A method for molecular typing of nk / t-cell lymphoma based on multiple gene expression characteristics and application thereof
By identifying malignant transcriptional program modules of NK/T-cell lymphoma through nonnegative matrix factorization of single-cell transcriptome data, constructing a molecular subtyping gene set and scoring the modules, the problem of inconsistent NK/T-cell lymphoma subtyping results in existing technologies is solved, enabling precise molecular subtyping and prognostic assessment of patients.
CN122290697APending Publication Date: 2026-06-26SUN YAT SEN UNIVERSITY CANCER CENTER (CANCER HOSPITAL AFFILIATED TO SUN YAT SEN UNIVERSITY CANCER RESEARCH INSTITUTE OF SUN YAT SEN UNIVERSITY)
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SUN YAT SEN UNIVERSITY CANCER CENTER (CANCER HOSPITAL AFFILIATED TO SUN YAT SEN UNIVERSITY CANCER RESEARCH INSTITUTE OF SUN YAT SEN UNIVERSITY)
- Filing Date
- 2026-03-04
- Publication Date
- 2026-06-26
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Figure CN122290697A_ABST
Abstract
This application relates to the field of molecular subtyping technology, specifically disclosing a molecular subtyping method for NK / T-cell lymphoma based on multi-gene expression characteristics and its application. The molecular subtyping method provided in this application can systematically reflect the molecular heterogeneity of NK / T-cell lymphoma, offers a standardized and reproducible molecular subtyping detection protocol, and can also assist in assessing patient prognostic risks and provide a reference for treatment decisions. The molecular subtyping method provided in this application is applicable to various conventional molecular detection platforms and has good clinical application value.
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