A traditional Chinese medicine extract compound preparation for promoting wine sobering and preventing drunkenness and a preparation method thereof

Abstract

This invention relates to a compound preparation of traditional Chinese medicine extracts for promoting hangover relief and preventing intoxication, and its preparation method. It belongs to the field of food processing and health product technology. This preparation innovatively adds 2-10 parts by weight of corn oligopeptides to the original extracts of Dendrobium, Pueraria, Poria, Lycium, and Licorice. The technical approach lies in the scientific compounding of corn oligopeptides, which have a high efficiency in promoting ethanol metabolism and increasing liver glutathione (GSH), with traditional Chinese medicine extracts that have absorption-inhibiting and antioxidant functions. This achieves a synergistic effect across multiple stages, including inhibiting alcohol absorption, accelerating enzymatic metabolism, directly binding to detoxification, and multi-level antioxidant activity. This technical solution significantly improves the speed of hangover relief and the ability to prevent intoxication, deeply enhances liver protection, and improves the solubility, stability, and taste of the final product.

Description

Technical Field

[0001] This invention relates to the fields of food processing and health products technology, specifically to a compound preparation of traditional Chinese medicine extracts that promotes sobering up and prevents drunkenness, and its preparation method. Background Technology

[0002] Acute alcohol poisoning caused by excessive drinking and its resulting health hazards (such as liver damage and nervous system depression) have become a significant public health issue. Alcohol (ethanol) is primarily absorbed through the gastrointestinal tract and metabolized by enzymes in the liver. This process produces toxic intermediates such as acetaldehyde and is accompanied by oxidative stress, which damages liver cells. Therefore, developing safe and effective products for relieving hangovers, preventing intoxication, and protecting the liver has significant social demand and market value.

[0003] Among existing technologies utilizing natural products for hangover relief and liver protection, traditional Chinese medicine compound preparations have attracted widespread attention due to their multi-component and multi-target characteristics. For example, Chinese patent CN102846963B discloses a compound preparation of traditional Chinese medicine extracts that promotes sobering up and prevents drunkenness. It is composed of extracts of Dendrobium, Kudzu Root, Poria, Goji Berry, and Licorice in a specific ratio and is made into a health drink containing Sophora japonica honey. This technical solution is based on the traditional Chinese medicine theory of "slowing down absorption, enhancing metabolism, and accelerating excretion." It utilizes the synergistic effects of Kudzu Root inhibiting alcohol absorption, Dendrobium nourishing yin and clearing heat, Poria strengthening the spleen and promoting diuresis, Goji Berry nourishing the liver and kidneys, and Licorice harmonizing the effects of the other herbs. In animal and human experiments, it has shown certain effects in sobering up and preventing drunkenness, and also has a certain liver-protective effect (manifested as increasing liver SOD activity and reducing MDA content).

[0004] However, after in-depth analysis and practical verification, there is still room for further optimization and improvement of the existing technical solution: First, in terms of efficacy, although its sobering speed and alcohol metabolism efficiency have been improved, its intensity and onset time still have the potential to be improved to meet the higher demands for rapid sobering and deep prevention of drunkenness; Second, in terms of liver protection mechanism, this solution mainly combats oxidative stress by increasing the activity of enzymes such as SOD, but its direct and efficient enhancement effect on another key detoxification and antioxidant substance in the liver—glutathione (GSH) system—is limited, and the depth of liver protection needs to be strengthened; Third, in terms of product attributes, since some Chinese herbal extracts may have inherent flavors and varying solubility, the palatability and physical stability of the final product still have room for optimization.

[0005] In recent years, research on bioactive peptides in the field of hangover relief and liver protection has provided new insights into solving the aforementioned problems. In particular, corn oligopeptides, a mixture of small-molecule peptides (typically composed of 2-10 amino acids) prepared from corn protein through enzymatic hydrolysis, have been approved as a national new resource food with high safety. Studies have confirmed that corn oligopeptides not only possess the physical advantages of being digest-free, directly absorbed, and highly water-soluble, but also have unique biological activities: they can significantly increase the activity of hepatic alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), thereby directly accelerating the metabolism and clearance of ethanol; simultaneously, they can efficiently increase hepatic glutathione (GSH) levels, directly enhancing the liver's detoxification and antioxidant defense capabilities. However, in existing technologies, there is no scientific combination of this corn oligopeptide, which has a clear and efficient metabolic promoting and GSH-enhancing effect, with the aforementioned validated traditional Chinese medicine hangover relief and liver protection compound to systematically construct a novel composite preparation that produces synergistic effects across multiple stages, including "absorption inhibition," "enzymatic metabolism," "direct detoxification," and "multi-level antioxidant effects."

[0006] Therefore, the question is how to inherit and retain the overall conditioning advantages of the original Chinese medicine compound formula, and then introduce new components with specific and potent biological activities (such as corn oligopeptides) to specifically compensate for the relative deficiencies of the original formula in terms of alcohol metabolism dynamics and core liver-protecting substance reserves, while simultaneously improving the application performance of the product, so as to develop a hangover prevention and liver protection product with more significant effects, deeper mechanisms, and better taste. Summary of the Invention

[0007] In order to solve the problems of the prior art, the present invention provides a compound preparation of traditional Chinese medicine extracts that promotes sobering up and prevents drunkenness, and a preparation method thereof.

[0008] To solve the above-mentioned technical problems, the present invention is achieved through the following technical solution: Firstly, a compound preparation of traditional Chinese medicine extracts for promoting sobering up and preventing drunkenness, and comprising the following raw materials in parts by weight: Dendrobium extract 10-16 parts; 12-18 parts of kudzu root extract; 2-8 parts of Poria cocos extract; 2-8 parts of wolfberry extract; 2-8 parts of licorice extract; And 2-10 parts of corn oligopeptides.

[0009] In one specific embodiment of the first aspect, the corn oligopeptide is present in parts by weight of 4-8 parts.

[0010] In one specific embodiment of the first aspect, the corn oligopeptide is a mixture of small molecule peptides consisting of 2-10 amino acids, derived from the enzymatic hydrolysis product of corn gliadin.

[0011] In one specific embodiment of the first aspect, the extracts of each raw material are prepared by the following method: qualified raw materials are added to 10-20 times the amount of extraction solvent, soaked at a constant temperature of 60-80℃ for 2-3 hours, extracted twice, the extracts are combined, concentrated to about 1 / 10 of the original volume and then freeze-dried; wherein the extraction solvent for Dendrobium, Poria, Lycium barbarum and Glycyrrhiza uralensis is distilled water, and the extraction solvent for Pueraria lobata is 40%-60% alcohol.

[0012] Secondly, a method for preparing a compound preparation of traditional Chinese medicine extracts that promotes sobering up and prevents drunkenness includes the following steps: S1: Prepare Dendrobium officinale extract, Pueraria lobata extract, Poria cocos extract, Lycium barbarum extract and Glycyrrhiza uralensis extract respectively; S2: Mix the herbal extracts obtained in step S1 with corn oligopeptides according to the stated weight proportions.

[0013] Thirdly, a health drink containing a compound preparation of traditional Chinese medicine extracts that promote sobering up and prevent drunkenness is made from the following raw materials: 0.5-1.5g of the compound preparation, 0.2-1.0g of corn oligopeptide, 5-15ml of locust honey, and 65-75ml of distilled water.

[0014] In one specific embodiment of the third aspect, the preparation method is as follows: after mixing the compound preparation, corn oligopeptide, locust honey and distilled water evenly, sterilize at 100-120℃ for 10-30 minutes.

[0015] Fourthly, the application of a compound preparation of traditional Chinese medicine extracts that promotes sobering up and prevents drunkenness, or a health drink containing a compound preparation of traditional Chinese medicine extracts that promotes sobering up and prevents drunkenness, in the preparation of products with sobering up and / or drunkenness prevention functions.

[0016] Fifthly, the application of a compound preparation of traditional Chinese medicine extracts that promote sobering up and prevent drunkenness, or a health drink containing a compound preparation of traditional Chinese medicine extracts that promote sobering up and prevent drunkenness, in the preparation of products with liver-protective functions.

[0017] In a specific embodiment of the fifth or sixth aspect, the combination of corn oligopeptides and the traditional Chinese medicine extract has a synergistic effect, which is manifested as follows: under the same dosage conditions, compared with the original compound preparation without corn oligopeptides, the compound preparation containing corn oligopeptides can increase the glutathione content in the liver tissue of rats with acute alcohol poisoning by no less than 20%, reduce the malondialdehyde content by no less than 15%, and shorten the sobering time by no less than 10%.

[0018] The beneficial effects of this invention are as follows: 1. By scientifically combining a specific ratio of corn oligopeptides (2-10 parts by weight) with standard extracts of Dendrobium, Kudzu Root, Poria, Lycium, and Licorice, this technical solution achieves multi-target, multi-stage synergistic effects. In terms of efficacy, corn oligopeptides enhance the activity of hepatic alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), complementing the metabolic processes of Kudzu Root and Licorice extracts in inhibiting gastrointestinal ethanol absorption. This significantly accelerates the clearance rate of ethanol in the blood, thus shortening the sobering-up time by more than 15% compared to the original formula. Regarding liver protection, corn oligopeptides specifically increase hepatic glutathione (GSH) reserves. Combined with the superoxide dismutase (SOD) and other enzymatic antioxidant systems enhanced by the herbal extracts, this produces a dual synergistic effect of non-enzymatic and enzymatic antioxidant activity, systematically enhancing the liver's ability to resist oxidative damage. Experimental data show that it can increase GSH content by more than 45% while effectively reducing the content of malondialdehyde (MDA), the end product of lipid peroxidation, by more than 34%, demonstrating a clear synergistic liver-protective effect.

[0019] 2. This compounding technology brings significant performance optimization at the final product application level. The excellent water solubility and thermal stability of corn oligopeptides effectively improve the solubility and stability of the system when blended with traditional Chinese medicine extracts and acacia honey to prepare health drinks, preventing precipitation and maintaining activity even after high-temperature sterilization. Its mild flavor characteristics help neutralize some of the inherent bitterness of the traditional Chinese medicine extracts, allowing the final beverage to maintain its functionality while achieving better taste and flavor acceptance without relying on additional flavoring agents. Therefore, this invention not only achieves a quantitative improvement in the effects of sobering up, preventing hangovers, and protecting the liver through component synergy, but also simultaneously optimizes the product's physical stability, processing adaptability, and sensory quality. Attached Figure Description

[0020] Figure 1 This is a diagram verifying the synergistic effect of liver-core antioxidant activity in this invention.

[0021] Figure 2 This is a comparison chart of the inhibitory effects of the present invention on lipid peroxidation damage in hepatocytes.

[0022] Figure 3 This is a comparison chart showing the accelerated sobering effect of the acute alcohol poisoning model of the present invention.

[0023] Figure 4 This is a diagram verifying the effectiveness of the present invention in preventing drunkenness in humans. Detailed Implementation

[0024] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0025] like Figures 1 to 4 This invention relates to a compound preparation of traditional Chinese medicine extracts that promotes sobering up and prevents drunkenness, and its preparation method.

[0026] The following, in conjunction with embodiments, details the preparation method, technical principles, synergistic effects, and beneficial effects of the compound preparation of traditional Chinese medicine extracts containing corn oligopeptides that promotes sobering up and prevents drunkenness (hereinafter referred to as "this compound preparation") and its health drink. The embodiments of this invention are intended to fully disclose technical details and enable those skilled in the art to implement them.

[0027] I. Explanation of Technical Principles This invention introduces corn oligopeptides that meet national standards. Its design principle and synergistic mechanism are as follows: Synergistic hangover prevention and sobering mechanism involving multiple targets and pathways: Synergistic effect of inhibiting absorption and accelerating metabolism: In the original formula, kudzu root extract (containing daidzein, etc.) and licorice extract mainly act on the gastrointestinal tract, delaying intoxication by inhibiting ethanol absorption and promoting gastric mucosal protection; at the same time, kudzu root and other ingredients help promote the breakdown of ethanol in the blood. The newly added corn oligopeptides have been proven by studies to significantly increase the activity of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) in the liver, directly accelerating the oxidation and metabolism of ethanol in the liver into carbon dioxide and water, thereby rapidly reducing blood alcohol concentration. The two work synergistically, effectively reducing intake at the source and accelerating elimination at the end.

[0028] Synergistic effect of enhanced metabolism and direct elimination: Extracts from Dendrobium and Lycium barbarum are rich in polysaccharides and antioxidants, which can indirectly assist alcohol metabolism by improving the body's overall antioxidant capacity (such as SOD levels). Meanwhile, corn oligopeptides themselves contain abundant hydrophobic amino acids (such as alanine and leucine), which can act as substrates or binding agents to directly bind with acetaldehyde, a toxic intermediate in ethanol metabolism, promoting its conversion into harmless carboxylic acids and accelerating its excretion in urine, thus achieving a direct "scavenger" effect on toxic substances.

[0029] A multi-layered, complementary, synergistic liver protection mechanism: Synergistic enhancement of the antioxidant system: Extracts of Poria cocos and Lycium barbarum can enhance the activity of endogenous antioxidant enzymes in the liver (such as SOD and GSH-Px). Numerous studies have shown that corn oligopeptides can significantly increase the synthesis and content of glutathione (GSH) in the liver. GSH is the most important non-enzymatic antioxidant and detoxifier in cells, capable of directly binding to free radicals and lipid peroxides (such as MDA) produced by alcohol metabolism, thus reducing oxidative stress damage. The traditional Chinese medicine components and corn peptides together construct a complex and enhanced defense system of "enzymatic antioxidants (SOD, etc.) + non-enzymatic antioxidants (GSH)".

[0030] Synergistic effects of cell protection and anti-inflammation: Some components of traditional Chinese medicine have anti-inflammatory and hepatocyte membrane-stabilizing effects. Specific peptides in corn oligopeptides (such as peptides containing a high proportion of glutamine) have been shown to inhibit alcohol-induced activation of hepatic Kupffer cells, reduce the expression of inflammatory factors (such as TNF-α and IL-6), and alleviate the damage of inflammatory responses to hepatocytes. These two components complement each other in terms of cell protection and anti-inflammation.

[0031] This synergistic effect is not a simple additive one, but rather a comprehensive effect of "1+1>2" produced by acting on different stages of alcohol metabolism (absorption, metabolism, excretion) and different levels of liver protection (antioxidation, anti-inflammation, direct detoxification). Specifically, in the subsequent examples, the sobering-up time is shorter, the blood alcohol concentration decreases faster, the liver damage index (MDA) is significantly reduced, and the protective index (GSH) is significantly improved.

[0032] II. Preparation of Traditional Chinese Medicine Extracts and Corn Oligopeptides Example 1: Preparation of extracts from each component Raw material preparation: Select Dendrobium, Pueraria, Poria, Lycium, and Glycyrrhiza uralensis that meet the quality standards of the current edition of the Pharmacopoeia of the People's Republic of China, clean and pulverize them (pass through a 20-mesh sieve) and set them aside.

[0033] extract: Dendrobium, Poria, Lycium, and Licorice: Accurately weigh the raw materials separately, add 15 times their weight of distilled water, and soak in a constant temperature water bath at 75℃±2℃ for 2.5 hours. Filter the solution through a 200-mesh filter cloth and collect the filtrate. Add 12 times their weight of distilled water to the residue again and repeat the extraction under the same conditions. Combine the two filtrates.

[0034] Kudzu root: Accurately weigh the raw material, add 15 times its weight of 50% edible ethanol aqueous solution (V / V), soak in a constant temperature water bath at 70℃±2℃ for 2.5 hours, filter and collect the filtrate. Add 12 times its weight of 50% ethanol to the residue again, and repeat the extraction under the same conditions. Combine the two filtrates. (Note: Kudzu root is extracted with a moderate concentration of alcohol to more efficiently dissolve its core hangover-relieving components such as puerarin and daidzein; this is a well-known optimization method in the field.) Post-processing: The above extracts were concentrated to approximately 1 / 10 of their original volume using a rotary evaporator at 60-65℃ and -0.09MPa (relative density measured to be approximately 1.20-1.25, measured at 60℃), yielding a thick extract. The thick extract was then placed in a freeze dryer and pre-frozen at -45℃ for 4 hours, followed by vacuum freeze-drying at a gradient from -20℃ to 25℃ until constant weight was achieved, yielding loose, porous powdered Dendrobium officinale extract, Pueraria lobata extract, Poria cocos extract, Lycium barbarum extract, and Glycyrrhiza uralensis extract. These were sealed and stored in a cool, dry place.

[0035] Preparation of corn oligopeptides: Directly purchase food-grade corn oligopeptide powder that meets the relevant national standards for new resource foods (such as GB 31617-2014 National Food Safety Standard for Food Fortification Agents: Corn Oligopeptide Powder). Its characteristics are: obtained from corn gliadin as raw material through directional enzymatic hydrolysis, membrane separation, and refined spray drying; protein content ≥80%, peptide content (molecular weight less than 1000 Da) ≥85%, and moisture ≤7%. No further processing is required; it can be used directly as raw material.

[0036] III. Examples of Preparation of Compound Preparations and Health Drinks Example 2: Compound Formulation Example. Using an electronic balance with an accuracy of 0.01g, accurately weigh the traditional Chinese medicine extract powder obtained in Example 1 and the purchased corn oligopeptide powder according to the weight proportions shown in the table below. Place all materials in a clean V-type mixer and mix at 15 rpm for 45 minutes until a sample is taken and the components are evenly distributed (relative standard deviation RSD < 5%). The finished compound formulation is then obtained, packaged in aluminum foil bags, and sealed with nitrogen.

[0037] Components Formula A (per serving) Formula B (portion) Formula C (servings) Dendrobium extract 12 14 10 Dendrobium extract 12 14 10 Poria cocos extract 3 5 8 Goji berry extract 3 4 2 Licorice extract 8 5 2 Corn oligopeptides 5 8 2 Note: Formula A is the preferred balanced formula, Formula B focuses on high doses of corn peptides and liver-protecting components (for more significant synergistic effects), and Formula C focuses on traditional hangover relief components (for better cost-effectiveness). The amount of corn oligopeptides added is effective in the range of 2-10 parts, with 4-8 parts being the preferred range for significant synergistic effects.

[0038] Example 3: Preparation of Health Drink Formula: Accurately weigh 1.0g of the compound preparation obtained in Example 2 (taking Formula A as an example), add 0.5g of corn oligopeptide, measure 10ml of locust honey, and measure 70ml of purified water (compliant with GB 5749 Standard for Drinking Water Quality).

[0039] Mixing and Volume Adjustment: In a clean preparation vessel, first add some purified water, then slowly add the compound preparation powder and corn oligopeptide powder while stirring, stirring until completely dissolved and free of particles. Then add acacia honey and adjust the volume with the remaining purified water to approximately 81 ml, continuing to stir for 10 minutes until completely homogenized.

[0040] Sterilization and filling: The homogenized liquid is filtered through a 0.22μm microporous membrane for sterilization and immediately filled with hot water. Then, terminal sterilization is performed by water bath sterilization at 110℃±1℃ for 20 minutes.

[0041] Finished product: After cooling to room temperature, a light amber-colored, clear, and transparent ready-to-drink health beverage with a sweet and sour taste and a slight medicinal and acacia blossom aroma is obtained. Testing showed that due to the excellent water solubility and thermal stability of corn oligopeptides, this beverage exhibited no precipitation or stratification after 90 days of storage at both 4℃ and 25℃, maintaining a stable taste. Sensory evaluation according to GB / T 29602-2013 Solid Beverages showed a significantly higher score than the original formula beverage without corn peptides, mainly due to its smoother taste and significantly reduced bitterness.

[0042] IV. Implementation Examples of Effect Verification Example 4: The rat experiment to verify the synergistic effect of sobering up, preventing drunkenness and protecting the liver was approved by the animal ethics committee. The design was based on the original patent but with more detailed grouping to compare the old and new formulas.

[0043] Animals and Materials: Fifty healthy SPF-grade SD rats, weighing 200±20g, half male and half female. This compound preparation (formulas A and B), the original compound preparation (prepared according to formula A with corn peptides removed), and 56° Red Star Erguotou (a type of Chinese liquor).

[0044] Grouping and treatment: After 3 days of acclimatization, the animals were randomly divided into 5 groups (n=10): Model control group: The same volume of distilled water was administered by gavage, followed by baijiu (Chinese liquor) 30 minutes later.

[0045] Original formula group: administer the original compound preparation aqueous solution (1g / 80ml) by gavage, followed by administering baijiu (Chinese liquor) by gavage 30 minutes later.

[0046] The low-peptide group of this formula: Gavage with the aqueous solution of the compound preparation C in Example 2 (1g / 80ml), followed by gavage with baijiu (Chinese liquor) 30 minutes later.

[0047] This formula is a high-peptide group: Administer an aqueous solution (1g / 80ml) of the compound preparation of Formula B in Example 2 by gavage, followed by 30 minutes of gavage with baijiu (Chinese liquor).

[0048] Blank control group: The same volume of distilled water was administered by gavage, but no baijiu (Chinese liquor) was given. (The dosage of baijiu administered by gavage was uniformly 5.2 g / kg bw, equivalent to a moderate amount of alcohol consumed by a human).

[0049] Sobering-up time test: The time required for rats to fully recover their righting reflex (able to roll over onto all fours) after being administered baijiu (Chinese liquor) by gavage was recorded. The results are shown in Table 1: Table 1. Comparison of sobering-up time among different groups of rats (x ± s, n=10) Group Sobering time (minutes) Compared to the model group, it is shorter Compared to the original formula, the shortening Model control group 185.6 ± 21.4 - - Original formula group 92.8 ± 11.2* 50.0% - This formula contains low-peptide groups. 78.0 ± 9.5*# 58.0% 15.9% This formula contains high peptides. 65.2 ± 8.1*# 64.9% 29.7% Blank control group - - - (*: Compared with the model control group, P<0.01; #: Compared with the original formula group, P<0.05).

[0050] Conclusion: The sobering-up time of this formula group, especially the high-peptide group, was significantly shorter than that of the original formula group, proving that the addition of corn oligopeptides brought an additional and significant improvement in the sobering-up effect. Liver biochemical index detection: 24 hours after the last administration, rats were sacrificed and liver tissue homogenates were collected. Superoxide dismutase (SOD) activity, glutathione (GSH), and malondialdehyde (MDA) content were detected according to the kit instructions (Nanjing Jiancheng Bioengineering Institute). The results are shown in Table 2: Table 2. Comparison of oxidative stress indices in the liver of rats in each group (x ± s, n=10) Group SOD activity (U / mg prot) GSH content (mg / g prot) MDA content (nmol / mg prot) Blank control group 56.3 ± 5.2 7.5 ± 0.8 2.1 ± 0.3 Model control group 38.4 ± 4.1▲ 2.8 ± 0.4▲ 8.5 ± 1.1▲ Original formula group 52.1 ± 5.0 6.9 ± 0.7 3.8 ± 0.5 This formula contains low-peptide groups. 55.8 ± 5.3 8.2 ± 0.9* 3.2 ± 0.4* This formula contains high peptides. 60.5 ± 5.8* 10.1 ± 1.2* 2.5 ± 0.3* (▲: Compared with the blank control group, P<0.01; *: Compared with the original formula group, P<0.05).

[0051] Conclusions and Quantitative Analysis of Synergistic Effects: This formulation (especially the high-peptide group) significantly increased liver GSH reserves while maintaining high SOD activity. The GSH content in the high-peptide group (10.1) increased by 46.4% compared to the original formulation group (6.9) and by 260.7% compared to the model group (2.8), fully demonstrating the outstanding contribution and synergistic effect of corn oligopeptides in enhancing core non-enzymatic antioxidants.

[0052] Meanwhile, this formulation group more effectively reduced the content of lipid peroxidation end product MDA. The MDA content of the high-peptide group (2.5) was reduced by 34.2% compared with the original formulation group (3.8), indicating that the degree of hepatocyte damage was milder.

[0053] In summary, the addition of corn oligopeptides produced a clear synergistic effect when combined with the original Chinese medicine extract. At equal dosages, the core liver-protecting indicator GSH content increased by over 45%, the liver damage indicator MDA content decreased by over 34%, and the functional indicator hangover relief time was shortened by over 15%.

[0054] Example 5: Human volunteer trial. All participants signed informed consent forms.

[0055] Protocol: A randomized, double-blind, crossover controlled design was adopted. Thirty healthy adult volunteers (15 men and 15 women), aged 25-40 years, with no serious systemic diseases or history of alcohol allergy, were recruited. Each participant was required to complete three trials on different days (with a washout period of at least 7 days): A. Drinking alcohol after consuming a placebo (80ml of fruit-flavored syrup with a simulated appearance and taste); B. Drinking alcohol after consuming the original formula health drink (80ml, prepared according to Example 2 of the original patent); C. Drinking alcohol after consuming the health drink of this invention (80ml, product of Example 3). The alcohol consumption standard was: 50ml (56° baijiu) for men and 35ml (56° baijiu) for women, consumed within 10 minutes. Breath alcohol concentration (BrAC) was measured using a calibrated police-grade breathalyzer (sensitivity 0.01mg / L) before (0 min) and at 30, 60, 90, 120, and 180 minutes after drinking.

[0056] Results: The average BrAC values ​​for each group at each time point were calculated, and pharmacokinetic curves were plotted. Key pharmacokinetic parameters were estimated as shown in Table 3: Table 3. Estimated values ​​of key parameters for human breath alcohol concentration (BrAC) (x ± s, n=30) Group Cmax (mg / L) Tmax (min) AUC0-180min (mg·min / L) placebo group 0.38 ± 0.05 45 ± 10 45.6 ± 6.8 Original formula group 0.32 ± 0.04* 40 ± 8 36.2 ± 5.1* This invention group 0.28 ± 0.03*# 35 ± 7* 28.5 ± 4.2*# (*: P<0.05 compared with placebo group; #: P<0.05 compared with original formula group).

[0057] Conclusion: Volunteers who consumed the health beverage of this invention showed significantly lower peak breath alcohol concentration (Cmax) than the original formulation group and the placebo group, with an earlier time to peak (Tmax) and the smallest area under the blood alcohol concentration-time curve (AUC). This indicates that the product of this invention can more effectively delay and reduce the peak alcohol absorption and generally accelerate the clearance and metabolism of alcohol in the body, quantitatively confirming its superior anti-drunkenness and alcohol metabolism-promoting effects from a human application perspective.

[0058] V. Stability and Security Product Stability: Accelerated stability testing was conducted on the health beverage prepared in Example 3 (temperature 37℃±2℃, relative humidity 75%±5%). Samples were taken and tested at the end of months 0, 1, 2, and 3. The results showed that the product's appearance, taste, pH value, content of major active ingredients (such as total flavonoids and total polysaccharides), and microbial indicators all met the company's internal control standards, indicating that the product has good stability under the described process.

[0059] Safety: All raw materials are made from medicinal and edible herbs, nationally approved new resource foods (corn oligopeptides), and common food ingredients (locust honey), ensuring high safety. Acute toxicity tests on animals (not listed) showed that the maximum tolerated dose was significantly higher than the recommended human dose, indicating that this product is safe to use.

[0060] As can be seen from the above specific embodiments, the present invention scientifically adds corn oligopeptides to the original traditional Chinese medicine formula: The technical details are fully disclosed: the raw material standards, complete process flow and specific technical parameters are clearly defined.

[0061] Synergistic effects are clearly quantified: The synergistic effects are clearly explained from both theoretical mechanisms and experimental data, and the improvement in effects is quantified with specific data (e.g., GSH increased by 46%, MDA decreased by 34%, and sobering time was shortened by 29%).

[0062] The effects are significantly improved across the board: statistically significant improvements were observed in sobering up speed, anti-drunkenness ability (reducing BrAC peak and AUC), and liver protection (significantly increasing GSH and reducing MDA).

[0063] Product performance improvements: Improved solubility, taste, and storage stability, leading to increased product acceptance.

[0064] The above embodiments are merely illustrative of specific implementations of the present invention and are not intended to limit the scope of protection of the present invention. Any modifications, equivalent substitutions, or improvements made by those skilled in the art based on the principles of the present invention should be included within the scope of protection of the claims of the present invention.

Claims

1. A compound preparation of traditional Chinese medicine extracts for promoting sobering up and preventing drunkenness, characterized in that, It consists of the following raw materials in parts by weight: Dendrobium extract 10-16 parts; 12-18 parts of kudzu root extract; 2-8 parts of Poria cocos extract; 2-8 parts of wolfberry extract; Licorice extract 2-8 parts; And 2-10 parts of corn oligopeptides.

2. The compound preparation of traditional Chinese medicine extracts for promoting sobering up and preventing drunkenness according to claim 1, characterized in that: The corn oligopeptide is present in 4-8 parts by weight.

3. The compound preparation of traditional Chinese medicine extracts for promoting sobering up and preventing drunkenness according to claim 1, characterized in that: The corn oligopeptides are a mixture of small molecule peptides consisting of 2-10 amino acids, derived from the enzymatic hydrolysis products of corn gliadin.

4. The compound preparation of traditional Chinese medicine extracts for promoting sobering up and preventing drunkenness according to claim 1, characterized in that: The extracts of each raw material were prepared by the following method: qualified raw materials were added to 10-20 times the amount of extraction solvent, soaked at a constant temperature of 60-80℃ for 2-3 hours, extracted twice, the extracts were combined, concentrated to about 1 / 10 of the original volume and then freeze-dried; the extraction solvent for Dendrobium, Poria, Lycium barbarum and Glycyrrhiza uralensis was distilled water, and the extraction solvent for Pueraria lobata was 40%-60% alcohol.

5. A method for preparing a compound preparation of traditional Chinese medicine extracts that promotes sobering up and prevents drunkenness, characterized in that, Includes the following steps: S1: Prepare Dendrobium officinale extract, Pueraria lobata extract, Poria cocos extract, Lycium barbarum extract and Glycyrrhiza uralensis extract respectively; S2: Mix the herbal extracts obtained in step S1 with corn oligopeptides according to the stated weight proportions.

6. A health drink comprising a compound preparation of traditional Chinese medicine extracts that promote sobering up and prevent intoxication, characterized in that, It is made from the following raw materials: 0.5-1.5g of the compound preparation, 0.2-1.0g of corn oligopeptide, 5-15ml of locust honey, and 65-75ml of distilled water.

7. A health drink comprising a compound preparation of traditional Chinese medicine extracts that promote sobering up and prevent drunkenness, as described in claim 6, characterized in that: The preparation method is as follows: after mixing the compound preparation, corn oligopeptide, locust honey and distilled water evenly, sterilize at 100-120℃ for 10-30 minutes.

8. The use of a compound preparation of traditional Chinese medicine extracts that promote sobering up and prevent drunkenness, or a health drink containing a compound preparation of traditional Chinese medicine extracts that promote sobering up and prevent drunkenness, in the preparation of products with sobering up and / or drunkenness prevention functions.

9. The use of a compound preparation of traditional Chinese medicine extracts that promote sobering up and prevent drunkenness, or a health drink containing a compound preparation of traditional Chinese medicine extracts that promote sobering up and prevent drunkenness, in the preparation of products with liver-protective functions.

10. The application according to claim 8 or 9, characterized in that, The combination of the corn oligopeptide and the traditional Chinese medicine extract has a synergistic effect, which is manifested as follows: under the same dosage conditions, compared with the original compound preparation without corn oligopeptide, the compound preparation containing corn oligopeptide can increase the glutathione content in the liver tissue of rats with acute alcohol poisoning by no less than 20%, reduce the malondialdehyde content by no less than 15%, and shorten the sobering time by no less than 10%.

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