In addition to the capsule and ulcerative spirit of Helicobacter pylori Yinling

Abstract

Helicobacter pylori (HP) is a chronic bacterium that infects the gastric mucosa. It is widespread in the general population, with an infection rate between 55% and 70%. HP is closely related to gastric ulcers and gastritis. Western medicine treatment for HP infection is relatively complex, including bismuth substituents and proton pump inhibitors plus two antibiotics. Gastric ulcers and gastritis are common digestive system diseases. Compound 1, "Exterminate the Ghost," is a traditional Chinese medicine composition mainly composed of Coptis chinensis, plus Scutellaria baicalensis and Fraxinus chinensis, which can eradicate HP. Compound 2, "Ulcer Relief," is a traditional Chinese medicine composition mainly composed of Coptis chinensis, plus Rheum palmatum and Bletilla striata, which can cure gastric ulcers. Compound 3, "Gasitis Relief," is a traditional Chinese medicine composition mainly composed of Coptis chinensis, plus Glycyrrhiza uralensis or Taraxacum mongolicum, made into a tea bag, which can cure chronic gastritis.

Description

[0001] Technical Field: This invention belongs to the field of traditional Chinese medicine compositions targeting or related to the eradication of Helicobacter pylori (HP) (i.e., Compound 1 for eliminating Helicobacter pylori, Compound 2 for ulcer treatment, and Compound 3 for gastritis treatment).

[0002] Relevant background technology:

[0003] (1) *Helicobacter pylori* (HP) is a bacterium that chronically infects the gastric mucosa. Because it is mainly transmitted through the oral digestive tract, close proximity during conversation, sharing braces, and other respiratory contact, *HP* is widespread in the general population, with an infection rate between 55% and 70%. Common symptoms include upper abdominal fullness and discomfort after eating, pain, belching, bloating, acid reflux, and decreased appetite. Some patients may experience minor upper gastrointestinal bleeding. Since *HP* infection is closely related to the occurrence of chronic gastritis, gastric and duodenal ulcers, atrophic gastritis, lymphoma, and gastric cancer, eradication of *HP* is essential.

[0004] However, current Western medicine treatments are quite complex (common first-line Hp eradication regimens include bismuth preparations plus two antibiotics and proton pump inhibitors plus two antibiotics, such as omeprazole, tripotassium bismuth dicitrate, or colloidal bismuth pectin, combined with amoxicillin and metronidazole. If first-line treatment is unsuccessful, a quadruple therapy regimen of bismuth preparations plus proton pump inhibitors plus two antibiotics is chosen), and the treatment time is relatively long (at least two weeks). Furthermore, prolonged use of antibiotics can cause adverse reactions, and the treatment cost is much higher than that of this invention (compound 1 of traditional Chinese medicine).

[0005] (2) Gastric ulcers and duodenal ulcers are common peptic ulcers, which are caused by the self-digestion of the gastrointestinal mucosa by gastric acid and pepsin. The ulcers can reach or penetrate the muscularis mucosa, and there may be mild tenderness in the upper abdomen during movement. At present, the main treatment in Western medicine is: drugs to reduce gastric acid, combined drugs to eradicate H. pylori, drugs to protect the gastric mucosa, and antispasmodics. Since the main cause of ulcers is H. pylori infection, and the disadvantages of Western medicine drugs for treating H. pylori infection are as mentioned above, antibiotics must be used for at least two weeks, which can lead to increased drug resistance, and there have been cases of more serious adverse reactions. Moreover, the eradication of H. pylori is not stable enough and is prone to recurrence. Summary of the Invention:

[0006] Compound 1, for eliminating phantoms; a traditional Chinese medicine combination with Coptis chinensis as the main ingredient, plus Scutellaria baicalensis and Fraxinus chinensis. Coptis chinensis clears heat and dries dampness, drains fire and detoxifies; Scutellaria baicalensis clears heat and dries dampness, drains fire and detoxifies, stops bleeding and calms the fetus; Fraxinus chinensis clears heat and dries dampness, astringes and stops dysentery, stops leukorrhea and improves eyesight.

[0007] In vitro experiments have confirmed that these three traditional Chinese medicines all have inhibitory effects on *Helicobacter pylori* (HP), with *Coptis chinensis* (Huanglian) showing the strongest effect. (The antibacterial strength of *Coptis chinensis* is concentration-dependent; low concentrations inhibit bacteria, while high concentrations kill bacteria. *Coptis chinensis* contains various alkaloids, mainly berberine, with a content as high as 3.6% or more. Alkaloids have antibacterial effects.) Therefore, a traditional Chinese medicine composition with *Coptis chinensis* as the main ingredient, combined with *Scutellaria baicalensis* (Huangqin) and *Fraxinus chinensis* (Qinpi), can eradicate *H. pylori*, thus replacing the four-drug regimen used in Western medicine.

[0008] Compound 2. Ulcer Relief: This is a traditional Chinese medicine composition with Coptis chinensis as the main ingredient, plus rhubarb and Bletilla striata. Rhubarb has the functions of purging and eliminating stagnation, clearing heat and purging fire, cooling blood and detoxifying, removing blood stasis and promoting menstruation, promoting diuresis and relieving jaundice, and also has the effect of inhibiting Helicobacter pylori. It can also improve the blood perfusion of the gastric mucosa, making the flow of qi and blood in the stomach and intestines smooth. In addition, rhubarb has a direct coagulation and hemostatic effect. Bletilla striata contains Bletilla striata gum, which can firmly adhere to the surface of the digestive tract to form a protective film, effectively protecting the ulcer surface and promoting repair and healing. At the site of ulcer bleeding, Bletilla striata can also enhance platelet function and promote blood coagulation to achieve hemostasis. Therefore, Compound 2 can effectively treat ulcers.

[0009] Compound 3. Gastritis Relief: Made primarily from Coptis chinensis, with the addition of licorice or dandelion, this tea bag can be consumed daily to treat chronic gastritis, a major cause of the disease (Hp infection). Licorice: tonifies the spleen and replenishes qi, clears heat and detoxifies, resolves phlegm and relieves cough, alleviates pain, harmonizes other herbs, and has antibacterial properties. Dandelion: clears heat and detoxifies, reduces swelling and dissipates nodules, promotes urination, and not only has antibacterial properties but also repairs gastric mucosal damage. Since Coptis chinensis tea is too bitter, adding a little honey can improve the bitterness. Honey also promotes gastric mucosal repair and healing. Therefore, with consistent use, Compound 3 can also achieve good results. Specific implementation plan:

[0010] Compound 1:

[0011] Coptis chinensis, Scutellaria baicalensis, and Fraxinus rhynchophylla in a 5:6:3 ratio are ground into a fine powder and made into capsules. Take 5 grams one hour before breakfast every day for half a month to one month to eradicate H. pylori.

[0012] Compound 2:

[0013] Coptis chinensis, rhubarb, and Bletilla striata in a 3:5:5 ratio are ground into a fine powder and made into capsules. Two capsules (5 grams) are taken with warm water one hour before breakfast every day. Continuous use for half a month to one month can cure ulcers.

[0014] Compound 3: Prepare tea bags with a ratio of 3 parts Coptis chinensis and 5 parts Glycyrrhiza uralensis. Steep in boiling water for 10 minutes, then add an appropriate amount of honey and stir. Drink three tea bags one hour before meals and continue for 15-30 days.

[0015] Alternatively, make tea bags with a ratio of 3 parts Coptis chinensis and 15 parts dandelion. Steep in boiling water for 10 minutes, then add or omit honey. Take once in the morning and once in the evening. Continue taking this for 15 to 30 days to cure chronic gastritis.

Claims

1. A Chinese medicine composition for eradicating Helicobacter pylori (Hp) as an objective, a compound 1: Ex-Hp, characterized in that It is mainly composed of Coptis chinensis, plus Scutellaria baicalensis and Fraxinus rhynchophylla.

2. A traditional Chinese medicine composition, Compound 2. Kuiyangling, characterized in that It is mainly composed of Coptis chinensis, plus rhubarb and Bletilla striata.

3. A traditional Chinese medicine composition, Compound 3. Weiyinling, for the purpose of eradicating HP, characterized in that It is mainly composed of Coptis chinensis, plus licorice or dandelion.