximately 210 to approximately 350 m 2 / g, approximately 230 to approximately 350 m 2 / g, approximately 250 to approximately 350 m 2 / g, approximately 270 to approximately 350 m 2 / g, approximately 290 to approximately 350 m 2 / g, approximately 310 to approximately 350 m 2 / g, approximately 330 to approximately 350 m 2 / g; approximately 150 to approximately 300 m 2 / g, approximately 170 to approximately 300 m 2 / g, approximately 190 to approximately 300m 2 / g, approximately 210 to approximately 300 m 2 / g, approximately 230 to approximately 300 m 2 / g, approximately 250 to approximately 300 m 2 / g, approximately 270 to approximately 300 m 2 / g; approximately 150 to approximately 275 m 2 / g, approximately 170 to approximately 275 m 2 / g, approximately 190 to approximately 275 m 2 / g, about 210 to about 275 m 2 / g, approximately 230 to approximately 275 m 2 / g, approximately 250 to approximately 275 m 2 / g; approximately 150 to approximately 250 m 2 / g, approximately 170 to approximately 250 m 2 / g, approximately 190 to approximately 250m 2 / g, approximately 210 to approximately 250 m 2 / g, approximately 230 to approximately 250 m 2 / g; approximately 150 to approximately 225 m 2 / g, approximately 170 to approximately 225 m 2 / g, approximately 190 to approximately 225 m 2 / g, about 210 to about 225 m 2 / g, or any of its ranges or subranges.

[0080] Alternatively or concurrently, the oil absorption capacity of the thickened silica may be greater than or equal to about 200 mL / 100 g, about 240 mL / 100 g, about 250 mL / 100 g, or any range thereof. For example, the oil absorption capacity of the thickened silica may be about 200 to about 250 mL / 100 g, about 210 to about 250 mL / 100 g, about 220 to about 250 mL / 100 g, about 230 to about 250 mL / 100 g; about 200 to about 240 mL / 100 g, about 210 to about 240 mL / 100 g, about 220 to about 240 mL / 100 g, about 230 to about 240 mL / 100 g; about 200 to about 230 mL / 100 g, about 210 to about 230 mL / 100 g, about 220 to about 230 mL / 100 g, or any range or subrange thereof.

[0081] Other thickeners that may or may not be included in oral care compositions in some cases include acrylates, polyvinylpyrrolidone, polyitacrylates, and acrylamide. Polyvinylpyrrolidone generally refers to polymers containing vinylpyrrolidone (e.g., N-vinyl-2-pyrrolidone, N-vinyl-2-pyrrolidinone, and N-vinyl-2-pyrrolidinone) as monomer units. The monomer unit may include a polar imide group, four nonpolar methylene groups, and a nonpolar methane group. The acrylate may be a diacrylate and / or a methacrylate. Examples of acrylates include, for example, isobutyl acrylate, tert-butyl acrylate, 2-ethylhexyl acrylate, lauryl acrylate, lauryl / tridecyl acrylate, hexadecyl acrylate, stearyl acrylate, cyclohexyl acrylate, benzyl acrylate, isobornyl acrylate, 2-methoxyethyl acrylate, 2-ethoxyethyl acrylate, 2-ethoxyethoxyethyl acrylate, 2-phenoxyethyl acrylate, tetrahydrofurfuryl acrylate, 2-hydroxyethyl acrylate, 2-hydroxypropyl acrylate, 4-hydroxybutyl acrylate, dimethylaminoethyl acrylate, 1,4-butanediol acrylate, or combinations of two or more thereof. Examples of acrylamides include, but are not limited to, acrylamide, methacrylamide, and bis(C1-C2)acrylamide. 30 )alkyl-acrylamide and di(C1-C 30 Alkyl-methacrylamides, such as those with methyl, ethyl, propyl, butyl, pentyl, hexyl, etc.

[0082] Oral care compositions may contain one or more polyols. In some cases, oral care compositions comprise a polyol system containing multiple polyols. Based on the total weight of the oral care composition, the total amount of polyols in the oral care composition is about 20 to 40 wt.%, about 20 to 37 wt.%, about 20 to 35 wt.%, about 20 to 33 wt.%, about 20 to 31 wt.%, about 20 to 29 wt.%, about 20 to 27 wt.%, about 20 to 25 wt.%; about 24 to 40 wt.%, about 24 to 37 wt.%, about 24 to 35 wt.%, about 24 to 33 wt.%, about 24 to 31 wt.%, about 24 to 29 wt.%; about 28 to 40 wt.%, about 28 to 37 wt.%, about 28 to 35 wt.%, about 28 to 33 wt.%, about 28 to 31 wt.%; about 30 to 40 wt.%, about 30 to 37 wt.%, about 30 to 35 wt.%, about 30 to 33 wt.%. wt.%; about 32 to about 40 wt.%, about 32 to about 37 wt.%, about 32 to about 35 wt.%; about 34 to about 40 wt.%, about 34 to about 37 wt.%, about 36 to about 40 wt.%, about 36 to about 38 wt.%, or any range or subrange thereof.

[0083] In some cases, based on the total weight of the oral care composition, the amount of each polyol in the oral care composition may be about 5 to about 35 wt.%, about 5 to about 30 wt.%, about 5 to about 25 wt.%, about 5 to about 21 wt.%, about 5 to about 17 wt.%, about 5 to about 14 wt.%, about 5 to about 11 wt.%; about 10 to about 35 wt.%, about 10 to about 30 wt.%, about 10 to about 25 wt.%, about 10 to about 21 wt.%, about 10 to about 17 wt.%, about 10 to about 14 wt.%; about 15 to about 35 wt.%, about 15 to about 30 wt.%, about 15 to about 25 wt.%, about 15 to about 21 wt.%, about 15 to about 19 wt.%; about 18 to about 35 wt.%, about 18 to about 30 wt.%, about 18 to about 25 wt.%, about 18 to about 21 wt.%; about 21 to about 35 wt.%. wt.%, about 21 to about 30 wt.%, about 21 to about 25 wt.%; about 24 to about 35 wt.%, about 24 to about 30 wt.%; about 27 to about 35 wt.%, about 27 to about 30 wt.%; or any range or subrange thereof.

[0084] The polyol may be selected from glycols or compounds having multiple hydroxyl groups. The one or more polyols may be liquid at ambient temperature (25°C). In some preferred embodiments, the polyol comprises a selection from glycerol, glycols, inositol, maltitol, mannitol, sorbitol, xylitol, propylene glycol, polypropylene glycol (PPG), polyethylene glycol (PEG), block copolymers of PPG and PEG, sugars (e.g., fructose, glucose, sucrose, and mixtures of sugars such as honey), or combinations of two or more thereof. For example, an oral care composition may comprise maltitol, mannitol, sorbitol, xylitol, polypropylene glycol (PPG), polyethylene glycol (PEG), block copolymers of PPG and PEG, or combinations of two or more thereof. Polyols can be humectants, including, for example, glycols, sorbitol, glycerol, inositol, maltitol, mannitol, xylitol, propylene glycol, polypropylene glycol (PPG), polyethylene glycol (PEG), sugars, polyoxypropylene-polyoxyethylene block copolymers, and combinations of two or more thereof.

[0085] In some cases, oral care compositions contain one or more C2-C derivatives. 32 The polyols in the group consisting of polyols. The one or more polyols may have 2 to 32 carbon atoms, 3 to 16 carbon atoms, or 3 to 12 carbon atoms. For example, an oral care composition may contain ethylene glycol, propylene glycol, butylene glycol, hexanediol, glycerin, diglycerin, diethylene glycol, and dipropylene glycol, or combinations of two or more thereof. Other non-limiting examples of polyols that may optionally be included in oral care products include and / or may be selected from alkanediols, such as glycerol, 1,2,6-hexanediol, trimethylolpropane, ethylene glycol, propylene glycol, butanediol, pentanediol, hexanediol, diethylene glycol, triethylene glycol, tetraethylene glycol, pentaethylene glycol, dipropylene glycol, 2-buten-1,4-diol, 2-ethyl-1,3-hexanediol, 2-methyl-2,4-pentanediol, octyl ethylene glycol, 1,2-hexanediol, 1,2-pentanediol, and 4-methyl-1,2-pentanediol; glycol ethers (glycol) Ethers, such as ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol monomethyl ether acetate, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol mono-n-propyl ether, ethylene glycol monoisopropyl ether, diethylene glycol monoisopropyl ether, ethylene glycol mono-n-butyl ether, ethylene glycol mono-tert-butyl ether, diethylene glycol mono-tert-butyl ether, 1-methyl-1-methoxybutanol, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol mono-tert-butyl ether, propylene glycol mono-n-propyl ether, propylene glycol monoisopropyl ether, dipropylene glycol monomethyl ether, dipropylene glycol monoethyl ether, dipropylene glycol mono-n-propyl ether, dipropylene glycol monoisopropyl ether, sorbitol, anhydrosorbitol, triacetin, and mixtures of two or more thereof.

[0086] Additionally or alternatively, the oral care composition may comprise a polyol with a molecular weight of about 100 to 5000 g / mol. For example, the polyol may comprise polyethylene glycol, polypropylene glycol, block polymers of polyethylene glycol and polypropylene glycol, or combinations of two or more thereof. In some embodiments, the polyol comprises polypropylene glycol, polypropylene glycol, and / or block polymers of polyethylene glycol and polypropylene glycol, having a molecular weight of about 100 to about 900, about 200 to about 800, about 400, about 1500 to about 2500, about 2000 to about 4500, or any range or subrange thereof. In some embodiments, the polyol is polyethylene glycol, such as polyethylene glycol 600. In some embodiments, the oral care composition comprises one or more polyethylene glycols, such as polyethylene glycol with a molecular weight range of 200 to 800. For example, the composition may contain one or more of polyethylene glycol 200, polyethylene glycol 300, polyethylene glycol 400, polyethylene glycol 600 or polyethylene glycol 800.

[0087] In some embodiments, the oral care composition comprises two or more polyols. In some preferred embodiments, at least one polyol is selected from or composed of glycerol and sorbitol. In at least one preferred embodiment, the oral care composition comprises glycerol and sorbitol. In some preferred embodiments, the oral care composition may have a polyol system comprising glycerol and sorbitol, wherein glycerol and sorbitol are present in a weight ratio of about 1:1 to about 3:1. For example, the weight ratio of glycerin to sorbitol in the oral care composition may preferably be from about 1:1 to about 3:1, from about 1:1 to about 2.75:1, from about 1:1 to about 2.5:1, from about 1:1 to about 2.25:1, from about 1:1 to about 2:1; from about 1:1 to about 3:1, from about 1:1 to about 2.75:1, from about 1:1 to about 2.5:1, from about 1:1 to about 2.25:1, from about 1:1 to about 2:1; from about 1.25:1 to about 3:1, from about 1.25:1 to about 2.75:1, from about 1.25:1 to about 2. 5:1, about 1.25:1 to about 2.25:1, about 1.25:1 to about 2:1; about 1.5:1 to about 3:1, about 1.5:1 to about 2.75:1, about 1.5:1 to about 2.5:1, about 1.5:1 to about 2.25:1, about 1.5:1 to about 2:1; about 1.75:1 to about 3:1, about 1.75:1 to about 2.75:1, about 1.75:1 to about 2.5:1, about 1.75:1 to about 2.25:1, about 1.75:1 to about 2:1, or a range or subrange thereof.

[0088] Oral care compositions may contain one or more abrasives, for example, in amounts from about 1 wt.% to about 35 wt.% based on the total weight of the oral care composition. In some embodiments, one or more abrasives are present in the following proportions: about 1 to about 30 wt.%, about 1 to about 25 wt.%, about 1 to about 21 wt.%, about 1 to about 17 wt.%, about 1 to about 14 wt.%, about 1 to about 11 wt.%; about 5 to about 30 wt.%, about 5 to about 25 wt.%, about 5 to about 21 wt.%, about 5 to about 17 wt.%, about 5 to about 14 wt.%, about 5 to about 11 wt.%; about 10 to about 35 wt.%, about 10 to about 30 wt.%, about 10 to about 25 wt.%, about 10 to about 21 wt.%, about 10 to about 17 wt.%, about 10 to about 14 wt.%; about 15 to about 35 wt.%, about 15 to about 30 wt.%, about 15 to about 25 wt.%, about 15 to about 21 wt.%, about 15 to about 19 wt.%; about 18 to about 35 wt.%, about 18 to about 30 wt.%. The presence of amounts of wt.%, about 18 to about 25 wt.%, about 18 to about 21 wt.%; about 21 to about 35 wt.%, about 21 to about 30 wt.%, about 21 to about 25 wt.%; about 24 to about 35 wt.%, about 24 to about 30 wt.%; about 27 to about 35 wt.%, about 27 to about 30 wt.%; or any range or subrange thereof.

[0089] The one or more abrasives may include: silica, silicates, silicon, alumina (including calcined aluminum oxide), aluminosilicates such as bentonite, zeolite, kaolin, and mica, siliceous clay or diatomaceous earth, pumice, calcium carbonate, cuttlebone, insoluble phosphates, composite resins such as melamine resin, phenolic resin and urea-formaldehyde resin, polycarbonate, silicon carbide, boron carbide, microcrystalline wax, microcrystalline cellulose, including combinations of colloidal microcrystalline cellulose and carboxymethyl cellulose, and combinations and derivatives thereof. For example, the one or more abrasives may be selected from silica including gels and precipitates, calcium carbonate, dicalcium dihydrate orthophosphate, calcium pyrophosphate, tricalcium phosphate, polymetaphosphate, insoluble sodium polymetaphosphate, hydrated alumina, resin abrasive materials such as particulate condensation products of urea and formaldehyde, and combinations thereof.

[0090] As used herein, “mica” refers to any of a group of hydrated aluminum silicate minerals having a platy morphology and / or perfect matrix (mica-like) cleavage. Mica can be, for example, platy mica, fragmented mica, or fragmented mica, such as muscovite, biotite, or phlogopite-type mica. Abrasives can be selected from insoluble phosphates, such as orthophosphates, polymetaphosphates, pyrophosphates, and combinations thereof. Synthetic silica includes silica gel and precipitated silica, which are prepared by neutralizing aqueous silicate solutions with strong inorganic acids. Abrasives containing silica can be used in certain embodiments of oral care compositions. In some embodiments, the oral composition may contain a particularly effective combination of silica abrasive particle types. For example, the abrasive is selected from high-cleanliness silica.

[0091] Oral care compositions may comprise an abrasive system containing two or more abrasives. For example, an abrasive system may contain 2 to 7, 2 to 6, 2 to 5, 2 to 5, or 2 to 4; 3 to 7, 3 to 6, 2 to 5, or 3 to 5 abrasives. The abrasive may comprise one or more cleaning abrasives and / or one or more polishing abrasives. As understood by those skilled in the art, a single abrasive species typically performs at least some cleaning and polishing simultaneously. However, particles are generally classified in the art according to their primary effect on the target oral surface. Generally, "polishing abrasives" are considered to be relatively small particles with high hardness, while abrasives with relatively large particle size and low hardness are considered "cleaning abrasives." In some embodiments, the oral care composition comprises two or more silica-containing abrasives. In some embodiments, the first abrasive is selected to be a harder and smaller abrasive, such as a higher-grade cleaning and / or polishing abrasive, and the second abrasive is a typical cleaning abrasive. In some embodiments, the oral care composition comprises at least one polishing abrasive and / or at least one cleaning abrasive. Further examples of abrasives are disclosed in U.S. Patent Publication No. 2007 / 140986, which is incorporated herein by reference in its entirety for all purposes.

[0092] In some cases, the abrasive is selected from: silica, silicates, silicon, bentonite, zeolite, kaolin, mica, pumice, calcium carbonate, cuttlebone, insoluble phosphates, polycarbonate, microcrystalline wax, microcrystalline cellulose, and combinations of two or more thereof. In some embodiments, the oral care composition may have an abrasive composed of: silica, silicates, silicon, bentonite, zeolite, kaolin, mica, pumice, calcium carbonate, cuttlebone, insoluble phosphates, polycarbonate, microcrystalline wax, microcrystalline cellulose, and combinations of two or more thereof. In at least one embodiment, the abrasive is a silica abrasive, such as a high-cleanliness silica abrasive.

[0093] Oral care compositions typically contain a certain amount of water. Based on the total weight of the oral care composition, the amount of water present in the oral care composition can be from about 5 to about 64 wt.% water. For example, based on the total weight of the oral care composition, the amount of water in the oral care composition may be about 5 to about 60 wt.%, about 5 to about 56 wt.%, about 5 to about 53 wt.%, about 5 to about 50 wt.%, about 5 to about 47 wt.%, about 5 to about 45 wt.%, about 5 to about 43 wt.%, about 5 to about 41 wt.%, about 5 to about 39 wt.%, about 5 to about 37 wt.%, about 5 to about 35 wt.%, about 5 to about 33 wt.%; about 10 to about 60 wt.%, about 10 to about 56 wt.%, about 10 to about 53 wt.%, about 10 to about 50 wt.%, about 10 to about 47 wt.%, about 10 to about 45 wt.%, about 10 to about 43 wt.%, about 10 to about 41 wt.%, about 10 to about 39 wt.%, about 10 to about 37 wt.%, about 10 to about 35 wt.%, about 10 to about 33 wt.%. wt.%; about 14 to about 64 wt.%, about 14 to about 60 wt.%, about 14 to about 56 wt.%, about 14 to about 53 wt.%, about 14 to about 50 wt.%, about 14 to about 47 wt.%, about 14 to about 45 wt.%, about 14 to about 43 wt.%, about 14 to about 41 wt.%, about 14 to about 39 wt.%, about 14 to about 37 wt.%, about 14 to about 35 wt.%, about 14 to about 33 wt.%; about 19 to about 64 wt.%, about 19 to about 60 wt.%, about 19 to about 56 wt.%, about 19 to about 53 wt.%, about 19 to about 50 wt.%, about 19 to about 47 wt.%, about 19 to about 45 wt.%, about 19 to about 43 wt.%, about 19 to about 41 wt.%, about 19 to about 39 wt.%, about 19 to about 37 wt.%, about 19 to about 35 wt.%, about 19 to about 33 wt.%; about 24 to about 64 wt.%, about 24 to about 60 wt.%, about 24 to about 56 wt.%, about 24 to about 53 wt.%, about 24 to about 50 wt.%, about 24 to about 47 wt.%, about 24 to about 45 wt.%, about 24 to about 43 wt.%, about 24 to about 41 wt.%, about 24 to about 39 wt.%, about 24 to about 37 wt.%, about 24 to about 35 wt.%, about 24 to about 33 wt.%; about 29 to about 64 wt.%, about 29 to about 60 wt.%, about 29 to about 56 wt.%, about 29 to about 53 wt.%, about 29 to about 50 wt.%, about 29 to about 47 wt.%, about 29 to about 45 wt.%, about 29 to about 43 wt.%.%, about 29 to about 41 wt.%, about 29 to about 39 wt.%, about 29 to about 37 wt.%; about 32 to about 64 wt.%, about 32 to about 60 wt.%, about 32 to about 56 wt.%, about 32 to about 53 wt.%, about 32 to about 50 wt.%, about 32 to about 47 wt.%, about 32 to about 45 wt.%, about 32 to about 43 wt.%, about 32 to about 41 wt.%, about 32 to about 39 wt.%; about 34 to about 64 wt.%, about 34 to about 60 wt.%, about 34 to about 56 wt.%, about 34 to about 53 wt.%, about 34 to about 50 wt.%, about 34 to about 47 wt.%, about 34 to about 45 wt.%, about 34 to about 43 wt.%, about 34 to about 41 wt.%; about 39 to about 64 wt.%, about 39 to about 60 wt.% wt.%, about 39 to about 56 wt.%, about 39 to about 53 wt.%, about 39 to about 50 wt.%, about 39 to about 47 wt.%, about 39 to about 45 wt.%, about 39 to about 43 wt.%; about 42 to about 64 wt.%, about 42 to about 60 wt.%, about 42 to about 56 wt.%, about 42 to about 53 wt.%, about 42 to about 50 wt.%, about 42 to about 47 wt.%; about 45 to about 64 wt.%, about 45 to about 60 wt.%, about 45 to about 56 wt.%, about 45 to about 53 wt.%, about 45 to about 50 wt.%; about 48 to about 64 wt.%, about 48 to about 60 wt.%, about 48 to about 56 wt.%, about 48 to about 53 wt.%; about 54 to about 64 wt.%, about 54 to about 60 wt.%, or any range or subrange thereof.

[0094] Oral care compositions may contain one or more surfactants, the amount of which may vary based on the total weight of the oral care composition, but is typically from about 0.1 to about 8 wt.%. For example, based on the total weight of the oral care composition, the amount of one or more surfactants present in the oral care composition may be from about 0.1 to about 6 wt.%, from about 0.1 to about 5 wt.%, from about 0.1 to about 4 wt.%, from about 0.1 to about 3 wt.%, from about 0.1 to about 2 wt.%, from about 0.1 to about 1 wt.%; from about 0.3 to about 8 wt.%, from about 0.3 to about 6 wt.%, from about 0.3 to about 5 wt.%, from about 0.3 to about 4 wt.%, from about 0.3 to about 3 wt.%, from about 0.3 to about 2 wt.%; from about 0.6 to about 8 wt.%, from about 0.6 to about 6 wt.%, from about 0.6 to about 5 wt.%, from about 0.6 to about 4 wt.%, from about 0.6 to about 3 wt.%, from about 0.6 to about 2 wt.%; from about 0.9 to about 8 wt.%, from about 0.9 to about 6 wt.%, from about 0.9 to about 5 wt.%, from about 0.9 to about 4 wt.%, from about 0.9 to about 3 wt.%; wt.%, about 0.9 to about 2 wt.%; about 1.2 to about 8 wt.%, about 1.2 to about 6 wt.%, about 1.2 to about 5 wt.%, about 1.2 to about 4 wt.%, about 1.2 to about 3 wt.%, about 1.2 to about 2 wt.%; about 1.5 to about 8 wt.%, about 1.5 to about 6 wt.%, about 1.5 to about 5 wt.%, about 1.5 to about 4 wt.%, about 1.5 to about 3 wt.%; about 2 to about 8 wt.%, about 2 to about 6 wt.%, about 2 to about 5 wt.%, about 2 to about 4 wt.%, about 2 to about 3 wt.%; about 3 to about 8 wt.%, about 3 to about 6 wt.%, about 3 to about 5 wt.%; about 4 to about 8 wt.%, about 4 to about 6 wt.%, about 4 to about 5 wt.%, or any range or subrange thereof.

[0095] One or more surfactants may comprise anionic surfactants, such as those selected from: water-soluble salts and water-miscible salts of alkyl sulfates (e.g., those with 8 to 20 carbon atoms in the alkyl group (e.g., sodium alkyl sulfate)); and water-soluble or water-miscible salts of sulfonated monoglycerides of fatty acids having 8 to 20 carbon atoms. Examples of anionic surfactants that may or may not be included in oral care compositions in some cases include sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium cocoyl methyl taurate, sodium monoglyceride sulfate, sodium cetearyl sulfate, potassium cocoyl glycinate, sodium lauryl phosphate, sodium lauryl lactate, sodium lauryl sulfoacetate, sodium lauroyl glutamate, sodium lauroyl hydroxyethyl sulfonate, sodium laureth carboxylate, sodium dodecylbenzene sulfonate, and combinations thereof. In one embodiment, sodium lauryl sulfate is a preferred surfactant. Other anionic surfactants, such as those disclosed in U.S. Patent No. 3,959,458, are incorporated herein by reference in their entirety for all purposes.

[0096] Other anionic surfactants mentioned include long-chain alkyl (C6-C4) surfactants. 22 Substances such as long-chain alkyl sulfates, long-chain alkyl sulfonates, long-chain alkyl phosphates, long-chain alkyl ether sulfates, long-chain alkyl α-olefin sulfonates, long-chain alkyl taurines, long-chain alkyl hydroxyethyl sulfonates (SCI), long-chain alkyl glycerol ether sulfonates (AGES), sulfosuccinates, etc., can be alkoxylated (e.g., ethoxylated), although alkoxylation is not required.

[0097] Oral care compositions may include surfactants other than anionic surfactants, such as nonionic surfactants, amphoteric surfactants, or cationic surfactants. Examples of amphoteric surfactants include betaine surfactants, such as cocamidopropyl betaine, dodecyl dimethyl betaine (sold under the trade name Macat LB), hexadecyl dimethyl betaine, and coacromamphodiacetate. Examples of nonionic surfactants that may be included in or not included in oral care compositions include glucosides and compounds formed by the condensation of an epoxy alkyl group (which is inherently hydrophilic) with an organic hydrophobic compound, which may be inherently aliphatic or alkyl aromatic. In some preferred embodiments, the oral care composition may be substantially free of or contain no amphoteric surfactants.

[0098] One or more nonionic surfactants may be selected from glucosides, compounds formed by the condensation of an epoxy alkyl group (which is inherently hydrophilic) with an organic hydrophobic compound, said organic hydrophobic compound being inherently aliphatic or alkyl aromatic. Examples of glucoside surfactants include decyl glucoside, stearyl glucoside, lauryl glucoside, cocoyl glucoside, cetearyl glucoside, decyl lauryl glucoside, lauroyl ethyl glucoside, myristoyl ethyl glucoside, oleoyl ethyl glucoside, or combinations of two or more thereof. In some preferred embodiments, the oral care composition may be substantially free of or contain no nonionic surfactants. In at least one preferred embodiment, the oral care composition may be substantially free of or contain no cationic surfactants.

[0099] In some embodiments, the oral care composition may contain one or more sweeteners. The oral care composition may contain calorie sweeteners and / or calorie-free sweeteners. Examples of calorie-free sweeteners include saccharin (e.g., sodium saccharin), acesulfame potassium, neotame, cyclohexylsulfamic acid, or sucralose; natural high-sweetness sweeteners such as kiwifruit protein, steviol, or glycyrrhizin; or sugar alcohols such as sorbitol, xylitol, maltitol, and mannitol. Examples of calorie sweeteners include sugars such as fructose, glucose, sucrose, and high-fructose corn syrup.

[0100] The amount of one or more sweeteners in the oral care composition may be from about 0.1 to about 50 wt.%, based on the total weight of the oral care composition. For example, the total amount of sweetener in an oral care composition may be from about 0.1 to about 40 wt.%, from about 0.1 to about 30 wt.%, from about 0.1 to about 20 wt.%, from about 0.1 to about 10 wt.%, from about 0.1 to about 5 wt.%, from about 0.1 to about 3 wt.%; from about 1 to about 50 wt.%, from about 1 to about 40 wt.%, from about 1 to about 30 wt.%, from about 1 to about 20 wt.%, from about 1 to about 10 wt.%, from about 1 to about 5 wt.%, from about 1 to about 3 wt.%; from about 5 to about 50 wt.%, from about 5 to about 40 wt.%, from about 5 to about 30 wt.%, from about 5 to about 20 wt.%, from about 5 to about 10 wt.%; from about 10 to about 50 wt.%, from about 10 to about 45 wt.%, from about 10 to about 40 wt.%, from about 10 to about 35 wt.%, from about 10 to about 30 wt.%, from about 10 to about 25 wt.%; from about 15 to about 50 wt.%. wt.%, about 15 to about 45 wt.%, about 15 to about 40 wt.%, about 15 to about 37 wt.%, about 15 to about 34 wt.%, about 15 to about 31 wt.%, about 15 to about 28 wt.%, about 15 to about 25 wt.%; about 20 to about 50 wt.%, about 20 to about 45 wt.%, about 20 to about 40 wt.%, about 20 to about 37 wt.%, about 20 to about 34 wt.%, about 20 to about 31 wt.%, about 20 to about 28 wt.%; about 25 to about 50 wt.%, about 25 to about 45 wt.%, about 25 to about 40 wt.%, about 25 to about 37 wt.%, about 25 to about 34 wt.%, about 25 to about 31 wt.%; about 28 to about 50 wt.%, about 28 to about 45 wt.%, about 28 to about 40 wt.%, about 28 to about 37 wt.%; wt.%, about 28 to about 34 wt.%, about 28 to about 31 wt.%; about 31 to about 50 wt.%, about 31 to about 45 wt.%, about 31 to about 40 wt.%, about 31 to about 37 wt.%; about 34 to about 50 wt.%, about 34 to about 45 wt.%, about 34 to about 40 wt.%; about 37 to about 50 wt.%, about 37 to about 45 wt.%, or any range or subrange thereof, based on the total weight of the oral care composition.

[0101] In some embodiments, the oral care composition is preferably substantially free of or free of calorie sweeteners. For example, the oral care composition may have about 4 wt.% or less, about 3 wt.% or less, about 2 wt.% or less, about 1 wt.% or less, about 0.5 wt.% or less, or about 0.1 wt.% or less of calorie sweeteners, based on the weight of the oral care composition. In at least one embodiment, the oral care composition contains about 0 wt.% or 0 wt.% of calorie sweeteners, based on the weight of the oral care composition.

[0102] Oral care compositions may contain a fluoride ion source. The fluoride ion source may be present in an effective amount. In some cases, the amount of the fluoride ion source present in the oral care composition is from about 0.01 to about 5 wt.%, based on the total weight of the oral care composition. For example, based on the total weight of the oral care composition, the fluoride ion source is present in amounts of about 0.01 to about 5 wt.%, about 0.01 to about 4 wt.%, about 0.01 to about 3 wt.%, about 0.01 to about 2 wt.%, about 0.01 to about 1 wt.%; about 0.05 to about 5 wt.%, about 0.05 to about 4 wt.%, about 0.05 to about 3 wt.%, about 0.05 to about 2 wt.%, about 0.05 to about 1 wt.%; about 0.1 to about 5 wt.%, about 0.1 to about 4 wt.%, about 0.1 to about 3 wt.%, about 0.1 to about 2 wt.%; about 0.3 to about 5 wt.%, about 0.3 to about 4 wt.%, about 0.3 to about 3 wt.%, about 0.3 to about 2 wt.%; about 0.6 to about 5 wt.%, about 0.6 to about 4 wt.%, about 0.6 to about 3 wt.%, about 0.6 to about 2 wt.%; wt.%; about 0.9 to about 5 wt.%, about 0.9 to about 4 wt.%, about 0.9 to about 3 wt.%, about 0.9 to about 2 wt.%; about 1.2 to about 5 wt.%, about 1.2 to about 4 wt.%, about 1.2 to about 3 wt.%, about 1.2 to about 2 wt.%; about 1.5 to about 5 wt.%, about 1.5 to about 4 wt.%, about 1.5 to about 3 wt.%; about 2 to about 5 wt.%, about 2 to about 4 wt.%, about 2 to about 3 wt.%; about 3 to about 5 wt.%, about 4 to about 5 wt.%, or any range or subrange thereof.

[0103] The fluoride ion source can be selected from soluble fluoride salts. For example, the fluoride ion source may include sodium fluoride, potassium fluoride, calcium fluoride, zinc fluoride, zinc ammonium fluoride, lithium fluoride, ammonium fluoride, stannous fluoride, stannous fluorozirconate, sodium monofluorophosphate, potassium monofluorophosphate, laurylamine hydrofluoride, diethylaminoethyloctoylamide hydrofluoride, dialcyldimethylammonium fluoride, hexadecylpyridinium fluoride, dilaurylmorpholinium fluoride, sarcosine stannous fluoride, potassium glycine fluoride, glycine hydrofluoride, amine fluorides, or combinations of two or more thereof. In some embodiments, the fluoride ion source includes sodium fluoride, sodium monofluorophosphate, or combinations thereof. Further examples of fluoride ion sources are disclosed in U.S. Patent Nos. 3,535,421, 4,885,155 and 3,678,154, the disclosures of which are incorporated herein by reference in their entirety.

[0104] In some embodiments, the oral care composition of this disclosure may contain stannous fluoride and a fluoride ion source or fluoride supplier in an amount sufficient to deliver a total of 25 ppm to 25,000 ppm (mass fraction) of fluoride ions, typically at least 500 ppm, such as about 500 to about 2,000 ppm, about 800 to about 1,800 ppm, about 1,000 to about 1,600 ppm, about 1,200 to about 1,550 ppm, or about 1,450 ppm.

[0105] The oral care composition may contain an anti-calculus agent. Based on the total weight of the oral care composition, the amount of anti-calculus agent present in the oral care composition may be from about 0.5 to about 10 wt.%. In some cases, based on the total weight of the oral care composition, the anti-calculant is present in amounts of about 0.5 to about 10 wt.%, about 0.5 to about 8 wt.%, about 0.5 to about 6 wt.%, about 0.5 to about 5 wt.%, about 0.5 to about 4 wt.%, about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%; about 1 to about 10 wt.%, about 1 to about 8 wt.%, about 1 to about 6 wt.%, about 1 to about 5 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%, about 1 to about 2 wt.%; about 2 to about 10 wt.%, about 2 to about 8 wt.%, about 2 to about 6 wt.%, about 2 to about 5 wt.%, about 2 to about 4 wt.%, about 2 to about 3 wt.%; about 3 to about 10 wt.%, about 3 to about 8 wt.%, about 3 to about 6 wt.%, about 3 to about 5 wt.%, about 3 to about 4 wt.%; about 5 to about 10 wt.%. wt.%, about 5 to about 8 wt.%, about 5 to about 6 wt.%, about 7 to about 10 wt.%, about 7 to about 8 wt.%, about 8 to about 10 wt.%, or any range or subrange thereof, are present in the oral care composition.

[0106] Anti-stone agents may be selected from phosphates and polyphosphates (e.g., pyrophosphates), polyaminopropanesulfonic acid (AMPS), hexametaphosphate, zinc citrate trihydrate, peptides, polyolefin sulfonates, polyolefin phosphates, bisphosphonates, and combinations of two or more thereof. Examples of anti-stone agents include tetrasodium pyrophosphate, ammonium tripolyphosphate, hexametaphosphate, polycarboxylate polymers, polyvinyl methyl ether / maleic anhydride (PVME / MA) copolymers, or combinations of two or more thereof. In some embodiments, the oral care composition comprises one or more alkali metal polyphosphates, such as tetrasodium pyrophosphate.

[0107] The oral care compositions disclosed herein may include flavoring agents. Flavoring agents are typically incorporated into the oral care composition at a concentration of about 0.01 to about 3 wt.% of the oral care composition by weight. For example, the amount of flavoring agent present in the oral care composition may be about 0.01 to about 2 wt.%, about 0.01 to about 1 wt.%, about 0.01 to about 0.5 wt.%, about 0.01 to about 0.1 wt.%; about 0.1 to about 3 wt.%, about 0.1 to about 2 wt.%, about 0.1 to about 1 wt.%, about 0.1 to about 0.5 wt.%; about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%; about 0.5 to about 1 wt.%; about 1 to about 3 wt.%, about 1 to about 2 wt.%; about 2 to about 3 wt.%, including any range or subrange thereof, based on the total weight of the oral care composition.

[0108] Suitable flavoring agents include, but are not limited to, essential oils and various flavoring aldehydes, esters, alcohols, and similar substances. Examples of essential oils include spearmint oil, peppermint oil, wintergreen oil, sassafras oil, clove oil, sage oil, eucalyptus oil, marjoram oil, cinnamon oil, lemon oil, lime oil, grapefruit oil, and orange oil. Also useful chemicals are menthol, carvone, and anethole. Other flavoring agents may include, but are not limited to, menthol, artificial vanilla, cinnamon derivatives, and various fruit spices, spearmint oil, peppermint oil, cinnamon oil, wintergreen oil (methyl salicylate), clove oil, laurel oil, anise oil, eucalyptus oil, thyme oil, cedarwood leaf oil, nutmeg oil, sage oil, bitter almond oil, cassia oil, and combinations of two or more thereof.

[0109] Oral care compositions may contain one or more colorants. Exemplary colorants may include natural or uncertified colors from natural sources, or colors with certified color effects. In some embodiments, colorants may include dyes, certified aluminum lakes, or colors derived from natural sources. Colorants may be water-based, oil-based, or drying. Colorants may be primary colors, mixed colors, or discontinuous mixed colors, such as confetti. The concentration of colorants in an oral care composition may be trace to about 0.6 wt.%, about 0.1 to about 0.5 wt.%, about 0.2 to about 0.4 wt.%, or about 0.15 to about 0.35 wt.%, based on the total weight of the oral care composition.

[0110] Oral care compositions may contain one or more pH adjusters to increase or decrease the overall pH of the oral care composition. For example, one or more acids may be contained to decrease the pH of the oral care composition. Examples of suitable acids for decreasing the pH of an oral care composition include, but are not limited to, citric acid, acetic acid, etc. Oral care compositions may contain one or more bases, such as sodium hydroxide, potassium hydroxide, etc., to increase the pH of the oral care composition. Additional or alternative acids and bases suitable for adjusting the pH of oral care compositions are readily known to those skilled in the art.

[0111] The amount of pH adjuster in an oral care composition may be based on the desired pH of the final oral care composition and / or product. For example, the total amount of pH adjuster may be from about 0.05 to about 20 wt.%, based on the total weight of the oral care composition. In some cases, the total amount of pH adjuster may be from about 0.05 to about 15 wt.%, from about 0.1 to about 10 wt.%, or from about 0.12 to about 5 wt.%, including ranges and subranges therein, based on the total weight of the oral care composition.

[0112] The pH of the oral care composition may be 4.5 to about 10, 4.5 to about 9, 4.5 to about 8, 4.5 to about 7, 4.5 to about 6; about 5 to about 10, about 5 to about 9, about 5 to about 8, about 5 to about 7, about 5 to about 6; about 6 to about 10, about 6 to about 9, about 6 to about 8, or about 6 to about 7; about 7 to about 10, about 7 to about 9, or about 7 to about 8, including any range and subrange therein.

[0113] Example

[0114] Example 1

[0115] According to various aspects of the present invention, two non-limiting oral care compositions (Example Compositions A and B) were prepared in the form of dental cleaning agents. A comparative oral care composition (Comparative Composition 1) was also prepared in the form of a dental cleaning agent. The formulations of Example Compositions A and B and Comparative Composition 1 are shown in Table 1 below.

[0116] Table 1

[0117]

[0118] Example 2

[0119] An in vitro brushing study using stained bovine teeth was conducted to evaluate Example Composition A, compared to Comparative Composition 1. The artificially stained bovine teeth were obtained from Therametric Technologies, Inc. TM Artificially stained bovine teeth are 10 mm in diameter and mounted in methacrylate resin.2 The teeth were prepared by circulating the staining solution between air and a solution containing coffee, tea, mucin, soybean extract, and *Dystropheus lutea* in an incubator at 37°C until the L* value of the teeth was between 25 and 40.1.

[0120] The bovine teeth used in this embodiment were selected after brushing with a toothpaste paste consisting of 250 grams of force and 1 part Max Fresh toothpaste to 1 part water for 20 minutes. Then, Spectroshade Micro-Oxygen was obtained using a Medical High Technology (MHT) instrument. TM Bovine teeth were evaluated to determine their initial whiteness level. To measure the initial whiteness level, the instrument was positioned so that a tooth was within the instrument's field of view, and then an image was captured. In this study, bovine teeth with an L* value close to 60 after brushing were selected. Specifically, eight bovine teeth were selected to evaluate each of Example Composition A and Comparative Composition 1.

[0121] The toothpaste slurry is then prepared by mixing 10 grams of water with 10 grams of one of the corresponding toothpaste compositions. The toothpaste slurry is mixed manually to ensure complete homogenization of the solution.

[0122] Then, use a brushing machine to brush the cow's teeth. Specifically, cut the head of a soft-bristled toothbrush from its handle and attach it to the brushing machine. Pour a sample of the corresponding dental cleaning agent onto the tray and begin brushing immediately. Brush the cow's teeth for 2 minutes using 250 grams of pressure. Set the brushing machine to 120 strokes per minute. After 2 minutes, stop brushing, remove the dental cleaning agent, and rinse the cow's teeth with 100 grams of deionized water. Repeat the brushing treatment a total of 14 times to simulate twice-daily use of each product for 7 days.

[0123] After scrubbing, use Spectroshade Micro TM Instruments are used to evaluate bovine teeth to determine their final whiteness. The procedure for evaluating the final whiteness level is essentially the same as that for evaluating the initial whiteness level. The L*, a*, and b* values ​​of each tooth are measured using MHT software. L* represents luminance from black to white, ranging from 0 to 100, while a* and b* represent chroma, with no specific numerical limit. Negative a* corresponds to green, positive a* to red, negative b* to blue, and positive b* to yellow. Using the software, the processed tooth image is overlaid on a baseline tooth image, selecting identical areas and capturing the L*, a*, and b* values ​​of the teeth before and after processing. The L*, a*, and b* values ​​are used to calculate the change in the whiteness index of each tooth after brushing compared to the initial whiteness level before brushing. The whiteness index is calculated as ΔW*, where...

[0124] W* = (a* 2 + b* 2 + (L* - 100) 2 ) 1 / 2

[0125] ΔW* = W* 最终 – W* 初始

[0126] It should be noted that the more negative the value of ΔW*, the closer the tooth color is to white. The whiteness index of Example Composition A and Comparative Composition 1 is summarized in Table 2 (below).

[0127] Table 2

[0128]

[0129] Example 3

[0130] Using HAP discs, Example Composition A was evaluated for its resistance to dental stains by comparison with Comparative Composition 1. To determine the initial color of the HAP discs, each HAP disc was placed in a well plate and immersed in 4 mL of water, then incubated for 1 hour. The HAP discs were then removed from the well plate, patted dry, and examined using a Spectroshade Micro... TM The instrument is evaluated to determine the L, a, and b values ​​for each disk. The procedure for evaluating the whiteness level of the HAP disks is similar to the procedure described in Example 1.

[0131] The dental cleaning agent slurry sample was then applied to the HAP plate. The dental cleaning agent slurry sample was prepared by mixing a sample of Example Composition A or Comparative Composition 1 with a certain amount of water to produce a corresponding dental cleaning agent slurry sample with a weight ratio of 1:2 (dental cleaning agent to water). The HAP plate was then placed in a separate well plate, and 4 mL of the corresponding dental cleaning agent slurry sample was added to it for 2 minutes. The HAP plate was then removed from the well plate and rinsed three times with 5 mL of water.

[0132] The HAP discs were then stained with a coffee solution prepared by dissolving 2 grams of coffee in 98 grams of water. Specifically, the HAP discs were placed in individual well plates, and 4 mL of the coffee solution was added. The HAP discs were left in the coffee solution for 90 minutes. The HAP discs were then removed from the well plates and rinsed three times with 5 mL of water. The HAP discs were gently patted dry and then evaluated immediately using a Spectroshade Micro... TM The instrument evaluates the final color of the HAP disk to determine the final L, a, and b values ​​of the HAP disk. A summary of the changes in color or whiteness (ΔW*) between Example Composition A and Comparative Composition 1 is shown in Table 3 (below).

[0133] Table 3

[0134]

Claims

1. An oral care composition comprising: Thickening system, comprising: Crosslinked polyacrylic acid and / or its salts, and One or more thickeners selected from polysaccharides, thickening silica, and combinations thereof; and Water, approximately 14 to approximately 64 wt.%, wherein all weight percentages are based on the total weight of the oral care composition.

2. The oral care composition of claim 1, wherein the crosslinked polyacrylic acid and / or its salt is branched polyacrylic acid and / or its salt.

3. The oral care composition according to claim 1 or 2, wherein the crosslinked polyacrylic acid and / or its salts comprise carbomer.

4. The oral care composition according to any one of the preceding claims, wherein the crosslinked polyacrylic acid and / or its salts are composed of one or more carbomers.

5. The oral care composition according to any one of the preceding claims, wherein the crosslinked polyacrylic acid and / or its salts are present in an amount of about 0.2 to about 5 wt.%.

6. The oral care composition according to any one of the preceding claims further comprises a polyol system present in a total amount of about 20 to about 40 wt.%, wherein the polyol system comprises at least two polyols selected from: glycerol, inositol, maltitol, mannitol, sorbitol, xylitol, propylene glycol, polypropylene glycol (PPG), polyethylene glycol (PEG), block copolymers of PPG and PEG, sugars, and combinations of two or more thereof.

7. The oral care composition of claim 6, wherein the polyol system comprises glycerol and sorbitol, wherein the glycerol and sorbitol are present in a weight ratio of about 1:1 to about 3:

1.

8. The oral care composition according to any one of the preceding claims further comprises about 1 to about 35 wt.% of an abrasive, wherein the abrasive is selected from the group consisting of: silica, silicates, silicon, bentonite, zeolite, kaolin, mica, pumice, calcium carbonate, cuttlebone, insoluble phosphates, polycarbonate, microcrystalline wax, microcrystalline cellulose, and combinations of two or more thereof.

9. The oral care composition according to any one of the preceding claims, wherein the water is present in an amount of about 30 to about 50 wt.%.

10. The oral care composition according to any one of the preceding claims further comprises about 0.1 to about 7 wt.% of a fluoride source, wherein the fluoride source is selected from: stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium fluorosilicate, amine fluoride, ammonium fluoride, and combinations of two or more thereof.

11. The oral care composition according to any one of the preceding claims further comprises about 0.5 to about 10 wt.% of an anti-calculus agent, wherein the anti-calculus agent is selected from: tetrasodium pyrophosphate, ammonium tripolyphosphate, hexametaphosphate, polycarboxylate polymers, polyvinyl methyl ether / maleic anhydride copolymers, and combinations of two or more thereof.

12. The oral care composition according to any one of the preceding claims, wherein the thickening system is present in an amount of about 2 to about 15 wt.%, wherein the thickening system comprises thickening silica and polysaccharides.

13. The oral care composition of claim 12, wherein the polysaccharide is selected from the following natural gums: alginate, pectin, carrageenan, gum arabic, tragacanth gum, ebony gum, agarose, guar gum, pectin, gellan gum, tara gum, locust bean gum, tamarind gum, locust bean gum, Seneca gum, sclerotium gum, gellan gum, xanthan gum, and combinations of two or more thereof.

14. The oral care composition according to any one of the preceding claims, wherein the oral care composition is substantially free of or free of polyvinyl thickener.

15. The oral care composition according to any one of the preceding claims, wherein the oral care composition is substantially free of or contains no peroxides.

16. The oral care composition according to any one of the preceding claims, wherein the oral care composition is substantially free of or contains no whitening agent.

17. An oral care composition comprising: Thickening system, comprising: About 0.2 to about 5 wt.% of crosslinked polyacrylic acid and / or its salts, and One or more thickeners selected from polysaccharides, thickening silica, and combinations of two or more thereof; A polyol system comprising glycerol and sorbitol, wherein the glycerol and sorbitol are present in a weight ratio of about 1:1 to about 3:1; and Approximately 5 to 64 wt.% water, The oral care composition is free of whitening agents, and all weight percentages are based on the total weight of the oral care composition.

18. The oral care composition of claim 17, wherein the crosslinked polyacrylic acid and / or its salts are present in an amount of about 0.5 to about 4 wt.%.

19. The oral care composition according to any one of the preceding claims, wherein the oral care composition is substantially free of or contains no calcium carbonate.

20. The oral care composition according to any one of the preceding claims, wherein the relative tooth abrasion of the oral care composition is from about 10 to about 250, as determined according to standard DIN EN ISO 11609.

21. An oral care composition for improving the stain resistance of an enamel substrate, said oral care composition comprising: Thickening system, comprising: Crosslinked polyacrylic acid and / or its salts, and One or more thickeners selected from polysaccharides, thickening silica, and combinations thereof; and Water, approximately 14 to approximately 64 wt.%, wherein all weight percentages are based on the total weight of the oral care composition.

22. A thickening system for manufacturing an oral care composition for improving the stain resistance of an enamel substrate, said oral care composition comprising: Thickening system, comprising: Crosslinked polyacrylic acid and / or its salts, and One or more thickeners selected from polysaccharides, thickening silica, and combinations thereof; and Water, approximately 14 to approximately 64 wt.%, wherein all weight percentages are based on the total weight of the oral care composition.

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