Bispyridinium antibacterial compounds, methods of synthesis and use thereof
By designing bispyridinium antibacterial compounds and utilizing nucleophilic substitution reactions to achieve dual targeting of bacterial cell membranes and DNA, the problem of large molecular weight and high toxicity in existing antibacterial research has been solved, providing a highly efficient and low-toxicity antibacterial solution, especially with significant inhibitory effects against multidrug-resistant bacteria.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- HUNAN UNIV
- Filing Date
- 2026-02-09
- Publication Date
- 2026-06-19
AI Technical Summary
In existing technologies, pyridine salt-based polymers have problems such as large molecular weight, low bioavailability, high toxicity, and difficulty in synthesis and purification in antibacterial research. Furthermore, the targeted intervention mechanism against bacterial cell membranes and DNA has not been fully explored, making it difficult to solve the problem of antibiotic resistance.
A bispyridinium antibacterial compound was designed and synthesized. By modularly combining hydrophobic and positively charged groups through nucleophilic substitution reactions, dual targeting of bacterial cell membranes and DNA was achieved. Small molecule compounds were used to improve bioavailability and reduce toxicity.
It has achieved significant antibacterial activity against both Gram-positive and Gram-negative bacteria, exhibits low toxicity and high biocompatibility, and shows potential in the treatment of bacterial-mediated diseases, especially demonstrating good inhibitory effects against multidrug-resistant bacteria.
Smart Images
Figure CN122233979A_ABST