A vitamin k2 nanoliposome dynamic high pressure microfluidization device

Abstract

This invention relates to the field of high-pressure fluid processing equipment technology, and discloses a dynamic high-pressure microjet device for vitamin K2 nanoliposomes. The device includes a base, with a housing fixedly connected to the upper part of the base. A high-pressure pump cylinder is mounted on the right side of the outer surface of the housing. A tubular heat exchanger is mounted on the upper left side of the high-pressure pump cylinder. A connecting seat is mounted on the upper right side of the high-pressure pump cylinder. A feed hopper is mounted on the top of the connecting seat, and a sealing cover is mounted on the top of the feed hopper. An impurity filtration mechanism is installed inside the feed hopper. A heating mechanism is installed outside the high-pressure pump cylinder. A heat dissipation hole is opened on the left side of the outer surface of the housing, and a ventilation mechanism is installed outside the heat dissipation hole. The impurity filtration mechanism includes a metal filter screen disposed inside the feed hopper. This structure can remove undissolved large particles, prevent impurities from entering the precision cavity, avoid microchannel blockage and high-pressure pump wear, and improve the operational stability of the equipment.

Description

Technical Field

[0001] This invention relates to the field of high-pressure fluid processing equipment technology, specifically to a dynamic high-pressure microjet device for vitamin K2 nanoliposomes. Background Technology

[0002] Vitamin K2 nanoliposomes are nanoscale carrier systems formed by encapsulating vitamin K2 with materials such as phospholipids. They have the characteristics of improving the stability, bioavailability and targeted delivery of lipid-soluble active substances and are widely used in pharmaceutical preparations and functional foods. However, since vitamin K2 and its excipients are mostly hydrophobic or semi-solid substances, problems such as uneven dispersion and unstable particle size are prone to occur during the preparation process.

[0003] To obtain nanoliposome systems with uniform particle size and stable distribution, dynamic high-pressure microfluidic equipment is typically required. High pressure induces intense shearing, impact, and cavitation effects within the microchannels, achieving nanoscale refinement and homogenization. However, such equipment demands high material purity and flowability. Especially given the precise microchannel structure, the entry of undissolved large particles or impurities can easily cause channel blockage, disrupting the equipment's normal operation.

[0004] Existing dynamic high-pressure microfluidic equipment for vitamin K2 nanoliposomes typically lacks a pre-filtration structure in the feeding stage. Undissolved particles and impurities in the material can easily enter the high-pressure structure with the fluid, causing not only microchannel blockage but also accelerated wear on critical components such as the high-pressure pump, shortening the equipment's lifespan. Furthermore, blockage can cause abnormal pressure fluctuations, reducing product quality stability. Summary of the Invention

[0005] To address the shortcomings of existing technologies, this invention provides a dynamic high-pressure microfluidic device for vitamin K2 nanoliposomes, which solves the problem that existing devices lack a filtration structure during the feeding process, leading to undissolved large particles and impurities easily entering the high-pressure structure, thereby causing microchannel blockage, increased wear of the high-pressure pump, and poor equipment operational stability.

[0006] To achieve the above objectives, the present invention provides the following technical solution: a dynamic high-pressure microfluidic device for vitamin K2 nanoliposomes, comprising a base, a housing fixedly connected to the upper part of the base, a high-pressure pump cylinder mounted on the right side of the outer side of the housing, a tubular heat exchanger mounted on the upper left side of the high-pressure pump cylinder, a connecting seat mounted on the upper right side of the high-pressure pump cylinder, a feed hopper mounted on the top of the connecting seat, a sealing cover mounted on the top of the feed hopper, an impurity filtration mechanism provided inside the feed hopper, a heating mechanism provided outside the high-pressure pump cylinder, and a heat dissipation hole opened on the left side of the outer side of the housing, with a ventilation mechanism installed outside the heat dissipation hole; The impurity filtration mechanism includes a metal filter screen, which is disposed inside the feed hopper. Both sides of the upper part of the metal filter screen are fixedly connected to protrusions. Guide rings are fixedly connected inside the two protrusions. Positioning pins are inserted inside the two guide rings. Grooves are formed on the outside of the two positioning pins.

[0007] Preferably, the ventilation mechanism includes a mounting housing disposed outside the heat dissipation holes. A dustproof plate is mounted on the left side of the mounting housing. A miniature dual-head motor is fixedly connected inside the mounting housing. A fan is fixedly connected to the left output end of the miniature dual-head motor, and a rotating rod is fixedly connected to the right output end of the miniature dual-head motor. The rotating rod passes through the interior of the dustproof plate. A cleaning brush is mounted on the exterior of the rotating rod and fits against the exterior of the dustproof plate. Sliding rods are fixedly connected to both sides inside the mounting housing. Moving blocks are slidably connected to both sides of the two sliding rods. Springs are fixedly connected to the middle of the two moving blocks and are sleeved on the exterior of the sliding rods. Pressing rods are fixedly connected to the left side of the two moving blocks, and L-shaped inserts are fixedly connected to the right side of the two moving blocks.

[0008] Preferably, the heating mechanism includes two arc-shaped jackets, which are disposed on the outer sides of the high-pressure pump cylinder. Connecting blocks are fixedly connected to the outer sides of both arc-shaped jackets, and fastening bolts are threaded into the inner sides of the connecting blocks. A heating water tank is fixedly connected to the upper right side of the base. A controller is installed on the top of the heating water tank, and heating wires are installed on both sides of the bottom of the controller. Two heating wires are disposed inside the heating water tank. Micro-circulation pumps are installed on the outer sides of the heating water tank. The input ends of the two micro-circulation pumps are fixedly connected to the inside of the heating water tank, and the output ends of the two micro-circulation pumps are fixedly connected to delivery pipes. The tops of the two delivery pipes are fixedly connected to the inside of the two arc-shaped jackets.

[0009] Preferably, a circulation return pipe is installed at the top of the tubular heat exchanger, and the bottom of the circulation return pipe is disposed inside the feed hopper through the sealing cover. Insertion holes are provided on both sides of the inside of the feed hopper, and two positioning pins are inserted into the two insertion holes.

[0010] Preferably, an observation window is installed on the front side of the feed hopper, and a scale is provided on the left side of the observation window.

[0011] Preferably, positioning holes are provided on both sides of the interior of the housing, and the two L-shaped inserts are inserted into the two positioning holes. Mounting cavities are provided on both sides of the interior of the mounting housing, and the slide rod is fixedly connected inside the mounting cavity.

[0012] Preferably, sliding holes are provided on both sides of the outer side of the mounting housing, and the two pressing rods are slidably connected inside the two sliding holes.

[0013] Preferably, a filling port is fixedly connected to the right side of the exterior of the heating water tank, and a cover plate is installed on the exterior of the filling port.

[0014] Preferably, a display screen is installed on the front side of the outer casing, and an operation button is installed on the left side of the outer casing.

[0015] Preferably, anti-slip blocks are fixedly connected to all four sides of the bottom of the base, and anti-slip textures are formed on the bottom of each of the anti-slip blocks.

[0016] This invention provides a dynamic high-pressure microfluidic device for vitamin K2 nanoliposomes. It has the following beneficial effects: 1. When installing the metal filter screen in the feed hopper, the sealing cap is first opened from the top of the feed hopper. After opening, the positioning pin is moved out of the guide ring through the groove and made flush with the protrusion. Then, the metal filter screen is placed into the feed hopper, and the positioning pin is aligned with the insertion hole inside the hopper. It is pressed to be inserted into the insertion hole with the cooperation of the guide ring to complete the fixation. After that, vitamin K nano-lipid material is added to the feed hopper. The material enters the lower part through the holes of the metal filter screen, while impurities are trapped on the filter screen to achieve solid-liquid separation. Finally, the sealing cap is tightened to start the equipment. This structure can remove undissolved large particles, prevent impurities from entering the precision cavity, avoid microchannel blockage and high-pressure pump wear, and improve the stability of equipment operation.

[0017] 2. When the device ventilates and dissipates heat through the left-side heat dissipation hole, the two pressing rods are pressed relative to each other, causing the moving block to move towards each other along the sliding rod and compress the spring. At the same time, the L-shaped insert rod is driven back into the mounting shell. After the mounting shell is inserted into the corresponding mounting hole, the pressing rods are released. Under the reaction of the spring, the L-shaped insert rod is inserted into the positioning hole to complete the fixation. During the heat dissipation process, the micro dual-head motor is started, driving the fan to rotate and exhausting air through the dustproof plate. At the same time, the rotating rod and cleaning brush are driven to rotate to remove impurities from the surface of the dustproof plate. This structure can achieve continuous dust prevention and anti-clogging, ensure smooth heat dissipation, avoid motor overheating, and improve the stability and service life of the equipment.

[0018] 2. In this invention, when material enters the high-pressure pump cylinder, liquid is first added to the heating water tank through the filling port, and heated under the action of the controller and heating wire. Subsequently, a micro-circulation pump sends the hot liquid through the delivery pipe into the arc-shaped jacket, allowing heat to be transferred to the high-pressure pump cylinder, achieving constant temperature flow of the material and preventing phospholipids from solidifying upon cooling. The arc-shaped jacket can be disassembled simply by removing the fastening bolts; installation is performed by reversing the operation. This structure facilitates installation and maintenance, avoids problems such as feeding obstruction, jamming, and pressure buildup caused by viscous materials, and improves equipment operating efficiency. Attached Figure Description

[0019] Figure 1 This is a perspective view of the present invention; Figure 2 The schematic diagram is provided to highlight the arc-shaped jacket structure of the present invention; Figure 3 A schematic diagram illustrating the anti-slip block structure of the present invention is provided. Figure 4 The schematic diagram of the heating water tank structure of the present invention is shown below; Figure 5 To highlight the structural diagram of the tubular heat exchanger of the present invention; Figure 6 A schematic diagram illustrating the filling port structure of the present invention is provided. Figure 7 The schematic diagram of the mounting shell structure of the present invention is shown in the figure. Figure 8 The schematic diagram of the cleaning brush structure of the present invention is shown in the figure. Figure 9 The schematic diagram of the housing structure of the present invention is shown in the figure. Figure 10 The schematic diagram of the feed hopper structure of the present invention is shown in the figure. Figure 11 for Figure 5 Enlarged view of the structure at point A in the middle; Figure 12 for Figure 9 Enlarged view of the structure at point B; Figure 13 for Figure 10 Enlarged view of the structure at point C.

[0020] The components include: 1. Base; 2. Anti-slip block; 3. Housing; 4. High-pressure pump cylinder; 5. Tubular heat exchanger; 6. Circulation return pipe; 7. Connecting seat; 8. Feed hopper; 9. Observation window; 10. Scale; 11. Sealing cover; 12. Impurity filtration mechanism; 1201. Metal filter screen; 1202. Protrusion; 1203. Guide ring; 1204. Positioning pin; 1205. Groove; 13. Insertion hole; 14. Heat dissipation hole; 15. Ventilation mechanism; 1501. Mounting shell; 1502. Miniature double-headed motor; 1503. Rotating rod; 1504. Cleaning brush. 1505. Fan; 1506. Dustproof plate; 1507. Slide rod; 1508. Moving block; 1509. Pressing rod; 1510. L-shaped insert rod; 1511. Spring; 16. Mounting cavity; 17. Sliding hole; 18. Positioning hole; 19. Heating mechanism; 1901. Heating water tank; 1902. Controller; 1903. Heating wire; 1904. Delivery pipe; 1905. Filling port; 1906. Miniature circulation pump; 1907. Arc-shaped jacket; 1908. Connecting block; 1909. Fastening bolt; 20. Display screen; 21. Operation button. Detailed Implementation

[0021] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention. Example

[0022] Please see the appendix Figure 1 -Appendix Figure 11 This invention provides a dynamic high-pressure microfluidic device for vitamin K2 nanoliposomes, including a base 1, a housing 3 fixedly connected to the upper part of the base 1, a high-pressure pump cylinder 4 installed on the right side of the outer side of the housing 3, a tubular heat exchanger 5 installed on the upper left side of the high-pressure pump cylinder 4, a connecting seat 7 installed on the upper right side of the high-pressure pump cylinder 4, a feed hopper 8 installed on the top of the connecting seat 7, the feed hopper 8 is used to store materials, a sealing cover 11 is installed on the top of the feed hopper 8, the sealing cover 11 is used to seal the feed hopper 8, an impurity filtration mechanism 12 is provided inside the feed hopper 8, the impurity filtration mechanism 12 is used to filter impurities in the materials, a heating mechanism 19 is provided outside the high-pressure pump cylinder 4, the heating mechanism 19 is used to heat the materials inside the high-pressure pump cylinder 4, a heat dissipation hole 14 is opened on the left side of the outer side of the housing 3, a ventilation mechanism 15 is installed outside the heat dissipation hole 14, the ventilation mechanism 15 is used to accelerate the heat dissipation efficiency of the device; The impurity filtration mechanism 12 includes a metal filter screen 1201, which is disposed inside the feed tank 8. Both sides of the upper part of the metal filter screen 1201 are fixedly connected to protrusions 1202. Guide rings 1203 are fixedly connected inside each of the two protrusions 1202. Positioning pins 1204 are inserted into each of the two guide rings 1203. Grooves 1205 are formed on the outside of each of the two positioning pins 1204. A circulation return pipe 6 is installed at the top of the tubular heat exchanger 5. The bottom of the circulation return pipe 6 is disposed inside the feed tank 8 through the sealing cap 11. Insertion holes 13 are formed on both sides inside the feed tank 8. The two positioning pins 1204 are inserted into the two insertion holes. The 13-phase plug-in system has an observation window 9 installed on the front of the feed hopper 8 for viewing the material inside. A scale 10 is installed on the left side of the observation window 9 for viewing the remaining material. A display screen 20 is installed on the front of the housing 3 for easy operation. An operation button 21 is installed on the left side of the display screen 20 for controlling the start and stop of the equipment. Anti-slip blocks 2 are fixedly connected to all four sides of the bottom of the base 1. The bottom of the anti-slip blocks 2 is provided with anti-slip texture, which improves the stability of the equipment.

[0023] Specifically, when installing the metal filter 1201 inside the feed hopper 8, first unscrew the sealing cap 11 from the top of the feed hopper 8. The feed hopper 8 and the sealing cap 11 are connected by a thread, which allows for quick installation and removal of the sealing cap 11. This facilitates cleaning, wiping, and subsequent maintenance of the inside of the feed hopper 8, preventing residual material from adhering to the inner wall of the hopper and affecting the next use. After the sealing cap 11 is completely removed, the operator can directly observe the installation position of the metal filter 1201. Subsequently, the positioning pin 1204 is moved by the groove 1205 on the metal filter 1201, causing the positioning pin 1204 to move outward along the guide direction of the guide ring 1203 until the positioning pin 1204 moves to a position that is basically flush with the protrusion 1202. At this time, the positioning pin 1204 is in a releasable state, which facilitates the placement and adjustment of the metal filter 1201. Next, the metal filter 1201 is placed inside the feed hopper 8, aligning the positioning pin 1204 with the pre-drilled insertion hole 13 inside the feed hopper 8. Once the positioning pin 1204 is fully aligned with the insertion hole 13, movement is stopped. Then, a pressing force is applied to the positioning pin 1204, causing it to enter the insertion hole 13 under the limiting and guiding action of the guide ring 1203, thus achieving the positioning and fixing of the metal filter 1201. This structure ensures that the metal filter 1201 is securely installed inside the feed hopper 8, while also preventing displacement or detachment due to equipment vibration or material impact. After the metal filter 1201 is installed, vitamin K2 nano-lipid material can be added to the feed hopper 8. Because the vitamin K2 nanolipid material may contain some undissolved lipid agglomerates, crystalline particles, or tiny solid impurities mixed in from the outside during the formulation process, when the material is poured into the feed tank 8, it will first fall to the upper area of ​​the liquid impurity filtration mechanism 12 and flow downwards under its own gravity. At this time, the liquid phase and smaller particle size components in the vitamin K2 nanolipid material can smoothly pass through the pores on the surface of the metal filter 1201 into the lower space, while larger undissolved particles or impurities are blocked and retained in the upper area of ​​the metal filter 1201, thereby achieving the separation of material and impurities and playing a filtering role.

[0024] This filtration process intercepts impurities before the material enters the equipment cavity, reducing the entry of large solid particles into the subsequent high-pressure pump delivery channel and micro-jet precision microchannels. After material addition and filtration, the sealing cap 11 is screwed back onto the outside of the feed tank 8. The sealing cap 11 is tightened through the threaded structure, forming a sealed space in the feed tank 8. This prevents material splashing, leakage, or secondary entry of external impurities during operation. The equipment can then be started for subsequent homogenization and micro-jet processing. This process allows for the removal of undissolved large particles and solid impurities from the material when vitamin K2 nanoliposomes are loaded into the feed tank 8. By setting and installing a metal filter 1201 inside the feed tank 8, impurities are prevented from entering the precision cavity and microchannel structure of the equipment. This solves the problems of easy clogging of microchannels and easy wear of high-pressure pumps in existing vitamin K2 nanoliposome dynamic high-pressure micro-jet equipment during operation, improving the stability and continuous reliability of the equipment.

[0025] Please see the appendix Figure 3 -Appendix Figure 12 The ventilation mechanism 15 includes a mounting housing 1501, which is located outside the heat dissipation hole 14. A dustproof plate 1506 is installed on the left side of the mounting housing 1501. A miniature dual-head motor 1502 is fixedly connected inside the mounting housing 1501. A fan 1505 is fixedly connected to the left output end of the miniature dual-head motor 1502, and a rotating rod 1503 is fixedly connected to the right output end of the miniature dual-head motor 1502. The rotating rod 1503 passes through the interior of the dustproof plate 1506. A cleaning brush 1504 is installed on the outside of the rotating rod 1503, and the cleaning brush 1504 is in contact with the outside of the dustproof plate 1506. Sliding rods 1507 are fixedly connected to both sides inside the mounting housing 1501. Moving blocks 1508 are slidably connected to both sides of the two sliding rods 1507. A spring 1511 is fixedly connected to the middle of the two moving blocks 1508. 1. A sliding rod 1507 is mounted on the outside of the slide rod 1507. Two moving blocks 1508 are fixedly connected to a pressing rod 1509 on their outer left side. The pressing rod 1509 facilitates operation. Two moving blocks 1508 are fixedly connected to an L-shaped insert rod 1510 on their outer right side. Positioning holes 18 are provided on both sides of the inside of the housing 3. The two L-shaped insert rods 1510 are inserted into the two positioning holes 18. The positioning holes 18 facilitate the installation of the L-shaped insert rods 1510. Mounting cavities 16 are provided on both sides of the inside of the mounting housing 1501. The slide rod 1507 is fixedly connected inside the mounting cavity 16. The mounting cavity 16 facilitates the installation of the slide rod 1507. Sliding holes 17 are provided on both sides of the outside of the mounting housing 1501. The two pressing rods 1509 are slidably connected inside the two sliding holes 17. The sliding holes 17 facilitate the movement of the pressing rods 1509.

[0026] Specifically, when the device dissipates heat and ventilates through the heat dissipation hole 14 on the left side of the outer casing 3, the two pressing rods 1509 on both sides of the mounting shell 1501 are pressed inward simultaneously. During the pressing process, the pressing rods 1509 drive the moving blocks 1508 fixedly connected to their bottoms to move relative to each other along the outer surface of the slide rod 1507. As the two pressing rods 1509 continue to be pressed closer, the two moving blocks 1508 are compressed towards the center synchronously, and apply a compressive force to the spring 1511 sleeved in the middle of the slide rod 1507, causing it to undergo elastic deformation and store elastic potential energy. During the compression process, the movement of the pressing rods 1509 simultaneously drives the two L-shaped inserts 1510 fixedly connected to the outside to retract inward synchronously, so that the L-shaped inserts 1510 originally protruding from the outside of the mounting shell 1501 gradually retract into the inside of the mounting shell 1501, thereby providing space for the mounting shell 1501 to be inserted. At this time, the mounting shell 1501 is aligned with the mounting hole pre-drilled on the left side of the casing 3 and inserted into the hole as a whole. Once the mounting shell 1501 is fully inserted into the corresponding position, the external force on the two pressing rods 1509 is released. Under the rebound action of the spring 1511, the two pressing rods 1509 are reset outward, and at the same time, the L-shaped insert rod 1510 is pushed outward, so that it is inserted into the positioning holes 18 provided on both sides of the housing 3, thereby realizing the positioning and stable installation of the mounting shell 1501. After the ventilation structure is installed, the micro dual-head motor 1502 can be started during equipment operation. When powered on, the micro dual-head motor 1502 outputs power simultaneously from both its left and right ends: the output end on the left drives the fan 1505 to rotate at high speed, creating a negative pressure airflow that continuously draws hot air out of the heat dissipation holes 14 and outputs it to the outside via the dustproof plate 1506, thus achieving rapid heat dissipation from the equipment and reducing the internal temperature of the casing 3. Simultaneously, the output end on the right side of the micro dual-head motor 1502 drives the rotating rod 1503 to rotate synchronously. The rotating rod 1503 further drives the externally fixed cleaning brush 1504 to rotate. The cleaning brush 1504 is in close contact with the outer surface of the dustproof plate 1506, brushing the surface of the dustproof plate 1506 during continuous rotation, promptly removing dust, particles, and other impurities adhering to its surface, preventing long-term accumulation of impurities on the surface of the dustproof plate 1506 and blockage of the ventilation holes. Through this dynamic cleaning method, real-time cleaning of the dustproof plate 1506 can be achieved during equipment operation. By setting a ventilation mechanism 15 outside the heat dissipation hole 14 of the equipment, dust in the outside air can be continuously filtered and prevented from being blocked during the operation of the equipment, keeping the heat dissipation channel unobstructed, thereby reducing the working temperature of the high-voltage motor and related components inside the equipment, avoiding the problem of performance degradation or even damage due to overheating, and improving the heat dissipation performance and overall service life of the equipment.

[0027] Please see the appendix Figure 4 -Appendix Figure 13 The heating mechanism 19 includes two arc-shaped sleeves 1907, which are located on both sides of the outside of the high-pressure pump cylinder 4. Connecting blocks 1908 are fixedly connected to both sides of the arc-shaped sleeves 1907, and fastening bolts 1909 are threaded into the two connecting blocks 1908. A heating water tank 1901 is fixedly connected to the upper right side of the base 1. A controller 1902 is mounted on the top of the heating water tank 1901, and heating wires 1903 are mounted on both sides of the bottom of the controller 1902. The two heating wires 1903 are located inside the heating water tank 1901. Miniature circulation pumps 1906 are installed on both sides of the exterior of the heating water tank 1901. The input ends of the two miniature circulation pumps 1906 are fixedly connected to the inside of the heating water tank 1901, and the output ends of the two miniature circulation pumps 1906 are fixedly connected to delivery pipes 1904. The tops of the two delivery pipes 1904 are fixedly connected to the inside of two arc-shaped jackets 1907. A filling port 1905 is fixedly connected to the right side of the exterior of the heating water tank 1901. A cover plate is installed on the outside of the filling port 1905. Liquid is added to the interior of the heating water tank 1901 through the filling port 1905.

[0028] Specifically, when the material enters the high-pressure pump cylinder 4, an appropriate amount of liquid is first injected into the heating water tank 1901 through the filling port 1905 located at the top of the heating water tank 1901 to serve as a carrier for subsequent heat transfer. After the filling is completed, the controller 1902 is activated to control the heating wire 1903 to gradually heat up and transfer heat to the liquid inside the heating water tank 1901, so that the liquid temperature rises slowly and is maintained within the set range. When the liquid inside the heating water tank 1901 reaches the predetermined temperature, the micro circulation pump 1906 is activated to stably transport the heated liquid through the delivery pipe 1904 to the arc-shaped jacket 1907 located outside the high-pressure pump cylinder 4. Because the arc-shaped jacket 1907 is tightly fitted to the outer wall of the high-pressure pump cylinder 4, the heated liquid can transfer heat evenly to the wall of the high-pressure pump cylinder 4 through heat conduction during the flow inside the jacket. The heat is then further transferred from the cylinder wall to the material flowing inside. This heating structure can keep the material in a good flow state, ensuring that it can smoothly enter the high-pressure pump and participate in the subsequent high-pressure micro-jet processing process. Meanwhile, when the equipment needs to be repaired, cleaned or parts replaced, simply use a tool to unscrew the fastening bolt 1909 from the connecting block 1908, and the arc-shaped jacket 1907 can be completely removed from the outside of the high-pressure pump cylinder 4 without complicated operations. When reinstalling, simply follow the reverse steps to reset the arc-shaped jacket 1907 and retighten the bolt 1909 to complete the installation. By setting a recirculating heated arc-shaped jacket 1907 structure on the outside of the high-pressure pump cylinder 4, the temperature of the material is controlled, the smoothness of material conveying is improved, the overall working efficiency and operational reliability of the vitamin K2 nanoliposome dynamic high-pressure microjet equipment are improved, and the service life of the equipment is extended.

[0029] Working principle: When installing the metal filter 1201 inside the feed hopper 8, first unscrew the sealing cap 11 from the top of the feed hopper 8. The feed hopper 8 and the sealing cap 11 are threaded together, facilitating cleaning of the inside of the feed hopper 8. After opening the sealing cap 11 from the top of the feed hopper 8, move the positioning pin 1204 out from inside the guide ring 1203 through the groove 1205 until the positioning pin 1204 is flush with the protrusion 1202. Then, place the metal filter 1201 inside the feed hopper 8. Align the positioning pin 1204 with the insertion hole 13 inside the feed hopper 8 and stop moving. Then, squeeze the positioning pin 1204 so that it is inserted into the insertion hole 13 with the help of the guide ring 1203 to complete the installation. Finally, add a mortar to the inside of the feed hopper 8. When the vitamin K2 nanoliposome material falls onto the upper part of the liquid impurity filtration mechanism 12, the vitamin K2 nanoliposome material will pass through the holes of the metal filter screen 1201, while the impurities will remain on the upper part of the metal filter screen 1201. This process separates the vitamin K2 nanoliposome material from the impurities. Afterward, the sealing cap 11 can be screwed onto the outside of the feed tank 8 to start the equipment for subsequent operations. This achieves the goal of removing undissolved large particles from the material by installing the metal filter screen 1201 inside the feed tank 8 when the vitamin K2 nanoliposome material is loaded into the feed tank 8, preventing impurities from entering the precision cavity. This solves the problems of easy clogging of microchannels and easy wear of high-pressure pumps in existing vitamin K2 nanoliposome dynamic high-pressure microjet equipment, and improves the operational stability of the equipment.

[0030] When the device dissipates heat and ventilates through the heat dissipation hole 14 on the outer left side, firstly, by pressing the two pressing rods 1509 relative to each other, the two pressing rods 1509 move relative to each other outside the slide rod 1507, along with the two moving blocks 1508 fixedly connected to the bottom. When the two moving blocks 1508 move relative to each other, they press the spring 1511 sleeved in the middle of the slide rod 1507, causing the spring 1511 to deform under force. Then, when the moving blocks 1508 move relative to each other, they move relative to each other along with the two L-shaped insert rods 1510 fixedly connected to the outer right side, causing the two L-shaped insert rods 1510 to retract into the interior of the mounting shell 1501. At this time, the mounting shell 1501 is locked into the corresponding mounting hole on the outer left side of the shell 3. Then, the two pressing rods 1509 are released, and under the reaction force of the spring 1511, the two L-shaped insert rods 1510 are inserted into the positioning holes 18 on both sides inside the shell 3. During heat dissipation, the micro dual-head motor 150 is started. 2. The miniature dual-head motor 1502 drives the fan 1505, which is fixedly connected to the left output end, to rotate. The rotation of the fan 1505 transports the air exhausted from the heat dissipation hole 14 out of the dustproof plate 1506. At the same time, the miniature dual-head motor 1502 drives the rotating rod 1503, which is fixedly connected to the right output end, to rotate. The rotation of the rotating rod 1503 drives the externally fixed cleaning brush 1504 to rotate. The cleaning brush 1504 rotates outside the dustproof plate 1506 to clean the impurities attached to the outside of the dustproof plate 1506. This achieves the effect of continuous dust filtration and anti-clogging by installing a ventilation and cleaning structure outside the heat dissipation hole 14 of the equipment during operation, thus maintaining the effect of rapid heat dissipation inside the equipment. This solves the problem that the heat dissipation hole 14 of the existing vitamin K2 nanoliposome dynamic high-pressure microjet equipment is prone to dust accumulation, which leads to overheating and damage to the internal high-pressure motor. This improves the heat dissipation performance and service life of the equipment.

[0031] When the material enters the high-pressure pump cylinder 4, liquid is first added to the heating water tank 1901 through the filling port 1905. Then, with the cooperation of the controller 1902 and the heating wire 1903, the liquid entering the heating water tank 1901 is heated. Then, the heated liquid is transported to the inside of the arc-shaped jacket 1907 through the delivery pipe 1904 by the micro circulation pump 1906. Then, the heat of the liquid is transferred to the inside of the high-pressure pump cylinder 4 through the arc-shaped jacket 1907, which achieves the problem of maintaining constant temperature flow of the material and preventing phospholipid from solidifying when it cools. At the same time, when disassembling the arc-shaped jacket 1907, only the fastening bolts need to be removed. The arc-shaped jacket 1907 can be separated by removing it from the inside of the connecting block 1908. The above operation steps can be repeated during installation. This makes it easy to install a heating structure on the outside of the high-pressure pump cylinder 4 of the equipment, which can maintain the constant temperature flow of materials and prevent phospholipids from solidifying when they encounter cold. At the same time, it solves the problem that viscous materials in the existing vitamin K2 nanoliposome dynamic high-pressure microjet equipment cause the high-pressure pump to be blocked and easily jammed, thus improving the working efficiency of the equipment.

[0032] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A dynamic high-pressure microfluidic device for vitamin K2 nanoliposomes, comprising a base (1), characterized in that, The base (1) is fixedly connected to the upper part of the housing (3). A high-pressure pump cylinder (4) is installed on the right side of the outer side of the housing (3). A tubular heat exchanger (5) is installed on the upper left side of the high-pressure pump cylinder (4). A connecting seat (7) is installed on the upper right side of the high-pressure pump cylinder (4). A feed hopper (8) is installed on the top of the connecting seat (7). A sealing cover (11) is installed on the top of the feed hopper (8). An impurity filtration mechanism (12) is provided inside the feed hopper (8). A heating mechanism (19) is provided outside the high-pressure pump cylinder (4). A heat dissipation hole (14) is opened on the left side of the outer side of the housing (3). A ventilation mechanism (15) is installed outside the heat dissipation hole (14). The impurity filtration mechanism (12) includes a metal filter screen (1201), which is disposed inside the feed hopper (8). Both sides of the upper part of the metal filter screen (1201) are fixedly connected to protrusions (1202). Guide rings (1203) are fixedly connected inside the two protrusions (1202). Positioning pins (1204) are inserted inside the two guide rings (1203). Grooves (1205) are opened on the outside of the two positioning pins (1204).

2. The vitamin K2 nanoliposome dynamic high-pressure microfluidic device according to claim 1, characterized in that, The ventilation mechanism (15) includes a mounting shell (1501) located outside the heat dissipation hole (14). A dustproof plate (1506) is mounted on the left side of the mounting shell (1501). A miniature dual-head motor (1502) is fixedly connected inside the mounting shell (1501). A fan (1505) is fixedly connected to the left output end of the miniature dual-head motor (1502). A rotating rod (1503) is fixedly connected to the right output end of the miniature dual-head motor (1502). The rotating rod (1503) penetrates the interior of the dustproof plate (1506). A cleaning device is installed on the outside of the rotating rod (1503). The cleaning brush (1504) is attached to the outside of the dustproof plate (1506). The mounting shell (1501) has slide rods (1507) fixedly connected to both sides inside. The two slide rods (1507) have movable blocks (1508) slidably connected to both sides outside. The two movable blocks (1508) have springs (1511) fixedly connected to the middle. The springs (1511) are sleeved on the outside of the slide rods (1507). The two movable blocks (1508) have pressing rods (1509) fixedly connected to the left side outside. The two movable blocks (1508) have L-shaped inserts (1510) fixedly connected to the right side outside.

3. The vitamin K2 nanoliposome dynamic high-pressure microfluidic device according to claim 1, characterized in that, The heating mechanism (19) includes two arc-shaped sleeves (1907), which are located on the outer sides of the high-pressure pump cylinder (4). Connecting blocks (1908) are fixedly connected to both outer sides of the two arc-shaped sleeves (1907), and fastening bolts (1909) are threaded into the two connecting blocks (1908). A heating water tank (1901) is fixedly connected to the upper right side of the base (1). A controller (1902) is installed on the top of the heating water tank (1901), and the controller (1902) has two... Each is equipped with a heating wire (1903), and the two heating wires (1903) are located inside the heating water tank (1901). Miniature circulation pumps (1906) are installed on both sides of the outside of the heating water tank (1901). The input ends of the two miniature circulation pumps (1906) are fixedly connected to the inside of the heating water tank (1901), and the output ends of the two miniature circulation pumps (1906) are fixedly connected to delivery pipes (1904). The tops of the two delivery pipes (1904) are fixedly connected to the inside of the two arc-shaped jackets (1907).

4. The vitamin K2 nanoliposome dynamic high-pressure microfluidic device according to claim 1, characterized in that, The top of the tubular heat exchanger (5) is equipped with a circulation return pipe (6), the bottom of which is located inside the feed hopper (8) through the sealing cover (11). Insertion holes (13) are provided on both sides inside the feed hopper (8), and two positioning pins (1204) are inserted into the two insertion holes (13).

5. The vitamin K2 nanoliposome dynamic high-pressure microfluidic device according to claim 1, characterized in that, An observation window (9) is installed on the front side of the feed hopper (8), and a scale (10) is provided on the left side of the observation window (9).

6. The vitamin K2 nanoliposome dynamic high-pressure microfluidic device according to claim 2, characterized in that, The housing (3) has positioning holes (18) on both sides inside. The two L-shaped plugs (1510) are inserted into the two positioning holes (18). The mounting shell (1501) has mounting cavities (16) on both sides inside. The slide rod (1507) is fixedly connected inside the mounting cavity (16).

7. The vitamin K2 nanoliposome dynamic high-pressure microfluidic device according to claim 2, characterized in that, The mounting housing (1501) has sliding holes (17) on both sides of its exterior, and the two pressing rods (1509) are slidably connected inside the two sliding holes (17).

8. The vitamin K2 nanoliposome dynamic high-pressure microfluidic device according to claim 3, characterized in that, The heating water tank (1901) is fixedly connected to the outside right side of the filling port (1905), and the filling port (1905) is covered with a cover plate.

9. The vitamin K2 nanoliposome dynamic high-pressure microfluidic device according to claim 1, characterized in that, A display screen (20) is installed on the front side of the outer shell (3), and an operation button (21) is installed on the left side of the outer shell (20).

10. The vitamin K2 nanoliposome dynamic high-pressure microfluidic device according to claim 1, characterized in that, The base (1) is fixedly connected with anti-slip blocks (2) around its bottom, and the bottom of each anti-slip block (2) has anti-slip texture.

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