Therapeutic agents for metabolic diseases comprising delivery systems based on metal nanoparticle-nucleic acid conjugates
By covalently binding double-stranded DNA to gold nanoparticles, the safety and stability issues of DNA delivery were resolved, enabling independent expression within the cell nucleus for the treatment of metabolic diseases.
CN122249240APending Publication Date: 2026-06-19NES BIOTECHNOLOGY CO LTD
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- NES BIOTECHNOLOGY CO LTD
- Filing Date
- 2024-11-21
- Publication Date
- 2026-06-19
AI Technical Summary
Technical Problem
Existing technologies cannot safely and effectively deliver double-stranded DNA into the cell nucleus, leading to side effects and gene integration risks in DNA vaccines. Furthermore, traditional vectors have biocompatibility and stability issues.
Method used
Using gold nanoparticles as a carrier, double-stranded DNA is directly bound to its surface via covalent bonds. Taking advantage of the high biocompatibility and stability of gold nanoparticles, DNA can be independently expressed in the cell nucleus, expressing insulin or substances that promote insulin secretion.
Benefits of technology
Stable delivery and independent expression of double-stranded DNA were achieved, reducing the risk of immune response and improving the efficacy of treatment for metabolic diseases.
✦ Generated by Eureka AI based on patent content.
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Figure CN122249240A_ABST
Abstract
This invention relates to the use of a gene carrier as a drug delivery carrier, the gene carrier comprising metal nanoparticles and a double-stranded nucleic acid molecule bound to the surface of the metal nanoparticles. The invention particularly relates to the use of the carrier for treating metabolic diseases, and to pharmaceutical compositions for the prevention or treatment of metabolic diseases, the pharmaceutical compositions comprising the carrier.
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