A conformal ultrasound patch structure for breast cancer monitoring

Abstract

This invention discloses a conformal ultrasound patch structure for breast cancer monitoring, belonging to the technical field of breast monitoring devices. It includes a four-piece patch, a three-piece patch, an integrated wearable device, and hardware components. The four-piece and three-piece patches are respectively positioned at the breast location on the chest of the integrated wearable device, and the hardware components are also mounted on the integrated wearable device. This invention fixes multiple ultrasound patch units to preset positions on a flexible substrate, achieving systematic, blind-spot-free imaging of the four quadrants of the breast and the axillary tail region through the coordinated coverage of multiple patches. This effectively overcomes the imaging blind spots in the near-chest wall and axillary regions existing in prior art.

Description

Technical Field

[0001] This invention relates to the field of breast monitoring device technology, and in particular to a conformal ultrasound patch structure for breast cancer monitoring. Background Technology

[0002] Breast cancer is one of the leading malignant tumors threatening women's health, and early detection and regular monitoring are crucial for improving prognosis. Ultrasound imaging, due to its advantages such as being non-invasive, ionizing, and real-time, has been widely used in breast disease screening and diagnosis.

[0003] However, existing breast ultrasound imaging technology still has the following shortcomings in clinical practice: (1) Incomplete imaging coverage and systematic blind spots exist. Although existing wearable ultrasound patches have achieved large-area conformal fitting to a certain extent, their open structure leads to incomplete imaging coverage and makes it difficult to systematically cover the four quadrants of the breast. At the same time, both automatic breast ultrasound systems and existing patches have imaging blind spots in the near chest wall and axillary regions. (2) Imaging results are highly dependent on the operator and lack standardization and repeatability. The imaging quality of traditional handheld ultrasound is highly dependent on the operator's experience. Images acquired by different technicians at different time points are difficult to compare directly, which seriously limits the application value of ultrasound in long-term dynamic monitoring. (3) Most existing commercial ultrasound probes are rigid structures and do not fit well with the curved surface of the breast. The operator needs to apply additional pressure to maintain good acoustic coupling, which not only causes discomfort to the patient but may also lead to changes in tissue morphology, thereby affecting the accuracy of diagnosis. (4) Although existing automated breast ultrasound (ABUS) can acquire whole breast images, its output is three-dimensional volume data, which is out of sync with the "quadrant-by-quadrant, region-by-region" diagnostic mode that clinicians are accustomed to. Current research on wearable ultrasound patches focuses more on engineering implementation and has not yet established a modular imaging architecture that matches the anatomical divisions of the breast. Summary of the Invention

[0004] The purpose of this invention is to provide a conformal ultrasound patch structure for breast cancer monitoring. It adopts a three-piece or four-piece patch layout, fixing multiple ultrasound patch units in preset positions on a flexible substrate. Through the coordinated coverage of multiple patches, it achieves systematic and blind-spot-free imaging of the four quadrants of the breast and the axillary tail region, effectively overcoming the imaging blind spots in the near chest wall and axillary regions of the existing technology.

[0005] To achieve the above objectives, the present invention provides a conformal ultrasound patch structure for breast cancer monitoring, comprising a four-piece patch, a three-piece patch, an integrated wearable device, and hardware components. The four-piece patch and the three-piece patch are respectively disposed at the breast position of the integrated wearable device, and the hardware components are also disposed on the integrated wearable device.

[0006] Preferably, the four-piece patch includes four patches, with the nipple as the center, and the mammary gland is divided into four main quadrants by horizontal and vertical lines, namely the upper inner quadrant, the upper outer quadrant, the lower inner quadrant, and the lower outer quadrant. The four patches are respectively placed in the upper outer quadrant, the upper inner quadrant, the lower inner quadrant, and the lower outer quadrant. Based on the quadrant division and using the correspondence of anatomical landmarks of the breast as the standard, it also includes the upper pole, lower pole, and axillary tail region. The axillary tail region is located in the upper outer quadrant, the upper pole is located in the upper inner quadrant, and the lower pole is located in the lower inner quadrant.

[0007] Preferably, the three-piece patch is evenly divided into three regions centered on the nipple, with the three patches located in the three regions respectively.

[0008] Preferably, the patch adopts a multi-layer composite structure, which includes, from the skin contact side outwards, an acoustic lens layer, a matching layer, a piezoelectric transducer element layer, a flexible electrode layer, and a backing layer.

[0009] Preferably, the acoustic lens layer is located at the innermost side of the patch to contact the skin surface, which is used to focus the ultrasonic beam and achieve acoustic coupling between the patch and the skin; room temperature vulcanizing silicone rubber or polydimethylsiloxane flexible polymer material is selected, whose acoustic impedance is consistent with that of human soft tissue, so as to reduce interface reflection loss. The matching layer is located between the acoustic lens layer and the piezoelectric transducer element layer to achieve a step-by-step transition of acoustic impedance from piezoelectric material to human tissue. The matching layer consists of multiple sub-layers, each of which is a composite system of epoxy resin and high-impedance filler. The acoustic impedance is gradually reduced by adjusting the filler volume fraction, and the thickness of each sub-layer is one-quarter of the wavelength of the corresponding operating frequency.

[0010] Preferably, the piezoelectric transducer element layer is the core functional layer for electro-acoustic energy conversion, and is made of polyvinylidene fluoride-trifluoroethylene copolymer material, which has low acoustic impedance, high flexibility and good biocompatibility. The piezoelectric transducer element layer is subjected to in-situ polarization treatment to form a stable piezoelectric phase for transmitting and receiving ultrasonic waves. The flexible electrode layer serves as both an electrode and a supporting substrate. A three-dimensional porous graphene conductive network is generated in situ on the surface of a polyimide substrate using laser-induced graphene technology.

[0011] Preferably, the backing layer is located on the outermost side of the patch and is used to absorb the sound waves radiated from the back of the piezoelectric transducer element and suppress reflection artifacts. It adopts a composite material system of polydimethylsiloxane and high-attenuation filler to maintain the overall flexibility of the patch while providing sound attenuation function.

[0012] Preferably, each layer of the patch constitutes a single transducer unit, and multiple transducer units are connected by a serpentine flexible interconnection structure to form a mechanically decoupled layout of "rigid island-flexible bridge", so that the patch as a whole conforms to the curved surface of the breast while the local array elements maintain stable acoustic performance.

[0013] Preferably, the hardware components adopt a modular structure, including a flexible transducer array electrically connected together, a wireless communication module, a core control module, a power management module, a multi-channel ultrasonic transceiver front end, and a sensor auxiliary module.

[0014] Preferably, the flexible ultrasonic transducer array consists of multiple transducer units integrated on a flexible substrate via a serpentine interconnect structure.

[0015] The advantages and positive effects of the conformal ultrasound patch structure for breast cancer monitoring described in this invention are as follows: (1) Achieve standardized coverage of the entire breast and eliminate imaging blind spots: To address the issue of incomplete imaging coverage in existing technologies, this invention employs a four- or three-piece patch layout, fixing multiple ultrasound patch units to preset positions on a flexible substrate. During use, each patch corresponds to one of the four quadrants of the breast or a specific monitoring area. This structural design resolves the imaging blind spots in the near-chest wall and axillary regions present in existing automated breast ultrasound and wearable ultrasound patches, and also overcomes the incomplete coverage problem caused by single-patch perforated structures. By utilizing a multi-patch collaborative coverage layout combined with the deformable characteristics of the flexible substrate, this invention achieves complete breast coverage without blind spots, effectively avoiding missed lesions due to incomplete scanning paths.

[0016] (2) Eliminating operator dependence and achieving highly repeatable imaging: Addressing the shortcomings of existing handheld ultrasound (HHUS) imaging, which heavily relies on operator experience and makes direct comparison of images from different operators and time points difficult, this invention transforms the traditional "dynamic process" of manual scanning into a one-time "static application" by fixing the positions and angles of multiple ultrasound patch units onto a flexible substrate. Structurally, this invention provides "spatial anchoring bound to anatomical structures," requiring only the patch to be applied as a whole to the breast surface without the need to manually adjust the angle or apply pressure. This structural design and workflow ensures strict spatial repeatability of examination results from different time points and by different operators, providing a standardized data foundation for long-term dynamic monitoring and radiomics analysis of breast cancer, eliminating reliance on the experience of professional ultrasound technicians.

[0017] (3) Achieve conformal fit to the curve of the breast, improving imaging quality and comfort: To address the shortcomings of existing rigid probes that mismatch with curved tissue interfaces, the flexible substrate of this invention is made of biocompatible conformal material. During operation, it deforms along the natural curve of the breast, allowing each ultrasound patch to achieve tight and uniform acoustic coupling with the skin surface through a matching layer and acoustic lenses. This invention overcomes the defects of interface mismatch, avoids the interference of pressure-induced tissue deformation on diagnostic accuracy, significantly improves patient comfort during examination, is suitable for long-term wear and frequent monitoring, and ensures the authenticity of imaging under natural tissue conditions.

[0018] (4) Construct a modular imaging architecture that is highly compatible with the clinical diagnostic system. To address the issue that existing automated breast ultrasound outputs three-dimensional volumetric data, which is disconnected from the "quadrant-by-quadrant, region-by-region" diagnostic model commonly used by clinicians, this invention features a preferred four-piece patch layout. Its structural design directly corresponds to the "four-quadrant" zoning system commonly used in clinical breast diagnosis. During operation, the system sequentially acquires ultrasound images from each quadrant and directly associates them with their anatomical locations upon output. This aligns perfectly with the diagnostic standards of the BI-RADS system, which require clearly reporting the quadrant, clock position, distance from the nipple, and depth of lesions. This design overcomes the shortcomings of existing technologies that are disconnected from clinical workflows, making the image information obtained by this invention more consistent with doctors' diagnostic habits, reducing the learning cost of image interpretation, and improving diagnostic efficiency and the intuitiveness of information integration.

[0019] (5) Supports long-term dynamic monitoring, providing technical support for early lesion identification: This invention ensures the reproducibility of probe positioning at different monitoring time points by pre-positioning fixed patches on a flexible substrate. By registering and comparing current images with historical images, it can accurately capture subtle evolutions of lesions, such as changes in size, boundary clarity, and elastic properties. This beneficial effect overcomes the shortcomings of existing technologies in achieving repeatable dynamic monitoring, providing a new technical means for the early detection, progression assessment, and treatment efficacy monitoring of breast cancer, and making it possible to analyze tissue evolution trajectories from the temporal dimension of radiomics.

[0020] The technical solution of the present invention will be further described in detail below with reference to the accompanying drawings and embodiments. Attached Figure Description

[0021] Figure 1 This is a schematic diagram of the four-piece patch structure of the present invention; Figure 2 This is a schematic diagram of the three-piece patch structure of the present invention; Figure 3 This is a schematic diagram of the exploded structure of the patch of the present invention; Figure 4 This is a schematic diagram of the overall structure of the patch of the present invention; Figure 5 This is a schematic diagram of the four-piece patch of the present invention in use; Figure 6 This is a schematic diagram of the three-piece patch of the present invention in use; Figure 7 A schematic diagram of a four-piece patch for the integrated wearable device of the present invention; Figure 8 A schematic diagram of a three-piece patch for the integrated wearable device of the present invention; Figure 9 This is a schematic diagram of the hardware components of the present invention; Figure 10 This is a system diagram of the hardware components of the present invention; Figure 11 This is a schematic diagram of the patch structure system of the present invention; Figure 12 This is a diagram of the signal processing system of the present invention; Figure 13 This is a system diagram of the overall design of the present invention.

[0022] Figure Labels 1. Patch; 2. Upper outer quadrant; 3. Upper inner quadrant; 4. Lower inner quadrant; 5. Lower outer quadrant; 6. Integrated wearable device; 7. Acoustic lens layer; 8. Matching layer; 9. Piezoelectric transducer element layer; 10. Flexible electrode layer; 11. Backing layer; 12. Hardware components; 13. Flexible ultrasonic transducer array; 14. Core control module; 15. Power management module; 16. Wireless communication module; 17. Sensor auxiliary module; 18. Nipple; 19. Four-piece patch; 20. Three-piece patch; 21. Multi-channel ultrasonic transceiver front end. Detailed Implementation

[0023] In the description of this invention, it should be noted that the terms "upper," "lower," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship commonly used when the product is in use. They are used only for the convenience of describing the invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the invention. In the description of this invention, it should also be noted that, unless otherwise explicitly specified and limited, the terms "set," "install," and "connect" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal communication between two components. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances.

[0024] In this application, unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application pertains. In case of any inconsistency, the meaning set forth in this specification or derived from the content described herein shall prevail. Furthermore, the terminology used herein is for the purpose of describing embodiments of this application only and is not intended to limit the scope of this application.

[0025] The embodiments of the present invention will now be described in detail with reference to the accompanying drawings.

[0026] like Figures 1-13 As shown, a conformal ultrasound patch structure for breast cancer monitoring includes a four-piece patch 19, a three-piece patch 20, an integrated wearable device 6, and a hardware component 12. The four-piece patch 19 and the three-piece patch 20 are respectively disposed at the breast position of the integrated wearable device 6, and the hardware component 12 is also disposed on the integrated wearable device 6.

[0027] The four-piece patch 19 includes four patches 1. Centered on the nipple 18, the mammary gland is divided into four main quadrants by horizontal and vertical lines, namely the upper inner quadrant 3, the upper outer quadrant 2, the lower inner quadrant 4, and the lower outer quadrant 5. The four patches are respectively placed in the upper outer quadrant 2, the upper inner quadrant 3, the lower inner quadrant 4, and the lower outer quadrant 5.

[0028] Based on the quadrant division and using the correspondence of breast anatomical landmarks as the standard, it also includes the upper pole, lower pole, and axillary tail region. The axillary tail region is located in the upper outer quadrant 2, the upper pole is located in the upper inner quadrant 3, and the lower pole is located in the lower inner quadrant 4.

[0029] The three-piece patch 20 is evenly divided into three areas with the nipple 18 as the center, and the three patches are located in the three areas respectively.

[0030] The patch adopts a multi-layer composite structure, which includes, from the skin contact side outwards: an acoustic lens layer 7, a matching layer 8, a piezoelectric transducer element layer 9, a flexible electrode layer 10, and a backing layer 11.

[0031] The acoustic lens layer 7 is located on the innermost side of the patch to contact the skin surface, used to focus the ultrasound beam and achieve acoustic coupling between the patch and the skin. Room temperature vulcanizing silicone rubber or polydimethylsiloxane flexible polymer material is selected, whose acoustic impedance is consistent with that of human soft tissue to reduce interface reflection loss.

[0032] Matching layer 8 is disposed between acoustic lens layer 7 and piezoelectric transducer element layer 9 to achieve a step-by-step gradual transition of acoustic impedance from piezoelectric material to human tissue. Matching layer 8 consists of multiple sublayers, each of which is a composite system of epoxy resin and high-impedance filler. The acoustic impedance decreases layer by layer by adjusting the filler volume fraction, and the thickness of each sublayer is one-quarter wavelength of the corresponding operating frequency.

[0033] The piezoelectric transducer element layer 9 is the core functional layer for electro-acoustic energy conversion. It is made of polyvinylidene fluoride-trifluoroethylene copolymer material, which has low acoustic impedance, high flexibility and good biocompatibility. The piezoelectric transducer element layer 9 is formed into a stable piezoelectric phase through in-situ polarization treatment, which is used to transmit and receive ultrasonic waves.

[0034] The flexible electrode layer 10 serves as both an electrode and a supporting substrate, and is formed by in-situ generation of a three-dimensional porous graphene conductive network on the surface of a polyimide substrate using laser-induced graphene technology.

[0035] The backing layer 11 is located on the outermost side of the patch and is used to absorb the sound waves radiated from the back of the piezoelectric transducer element and suppress reflection artifacts. It is made of a composite material of polydimethylsiloxane and high-attenuation filler, which provides sound attenuation function while maintaining the overall flexibility of the patch.

[0036] Each layer of the patch constitutes a single transducer unit, and multiple transducer units are connected by a serpentine flexible interconnection structure to form a mechanical decoupling layout of "rigid island-flexible bridge", which enables the patch as a whole to conformally fit the breast surface while the local array elements maintain stable acoustic performance.

[0037] The hardware component 12 adopts a modular structure, including a flexible ultrasonic transducer array 13 electrically connected together, a wireless communication module 16, a core control module 14, a power management module 15, a multi-channel ultrasonic transceiver front end 21, and a sensor auxiliary module 17.

[0038] Specifically, the core control module 14 adopts a heterogeneous multi-core chip system, integrating an application processing unit, a real-time processing unit, and a programmable logic unit. The application processing unit is responsible for system main control and communication protocols, the real-time processing unit controls the ultrasonic transmission timing and channel management, and the programmable logic unit completes high-speed signal preprocessing such as beamforming. The module supports dynamic power management, entering a low-power state during non-operating periods.

[0039] The multi-channel ultrasonic transceiver front-end 21 connects the control module and the transducer array, employing a hybrid solution of flexible multiplexing and silicon chips. Each channel includes a high-voltage pulse generator, transceiver switch, low-noise transimpedance amplifier, variable gain amplifier, and analog-to-digital converter to generate excitation pulses and receive and condition echo signals. The system supports both time-division multiplexing and parallel excitation modes. At the physical level, a flexible circuit board is used for close connection to the ultrasonic transducer array to reduce signal loss; at the signal level, a high-speed data bus and control bus enable bidirectional interaction with the core control module.

[0040] The flexible ultrasound transducer array 13 consists of multiple transducer units integrated onto a flexible substrate via a serpentine interconnection structure, forming a "rigid island-flexible bridge" layout. A single wear allows for alignment based on anatomical landmarks, establishing a spatial coordinate system bound to the breast's anatomical structure.

[0041] The power management module 15 includes an intelligent rechargeable energy storage unit, a charging management circuit, and a multi-channel voltage conversion circuit, providing digital low-voltage, analog low-noise, and high-voltage boost power supplies, respectively. The module works in conjunction with the core control to achieve channel-level dynamic power supply and sleep mode switching.

[0042] The wireless communication module supports dual-mode transmission of Bluetooth Low Energy and Wi-Fi, and integrates a flexible antenna and a data buffer unit.

[0043] The sensor auxiliary module 17 is equipped with an attitude sensor to detect the spatial attitude of the patch, a contact sensor to monitor the bonding quality, a temperature sensor to ensure safe use, and real-time monitoring of the wearing status and environmental conditions to provide data support for system status judgment and user prompts.

[0044] The various hardware modules work together. After being worn, the core control module controls the transducer array at the transceiver front end according to a preset timing sequence. The echo signal is amplified, filtered, converted from analog to digital, and processed by beamforming before being transmitted to an external terminal by the wireless module. Through the above design, the system achieves multi-quadrant ultrasound signal acquisition and transmission under the premise of miniaturization and low power consumption, providing a hardware foundation for long-term repeatable monitoring of breast cancer.

[0045] The working process of this invention is as follows: During use, the operator selects either a three-piece patch (20) or a four-piece patch (19) based on the patient's breast size, aligns and calibrates the device using anatomical landmarks (nipple, parasternal line, anterior axillary line), and then applies the device to the breast surface. After the system is powered on, the core control module uses a sensor-assisted module to detect the bonding pressure and temperature of each transducer unit, and enters the working mode after confirming good coupling.

[0046] Under the timing control of the core control module, the multi-channel ultrasound transceiver front-end 21 sequentially excites each transducer unit to emit high-voltage pulses. The transducers convert the electrical signals into ultrasound beams, which are transmitted through the matching layer into the breast tissue. The echo signals reflected by the tissue are received by the same transducer unit, switched to the receiving link by the transceiver front-end, and sequentially converted into digital signals through a transimpedance amplifier, a variable gain amplifier, an anti-aliasing filter, and an analog-to-digital converter.

[0047] After receiving the digital signals from each channel, the core control module 14 performs preprocessing such as digital filtering, quadrature demodulation, and pulse compression in sequence. Then, it uses a delay multiplication and beamforming algorithm to achieve dynamic focusing and apodization weighting to synthesize a high-resolution scan line signal. The beam-synthesized signal is then subjected to envelope detection, logarithmic compression, scan conversion, and frame averaging to generate local images of each patch unit.

[0048] For the four-piece patch layout, the spatial registration module uses the preset spatial coordinates of each patch unit on the flexible substrate and combines the attitude sensor data to rigidly register the images in the four quadrants. Then, it uses a weighted average algorithm to achieve seamless stitching and form a complete image covering the entire breast.

[0049] For the three-piece patch layout, the three images are stitched together according to a preset geometric relationship to cover the main area of ​​the breast and the axillary tail area.

[0050] The final images are transmitted to an external display terminal via a wireless communication module for doctors to perform BI-RADS classification and diagnostic analysis. The system supports both time-sharing imaging and spatial composite imaging modes, which can be dynamically switched according to monitoring needs.

[0051] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and not to limit them. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can still be made to the technical solutions of the present invention, and these modifications or equivalent substitutions cannot cause the modified technical solutions to deviate from the spirit and scope of the technical solutions of the present invention.

Claims

1. A conformal ultrasound patch structure for breast cancer monitoring, characterized in that: It includes a four-piece patch, a three-piece patch, an integrated wearable device, and hardware components. The four-piece patch and the three-piece patch are respectively disposed at the breast position of the integrated wearable device, and the hardware components are also disposed on the integrated wearable device.

2. The conformal ultrasound patch structure for breast cancer monitoring according to claim 1, characterized in that: The four-piece patch includes four patches. With the nipple as the center, the mammary gland is divided into four main quadrants by horizontal and vertical lines, namely the upper inner quadrant, the upper outer quadrant, the lower inner quadrant, and the lower outer quadrant. The four patches are respectively placed in the upper outer quadrant, the upper inner quadrant, the lower inner quadrant, and the lower outer quadrant. Based on the quadrant division and using the correspondence of anatomical landmarks of the breast as the standard, it also includes the upper pole, lower pole, and axillary tail region. The axillary tail region is located in the upper outer quadrant, the upper pole is located in the upper inner quadrant, and the lower pole is located in the lower inner quadrant.

3. The conformal ultrasound patch structure for breast cancer monitoring according to claim 1, characterized in that: The three-piece patch is evenly divided into three regions centered on the nipple, with the three patches located in the three regions respectively.

4. The conformal ultrasound patch structure for breast cancer monitoring according to claim 1, characterized in that: The patch adopts a multi-layer composite structure, which includes, from the skin contact side outwards: an acoustic lens layer, a matching layer, a piezoelectric transducer element layer, a flexible electrode layer, and a backing layer.

5. The conformal ultrasound patch structure for breast cancer monitoring according to claim 4, characterized in that: The acoustic lens layer is located on the innermost side of the patch to contact the skin surface, and is used to focus the ultrasonic beam and achieve acoustic coupling between the patch and the skin; room temperature vulcanizing silicone rubber or polydimethylsiloxane flexible polymer material is selected, and its acoustic impedance is consistent with that of human soft tissue to reduce interface reflection loss. A matching layer is placed between the acoustic lens layer and the piezoelectric transducer element layer to achieve a step-like gradual transition of acoustic impedance from the piezoelectric material to human tissue. The matching layer consists of multiple sub-layers, each made of a composite system of epoxy resin and high-impedance filler. The acoustic impedance is gradually reduced by adjusting the filler volume fraction, and the thickness of each sub-layer is one-quarter of the wavelength of the corresponding operating frequency.

6. The conformal ultrasound patch structure for breast cancer monitoring according to claim 5, characterized in that: The piezoelectric transducer element layer is the core functional layer for electro-acoustic energy conversion. It is made of polyvinylidene fluoride-trifluoroethylene copolymer material, which has low acoustic impedance, high flexibility and good biocompatibility. The piezoelectric transducer element layer is formed into a stable piezoelectric phase through in-situ polarization treatment, which is used to transmit and receive ultrasonic waves. The flexible electrode layer serves as both an electrode and a supporting substrate. A three-dimensional porous graphene conductive network is generated in situ on the surface of a polyimide substrate using laser-induced graphene technology.

7. The conformal ultrasound patch structure for breast cancer monitoring according to claim 6, characterized in that: The backing layer is located on the outermost side of the patch and is used to absorb the sound waves radiated from the back of the piezoelectric transducer element and suppress reflection artifacts. It adopts a composite material system of polydimethylsiloxane and high-attenuation filler, which provides sound attenuation function while maintaining the overall flexibility of the patch.

8. The conformal ultrasound patch structure for breast cancer monitoring according to claim 7, characterized in that: Each layer of the patch constitutes a single transducer unit, and multiple transducer units are connected by a serpentine flexible interconnection structure to form a mechanical decoupling layout of "rigid island-flexible bridge", so that the patch as a whole conforms to the curved surface of the breast while the local array elements maintain stable acoustic performance.

9. The conformal ultrasound patch structure for breast cancer monitoring according to claim 8, characterized in that: The hardware components adopt a modular structure, including a flexible ultrasonic transducer array electrically connected together, a wireless communication module, a core control module, a power management module, a multi-channel ultrasonic transceiver front end, and a sensor auxiliary module.

10. A conformal ultrasound patch structure for breast cancer monitoring according to claim 9, characterized in that: The flexible ultrasonic transducer array consists of multiple transducer units integrated on a flexible substrate via a serpentine interconnect structure.

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